| Stem definition | Drug id | CAS RN |
|---|---|---|
| granulocyte colony stimulating factor (G-CSF) type substances | 4987 | 121181-53-1 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of NEUTROPENIA, preparation and collection of blood progenitor cells, and for use in PERIPHERAL BLOOD STEM CELL TRANSPLANTATION.
|
| Dose | Unit | Route |
|---|---|---|
| 0.35 | mg | P |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 15, 2008 | EMA | ||
| Feb. 20, 1991 | FDA | AMGEN | |
| June 23, 2021 | PMDA | KYOWA KIRIN Co., Ltd. |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 2172.81 | 12.97 | 1276 | 48575 | 117173 | 63321998 |
| Neutropenia | 1163.89 | 12.97 | 1017 | 48834 | 173988 | 63265183 |
| Thrombocytopenia | 570.02 | 12.97 | 646 | 49205 | 150511 | 63288660 |
| Bone pain | 543.92 | 12.97 | 403 | 49448 | 54238 | 63384933 |
| Pyrexia | 460.80 | 12.97 | 1087 | 48764 | 469391 | 62969780 |
| Pancytopenia | 390.22 | 12.97 | 429 | 49422 | 96504 | 63342667 |
| White blood cell count decreased | 344.18 | 12.97 | 482 | 49369 | 138622 | 63300549 |
| Mucosal inflammation | 321.22 | 12.97 | 278 | 49573 | 46650 | 63392521 |
| Neutrophil count decreased | 316.94 | 12.97 | 299 | 49552 | 56107 | 63383064 |
| Neutropenic sepsis | 291.79 | 12.97 | 174 | 49677 | 16264 | 63422907 |
| Platelet count decreased | 263.06 | 12.97 | 386 | 49465 | 115736 | 63323435 |
| Staphylococcal bacteraemia | 246.76 | 12.97 | 109 | 49742 | 5421 | 63433750 |
| Anaemia | 226.67 | 12.97 | 621 | 49230 | 292809 | 63146362 |
| Sepsis | 178.20 | 12.97 | 380 | 49471 | 152743 | 63286428 |
| Cytokine release syndrome | 175.53 | 12.97 | 120 | 49731 | 14194 | 63424977 |
| Leukopenia | 169.26 | 12.97 | 253 | 49598 | 77037 | 63362134 |
| Drug ineffective | 158.61 | 12.97 | 369 | 49482 | 1044396 | 62394775 |
| Death | 157.05 | 12.97 | 645 | 49206 | 373736 | 63065435 |
| Rheumatoid arthritis | 153.93 | 12.97 | 12 | 49839 | 253807 | 63185364 |
| Computerised tomogram thorax abnormal | 145.26 | 12.97 | 54 | 49797 | 1709 | 63437462 |
| Contraindicated product administered | 145.07 | 12.97 | 6 | 49845 | 217642 | 63221529 |
| Septic shock | 144.29 | 12.97 | 217 | 49634 | 66412 | 63372759 |
| Disease progression | 140.86 | 12.97 | 303 | 49548 | 122455 | 63316716 |
| Acute myeloid leukaemia | 134.61 | 12.97 | 110 | 49741 | 17037 | 63422134 |
| Joint swelling | 130.83 | 12.97 | 47 | 49804 | 327619 | 63111552 |
| Off label use | 130.66 | 12.97 | 940 | 48911 | 673522 | 62765649 |
| Drug intolerance | 128.92 | 12.97 | 41 | 49810 | 308620 | 63130551 |
| Synovitis | 128.56 | 12.97 | 4 | 49847 | 186914 | 63252257 |
| White blood cell count abnormal | 118.42 | 12.97 | 69 | 49782 | 6173 | 63432998 |
| Glossodynia | 115.72 | 12.97 | 6 | 49845 | 178870 | 63260301 |
| Arthropathy | 113.75 | 12.97 | 23 | 49828 | 234769 | 63204402 |
| Systemic lupus erythematosus | 113.38 | 12.97 | 15 | 49836 | 208903 | 63230268 |
| Disease recurrence | 109.04 | 12.97 | 122 | 49729 | 27908 | 63411263 |
| Bone marrow failure | 108.02 | 12.97 | 124 | 49727 | 29166 | 63410005 |
| Fall | 107.79 | 12.97 | 90 | 49761 | 392244 | 63046927 |
| Hypoxia | 107.69 | 12.97 | 179 | 49672 | 59613 | 63379558 |
| Abdominal discomfort | 103.39 | 12.97 | 62 | 49789 | 320823 | 63118348 |
| Computerised tomogram thorax | 99.25 | 12.97 | 29 | 49822 | 420 | 63438751 |
| Atelectasis | 98.49 | 12.97 | 102 | 49749 | 21381 | 63417790 |
| Aplastic anaemia | 98.27 | 12.97 | 72 | 49779 | 9497 | 63429674 |
| Swelling | 97.78 | 12.97 | 47 | 49804 | 275331 | 63163840 |
| Aortitis | 95.85 | 12.97 | 35 | 49816 | 1052 | 63438119 |
| Therapeutic product effect decreased | 95.50 | 12.97 | 18 | 49833 | 193169 | 63246002 |
| Musculoskeletal stiffness | 93.87 | 12.97 | 16 | 49835 | 184602 | 63254569 |
| Wound | 90.32 | 12.97 | 11 | 49840 | 163252 | 63275919 |
| Diarrhoea | 88.11 | 12.97 | 902 | 48949 | 714464 | 62724707 |
| Peripheral sensory neuropathy | 87.89 | 12.97 | 61 | 49790 | 7390 | 63431781 |
| Treatment failure | 87.50 | 12.97 | 24 | 49827 | 199019 | 63240152 |
| Hepatic enzyme increased | 85.98 | 12.97 | 26 | 49825 | 202302 | 63236869 |
| Drug hypersensitivity | 83.17 | 12.97 | 73 | 49778 | 310614 | 63128557 |
| Pain | 81.78 | 12.97 | 303 | 49548 | 740325 | 62698846 |
| Cytomegalovirus infection | 79.45 | 12.97 | 90 | 49761 | 20862 | 63418309 |
| Pneumonia | 78.16 | 12.97 | 619 | 49232 | 456148 | 62983023 |
| Plasma cell myeloma | 76.36 | 12.97 | 116 | 49735 | 35789 | 63403382 |
| Neuropathy peripheral | 72.48 | 12.97 | 225 | 49626 | 113442 | 63325729 |
| Pericarditis | 72.44 | 12.97 | 9 | 49842 | 131570 | 63307601 |
| Blood magnesium decreased | 72.21 | 12.97 | 69 | 49782 | 13129 | 63426042 |
| Discomfort | 72.03 | 12.97 | 21 | 49830 | 167353 | 63271818 |
| Multiple organ dysfunction syndrome | 71.93 | 12.97 | 146 | 49705 | 56606 | 63382565 |
| Acute respiratory distress syndrome | 71.02 | 12.97 | 90 | 49761 | 23444 | 63415727 |
| Myelodysplastic syndrome | 70.49 | 12.97 | 76 | 49775 | 16678 | 63422493 |
| Tonsillar disorder | 65.59 | 12.97 | 27 | 49824 | 1126 | 63438045 |
| Clostridium difficile infection | 64.09 | 12.97 | 97 | 49754 | 29825 | 63409346 |
| Capillary leak syndrome | 63.15 | 12.97 | 32 | 49819 | 2168 | 63437003 |
| Arthralgia | 62.82 | 12.97 | 233 | 49618 | 569477 | 62869694 |
| Human bocavirus infection | 62.77 | 12.97 | 20 | 49831 | 393 | 63438778 |
| Toxicity to various agents | 62.70 | 12.97 | 61 | 49790 | 247189 | 63191982 |
| Heart rate abnormal | 59.52 | 12.97 | 41 | 49810 | 4906 | 63434265 |
| Hypokalaemia | 59.39 | 12.97 | 198 | 49653 | 103606 | 63335565 |
| Lymphadenitis | 58.96 | 12.97 | 35 | 49816 | 3240 | 63435931 |
| Colitis | 58.15 | 12.97 | 122 | 49729 | 48406 | 63390765 |
| Neurotoxicity | 57.76 | 12.97 | 69 | 49782 | 16921 | 63422250 |
| Neutrophil count abnormal | 57.60 | 12.97 | 33 | 49818 | 2859 | 63436312 |
| Febrile bone marrow aplasia | 57.50 | 12.97 | 47 | 49804 | 7278 | 63431893 |
| Asthma | 54.88 | 12.97 | 16 | 49835 | 127545 | 63311626 |
| Helicobacter infection | 54.51 | 12.97 | 5 | 49846 | 92780 | 63346391 |
| Nasopharyngitis | 54.38 | 12.97 | 72 | 49779 | 254185 | 63184986 |
| Acute febrile neutrophilic dermatosis | 54.11 | 12.97 | 32 | 49819 | 2942 | 63436229 |
| Somnolence | 54.09 | 12.97 | 37 | 49814 | 178648 | 63260523 |
| Infusion related reaction | 54.08 | 12.97 | 68 | 49783 | 245453 | 63193718 |
| Hypoalbuminaemia | 54.02 | 12.97 | 56 | 49795 | 11749 | 63427422 |
| Irritable bowel syndrome | 52.53 | 12.97 | 3 | 49848 | 82409 | 63356762 |
| Alveolitis | 52.08 | 12.97 | 31 | 49820 | 2884 | 63436287 |
| Headache | 51.84 | 12.97 | 289 | 49562 | 632952 | 62806219 |
| Leukocytosis | 51.24 | 12.97 | 81 | 49770 | 25854 | 63413317 |
| Rheumatoid factor positive | 51.08 | 12.97 | 4 | 49847 | 84402 | 63354769 |
| Immune effector cell-associated neurotoxicity syndrome | 50.83 | 12.97 | 28 | 49823 | 2249 | 63436922 |
| Neutropenic colitis | 50.37 | 12.97 | 31 | 49820 | 3064 | 63436107 |
| Excessive eye blinking | 50.01 | 12.97 | 23 | 49828 | 1257 | 63437914 |
| Palmar-plantar erythrodysaesthesia syndrome | 49.84 | 12.97 | 75 | 49776 | 22940 | 63416231 |
| Gait disturbance | 49.01 | 12.97 | 43 | 49808 | 183135 | 63256036 |
| Sinusitis | 47.63 | 12.97 | 65 | 49786 | 226588 | 63212583 |
| Acute graft versus host disease in skin | 47.26 | 12.97 | 31 | 49820 | 3421 | 63435750 |
| Crystal nephropathy | 46.81 | 12.97 | 20 | 49831 | 916 | 63438255 |
| Peripheral swelling | 46.68 | 12.97 | 86 | 49765 | 265856 | 63173315 |
| Hypophosphataemia | 46.62 | 12.97 | 51 | 49800 | 11375 | 63427796 |
| Bronchopulmonary aspergillosis | 45.08 | 12.97 | 44 | 49807 | 8591 | 63430580 |
| Acute myeloid leukaemia recurrent | 44.82 | 12.97 | 23 | 49828 | 1600 | 63437571 |
| Osteoarthritis | 44.77 | 12.97 | 10 | 49841 | 95333 | 63343838 |
| Neoplasm progression | 44.13 | 12.97 | 92 | 49759 | 36336 | 63402835 |
| Blood cholesterol increased | 43.88 | 12.97 | 10 | 49841 | 94022 | 63345149 |
| Enterobacter infection | 43.26 | 12.97 | 25 | 49826 | 2202 | 63436969 |
| Fibromyalgia | 43.06 | 12.97 | 6 | 49845 | 80414 | 63358757 |
| Depression | 42.65 | 12.97 | 55 | 49796 | 196437 | 63242734 |
| Drug abuse | 42.35 | 12.97 | 4 | 49847 | 72514 | 63366657 |
| Colony stimulating factor therapy | 42.24 | 12.97 | 14 | 49837 | 313 | 63438858 |
| Rhinovirus infection | 41.87 | 12.97 | 32 | 49819 | 4497 | 63434674 |
| Overdose | 41.78 | 12.97 | 19 | 49832 | 115059 | 63324112 |
| Weight increased | 41.75 | 12.97 | 89 | 49762 | 260703 | 63178468 |
| Product use issue | 41.71 | 12.97 | 68 | 49783 | 220452 | 63218719 |
| Clostridium difficile colitis | 41.68 | 12.97 | 65 | 49786 | 20504 | 63418667 |
| Escherichia bacteraemia | 41.65 | 12.97 | 30 | 49821 | 3853 | 63435318 |
| Human herpesvirus 6 infection | 41.57 | 12.97 | 27 | 49824 | 2930 | 63436241 |
| Pseudomonal sepsis | 41.51 | 12.97 | 25 | 49826 | 2376 | 63436795 |
| Drug interaction | 41.18 | 12.97 | 73 | 49778 | 229058 | 63210113 |
| Agranulocytosis | 40.95 | 12.97 | 72 | 49779 | 25062 | 63414109 |
| Cytopenia | 40.90 | 12.97 | 48 | 49803 | 11553 | 63427618 |
| Therapeutic product effect incomplete | 40.44 | 12.97 | 24 | 49827 | 125032 | 63314139 |
| Injury | 40.33 | 12.97 | 5 | 49846 | 73242 | 63365929 |
| Acute graft versus host disease | 40.31 | 12.97 | 31 | 49820 | 4397 | 63434774 |
| Nasal disorder | 39.90 | 12.97 | 26 | 49825 | 2838 | 63436333 |
| Lymphadenopathy | 39.62 | 12.97 | 91 | 49760 | 38367 | 63400804 |
| Thrombotic microangiopathy | 39.42 | 12.97 | 45 | 49806 | 10516 | 63428655 |
| Intentional product use issue | 38.01 | 12.97 | 27 | 49824 | 127865 | 63311306 |
| Chronic graft versus host disease | 38.01 | 12.97 | 26 | 49825 | 3076 | 63436095 |
| Ejection fraction decreased | 37.72 | 12.97 | 65 | 49786 | 22267 | 63416904 |
| Condition aggravated | 37.70 | 12.97 | 175 | 49676 | 402042 | 63037129 |
| Herpes simplex | 37.42 | 12.97 | 39 | 49812 | 8232 | 63430939 |
| Lymphopenia | 37.26 | 12.97 | 58 | 49793 | 18269 | 63420902 |
| Psoriasis | 37.23 | 12.97 | 11 | 49840 | 86946 | 63352225 |
| Blood stem cell harvest failure | 36.69 | 12.97 | 9 | 49842 | 63 | 63439108 |
| Secondary immunodeficiency | 36.47 | 12.97 | 19 | 49832 | 1364 | 63437807 |
| Cytomegalovirus test positive | 36.28 | 12.97 | 25 | 49826 | 2993 | 63436178 |
| Constipation | 36.24 | 12.97 | 301 | 49550 | 224642 | 63214529 |
| Diffuse large B-cell lymphoma refractory | 35.62 | 12.97 | 18 | 49833 | 1212 | 63437959 |
| Myocardial infarction | 35.48 | 12.97 | 17 | 49834 | 99876 | 63339295 |
| Nausea | 35.23 | 12.97 | 898 | 48953 | 853573 | 62585598 |
| Suicidal ideation | 35.01 | 12.97 | 4 | 49847 | 62417 | 63376754 |
| Toxic erythema of chemotherapy | 34.87 | 12.97 | 10 | 49841 | 135 | 63439036 |
| Injection site erythema | 34.74 | 12.97 | 11 | 49840 | 83163 | 63356008 |
| Hypersensitivity | 34.64 | 12.97 | 116 | 49735 | 292569 | 63146602 |
| White blood cell count increased | 34.59 | 12.97 | 100 | 49751 | 48461 | 63390710 |
| Pleural effusion | 34.57 | 12.97 | 155 | 49696 | 93055 | 63346116 |
| Neoplasm recurrence | 34.44 | 12.97 | 23 | 49828 | 2615 | 63436556 |
| Mobility decreased | 34.18 | 12.97 | 27 | 49824 | 121132 | 63318039 |
| Impaired healing | 34.12 | 12.97 | 19 | 49832 | 102523 | 63336648 |
| Loss of personal independence in daily activities | 33.88 | 12.97 | 17 | 49834 | 97273 | 63341898 |
| Pneumatosis intestinalis | 33.84 | 12.97 | 22 | 49829 | 2391 | 63436780 |
| Folliculitis | 33.78 | 12.97 | 7 | 49844 | 70310 | 63368861 |
| Pneumonia moraxella | 33.67 | 12.97 | 8 | 49843 | 48 | 63439123 |
| Cystitis haemorrhagic | 33.51 | 12.97 | 27 | 49824 | 4096 | 63435075 |
| Anxiety | 33.36 | 12.97 | 76 | 49775 | 217465 | 63221706 |
| Engraft failure | 33.07 | 12.97 | 12 | 49839 | 354 | 63438817 |
| Maternal exposure before pregnancy | 32.88 | 12.97 | 35 | 49816 | 7568 | 63431603 |
| Blood pressure increased | 32.52 | 12.97 | 48 | 49803 | 162014 | 63277157 |
| Bacillus infection | 32.31 | 12.97 | 15 | 49836 | 838 | 63438333 |
| Balance disorder | 32.14 | 12.97 | 13 | 49838 | 84409 | 63354762 |
| Sleep disorder | 31.98 | 12.97 | 12 | 49839 | 81554 | 63357617 |
| Gastroenteritis norovirus | 31.85 | 12.97 | 20 | 49831 | 2048 | 63437123 |
| Venoocclusive liver disease | 31.75 | 12.97 | 28 | 49823 | 4807 | 63434364 |
| Cerebellar stroke | 31.74 | 12.97 | 11 | 49840 | 283 | 63438888 |
| Epistaxis | 30.87 | 12.97 | 126 | 49725 | 72599 | 63366572 |
| Bacterial infection | 30.66 | 12.97 | 55 | 49796 | 19444 | 63419727 |
| Acute lymphocytic leukaemia | 30.62 | 12.97 | 21 | 49830 | 2495 | 63436676 |
| Ill-defined disorder | 30.46 | 12.97 | 13 | 49838 | 81742 | 63357429 |
| Decreased appetite | 30.39 | 12.97 | 316 | 49535 | 250736 | 63188435 |
| Vomiting | 30.14 | 12.97 | 611 | 49240 | 559006 | 62880165 |
| Bacteraemia | 29.97 | 12.97 | 51 | 49800 | 17297 | 63421874 |
| Immune reconstitution inflammatory syndrome | 29.90 | 12.97 | 30 | 49821 | 6054 | 63433117 |
| Haemophagocytic lymphohistiocytosis | 29.49 | 12.97 | 39 | 49812 | 10588 | 63428583 |
| Cholangitis infective | 29.38 | 12.97 | 11 | 49840 | 355 | 63438816 |
| Wheezing | 28.64 | 12.97 | 20 | 49831 | 95575 | 63343596 |
| Stress | 27.85 | 12.97 | 9 | 49842 | 67158 | 63372013 |
| Acute lymphocytic leukaemia recurrent | 27.76 | 12.97 | 19 | 49832 | 2250 | 63436921 |
| Pulmonary haemorrhage | 27.48 | 12.97 | 31 | 49820 | 7150 | 63432021 |
| Platelet count abnormal | 27.28 | 12.97 | 22 | 49829 | 3342 | 63435829 |
| Confusional state | 27.06 | 12.97 | 95 | 49756 | 236285 | 63202886 |
| Alopecia | 27.01 | 12.97 | 155 | 49696 | 337381 | 63101790 |
| Autoimmune haemolytic anaemia | 26.98 | 12.97 | 25 | 49826 | 4576 | 63434595 |
| Product dose omission issue | 26.94 | 12.97 | 94 | 49757 | 234219 | 63204952 |
| Oral candidiasis | 26.93 | 12.97 | 57 | 49794 | 22741 | 63416430 |
| Injection site swelling | 26.80 | 12.97 | 3 | 49848 | 47569 | 63391602 |
| Bone marrow disorder | 26.69 | 12.97 | 19 | 49832 | 2395 | 63436776 |
| Haemoglobin decreased | 26.32 | 12.97 | 200 | 49651 | 145285 | 63293886 |
| White blood cell disorder | 25.87 | 12.97 | 19 | 49832 | 2515 | 63436656 |
| Graft versus host disease | 25.55 | 12.97 | 29 | 49822 | 6734 | 63432437 |
| Biliary tract infection | 25.52 | 12.97 | 12 | 49839 | 690 | 63438481 |
| Enteritis | 25.49 | 12.97 | 32 | 49819 | 8254 | 63430917 |
| Aspergilloma | 25.35 | 12.97 | 9 | 49842 | 249 | 63438922 |
| Blood lactate dehydrogenase increased | 25.26 | 12.97 | 56 | 49795 | 23060 | 63416111 |
| Contusion | 25.01 | 12.97 | 50 | 49801 | 149994 | 63289177 |
| Hypertension | 24.69 | 12.97 | 124 | 49727 | 279179 | 63159992 |
| Blood culture positive | 24.48 | 12.97 | 24 | 49827 | 4711 | 63434460 |
| Blood pressure systolic increased | 24.31 | 12.97 | 4 | 49847 | 47393 | 63391778 |
| Stem cell transplant | 24.06 | 12.97 | 16 | 49835 | 1806 | 63437365 |
| Deep vein thrombosis | 23.68 | 12.97 | 129 | 49722 | 83671 | 63355500 |
| Arthritis | 23.57 | 12.97 | 34 | 49817 | 115887 | 63323284 |
| Graft versus host disease in skin | 23.56 | 12.97 | 19 | 49832 | 2886 | 63436285 |
| Pseudomonas infection | 23.51 | 12.97 | 36 | 49815 | 11177 | 63427994 |
| Respiratory failure | 23.11 | 12.97 | 148 | 49703 | 101710 | 63337461 |
| Acute graft versus host disease in liver | 22.95 | 12.97 | 11 | 49840 | 660 | 63438511 |
| Thrombosis | 22.75 | 12.97 | 106 | 49745 | 64649 | 63374522 |
| Blister | 22.73 | 12.97 | 42 | 49809 | 129772 | 63309399 |
| Feeling abnormal | 22.61 | 12.97 | 52 | 49799 | 148340 | 63290831 |
| Cytogenetic abnormality | 22.41 | 12.97 | 10 | 49841 | 509 | 63438662 |
| Biliary sepsis | 22.31 | 12.97 | 12 | 49839 | 919 | 63438252 |
| Dizziness | 22.25 | 12.97 | 223 | 49628 | 429702 | 63009469 |
| Vulvovaginal candidiasis | 22.08 | 12.97 | 19 | 49832 | 3156 | 63436015 |
| Follicular lymphoma stage IV | 21.83 | 12.97 | 4 | 49847 | 4 | 63439167 |
| Systemic candida | 21.73 | 12.97 | 19 | 49832 | 3226 | 63435945 |
| Hyperchlorhydria | 21.52 | 12.97 | 15 | 49836 | 1829 | 63437342 |
| Blood pressure fluctuation | 21.46 | 12.97 | 5 | 49846 | 46312 | 63392859 |
| Metastases to liver | 21.18 | 12.97 | 53 | 49798 | 23586 | 63415585 |
| Neuroblastoma recurrent | 21.06 | 12.97 | 6 | 49845 | 79 | 63439092 |
| Tumour necrosis | 20.88 | 12.97 | 11 | 49840 | 808 | 63438363 |
| Muscle twitching | 20.76 | 12.97 | 47 | 49804 | 19621 | 63419550 |
| Splenic rupture | 20.76 | 12.97 | 13 | 49838 | 1325 | 63437846 |
| Injection site reaction | 20.72 | 12.97 | 10 | 49841 | 58514 | 63380657 |
| Cerebrovascular accident | 20.69 | 12.97 | 33 | 49818 | 107991 | 63331180 |
| Abdominal wall wound | 20.59 | 12.97 | 6 | 49845 | 86 | 63439085 |
| Device related infection | 20.49 | 12.97 | 52 | 49799 | 23340 | 63415831 |
| Peripheral motor neuropathy | 20.38 | 12.97 | 14 | 49837 | 1667 | 63437504 |
| Rash maculo-papular | 20.18 | 12.97 | 63 | 49788 | 31833 | 63407338 |
| Acute graft versus host disease in intestine | 19.88 | 12.97 | 14 | 49837 | 1735 | 63437436 |
| Escherichia sepsis | 19.82 | 12.97 | 22 | 49829 | 4985 | 63434186 |
| Staphylococcal sepsis | 19.79 | 12.97 | 28 | 49823 | 8100 | 63431071 |
| Myeloblast percentage decreased | 19.58 | 12.97 | 5 | 49846 | 42 | 63439129 |
| Splenomegaly | 19.53 | 12.97 | 33 | 49818 | 11124 | 63428047 |
| Exposure during pregnancy | 19.53 | 12.97 | 60 | 49791 | 155487 | 63283684 |
| Nasal congestion | 19.32 | 12.97 | 14 | 49837 | 65646 | 63373525 |
| Diffuse large B-cell lymphoma | 19.19 | 12.97 | 25 | 49826 | 6687 | 63432484 |
| Tumour lysis syndrome | 19.04 | 12.97 | 29 | 49822 | 8961 | 63430210 |
| Liver injury | 19.02 | 12.97 | 12 | 49839 | 60508 | 63378663 |
| Bone marrow transplant | 19.01 | 12.97 | 10 | 49841 | 732 | 63438439 |
| Adult T-cell lymphoma/leukaemia | 18.93 | 12.97 | 7 | 49844 | 218 | 63438953 |
| Embolism | 18.90 | 12.97 | 27 | 49824 | 7879 | 63431292 |
| Pruritus | 18.89 | 12.97 | 187 | 49664 | 361266 | 63077905 |
| Chronic graft versus host disease in skin | 18.87 | 12.97 | 10 | 49841 | 743 | 63438428 |
| Gait inability | 18.82 | 12.97 | 9 | 49842 | 52950 | 63386221 |
| Blood bilirubin abnormal | 18.75 | 12.97 | 11 | 49840 | 996 | 63438175 |
| Interstitial lung disease | 18.65 | 12.97 | 97 | 49754 | 61811 | 63377360 |
| Cystitis bacterial | 18.61 | 12.97 | 7 | 49844 | 229 | 63438942 |
| Pneumonitis | 18.22 | 12.97 | 65 | 49786 | 35157 | 63404014 |
| Neutropenic infection | 18.04 | 12.97 | 12 | 49839 | 1355 | 63437816 |
| Full blood count decreased | 17.96 | 12.97 | 53 | 49798 | 25971 | 63413200 |
| Breast cancer metastatic | 17.76 | 12.97 | 33 | 49818 | 11985 | 63427186 |
| Folate deficiency | 17.60 | 12.97 | 15 | 49836 | 2460 | 63436711 |
| Migraine | 17.59 | 12.97 | 34 | 49817 | 103312 | 63335859 |
| Immune-mediated enterocolitis | 17.53 | 12.97 | 14 | 49837 | 2097 | 63437074 |
| Lymph node pain | 17.49 | 12.97 | 12 | 49839 | 1426 | 63437745 |
| Sciatica | 17.37 | 12.97 | 3 | 49848 | 34321 | 63404850 |
| Aplasia | 17.35 | 12.97 | 19 | 49832 | 4240 | 63434931 |
| Sinusitis fungal | 17.06 | 12.97 | 13 | 49838 | 1818 | 63437353 |
| Muscular weakness | 16.97 | 12.97 | 45 | 49806 | 122308 | 63316863 |
| Radiation fibrosis - lung | 16.84 | 12.97 | 4 | 49847 | 24 | 63439147 |
| Venous thrombosis | 16.81 | 12.97 | 20 | 49831 | 4882 | 63434289 |
| Syphilis | 16.80 | 12.97 | 6 | 49845 | 169 | 63439002 |
| Hypotension | 16.78 | 12.97 | 304 | 49547 | 272300 | 63166871 |
| Kidney malrotation | 16.70 | 12.97 | 4 | 49847 | 25 | 63439146 |
| Pneumonia fungal | 16.67 | 12.97 | 21 | 49830 | 5434 | 63433737 |
| Hydronephrosis | 16.67 | 12.97 | 30 | 49821 | 10632 | 63428539 |
| Acute interstitial pneumonitis | 16.66 | 12.97 | 9 | 49842 | 695 | 63438476 |
| Femur fracture | 16.60 | 12.97 | 6 | 49845 | 41750 | 63397421 |
| Chemotherapy | 16.48 | 12.97 | 12 | 49839 | 1567 | 63437604 |
| Engraftment syndrome | 16.39 | 12.97 | 8 | 49843 | 500 | 63438671 |
| Disseminated intravascular coagulation | 16.33 | 12.97 | 42 | 49809 | 19009 | 63420162 |
| Enterococcal infection | 16.18 | 12.97 | 25 | 49826 | 7823 | 63431348 |
| Onycholysis | 16.10 | 12.97 | 12 | 49839 | 1624 | 63437547 |
| Myelosuppression | 16.10 | 12.97 | 48 | 49803 | 23655 | 63415516 |
| Product storage error | 16.08 | 12.97 | 36 | 49815 | 14920 | 63424251 |
| Dermatitis bullous | 16.02 | 12.97 | 26 | 49825 | 8482 | 63430689 |
| Dry eye | 15.97 | 12.97 | 6 | 49845 | 40755 | 63398416 |
| Granulomatous liver disease | 15.82 | 12.97 | 9 | 49842 | 769 | 63438402 |
| Cardiac failure | 15.81 | 12.97 | 122 | 49729 | 89020 | 63350151 |
| Urticaria | 15.58 | 12.97 | 72 | 49779 | 165730 | 63273441 |
| Maternal exposure during pregnancy | 15.53 | 12.97 | 105 | 49746 | 219957 | 63219214 |
| Memory impairment | 15.50 | 12.97 | 37 | 49814 | 104221 | 63334950 |
| Psychiatric decompensation | 15.43 | 12.97 | 11 | 49840 | 1390 | 63437781 |
| Therapy partial responder | 15.41 | 12.97 | 29 | 49822 | 10629 | 63428542 |
| Ascites | 15.29 | 12.97 | 68 | 49783 | 40660 | 63398511 |
| Chronic obstructive pulmonary disease | 15.25 | 12.97 | 16 | 49835 | 62670 | 63376501 |
| Tumour marker increased | 15.15 | 12.97 | 19 | 49832 | 4896 | 63434275 |
| Splenic haematoma | 15.12 | 12.97 | 5 | 49846 | 111 | 63439060 |
| Norovirus test positive | 15.10 | 12.97 | 6 | 49845 | 228 | 63438943 |
| Klebsiella sepsis | 15.06 | 12.97 | 11 | 49840 | 1444 | 63437727 |
| Road traffic accident | 15.02 | 12.97 | 5 | 49846 | 36627 | 63402544 |
| Injection site pain | 14.95 | 12.97 | 52 | 49799 | 129748 | 63309423 |
| Aplasia pure red cell | 14.88 | 12.97 | 18 | 49833 | 4469 | 63434702 |
| Chronic lymphocytic leukaemia recurrent | 14.86 | 12.97 | 6 | 49845 | 238 | 63438933 |
| Choriocarcinoma | 14.78 | 12.97 | 4 | 49847 | 43 | 63439128 |
| Metastases to bone | 14.69 | 12.97 | 43 | 49808 | 20976 | 63418195 |
| Back pain | 14.68 | 12.97 | 290 | 49561 | 263855 | 63175316 |
| Candida test positive | 14.64 | 12.97 | 9 | 49842 | 887 | 63438284 |
| Cytomegalovirus viraemia | 14.56 | 12.97 | 20 | 49831 | 5629 | 63433542 |
| Muscle spasms | 14.55 | 12.97 | 68 | 49783 | 156082 | 63283089 |
| Naevus haemorrhage | 14.52 | 12.97 | 5 | 49846 | 126 | 63439045 |
| Bronchitis | 14.42 | 12.97 | 50 | 49801 | 124885 | 63314286 |
| Hilar lymphadenopathy | 14.40 | 12.97 | 10 | 49841 | 1212 | 63437959 |
| Blood bilirubin | 14.30 | 12.97 | 3 | 49848 | 9 | 63439162 |
| Toxic epidermal necrolysis | 14.18 | 12.97 | 48 | 49803 | 25286 | 63413885 |
| Haematotoxicity | 14.17 | 12.97 | 26 | 49825 | 9350 | 63429821 |
| Bone marrow infiltration | 14.15 | 12.97 | 8 | 49843 | 676 | 63438495 |
| Colitis ischaemic | 14.10 | 12.97 | 28 | 49823 | 10680 | 63428491 |
| Joint injury | 14.09 | 12.97 | 3 | 49848 | 29569 | 63409602 |
| Minimal residual disease | 14.06 | 12.97 | 5 | 49846 | 139 | 63439032 |
| Craniocerebral injury | 13.98 | 12.97 | 14 | 49837 | 2818 | 63436353 |
| Tremor | 13.91 | 12.97 | 55 | 49796 | 132184 | 63306987 |
| Face oedema | 13.79 | 12.97 | 41 | 49810 | 20171 | 63419000 |
| Venoocclusive disease | 13.68 | 12.97 | 12 | 49839 | 2046 | 63437125 |
| Nephrolithiasis | 13.64 | 12.97 | 8 | 49843 | 41976 | 63397195 |
| Irritability | 13.58 | 12.97 | 4 | 49847 | 31690 | 63407481 |
| Diarrhoea haemorrhagic | 13.57 | 12.97 | 25 | 49826 | 9017 | 63430154 |
| Osteoporosis | 13.54 | 12.97 | 15 | 49836 | 57323 | 63381848 |
| Terminal ileitis | 13.50 | 12.97 | 8 | 49843 | 738 | 63438433 |
| Monocytopenia | 13.44 | 12.97 | 4 | 49847 | 62 | 63439109 |
| Enterocolitis | 13.44 | 12.97 | 23 | 49828 | 7835 | 63431336 |
| Nasal crusting | 13.36 | 12.97 | 6 | 49845 | 310 | 63438861 |
| Wrong product administered | 13.28 | 12.97 | 20 | 49831 | 6121 | 63433050 |
| Malignant neoplasm progression | 13.25 | 12.97 | 110 | 49741 | 82011 | 63357160 |
| Hepatic function abnormal | 13.19 | 12.97 | 61 | 49790 | 37081 | 63402090 |
| Pneumocystis jirovecii pneumonia | 13.19 | 12.97 | 36 | 49815 | 16878 | 63422293 |
| Sedation | 13.18 | 12.97 | 7 | 49844 | 38802 | 63400369 |
| Ileus | 13.18 | 12.97 | 33 | 49818 | 14692 | 63424479 |
| Viral uveitis | 13.04 | 12.97 | 4 | 49847 | 69 | 63439102 |
| Cytomegalovirus chorioretinitis | 13.02 | 12.97 | 11 | 49840 | 1782 | 63437389 |
| Hepatic failure | 12.99 | 12.97 | 59 | 49792 | 35597 | 63403574 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 1602.07 | 13.20 | 1333 | 41941 | 135516 | 34778141 |
| Neutropenia | 669.78 | 13.20 | 893 | 42381 | 155885 | 34757772 |
| Pancytopenia | 270.86 | 13.20 | 449 | 42825 | 94708 | 34818949 |
| Thrombocytopenia | 270.03 | 13.20 | 596 | 42678 | 155651 | 34758006 |
| White blood cell count decreased | 234.44 | 13.20 | 422 | 42852 | 95023 | 34818634 |
| Pyrexia | 226.51 | 13.20 | 911 | 42363 | 332102 | 34581555 |
| Neutrophil count decreased | 215.41 | 13.20 | 290 | 42984 | 50814 | 34862843 |
| Bone pain | 191.06 | 13.20 | 177 | 43097 | 20509 | 34893148 |
| Bone marrow failure | 154.83 | 13.20 | 186 | 43088 | 29067 | 34884590 |
| Sepsis | 144.78 | 13.20 | 494 | 42780 | 166067 | 34747590 |
| Platelet count decreased | 131.40 | 13.20 | 385 | 42889 | 119332 | 34794325 |
| Haematotoxicity | 129.99 | 13.20 | 96 | 43178 | 8098 | 34905559 |
| Mucosal inflammation | 128.59 | 13.20 | 196 | 43078 | 38426 | 34875231 |
| Myelodysplastic syndrome | 126.84 | 13.20 | 137 | 43137 | 19071 | 34894586 |
| Leukopenia | 125.86 | 13.20 | 255 | 43019 | 62601 | 34851056 |
| Septic shock | 118.06 | 13.20 | 269 | 43005 | 71565 | 34842092 |
| Cytokine release syndrome | 112.20 | 13.20 | 140 | 43134 | 22737 | 34890920 |
| Drug interaction | 105.16 | 13.20 | 76 | 43198 | 225870 | 34687787 |
| Acute myeloid leukaemia recurrent | 104.80 | 13.20 | 52 | 43222 | 2118 | 34911539 |
| Acute myeloid leukaemia | 99.66 | 13.20 | 118 | 43156 | 18152 | 34895505 |
| Neutropenic sepsis | 94.07 | 13.20 | 100 | 43174 | 13667 | 34899990 |
| Febrile bone marrow aplasia | 93.23 | 13.20 | 79 | 43195 | 8130 | 34905527 |
| Acute graft versus host disease | 89.49 | 13.20 | 70 | 43204 | 6433 | 34907224 |
| Pneumonia | 83.88 | 13.20 | 748 | 42526 | 361879 | 34551778 |
| Toxicity to various agents | 76.71 | 13.20 | 81 | 43193 | 200281 | 34713376 |
| Aplastic anaemia | 76.18 | 13.20 | 76 | 43198 | 9640 | 34904017 |
| Clostridium difficile colitis | 70.39 | 13.20 | 92 | 43182 | 15638 | 34898019 |
| Neutropenic colitis | 66.62 | 13.20 | 44 | 43230 | 3100 | 34910557 |
| Multiple organ dysfunction syndrome | 64.50 | 13.20 | 225 | 43049 | 76341 | 34837316 |
| Anaemia | 63.17 | 13.20 | 499 | 42775 | 232836 | 34680821 |
| Splenic rupture | 62.99 | 13.20 | 33 | 43241 | 1508 | 34912149 |
| Graft versus host disease | 62.21 | 13.20 | 71 | 43203 | 10498 | 34903159 |
| Agranulocytosis | 61.76 | 13.20 | 108 | 43166 | 23713 | 34889944 |
| Lymphopenia | 60.22 | 13.20 | 87 | 43187 | 16248 | 34897409 |
| Fall | 59.33 | 13.20 | 100 | 43174 | 202785 | 34710872 |
| Thymus hypoplasia | 57.29 | 13.20 | 21 | 43253 | 397 | 34913260 |
| Lymphoid tissue hypoplasia | 57.29 | 13.20 | 21 | 43253 | 397 | 34913260 |
| Colony stimulating factor therapy | 57.10 | 13.20 | 17 | 43257 | 161 | 34913496 |
| Off label use | 56.98 | 13.20 | 779 | 42495 | 418745 | 34494912 |
| Blood pressure increased | 56.96 | 13.20 | 19 | 43255 | 88083 | 34825574 |
| Neutropenic infection | 55.37 | 13.20 | 30 | 43244 | 1468 | 34912189 |
| Cytomegalovirus infection | 54.61 | 13.20 | 108 | 43166 | 26027 | 34887630 |
| Herpes simplex | 54.09 | 13.20 | 49 | 43225 | 5510 | 34908147 |
| Drug ineffective | 53.60 | 13.20 | 339 | 42935 | 456412 | 34457245 |
| Somnolence | 53.42 | 13.20 | 36 | 43238 | 111080 | 34802577 |
| Overdose | 53.26 | 13.20 | 23 | 43251 | 91036 | 34822621 |
| Cystitis haemorrhagic | 53.19 | 13.20 | 49 | 43225 | 5630 | 34908027 |
| Plasma cell myeloma | 52.68 | 13.20 | 142 | 43132 | 41895 | 34871762 |
| Venoocclusive disease | 50.97 | 13.20 | 36 | 43238 | 2831 | 34910826 |
| Cytomegalovirus viraemia | 50.80 | 13.20 | 54 | 43220 | 7376 | 34906281 |
| Acute graft versus host disease in skin | 48.95 | 13.20 | 45 | 43229 | 5156 | 34908501 |
| Dizziness | 48.49 | 13.20 | 126 | 43148 | 218395 | 34695262 |
| Cytomegalovirus test positive | 47.44 | 13.20 | 39 | 43235 | 3847 | 34909810 |
| Myocardial infarction | 46.23 | 13.20 | 49 | 43225 | 121036 | 34792621 |
| Escherichia infection | 46.19 | 13.20 | 54 | 43220 | 8191 | 34905466 |
| Face oedema | 44.90 | 13.20 | 63 | 43211 | 11453 | 34902204 |
| Disseminated aspergillosis | 44.64 | 13.20 | 21 | 43253 | 759 | 34912898 |
| Escherichia bacteraemia | 44.46 | 13.20 | 35 | 43239 | 3245 | 34910412 |
| Skin toxicity | 44.27 | 13.20 | 41 | 43233 | 4743 | 34908914 |
| Aplasia | 43.77 | 13.20 | 40 | 43234 | 4548 | 34909109 |
| Infection | 43.56 | 13.20 | 225 | 43049 | 90690 | 34822967 |
| Chronic graft versus host disease | 43.44 | 13.20 | 39 | 43235 | 4334 | 34909323 |
| Bronchopulmonary aspergillosis | 42.68 | 13.20 | 70 | 43204 | 14589 | 34899068 |
| Bacterial infection | 42.47 | 13.20 | 76 | 43198 | 16987 | 34896670 |
| Pneumonia klebsiella | 42.14 | 13.20 | 34 | 43240 | 3266 | 34910391 |
| Headache | 42.01 | 13.20 | 119 | 43155 | 200516 | 34713141 |
| Splenomegaly | 41.09 | 13.20 | 70 | 43204 | 15047 | 34898610 |
| Venoocclusive liver disease | 41.05 | 13.20 | 50 | 43224 | 7916 | 34905741 |
| Anxiety | 39.34 | 13.20 | 39 | 43235 | 99389 | 34814268 |
| Streptococcal infection | 39.25 | 13.20 | 39 | 43235 | 4922 | 34908735 |
| Gait disturbance | 39.04 | 13.20 | 29 | 43245 | 85111 | 34828546 |
| Drug hypersensitivity | 38.81 | 13.20 | 26 | 43248 | 80503 | 34833154 |
| Tumour lysis syndrome | 38.69 | 13.20 | 73 | 43201 | 16986 | 34896671 |
| Dyspnoea | 38.50 | 13.20 | 291 | 42983 | 376491 | 34537166 |
| Candida infection | 36.75 | 13.20 | 73 | 43201 | 17642 | 34896015 |
| Hypoalbuminaemia | 36.62 | 13.20 | 59 | 43215 | 12115 | 34901542 |
| Rheumatoid arthritis | 36.08 | 13.20 | 3 | 43271 | 38235 | 34875422 |
| Pleural effusion | 35.10 | 13.20 | 196 | 43078 | 81350 | 34832307 |
| Platelet transfusion | 33.90 | 13.20 | 22 | 43252 | 1504 | 34912153 |
| Bacteraemia | 33.63 | 13.20 | 75 | 43199 | 19642 | 34894015 |
| Neutrophil count increased | 33.60 | 13.20 | 69 | 43205 | 17077 | 34896580 |
| Stomatitis | 33.26 | 13.20 | 122 | 43152 | 42392 | 34871265 |
| Streptococcal bacteraemia | 32.84 | 13.20 | 24 | 43250 | 1991 | 34911666 |
| Pneumonia fungal | 32.50 | 13.20 | 42 | 43232 | 7058 | 34906599 |
| Pseudomonal bacteraemia | 32.46 | 13.20 | 21 | 43253 | 1428 | 34912229 |
| Cytopenia | 32.08 | 13.20 | 57 | 43217 | 12666 | 34900991 |
| Coronary artery disease | 31.94 | 13.20 | 10 | 43264 | 48295 | 34865362 |
| Meningitis tuberculous | 31.85 | 13.20 | 16 | 43258 | 669 | 34912988 |
| Neutrophil count abnormal | 31.78 | 13.20 | 23 | 43251 | 1879 | 34911778 |
| Stem cell transplant | 31.56 | 13.20 | 24 | 43250 | 2115 | 34911542 |
| Acute graft versus host disease in intestine | 30.62 | 13.20 | 26 | 43248 | 2682 | 34910975 |
| Pseudomonal sepsis | 30.14 | 13.20 | 29 | 43245 | 3518 | 34910139 |
| Chronic kidney disease | 30.13 | 13.20 | 7 | 43267 | 41203 | 34872454 |
| Asthma | 29.73 | 13.20 | 8 | 43266 | 42648 | 34871009 |
| Cerebrovascular accident | 29.45 | 13.20 | 37 | 43237 | 84774 | 34828883 |
| Pseudomonas infection | 29.35 | 13.20 | 54 | 43220 | 12328 | 34901329 |
| International normalised ratio increased | 29.22 | 13.20 | 11 | 43263 | 47316 | 34866341 |
| Depression | 29.13 | 13.20 | 47 | 43227 | 97051 | 34816606 |
| Cytokine storm | 28.44 | 13.20 | 15 | 43259 | 695 | 34912962 |
| Neuropathy peripheral | 28.15 | 13.20 | 188 | 43086 | 83075 | 34830582 |
| Campylobacter gastroenteritis | 28.07 | 13.20 | 16 | 43258 | 865 | 34912792 |
| Pulmonary sarcoidosis | 27.94 | 13.20 | 14 | 43260 | 582 | 34913075 |
| Enterococcal infection | 27.85 | 13.20 | 45 | 43229 | 9261 | 34904396 |
| Rhabdomyolysis | 27.81 | 13.20 | 26 | 43248 | 68137 | 34845520 |
| Loss of personal independence in daily activities | 27.77 | 13.20 | 4 | 43270 | 33175 | 34880482 |
| Fungal infection | 27.61 | 13.20 | 61 | 43213 | 15874 | 34897783 |
| Inappropriate schedule of product administration | 27.56 | 13.20 | 22 | 43252 | 62274 | 34851383 |
| Intentional product misuse | 27.49 | 13.20 | 11 | 43263 | 45600 | 34868057 |
| Bone marrow necrosis | 27.43 | 13.20 | 10 | 43264 | 186 | 34913471 |
| Aspergillus infection | 27.25 | 13.20 | 52 | 43222 | 12202 | 34901455 |
| Joint swelling | 26.68 | 13.20 | 21 | 43253 | 59869 | 34853788 |
| Extramedullary haemopoiesis | 25.96 | 13.20 | 8 | 43266 | 86 | 34913571 |
| Aggression | 25.88 | 13.20 | 8 | 43266 | 38956 | 34874701 |
| Hypoglycaemia | 25.84 | 13.20 | 18 | 43256 | 54622 | 34859035 |
| Gene mutation | 25.77 | 13.20 | 18 | 43256 | 1390 | 34912267 |
| Psoriasis | 25.72 | 13.20 | 8 | 43266 | 38804 | 34874853 |
| Neuroblastoma recurrent | 25.66 | 13.20 | 9 | 43265 | 149 | 34913508 |
| Musculoskeletal stiffness | 25.42 | 13.20 | 13 | 43261 | 46667 | 34866990 |
| Systemic candida | 25.33 | 13.20 | 27 | 43247 | 3699 | 34909958 |
| Cytogenetic abnormality | 25.19 | 13.20 | 15 | 43259 | 880 | 34912777 |
| Bradycardia | 25.06 | 13.20 | 34 | 43240 | 75384 | 34838273 |
| Stress | 24.62 | 13.20 | 4 | 43270 | 30343 | 34883314 |
| Device related infection | 24.43 | 13.20 | 61 | 43213 | 17176 | 34896481 |
| Haemophagocytic lymphohistiocytosis | 24.01 | 13.20 | 51 | 43223 | 12922 | 34900735 |
| Adenovirus infection | 23.91 | 13.20 | 31 | 43243 | 5226 | 34908431 |
| Pain in extremity | 23.62 | 13.20 | 79 | 43195 | 126434 | 34787223 |
| Chronic obstructive pulmonary disease | 23.28 | 13.20 | 16 | 43258 | 48902 | 34864755 |
| Aortitis | 22.61 | 13.20 | 11 | 43263 | 429 | 34913228 |
| Hypogonadism | 22.18 | 13.20 | 20 | 43254 | 2235 | 34911422 |
| Agitation | 22.14 | 13.20 | 23 | 43251 | 57376 | 34856281 |
| Herpes simplex encephalitis | 22.10 | 13.20 | 10 | 43264 | 330 | 34913327 |
| Cellulitis | 21.93 | 13.20 | 126 | 43148 | 52825 | 34860832 |
| White blood cell count increased | 21.92 | 13.20 | 105 | 43169 | 41046 | 34872611 |
| Ecthyma | 21.87 | 13.20 | 11 | 43263 | 461 | 34913196 |
| Wheezing | 21.85 | 13.20 | 12 | 43262 | 41390 | 34872267 |
| Disease progression | 21.82 | 13.20 | 217 | 43057 | 107860 | 34805797 |
| Condition aggravated | 21.72 | 13.20 | 144 | 43130 | 192052 | 34721605 |
| Drug effective for unapproved indication | 21.60 | 13.20 | 21 | 43253 | 2581 | 34911076 |
| Diabetes mellitus | 21.43 | 13.20 | 16 | 43258 | 46857 | 34866800 |
| Klebsiella infection | 21.23 | 13.20 | 38 | 43236 | 8493 | 34905164 |
| Hypertension | 21.08 | 13.20 | 92 | 43182 | 136351 | 34777306 |
| Flushing | 20.92 | 13.20 | 7 | 43267 | 32413 | 34881244 |
| Pulmonary haemorrhage | 20.82 | 13.20 | 42 | 43232 | 10262 | 34903395 |
| Clostridium bacteraemia | 20.57 | 13.20 | 8 | 43266 | 179 | 34913478 |
| Arthralgia | 20.44 | 13.20 | 125 | 43149 | 169916 | 34743741 |
| Hyperkalaemia | 20.42 | 13.20 | 34 | 43240 | 69355 | 34844302 |
| Heart rate decreased | 20.23 | 13.20 | 7 | 43267 | 31738 | 34881919 |
| Adenoviral haemorrhagic cystitis | 20.22 | 13.20 | 10 | 43264 | 404 | 34913253 |
| Sleep disorder | 20.18 | 13.20 | 7 | 43267 | 31681 | 34881976 |
| Acute febrile neutrophilic dermatosis | 20.06 | 13.20 | 15 | 43259 | 1288 | 34912369 |
| Hypokalaemia | 20.00 | 13.20 | 132 | 43142 | 58082 | 34855575 |
| Hypogammaglobulinaemia | 19.93 | 13.20 | 35 | 43239 | 7705 | 34905952 |
| Thrombotic microangiopathy | 19.91 | 13.20 | 42 | 43232 | 10588 | 34903069 |
| Diarrhoea | 19.68 | 13.20 | 626 | 42648 | 389286 | 34524371 |
| Respiratory failure | 19.55 | 13.20 | 213 | 43061 | 108359 | 34805298 |
| Myelosuppression | 19.22 | 13.20 | 60 | 43214 | 19205 | 34894452 |
| Acute lymphocytic leukaemia recurrent | 18.85 | 13.20 | 21 | 43253 | 3023 | 34910634 |
| Escherichia sepsis | 18.73 | 13.20 | 26 | 43248 | 4678 | 34908979 |
| Red blood cell count decreased | 18.32 | 13.20 | 78 | 43196 | 29012 | 34884645 |
| Myocardial calcification | 18.25 | 13.20 | 5 | 43269 | 34 | 34913623 |
| Fungaemia | 18.15 | 13.20 | 19 | 43255 | 2549 | 34911108 |
| Pain | 18.13 | 13.20 | 164 | 43110 | 204511 | 34709146 |
| Death | 17.77 | 13.20 | 630 | 42644 | 397419 | 34516238 |
| Angiodysplasia | 17.76 | 13.20 | 11 | 43263 | 693 | 34912964 |
| Leukaemia | 17.67 | 13.20 | 25 | 43249 | 4578 | 34909079 |
| Cord blood transplant therapy | 17.65 | 13.20 | 5 | 43269 | 39 | 34913618 |
| Blood glucose increased | 17.57 | 13.20 | 35 | 43239 | 66683 | 34846974 |
| Candida test positive | 17.55 | 13.20 | 9 | 43265 | 393 | 34913264 |
| Petechiae | 17.40 | 13.20 | 37 | 43237 | 9381 | 34904276 |
| Granulocyte count increased | 17.39 | 13.20 | 9 | 43265 | 401 | 34913256 |
| Inadequate osteointegration | 17.25 | 13.20 | 4 | 43270 | 12 | 34913645 |
| Rectosigmoid cancer metastatic | 17.25 | 13.20 | 4 | 43270 | 12 | 34913645 |
| Growth of eyelashes | 17.24 | 13.20 | 6 | 43268 | 97 | 34913560 |
| Tremor | 17.23 | 13.20 | 49 | 43225 | 82538 | 34831119 |
| Leukaemia recurrent | 17.23 | 13.20 | 15 | 43259 | 1600 | 34912057 |
| Myeloid leukaemia | 17.12 | 13.20 | 9 | 43265 | 414 | 34913243 |
| Fusarium infection | 17.08 | 13.20 | 13 | 43261 | 1147 | 34912510 |
| Lactic acidosis | 17.05 | 13.20 | 11 | 43263 | 34761 | 34878896 |
| Hypoxia | 16.61 | 13.20 | 121 | 43153 | 54974 | 34858683 |
| Urinary bladder haematoma | 16.57 | 13.20 | 4 | 43270 | 15 | 34913642 |
| Tubulointerstitial nephritis | 16.55 | 13.20 | 3 | 43271 | 21021 | 34892636 |
| Capillary leak syndrome | 16.49 | 13.20 | 17 | 43257 | 2241 | 34911416 |
| Bone marrow transplant rejection | 16.41 | 13.20 | 7 | 43267 | 200 | 34913457 |
| Chemotherapy | 16.31 | 13.20 | 10 | 43264 | 619 | 34913038 |
| Product storage error | 16.28 | 13.20 | 33 | 43241 | 8089 | 34905568 |
| Peripheral swelling | 16.27 | 13.20 | 45 | 43229 | 76496 | 34837161 |
| Chronic lymphocytic leukaemia | 16.27 | 13.20 | 23 | 43251 | 4209 | 34909448 |
| Transplant failure | 16.23 | 13.20 | 21 | 43253 | 3532 | 34910125 |
| Rash maculo-papular | 16.18 | 13.20 | 74 | 43200 | 28377 | 34885280 |
| Avian influenza | 16.17 | 13.20 | 4 | 43270 | 17 | 34913640 |
| Lymphadenopathy | 16.16 | 13.20 | 74 | 43200 | 28389 | 34885268 |
| Peripheral T-cell lymphoma unspecified | 16.16 | 13.20 | 9 | 43265 | 465 | 34913192 |
| Erectile dysfunction | 16.13 | 13.20 | 3 | 43271 | 20634 | 34893023 |
| White blood cell count abnormal | 16.08 | 13.20 | 20 | 43254 | 3233 | 34910424 |
| Raoultella ornithinolytica infection | 16.04 | 13.20 | 5 | 43269 | 56 | 34913601 |
| Speech disorder | 15.80 | 13.20 | 6 | 43268 | 25680 | 34887977 |
| Sleep apnoea syndrome | 15.78 | 13.20 | 3 | 43271 | 20318 | 34893339 |
| Coma | 15.78 | 13.20 | 20 | 43254 | 45658 | 34867999 |
| Periumbilical abscess | 15.73 | 13.20 | 5 | 43269 | 60 | 34913597 |
| Disseminated intravascular coagulation | 15.72 | 13.20 | 61 | 43213 | 21755 | 34891902 |
| Pulmonary artery stenosis congenital | 15.70 | 13.20 | 9 | 43265 | 492 | 34913165 |
| Acute graft versus host disease in liver | 15.62 | 13.20 | 14 | 43260 | 1552 | 34912105 |
| Systemic mycosis | 15.57 | 13.20 | 14 | 43260 | 1559 | 34912098 |
| Serotonin syndrome | 15.36 | 13.20 | 3 | 43271 | 19930 | 34893727 |
| Erythropenia | 15.33 | 13.20 | 7 | 43267 | 236 | 34913421 |
| Hyperpyrexia | 15.18 | 13.20 | 18 | 43256 | 2770 | 34910887 |
| Laryngeal cancer stage IV | 15.17 | 13.20 | 4 | 43270 | 23 | 34913634 |
| Combined immunodeficiency | 15.16 | 13.20 | 5 | 43269 | 68 | 34913589 |
| Abnormal behaviour | 15.08 | 13.20 | 6 | 43268 | 24963 | 34888694 |
| Dental restoration failure | 15.03 | 13.20 | 4 | 43270 | 24 | 34913633 |
| Selective IgG subclass deficiency | 15.01 | 13.20 | 3 | 43271 | 3 | 34913654 |
| White blood cell disorder | 14.97 | 13.20 | 14 | 43260 | 1639 | 34912018 |
| Cardiac failure congestive | 14.85 | 13.20 | 53 | 43221 | 83217 | 34830440 |
| Enterococcal sepsis | 14.83 | 13.20 | 14 | 43260 | 1658 | 34911999 |
| Epstein-Barr virus associated lymphoproliferative disorder | 14.73 | 13.20 | 15 | 43259 | 1949 | 34911708 |
| Myeloblast count increased | 14.55 | 13.20 | 3 | 43271 | 4 | 34913653 |
| CSF white blood cell count decreased | 14.50 | 13.20 | 4 | 43270 | 28 | 34913629 |
| Cognitive disorder | 14.17 | 13.20 | 9 | 43265 | 28684 | 34884973 |
| Mobility decreased | 14.14 | 13.20 | 10 | 43264 | 30118 | 34883539 |
| Encephalitis brain stem | 14.08 | 13.20 | 5 | 43269 | 86 | 34913571 |
| Haemorrhagic necrotic pancreatitis | 14.05 | 13.20 | 6 | 43268 | 172 | 34913485 |
| Enteritis | 13.91 | 13.20 | 31 | 43243 | 8111 | 34905546 |
| Arthropathy | 13.91 | 13.20 | 8 | 43266 | 26899 | 34886758 |
| Product dose omission issue | 13.85 | 13.20 | 89 | 43185 | 119622 | 34794035 |
| Corynebacterium sepsis | 13.80 | 13.20 | 3 | 43271 | 6 | 34913651 |
| Gastrooesophageal reflux disease | 13.74 | 13.20 | 16 | 43258 | 37908 | 34875749 |
| Cytomegalovirus hepatitis | 13.66 | 13.20 | 8 | 43266 | 455 | 34913202 |
| Enterobacter sepsis | 13.63 | 13.20 | 10 | 43264 | 834 | 34912823 |
| B-lymphocyte count decreased | 13.63 | 13.20 | 9 | 43265 | 634 | 34913023 |
| Treatment failure | 13.62 | 13.20 | 23 | 43251 | 46674 | 34866983 |
| Weight increased | 13.60 | 13.20 | 64 | 43210 | 92969 | 34820688 |
| Metastases to pelvis | 13.56 | 13.20 | 7 | 43267 | 310 | 34913347 |
| Diffuse large B-cell lymphoma stage II | 13.52 | 13.20 | 4 | 43270 | 37 | 34913620 |
| Neurotoxicity | 13.51 | 13.20 | 51 | 43223 | 17959 | 34895698 |
| Glomerulonephritis rapidly progressive | 13.44 | 13.20 | 9 | 43265 | 649 | 34913008 |
| Engraft failure | 13.29 | 13.20 | 8 | 43266 | 479 | 34913178 |
| Psoriatic arthropathy | 13.26 | 13.20 | 4 | 43270 | 19794 | 34893863 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 3445.80 | 11.93 | 2361 | 75242 | 228638 | 79438147 |
| Neutropenia | 1487.20 | 11.93 | 1604 | 75999 | 286106 | 79380679 |
| Thrombocytopenia | 723.93 | 11.93 | 1077 | 76526 | 264182 | 79402603 |
| Pyrexia | 598.90 | 11.93 | 1725 | 75878 | 676984 | 78989801 |
| Pancytopenia | 543.16 | 11.93 | 735 | 76868 | 165010 | 79501775 |
| Neutrophil count decreased | 426.74 | 11.93 | 491 | 77112 | 93468 | 79573317 |
| White blood cell count decreased | 404.47 | 11.93 | 686 | 76917 | 187602 | 79479183 |
| Mucosal inflammation | 398.37 | 11.93 | 427 | 77176 | 75153 | 79591632 |
| Bone pain | 391.44 | 11.93 | 368 | 77235 | 55374 | 79611411 |
| Platelet count decreased | 334.80 | 11.93 | 644 | 76959 | 194020 | 79472765 |
| Neutropenic sepsis | 310.33 | 11.93 | 237 | 77366 | 26827 | 79639958 |
| Sepsis | 294.61 | 11.93 | 743 | 76860 | 268685 | 79398100 |
| Cytokine release syndrome | 286.52 | 11.93 | 255 | 77348 | 35743 | 79631042 |
| Leukopenia | 245.29 | 11.93 | 421 | 77182 | 116092 | 79550693 |
| Septic shock | 226.73 | 11.93 | 419 | 77184 | 122382 | 79544403 |
| Anaemia | 226.36 | 11.93 | 944 | 76659 | 444071 | 79222714 |
| Bone marrow failure | 221.71 | 11.93 | 261 | 77342 | 50846 | 79615939 |
| Secondary immunodeficiency | 214.99 | 11.93 | 90 | 77513 | 3144 | 79663641 |
| Myelodysplastic syndrome | 178.89 | 11.93 | 182 | 77421 | 30119 | 79636666 |
| Pneumonia | 176.19 | 11.93 | 1171 | 76432 | 659075 | 79007710 |
| Acute myeloid leukaemia | 174.18 | 11.93 | 181 | 77422 | 30704 | 79636081 |
| Bacterial infection | 170.48 | 11.93 | 180 | 77423 | 31100 | 79635685 |
| Drug ineffective | 157.61 | 11.93 | 534 | 77069 | 1080379 | 78586406 |
| Aplastic anaemia | 156.87 | 11.93 | 134 | 77469 | 17771 | 79649014 |
| Clostridium difficile colitis | 155.39 | 11.93 | 174 | 77429 | 32109 | 79634676 |
| Rheumatoid arthritis | 154.39 | 11.93 | 13 | 77590 | 208457 | 79458328 |
| Joint swelling | 153.85 | 11.93 | 45 | 77558 | 288601 | 79378184 |
| Febrile bone marrow aplasia | 151.39 | 11.93 | 115 | 77488 | 12905 | 79653880 |
| Fall | 150.16 | 11.93 | 152 | 77451 | 487477 | 79179308 |
| Pseudomonal sepsis | 148.91 | 11.93 | 86 | 77517 | 6088 | 79660697 |
| Acute graft versus host disease | 145.92 | 11.93 | 102 | 77501 | 10065 | 79656720 |
| Drug abuse | 143.58 | 11.93 | 3 | 77600 | 162688 | 79504097 |
| Off label use | 142.02 | 11.93 | 1425 | 76178 | 905790 | 78760995 |
| Haematotoxicity | 141.82 | 11.93 | 119 | 77484 | 15400 | 79651385 |
| Acute myeloid leukaemia recurrent | 135.19 | 11.93 | 66 | 77537 | 3317 | 79663468 |
| Lymphoid tissue hypoplasia | 131.71 | 11.93 | 45 | 77558 | 885 | 79665900 |
| Bronchopulmonary aspergillosis | 129.94 | 11.93 | 133 | 77470 | 22161 | 79644624 |
| Thymus hypoplasia | 129.72 | 11.93 | 45 | 77558 | 928 | 79665857 |
| Synovitis | 128.41 | 11.93 | 4 | 77599 | 150730 | 79516055 |
| Contraindicated product administered | 128.00 | 11.93 | 6 | 77597 | 157532 | 79509253 |
| Multiple organ dysfunction syndrome | 127.37 | 11.93 | 328 | 77275 | 119918 | 79546867 |
| Toxicity to various agents | 126.79 | 11.93 | 134 | 77469 | 421406 | 79245379 |
| Arthropathy | 120.89 | 11.93 | 15 | 77588 | 177096 | 79489689 |
| Disease progression | 120.46 | 11.93 | 424 | 77179 | 183938 | 79482847 |
| Mycobacterium chelonae infection | 119.89 | 11.93 | 55 | 77548 | 2401 | 79664384 |
| Drug interaction | 118.25 | 11.93 | 138 | 77465 | 415045 | 79251740 |
| Computerised tomogram thorax abnormal | 117.55 | 11.93 | 54 | 77549 | 2365 | 79664420 |
| Drug hypersensitivity | 114.53 | 11.93 | 75 | 77528 | 298841 | 79367944 |
| Aortitis | 110.55 | 11.93 | 45 | 77558 | 1462 | 79665323 |
| Hypoxia | 109.72 | 11.93 | 282 | 77321 | 102961 | 79563824 |
| Pain | 109.69 | 11.93 | 337 | 77266 | 703465 | 78963320 |
| Lymphopenia | 108.27 | 11.93 | 141 | 77462 | 30416 | 79636369 |
| Cytomegalovirus infection | 105.73 | 11.93 | 166 | 77437 | 42478 | 79624307 |
| Musculoskeletal stiffness | 103.43 | 11.93 | 22 | 77581 | 174986 | 79491799 |
| Plasma cell myeloma | 102.34 | 11.93 | 185 | 77418 | 53074 | 79613711 |
| Cytomegalovirus viraemia | 102.33 | 11.93 | 91 | 77512 | 12730 | 79654055 |
| Staphylococcal bacteraemia | 100.07 | 11.93 | 88 | 77515 | 12130 | 79654655 |
| Arthralgia | 97.66 | 11.93 | 262 | 77341 | 571541 | 79095244 |
| Headache | 96.96 | 11.93 | 320 | 77283 | 653452 | 79013333 |
| Somnolence | 94.22 | 11.93 | 58 | 77545 | 238923 | 79427862 |
| Human bocavirus infection | 93.73 | 11.93 | 33 | 77570 | 712 | 79666073 |
| Computerised tomogram thorax | 93.04 | 11.93 | 29 | 77574 | 421 | 79666364 |
| Chronic graft versus host disease | 90.31 | 11.93 | 65 | 77538 | 6716 | 79660069 |
| Agranulocytosis | 89.83 | 11.93 | 159 | 77444 | 44871 | 79621914 |
| Abdominal discomfort | 86.78 | 11.93 | 70 | 77533 | 250657 | 79416128 |
| Therapeutic product effect decreased | 86.42 | 11.93 | 26 | 77577 | 163837 | 79502948 |
| Parainfluenzae virus infection | 86.23 | 11.93 | 59 | 77544 | 5623 | 79661162 |
| Blood pressure increased | 85.13 | 11.93 | 50 | 77553 | 211310 | 79455475 |
| Drug intolerance | 85.03 | 11.93 | 79 | 77524 | 264040 | 79402745 |
| Swelling | 84.86 | 11.93 | 53 | 77550 | 216658 | 79450127 |
| Glossodynia | 83.72 | 11.93 | 4 | 77599 | 103333 | 79563452 |
| Gait disturbance | 83.70 | 11.93 | 49 | 77554 | 207457 | 79459328 |
| White blood cell count abnormal | 83.29 | 11.93 | 58 | 77545 | 5687 | 79661098 |
| Cystitis haemorrhagic | 83.12 | 11.93 | 70 | 77533 | 9102 | 79657683 |
| Peripheral swelling | 82.91 | 11.93 | 84 | 77519 | 269533 | 79397252 |
| Colony stimulating factor therapy | 80.69 | 11.93 | 27 | 77576 | 497 | 79666288 |
| Atelectasis | 80.56 | 11.93 | 126 | 77477 | 32131 | 79634654 |
| Human herpesvirus 6 infection | 79.70 | 11.93 | 55 | 77548 | 5315 | 79661470 |
| Overdose | 79.39 | 11.93 | 40 | 77563 | 184166 | 79482619 |
| Anxiety | 79.21 | 11.93 | 75 | 77528 | 248437 | 79418348 |
| Herpes simplex | 78.93 | 11.93 | 77 | 77526 | 12110 | 79654675 |
| Cytopenia | 78.43 | 11.93 | 98 | 77505 | 20285 | 79646500 |
| Graft versus host disease | 77.51 | 11.93 | 84 | 77519 | 14942 | 79651843 |
| Aspergillus infection | 76.74 | 11.93 | 94 | 77509 | 19067 | 79647718 |
| Neutropenic colitis | 76.68 | 11.93 | 55 | 77548 | 5652 | 79661133 |
| Immune reconstitution inflammatory syndrome | 76.03 | 11.93 | 80 | 77523 | 13761 | 79653024 |
| Acute graft versus host disease in skin | 74.71 | 11.93 | 61 | 77542 | 7597 | 79659188 |
| Asthma | 73.89 | 11.93 | 20 | 77583 | 135075 | 79531710 |
| Diarrhoea | 72.78 | 11.93 | 1231 | 76372 | 879258 | 78787527 |
| Cystitis bacterial | 72.67 | 11.93 | 27 | 77576 | 683 | 79666102 |
| Treatment failure | 72.01 | 11.93 | 38 | 77565 | 170448 | 79496337 |
| Wound | 72.01 | 11.93 | 13 | 77590 | 116166 | 79550619 |
| Disseminated aspergillosis | 70.60 | 11.93 | 30 | 77573 | 1088 | 79665697 |
| Hypoalbuminaemia | 70.40 | 11.93 | 95 | 77508 | 21202 | 79645583 |
| Death | 69.89 | 11.93 | 850 | 76753 | 565664 | 79101121 |
| Myocardial infarction | 68.07 | 11.93 | 48 | 77555 | 184081 | 79482704 |
| Norovirus test positive | 67.11 | 11.93 | 25 | 77578 | 637 | 79666148 |
| Venoocclusive liver disease | 66.38 | 11.93 | 69 | 77534 | 11702 | 79655083 |
| Nasopharyngitis | 66.34 | 11.93 | 90 | 77513 | 253791 | 79412994 |
| Dizziness | 65.96 | 11.93 | 276 | 77327 | 526165 | 79140620 |
| Clostridium difficile infection | 65.71 | 11.93 | 135 | 77468 | 42550 | 79624235 |
| Bacteraemia | 65.59 | 11.93 | 116 | 77487 | 32708 | 79634077 |
| Escherichia bacteraemia | 65.56 | 11.93 | 53 | 77550 | 6509 | 79660276 |
| Neuropathy peripheral | 65.56 | 11.93 | 292 | 77311 | 141013 | 79525772 |
| Depression | 64.98 | 11.93 | 69 | 77534 | 216721 | 79450064 |
| Suicide attempt | 64.73 | 11.93 | 4 | 77599 | 82928 | 79583857 |
| Systemic lupus erythematosus | 64.28 | 11.93 | 19 | 77584 | 121130 | 79545655 |
| Neurotoxicity | 62.52 | 11.93 | 113 | 77490 | 32405 | 79634380 |
| Splenic rupture | 61.70 | 11.93 | 35 | 77568 | 2394 | 79664391 |
| Aplasia | 61.41 | 11.93 | 55 | 77548 | 7765 | 79659020 |
| Enterobacter infection | 61.37 | 11.93 | 44 | 77559 | 4518 | 79662267 |
| Colitis | 60.81 | 11.93 | 183 | 77420 | 73124 | 79593661 |
| Cytomegalovirus chorioretinitis | 60.55 | 11.93 | 47 | 77556 | 5443 | 79661342 |
| Blood cholesterol increased | 59.86 | 11.93 | 6 | 77597 | 83714 | 79583071 |
| Suicidal ideation | 58.64 | 11.93 | 4 | 77599 | 76336 | 79590449 |
| Acute febrile neutrophilic dermatosis | 58.27 | 11.93 | 40 | 77563 | 3832 | 79662953 |
| Pleural effusion | 57.74 | 11.93 | 287 | 77316 | 144975 | 79521810 |
| Tumour lysis syndrome | 57.69 | 11.93 | 92 | 77511 | 23847 | 79642938 |
| Tonsillar disorder | 57.59 | 11.93 | 27 | 77576 | 1239 | 79665546 |
| Psoriatic arthropathy | 57.34 | 11.93 | 5 | 77598 | 77994 | 79588791 |
| Hepatic enzyme increased | 57.13 | 11.93 | 56 | 77547 | 182554 | 79484231 |
| Neutrophil count abnormal | 56.82 | 11.93 | 38 | 77565 | 3488 | 79663297 |
| Hypokalaemia | 56.13 | 11.93 | 283 | 77320 | 143757 | 79523028 |
| Weight increased | 56.12 | 11.93 | 116 | 77487 | 277270 | 79389515 |
| Discomfort | 56.06 | 11.93 | 26 | 77577 | 125591 | 79541194 |
| Acute respiratory distress syndrome | 56.00 | 11.93 | 129 | 77474 | 43938 | 79622847 |
| Immune effector cell-associated neurotoxicity syndrome | 55.83 | 11.93 | 46 | 77557 | 5802 | 79660983 |
| Product dose omission issue | 55.79 | 11.93 | 97 | 77506 | 247440 | 79419345 |
| Abscess bacterial | 54.73 | 11.93 | 23 | 77580 | 811 | 79665974 |
| Haemophagocytic lymphohistiocytosis | 54.11 | 11.93 | 85 | 77518 | 21752 | 79645033 |
| Capillary leak syndrome | 53.13 | 11.93 | 38 | 77565 | 3887 | 79662898 |
| Enteritis | 52.76 | 11.93 | 68 | 77535 | 14515 | 79652270 |
| Helicobacter infection | 52.54 | 11.93 | 4 | 77599 | 69700 | 79597085 |
| Sleep disorder | 52.20 | 11.93 | 10 | 77593 | 85667 | 79581118 |
| Psoriasis | 51.42 | 11.93 | 12 | 77591 | 89575 | 79577210 |
| Viraemia | 51.30 | 11.93 | 33 | 77570 | 2836 | 79663949 |
| Neutropenic infection | 51.18 | 11.93 | 31 | 77572 | 2396 | 79664389 |
| Rhinovirus infection | 51.04 | 11.93 | 50 | 77553 | 7903 | 79658882 |
| Sinusitis | 50.36 | 11.93 | 70 | 77533 | 195431 | 79471354 |
| Splenomegaly | 50.34 | 11.93 | 80 | 77523 | 20674 | 79646111 |
| Blood pressure fluctuation | 50.19 | 11.93 | 4 | 77599 | 67141 | 79599644 |
| Blood pressure systolic increased | 50.05 | 11.93 | 4 | 77599 | 66982 | 79599803 |
| Pseudomonas infection | 49.91 | 11.93 | 80 | 77523 | 20823 | 79645962 |
| Osteoarthritis | 49.51 | 11.93 | 12 | 77591 | 87297 | 79579488 |
| Loss of personal independence in daily activities | 49.35 | 11.93 | 19 | 77584 | 102561 | 79564224 |
| Neuroblastoma recurrent | 49.30 | 11.93 | 15 | 77588 | 200 | 79666585 |
| Wheezing | 49.26 | 11.93 | 26 | 77577 | 116638 | 79550147 |
| Stress | 49.13 | 11.93 | 9 | 77594 | 79603 | 79587182 |
| Peripheral sensory neuropathy | 49.09 | 11.93 | 62 | 77541 | 12971 | 79653814 |
| Cytogenetic abnormality | 48.13 | 11.93 | 23 | 77580 | 1102 | 79665683 |
| Venoocclusive disease | 47.95 | 11.93 | 38 | 77565 | 4535 | 79662250 |
| Acute graft versus host disease in intestine | 47.65 | 11.93 | 36 | 77567 | 4005 | 79662780 |
| Fibromyalgia | 47.63 | 11.93 | 4 | 77599 | 64336 | 79602449 |
| Pain in extremity | 47.56 | 11.93 | 188 | 77415 | 364350 | 79302435 |
| Lymphadenopathy | 47.09 | 11.93 | 136 | 77467 | 53111 | 79613674 |
| Thrombotic microangiopathy | 46.54 | 11.93 | 76 | 77527 | 20093 | 79646692 |
| Systemic candida | 46.51 | 11.93 | 44 | 77559 | 6662 | 79660123 |
| Balance disorder | 46.42 | 11.93 | 19 | 77584 | 98838 | 79567947 |
| Heart rate abnormal | 46.38 | 11.93 | 42 | 77561 | 6015 | 79660770 |
| Blood magnesium decreased | 46.19 | 11.93 | 68 | 77535 | 16444 | 79650341 |
| Cellulitis | 45.86 | 11.93 | 219 | 77384 | 108841 | 79557944 |
| Injury | 45.24 | 11.93 | 10 | 77593 | 77486 | 79589299 |
| Viral infection | 45.15 | 11.93 | 117 | 77486 | 42899 | 79623886 |
| Cytomegalovirus test positive | 45.07 | 11.93 | 41 | 77562 | 5906 | 79660879 |
| Mobility decreased | 44.94 | 11.93 | 32 | 77571 | 122143 | 79544642 |
| Hypophosphataemia | 44.55 | 11.93 | 74 | 77529 | 19839 | 79646946 |
| Respiratory failure | 44.44 | 11.93 | 315 | 77288 | 180596 | 79486189 |
| Stem cell transplant | 43.68 | 11.93 | 33 | 77570 | 3671 | 79663114 |
| Condition aggravated | 43.62 | 11.93 | 297 | 77306 | 500827 | 79165958 |
| Rheumatoid factor positive | 43.54 | 11.93 | 4 | 77599 | 59835 | 79606950 |
| Leukocytosis | 43.38 | 11.93 | 116 | 77487 | 43339 | 79623446 |
| Pneumonia klebsiella | 42.59 | 11.93 | 37 | 77566 | 5017 | 79661768 |
| Face oedema | 42.15 | 11.93 | 88 | 77515 | 28048 | 79638737 |
| Rash maculo-papular | 41.89 | 11.93 | 135 | 77468 | 55943 | 79610842 |
| Contusion | 41.68 | 11.93 | 50 | 77553 | 148726 | 79518059 |
| Lymphadenitis | 41.10 | 11.93 | 35 | 77568 | 4620 | 79662165 |
| Type 2 diabetes mellitus | 41.08 | 11.93 | 4 | 77599 | 57118 | 79609667 |
| Gene mutation | 41.02 | 11.93 | 28 | 77575 | 2658 | 79664127 |
| Feeling abnormal | 40.99 | 11.93 | 57 | 77546 | 159142 | 79507643 |
| Device related infection | 40.97 | 11.93 | 98 | 77505 | 34196 | 79632589 |
| Pneumatosis intestinalis | 40.64 | 11.93 | 40 | 77563 | 6357 | 79660428 |
| Escherichia infection | 40.37 | 11.93 | 67 | 77536 | 17950 | 79648835 |
| Enterococcal infection | 40.26 | 11.93 | 62 | 77541 | 15598 | 79651187 |
| Pneumonia fungal | 40.13 | 11.93 | 52 | 77551 | 11158 | 79655627 |
| Coronary artery disease | 39.14 | 11.93 | 8 | 77595 | 65466 | 79601319 |
| White blood cell count increased | 39.05 | 11.93 | 160 | 77443 | 74473 | 79592312 |
| Skin toxicity | 38.61 | 11.93 | 44 | 77559 | 8270 | 79658515 |
| Bradycardia | 38.57 | 11.93 | 45 | 77558 | 135512 | 79531273 |
| Alveolitis | 38.08 | 11.93 | 32 | 77571 | 4148 | 79662637 |
| Streptococcal bacteraemia | 37.89 | 11.93 | 30 | 77573 | 3576 | 79663209 |
| Hypertension | 37.49 | 11.93 | 180 | 77423 | 330812 | 79335973 |
| Neutrophil count increased | 37.29 | 11.93 | 86 | 77517 | 29310 | 79637475 |
| Fungal infection | 37.27 | 11.93 | 107 | 77496 | 41641 | 79625144 |
| Therapeutic product effect incomplete | 37.19 | 11.93 | 50 | 77553 | 141595 | 79525190 |
| Tremor | 37.09 | 11.93 | 68 | 77535 | 170015 | 79496770 |
| Crystal nephropathy | 37.05 | 11.93 | 21 | 77582 | 1434 | 79665351 |
| Injection site erythema | 36.76 | 11.93 | 15 | 77588 | 78182 | 79588603 |
| Acute lymphocytic leukaemia recurrent | 36.65 | 11.93 | 33 | 77570 | 4691 | 79662094 |
| Pulmonary haemorrhage | 36.07 | 11.93 | 57 | 77546 | 14660 | 79652125 |
| Cerebrovascular accident | 35.75 | 11.93 | 60 | 77543 | 155232 | 79511553 |
| Campylobacter gastroenteritis | 35.57 | 11.93 | 20 | 77583 | 1345 | 79665440 |
| Nasal congestion | 35.48 | 11.93 | 15 | 77588 | 76537 | 79590248 |
| Streptococcal infection | 34.84 | 11.93 | 43 | 77560 | 8787 | 79657998 |
| Platelet transfusion | 34.79 | 11.93 | 24 | 77579 | 2318 | 79664467 |
| Multiple sclerosis relapse | 34.15 | 11.93 | 3 | 77600 | 46530 | 79620255 |
| Excessive eye blinking | 34.01 | 11.93 | 21 | 77582 | 1680 | 79665105 |
| Acute graft versus host disease in liver | 33.97 | 11.93 | 22 | 77581 | 1913 | 79664872 |
| Muscle spasms | 33.71 | 11.93 | 75 | 77528 | 174655 | 79492130 |
| Rash pustular | 33.70 | 11.93 | 48 | 77555 | 11263 | 79655522 |
| Hypersensitivity | 33.69 | 11.93 | 136 | 77467 | 262103 | 79404682 |
| Stomatitis | 33.43 | 11.93 | 251 | 77352 | 146506 | 79520279 |
| Infection | 33.40 | 11.93 | 371 | 77232 | 241341 | 79425444 |
| Blood culture positive | 33.18 | 11.93 | 41 | 77562 | 8388 | 79658397 |
| Pseudomonal bacteraemia | 33.16 | 11.93 | 26 | 77577 | 3056 | 79663729 |
| Confusional state | 33.13 | 11.93 | 178 | 77425 | 317819 | 79348966 |
| Bacillus infection | 33.05 | 11.93 | 18 | 77585 | 1137 | 79665648 |
| Escherichia sepsis | 32.88 | 11.93 | 41 | 77562 | 8467 | 79658318 |
| Infusion related reaction | 32.43 | 11.93 | 115 | 77488 | 230122 | 79436663 |
| Pneumonitis | 32.25 | 11.93 | 131 | 77472 | 60729 | 79606056 |
| Heart rate decreased | 32.23 | 11.93 | 14 | 77589 | 70302 | 79596483 |
| Myelosuppression | 31.92 | 11.93 | 99 | 77504 | 40197 | 79626588 |
| Drug effective for unapproved indication | 31.74 | 11.93 | 34 | 77569 | 5967 | 79660818 |
| Leukaemia recurrent | 31.14 | 11.93 | 24 | 77579 | 2750 | 79664035 |
| Injection site pain | 30.98 | 11.93 | 49 | 77554 | 129789 | 79536996 |
| Intentional product use issue | 30.41 | 11.93 | 64 | 77539 | 152048 | 79514737 |
| Pericarditis | 30.30 | 11.93 | 34 | 77569 | 104202 | 79562583 |
| Haemoglobin decreased | 30.26 | 11.93 | 340 | 77263 | 221779 | 79445006 |
| Serotonin syndrome | 30.25 | 11.93 | 4 | 77599 | 45023 | 79621762 |
| Injection site swelling | 29.80 | 11.93 | 5 | 77598 | 47127 | 79619658 |
| Diffuse alveolar damage | 29.60 | 11.93 | 26 | 77577 | 3578 | 79663207 |
| Clostridium bacteraemia | 29.59 | 11.93 | 12 | 77591 | 386 | 79666399 |
| International normalised ratio increased | 28.85 | 11.93 | 24 | 77579 | 84697 | 79582088 |
| Red blood cell sedimentation rate increased | 28.77 | 11.93 | 5 | 77598 | 45937 | 79620848 |
| Nasal disorder | 28.59 | 11.93 | 26 | 77577 | 3743 | 79663042 |
| Disseminated intravascular coagulation | 28.34 | 11.93 | 88 | 77515 | 35754 | 79631031 |
| Epistaxis | 27.85 | 11.93 | 195 | 77408 | 111320 | 79555465 |
| Lactic acidosis | 27.80 | 11.93 | 17 | 77586 | 70342 | 79596443 |
| Inappropriate schedule of product administration | 27.75 | 11.93 | 55 | 77548 | 133573 | 79533212 |
| Impaired healing | 27.26 | 11.93 | 27 | 77576 | 87628 | 79579157 |
| Toxic erythema of chemotherapy | 27.21 | 11.93 | 10 | 77593 | 245 | 79666540 |
| Gastrooesophageal reflux disease | 27.16 | 11.93 | 37 | 77566 | 104209 | 79562576 |
| Adenovirus infection | 26.89 | 11.93 | 37 | 77566 | 8410 | 79658375 |
| Arthritis | 26.80 | 11.93 | 44 | 77559 | 114836 | 79551949 |
| Intentional product misuse | 26.63 | 11.93 | 32 | 77571 | 95133 | 79571652 |
| Gait inability | 26.58 | 11.93 | 12 | 77591 | 58905 | 79607880 |
| Rhabdomyolysis | 26.47 | 11.93 | 37 | 77566 | 103094 | 79563691 |
| Pneumonia moraxella | 26.41 | 11.93 | 8 | 77595 | 105 | 79666680 |
| Blood lactate dehydrogenase increased | 26.32 | 11.93 | 91 | 77512 | 39079 | 79627706 |
| Graft versus host disease in skin | 26.29 | 11.93 | 31 | 77572 | 6042 | 79660743 |
| Neoplasm recurrence | 26.12 | 11.93 | 26 | 77577 | 4188 | 79662597 |
| Chemotherapy | 26.08 | 11.93 | 18 | 77585 | 1739 | 79665046 |
| Fungaemia | 26.04 | 11.93 | 27 | 77576 | 4564 | 79662221 |
| Bone marrow necrosis | 26.03 | 11.93 | 10 | 77593 | 278 | 79666507 |
| Sedation | 25.99 | 11.93 | 9 | 77594 | 51886 | 79614899 |
| Candida test positive | 25.60 | 11.93 | 15 | 77588 | 1091 | 79665694 |
| Memory impairment | 24.95 | 11.93 | 44 | 77559 | 111690 | 79555095 |
| Marrow hyperplasia | 24.74 | 11.93 | 17 | 77586 | 1631 | 79665154 |
| Chronic lymphocytic leukaemia | 24.74 | 11.93 | 27 | 77576 | 4839 | 79661946 |
| Chronic obstructive pulmonary disease | 24.68 | 11.93 | 28 | 77575 | 85391 | 79581394 |
| Meningitis tuberculous | 24.41 | 11.93 | 15 | 77588 | 1190 | 79665595 |
| Agitation | 24.39 | 11.93 | 37 | 77566 | 99678 | 79567107 |
| Acute lymphocytic leukaemia | 24.27 | 11.93 | 27 | 77576 | 4942 | 79661843 |
| Muscular weakness | 24.18 | 11.93 | 78 | 77525 | 160651 | 79506134 |
| Coronavirus infection | 24.10 | 11.93 | 33 | 77570 | 7464 | 79659321 |
| Pneumocystis jirovecii pneumonia | 24.04 | 11.93 | 78 | 77525 | 32430 | 79634355 |
| Prescribed overdose | 23.99 | 11.93 | 4 | 77599 | 37879 | 79628906 |
| Cardio-respiratory arrest | 23.99 | 11.93 | 43 | 77560 | 108467 | 79558318 |
| Medication error | 23.93 | 11.93 | 19 | 77584 | 68623 | 79598162 |
| Intracardiac thrombus | 23.91 | 11.93 | 25 | 77578 | 4268 | 79662517 |
| Cytokine storm | 23.72 | 11.93 | 14 | 77589 | 1032 | 79665753 |
| Colitis ulcerative | 23.55 | 11.93 | 3 | 77600 | 34739 | 79632046 |
| Drug withdrawal syndrome | 23.53 | 11.93 | 3 | 77600 | 34715 | 79632070 |
| Cholangitis infective | 23.49 | 11.93 | 12 | 77591 | 665 | 79666120 |
| Hypoaesthesia | 23.03 | 11.93 | 93 | 77510 | 179259 | 79487526 |
| Oesophageal candidiasis | 23 | 11.93 | 36 | 77567 | 9182 | 79657603 |
| Diabetic ketoacidosis | 23.00 | 11.93 | 3 | 77600 | 34119 | 79632666 |
| Sleep apnoea syndrome | 22.77 | 11.93 | 4 | 77599 | 36474 | 79630311 |
| Cerebellar stroke | 22.62 | 11.93 | 11 | 77592 | 548 | 79666237 |
| Myeloid leukaemia | 22.59 | 11.93 | 12 | 77591 | 721 | 79666064 |
| Pulmonary sarcoidosis | 22.57 | 11.93 | 15 | 77588 | 1362 | 79665423 |
| Exposure during pregnancy | 22.43 | 11.93 | 40 | 77563 | 101092 | 79565693 |
| Vulvovaginal candidiasis | 22.39 | 11.93 | 19 | 77584 | 2495 | 79664290 |
| White blood cell disorder | 22.24 | 11.93 | 21 | 77582 | 3171 | 79663614 |
| Bursitis | 22.23 | 11.93 | 4 | 77599 | 35840 | 79630945 |
| Therapy partial responder | 22.18 | 11.93 | 51 | 77552 | 17346 | 79649439 |
| Injection site reaction | 21.98 | 11.93 | 13 | 77590 | 54772 | 79612013 |
| Malaise | 21.93 | 11.93 | 340 | 77263 | 489529 | 79177256 |
| Diffuse large B-cell lymphoma | 21.81 | 11.93 | 41 | 77562 | 12108 | 79654677 |
| Deep vein thrombosis | 21.71 | 11.93 | 196 | 77407 | 120723 | 79546062 |
| Corynebacterium sepsis | 21.56 | 11.93 | 6 | 77597 | 57 | 79666728 |
| Splenic haematoma | 21.51 | 11.93 | 9 | 77594 | 314 | 79666471 |
| Interstitial lung disease | 21.50 | 11.93 | 185 | 77418 | 112415 | 79554370 |
| Intentional self-injury | 21.50 | 11.93 | 3 | 77600 | 32416 | 79634369 |
| Hypogonadism | 21.47 | 11.93 | 16 | 77587 | 1744 | 79665041 |
| Palmar-plantar erythrodysaesthesia syndrome | 21.42 | 11.93 | 76 | 77527 | 33058 | 79633727 |
| Aspergilloma | 21.41 | 11.93 | 11 | 77592 | 617 | 79666168 |
| Urticaria | 21.36 | 11.93 | 100 | 77503 | 185101 | 79481684 |
| Musculoskeletal pain | 21.36 | 11.93 | 42 | 77561 | 102312 | 79564473 |
| Raoultella ornithinolytica infection | 21.29 | 11.93 | 6 | 77597 | 60 | 79666725 |
| Sinusitis fungal | 21.27 | 11.93 | 18 | 77585 | 2356 | 79664429 |
| Coma | 21.26 | 11.93 | 41 | 77562 | 100608 | 79566177 |
| Cognitive disorder | 21.22 | 11.93 | 22 | 77581 | 69904 | 79596881 |
| Incorrect dose administered | 21.19 | 11.93 | 26 | 77577 | 76604 | 79590181 |
| Onycholysis | 21.18 | 11.93 | 17 | 77586 | 2066 | 79664719 |
| Klebsiella infection | 21.06 | 11.93 | 47 | 77556 | 15673 | 79651112 |
| Folliculitis | 21.03 | 11.93 | 14 | 77589 | 55366 | 79611419 |
| Oral candidiasis | 20.93 | 11.93 | 70 | 77533 | 29558 | 79637227 |
| Nephrolithiasis | 20.88 | 11.93 | 13 | 77590 | 53278 | 79613507 |
| Extramedullary haemopoiesis | 20.81 | 11.93 | 7 | 77596 | 131 | 79666654 |
| Chest discomfort | 20.76 | 11.93 | 67 | 77536 | 137977 | 79528808 |
| Transplant failure | 20.61 | 11.93 | 24 | 77579 | 4617 | 79662168 |
| Joint injury | 20.54 | 11.93 | 3 | 77600 | 31332 | 79635453 |
| Leukaemia | 20.45 | 11.93 | 27 | 77576 | 5898 | 79660887 |
| Insomnia | 20.45 | 11.93 | 147 | 77456 | 245023 | 79421762 |
| Dyspnoea | 20.24 | 11.93 | 658 | 76945 | 856367 | 78810418 |
| Paronychia | 20.19 | 11.93 | 31 | 77572 | 7777 | 79659008 |
| Osteoporosis | 20.12 | 11.93 | 14 | 77589 | 54098 | 79612687 |
| Engraft failure | 20.09 | 11.93 | 11 | 77592 | 702 | 79666083 |
| Blood glucose increased | 20.07 | 11.93 | 52 | 77551 | 114923 | 79551862 |
| Respiratory arrest | 19.97 | 11.93 | 16 | 77587 | 57534 | 79609251 |
| Migraine | 19.95 | 11.93 | 34 | 77569 | 87459 | 79579326 |
| Sopor | 19.80 | 11.93 | 4 | 77599 | 33006 | 79633779 |
| Dysarthria | 19.71 | 11.93 | 22 | 77581 | 67600 | 79599185 |
| Bone marrow transplant rejection | 19.34 | 11.93 | 8 | 77595 | 271 | 79666514 |
| Alpha haemolytic streptococcal infection | 19.33 | 11.93 | 17 | 77586 | 2343 | 79664442 |
| Diabetes mellitus | 19.25 | 11.93 | 29 | 77574 | 78361 | 79588424 |
| Extravasation blood | 19.16 | 11.93 | 9 | 77594 | 415 | 79666370 |
| Urinary tract infection pseudomonal | 18.98 | 11.93 | 15 | 77588 | 1783 | 79665002 |
| Subclavian vein thrombosis | 18.74 | 11.93 | 17 | 77586 | 2440 | 79664345 |
| Fusarium infection | 18.73 | 11.93 | 15 | 77588 | 1817 | 79664968 |
| Abdominal wall wound | 18.65 | 11.93 | 6 | 77597 | 97 | 79666688 |
| Stomatococcal infection | 18.65 | 11.93 | 8 | 77595 | 297 | 79666488 |
| Chills | 18.61 | 11.93 | 238 | 77365 | 159996 | 79506789 |
| Product quality issue | 18.59 | 11.93 | 5 | 77598 | 33935 | 79632850 |
| Staphylococcal sepsis | 18.59 | 11.93 | 43 | 77560 | 14683 | 79652102 |
| Progressive multifocal leukoencephalopathy | 18.58 | 11.93 | 53 | 77550 | 20547 | 79646238 |
| Myeloblast percentage decreased | 18.52 | 11.93 | 5 | 77598 | 42 | 79666743 |
| Candida infection | 18.48 | 11.93 | 80 | 77523 | 38134 | 79628651 |
| Hypoglycaemia | 18.47 | 11.93 | 45 | 77558 | 101549 | 79565236 |
| Myocardial calcification | 18.41 | 11.93 | 5 | 77598 | 43 | 79666742 |
| Product use issue | 18.38 | 11.93 | 124 | 77479 | 209698 | 79457087 |
| Inadequate osteointegration | 18.21 | 11.93 | 4 | 77599 | 12 | 79666773 |
| Road traffic accident | 18.03 | 11.93 | 10 | 77593 | 43654 | 79623131 |
| Ejection fraction decreased | 17.98 | 11.93 | 74 | 77529 | 34503 | 79632282 |
| Blister | 17.95 | 11.93 | 58 | 77545 | 119418 | 79547367 |
| Pulmonary arterial hypertension | 17.95 | 11.93 | 3 | 77600 | 28363 | 79638422 |
| Gastric disorder | 17.89 | 11.93 | 7 | 77596 | 37426 | 79629359 |
| Speech disorder | 17.83 | 11.93 | 16 | 77587 | 54429 | 79612356 |
| Biliary tract infection | 17.79 | 11.93 | 13 | 77590 | 1375 | 79665410 |
| Bacterial sepsis | 17.72 | 11.93 | 30 | 77573 | 8168 | 79658617 |
| Blood stem cell harvest failure | 17.70 | 11.93 | 6 | 77597 | 115 | 79666670 |
| Red blood cell count decreased | 17.68 | 11.93 | 106 | 77497 | 57407 | 79609378 |
| Pruritus | 17.61 | 11.93 | 274 | 77329 | 394374 | 79272411 |
| Engraftment syndrome | 17.61 | 11.93 | 13 | 77590 | 1396 | 79665389 |
| Hyperkalaemia | 17.56 | 11.93 | 55 | 77548 | 114343 | 79552442 |
| Urinary bladder haematoma | 17.53 | 11.93 | 4 | 77599 | 15 | 79666770 |
| Injection site bruising | 17.51 | 11.93 | 9 | 77594 | 40993 | 79625792 |
| Cardiac disorder | 17.47 | 11.93 | 23 | 77580 | 65734 | 79601051 |
| Blood pressure diastolic decreased | 17.43 | 11.93 | 4 | 77599 | 30212 | 79636573 |
| Myoclonus | 17.34 | 11.93 | 3 | 77600 | 27657 | 79639128 |
| Bone marrow transplant | 17.30 | 11.93 | 13 | 77590 | 1435 | 79665350 |
| Neuroleptic malignant syndrome | 17.25 | 11.93 | 3 | 77600 | 27556 | 79639229 |
| Lymphocytosis | 17.16 | 11.93 | 22 | 77581 | 4671 | 79662114 |
| Abnormal behaviour | 17.09 | 11.93 | 7 | 77596 | 36414 | 79630371 |
| Herpes simplex encephalitis | 17.08 | 11.93 | 10 | 77593 | 726 | 79666059 |
| Hyperpyrexia | 16.91 | 11.93 | 25 | 77578 | 6067 | 79660718 |
| Product storage error | 16.89 | 11.93 | 44 | 77559 | 16182 | 79650603 |
| COVID-19 pneumonia | 16.82 | 11.93 | 64 | 77539 | 28785 | 79638000 |
| Neuroblastoma | 16.76 | 11.93 | 7 | 77596 | 243 | 79666542 |
| Drug-induced liver injury | 16.68 | 11.93 | 24 | 77579 | 66093 | 79600692 |
| Depressed level of consciousness | 16.65 | 11.93 | 44 | 77559 | 96608 | 79570177 |
| Haematochezia | 16.58 | 11.93 | 38 | 77565 | 87607 | 79579178 |
| Disturbance in attention | 16.56 | 11.93 | 15 | 77588 | 50786 | 79615999 |
| Neoplasm progression | 16.37 | 11.93 | 96 | 77507 | 51586 | 79615199 |
| Treatment noncompliance | 16.37 | 11.93 | 16 | 77587 | 52252 | 79614533 |
| Joint range of motion decreased | 16.28 | 11.93 | 6 | 77597 | 33276 | 79633509 |
| Sciatica | 16.23 | 11.93 | 6 | 77597 | 33216 | 79633569 |
| Cataract | 16.22 | 11.93 | 22 | 77581 | 62098 | 79604687 |
| Periumbilical abscess | 16.14 | 11.93 | 5 | 77598 | 71 | 79666714 |
| Lung infiltration | 16.07 | 11.93 | 54 | 77549 | 22858 | 79643927 |
| Restlessness | 16.04 | 11.93 | 13 | 77590 | 46479 | 79620306 |
| Fluid retention | 16.03 | 11.93 | 27 | 77576 | 69782 | 79597003 |
| Monocytopenia | 15.92 | 11.93 | 6 | 77597 | 158 | 79666627 |
| Laryngeal cancer stage IV | 15.84 | 11.93 | 4 | 77599 | 25 | 79666760 |
| Central nervous system lymphoma | 15.84 | 11.93 | 15 | 77588 | 2274 | 79664511 |
| Petechiae | 15.80 | 11.93 | 50 | 77553 | 20515 | 79646270 |
| Delayed engraftment | 15.71 | 11.93 | 7 | 77596 | 285 | 79666500 |
| Angiodysplasia | 15.68 | 11.93 | 11 | 77592 | 1091 | 79665694 |
| Transfusion | 15.61 | 11.93 | 51 | 77552 | 21279 | 79645506 |
| Hepatosplenomegaly | 15.56 | 11.93 | 24 | 77579 | 6045 | 79660740 |
| Chronic lymphocytic leukaemia recurrent | 15.56 | 11.93 | 9 | 77594 | 639 | 79666146 |
| Enterococcal sepsis | 15.41 | 11.93 | 16 | 77587 | 2710 | 79664075 |
| Bronchitis | 15.38 | 11.93 | 70 | 77533 | 130574 | 79536211 |
| Malignant neoplasm progression | 15.38 | 11.93 | 201 | 77402 | 135789 | 79530996 |
| Neutrophil/lymphocyte ratio increased | 15.27 | 11.93 | 3 | 77600 | 4 | 79666781 |
| Viral haemorrhagic cystitis | 15.21 | 11.93 | 14 | 77589 | 2047 | 79664738 |
| Accidental overdose | 15.04 | 11.93 | 10 | 77593 | 39571 | 79627214 |
| Peripheral T-cell lymphoma unspecified | 15.03 | 11.93 | 9 | 77594 | 681 | 79666104 |
| Adverse drug reaction | 14.95 | 11.93 | 26 | 77577 | 66366 | 79600419 |
| Enterobacter sepsis | 14.91 | 11.93 | 11 | 77592 | 1180 | 79665605 |
| Acanthosis | 14.90 | 11.93 | 8 | 77595 | 491 | 79666294 |
| Illness | 14.84 | 11.93 | 14 | 77589 | 46497 | 79620288 |
| Growth of eyelashes | 14.82 | 11.93 | 6 | 77597 | 192 | 79666593 |
| Feeling hot | 14.76 | 11.93 | 22 | 77581 | 59712 | 79607073 |
| Autoimmune haemolytic anaemia | 14.70 | 11.93 | 28 | 77575 | 8352 | 79658433 |
| Staphylococcal infection | 14.58 | 11.93 | 102 | 77501 | 58193 | 79608592 |
| Swollen tongue | 14.56 | 11.93 | 12 | 77591 | 42558 | 79624227 |
| Streptococcal sepsis | 14.55 | 11.93 | 16 | 77587 | 2891 | 79663894 |
| Dry eye | 14.48 | 11.93 | 9 | 77594 | 36922 | 79629863 |
| Oral herpes | 14.47 | 11.93 | 59 | 77544 | 27395 | 79639390 |
| Full blood count decreased | 14.42 | 11.93 | 58 | 77545 | 26761 | 79640024 |
| Lymph node pain | 14.40 | 11.93 | 12 | 77591 | 1538 | 79665247 |
| Ileus | 14.35 | 11.93 | 57 | 77546 | 26154 | 79640631 |
| Transformation to acute myeloid leukaemia | 14.30 | 11.93 | 10 | 77593 | 987 | 79665798 |
| Ecthyma | 14.27 | 11.93 | 9 | 77594 | 747 | 79666038 |
| Odynophagia | 14.21 | 11.93 | 33 | 77570 | 11294 | 79655491 |
| Neutrophil Pelger-Huet anomaly present | 14.19 | 11.93 | 7 | 77596 | 360 | 79666425 |
| Cardiac failure congestive | 14.10 | 11.93 | 81 | 77522 | 142321 | 79524464 |
| Tumour necrosis | 14.08 | 11.93 | 13 | 77590 | 1909 | 79664876 |
| Hyperhidrosis | 14.04 | 11.93 | 88 | 77515 | 151404 | 79515381 |
| Emotional distress | 14.01 | 11.93 | 11 | 77592 | 39958 | 79626827 |
| Biliary sepsis | 13.95 | 11.93 | 12 | 77591 | 1605 | 79665180 |
| Amnesia | 13.92 | 11.93 | 25 | 77578 | 63032 | 79603753 |
| Cytomegalovirus infection reactivation | 13.92 | 11.93 | 28 | 77575 | 8688 | 79658097 |
| Device dislocation | 13.90 | 11.93 | 4 | 77599 | 25966 | 79640819 |
| Depressed mood | 13.88 | 11.93 | 16 | 77587 | 48464 | 79618321 |
| Maternal exposure during pregnancy | 13.88 | 11.93 | 77 | 77526 | 136461 | 79530324 |
| Angina pectoris | 13.84 | 11.93 | 18 | 77585 | 51714 | 79615071 |
| Constipation | 13.82 | 11.93 | 367 | 77236 | 282683 | 79384102 |
| Nightmare | 13.81 | 11.93 | 4 | 77599 | 25857 | 79640928 |
| Anaphylactic reaction | 13.76 | 11.93 | 39 | 77564 | 83704 | 79583081 |
| Gastroenteritis norovirus | 13.69 | 11.93 | 16 | 77587 | 3090 | 79663695 |
| Dyskinesia | 13.68 | 11.93 | 14 | 77589 | 44759 | 79622026 |
| Injection site haemorrhage | 13.67 | 11.93 | 5 | 77598 | 27865 | 79638920 |
| Neutrophilic dermatosis | 13.65 | 11.93 | 8 | 77595 | 582 | 79666203 |
| Rectosigmoid cancer metastatic | 13.53 | 11.93 | 4 | 77599 | 48 | 79666737 |
| Naevus haemorrhage | 13.47 | 11.93 | 5 | 77598 | 126 | 79666659 |
| Lip swelling | 13.43 | 11.93 | 12 | 77591 | 40899 | 79625886 |
| Aggression | 13.36 | 11.93 | 18 | 77585 | 50940 | 79615845 |
| Limb injury | 13.34 | 11.93 | 6 | 77597 | 29522 | 79637263 |
| Hallucination | 13.32 | 11.93 | 41 | 77562 | 85704 | 79581081 |
| Obstructive airways disorder | 13.29 | 11.93 | 7 | 77596 | 31452 | 79635333 |
| Cord blood transplant therapy | 13.24 | 11.93 | 4 | 77599 | 52 | 79666733 |
| Hyperchlorhydria | 13.21 | 11.93 | 13 | 77590 | 2066 | 79664719 |
| Skin oedema | 13.19 | 11.93 | 12 | 77591 | 1729 | 79665056 |
| Movement disorder | 13.19 | 11.93 | 5 | 77598 | 27254 | 79639531 |
| Erythropenia | 13.12 | 11.93 | 7 | 77596 | 424 | 79666361 |
| Intestinal fistula | 13.08 | 11.93 | 11 | 77592 | 1427 | 79665358 |
| Enterococcus test positive | 13.08 | 11.93 | 13 | 77590 | 2091 | 79664694 |
| Chronic kidney disease | 13.07 | 11.93 | 28 | 77575 | 66126 | 79600659 |
| Oesophageal haemorrhage | 13.03 | 11.93 | 12 | 77591 | 1755 | 79665030 |
| Radiation fibrosis - lung | 12.97 | 11.93 | 4 | 77599 | 56 | 79666729 |
| Sinus disorder | 12.91 | 11.93 | 3 | 77600 | 22461 | 79644324 |
| Hypomagnesaemia | 12.88 | 11.93 | 84 | 77519 | 46827 | 79619958 |
| Candida sepsis | 12.87 | 11.93 | 14 | 77589 | 2499 | 79664286 |
| Heart rate increased | 12.87 | 11.93 | 67 | 77536 | 120657 | 79546128 |
| Thymoma | 12.74 | 11.93 | 6 | 77597 | 278 | 79666507 |
| Febrile infection | 12.73 | 11.93 | 16 | 77587 | 3330 | 79663455 |
| Alopecia | 12.69 | 11.93 | 154 | 77449 | 231201 | 79435584 |
| Paroxysmal nocturnal haemoglobinuria | 12.68 | 11.93 | 6 | 77597 | 281 | 79666504 |
| Renal failure | 12.68 | 11.93 | 270 | 77333 | 200698 | 79466087 |
| Peripheral motor neuropathy | 12.65 | 11.93 | 16 | 77587 | 3351 | 79663434 |
| Choriocarcinoma | 12.59 | 11.93 | 4 | 77599 | 62 | 79666723 |
| Acute myocardial infarction | 12.57 | 11.93 | 36 | 77567 | 77000 | 79589785 |
| Urinary tract pain | 12.51 | 11.93 | 6 | 77597 | 290 | 79666495 |
| Amniotic fluid volume decreased | 12.51 | 11.93 | 6 | 77597 | 290 | 79666495 |
| Fear | 12.50 | 11.93 | 3 | 77600 | 21983 | 79644802 |
| B-cell lymphoma | 12.46 | 11.93 | 22 | 77581 | 6193 | 79660592 |
| Irritability | 12.42 | 11.93 | 13 | 77590 | 41131 | 79625654 |
| Kidney infection | 12.39 | 11.93 | 3 | 77600 | 21848 | 79644937 |
| Hypogammaglobulinaemia | 12.35 | 11.93 | 34 | 77569 | 12917 | 79653868 |
| Product use in unapproved indication | 12.33 | 11.93 | 325 | 77278 | 250034 | 79416751 |
| Visual impairment | 12.31 | 11.93 | 47 | 77556 | 92084 | 79574701 |
| Pneumovirus test positive | 12.30 | 11.93 | 4 | 77599 | 67 | 79666718 |
| Blood creatine phosphokinase increased | 12.23 | 11.93 | 29 | 77574 | 66061 | 79600724 |
| Campylobacter test positive | 12.19 | 11.93 | 4 | 77599 | 69 | 79666716 |
| Antithrombin III decreased | 12.15 | 11.93 | 7 | 77596 | 493 | 79666292 |
| Platelet count abnormal | 12.15 | 11.93 | 19 | 77584 | 4843 | 79661942 |
| Hydronephrosis | 12.12 | 11.93 | 41 | 77562 | 17413 | 79649372 |
| Musculoskeletal disorder | 12.06 | 11.93 | 3 | 77600 | 21445 | 79645340 |
| Epstein-Barr virus associated lymphoproliferative disorder | 12.05 | 11.93 | 16 | 77587 | 3516 | 79663269 |
| Iatrogenic infection | 11.99 | 11.93 | 4 | 77599 | 73 | 79666712 |
None
| Source | Code | Description |
|---|---|---|
| ATC | L03AA02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSTIMULANTS IMMUNOSTIMULANTS Colony stimulating factors |
| FDA CS | M0024695 | Granulocyte-Macrophage Colony-Stimulating Factor |
| FDA CS | M0024696 | Granulocyte Colony-Stimulating Factor |
| FDA PE | N0000009451 | Increased Myeloid Cell Production |
| MeSH PA | D006401 | Hematologic Agents |
| FDA EPC | N0000175666 | Leukocyte Growth Factor |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Congenital neutropenia | indication | 89655007 | |
| Cyclical neutropenia | indication | 191347008 | DOID:5339 |
| Chronic idiopathic neutropenia | indication | 248693006 | |
| Chemotherapy-induced neutropenia | indication | 425229001 | |
| Relapsed acute myeloid leukemia | indication | 12281000132104 | |
| Refractory acute myeloid leukemia | indication | 12291000132102 | |
| Enhancement of an antitumor effect of dinutuximab for neuroblastoma | indication |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Granulocyte colony-stimulating factor receptor | Membrane receptor | ACTIVATOR | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| PVI5M0M1GW | UNII |
| D03235 | KEGG_DRUG |
| 4019570 | VUID |
| N0000147669 | NUI |
| 4019570 | VANDF |
| 4034460 | VANDF |
| C0210630 | UMLSCUI |
| CHEMBL1201567 | ChEMBL_ID |
| DB00099 | DRUGBANK_ID |
| D000069585 | MESH_DESCRIPTOR_UI |
| 6739 | INN_ID |
| 6968 | IUPHAR_LIGAND_ID |
| 1605064 | RXNORM |
| 2266 | MMSL |
| 234064 | MMSL |
| 33394 | MMSL |
| 4727 | MMSL |
| d00512 | MMSL |
| 003574 | NDDF |
| 015943 | NDDF |
| 108965009 | SNOMEDCT_US |
| 386948008 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0291 | INJECTION, SOLUTION | 300 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0291 | INJECTION, SOLUTION | 300 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0291 | INJECTION, SOLUTION | 300 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0292 | INJECTION, SOLUTION | 480 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0292 | INJECTION, SOLUTION | 480 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0292 | INJECTION, SOLUTION | 480 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0293 | INJECTION, SOLUTION | 300 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0293 | INJECTION, SOLUTION | 300 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0293 | INJECTION, SOLUTION | 300 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0294 | INJECTION, SOLUTION | 480 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0294 | INJECTION, SOLUTION | 480 ug | SUBCUTANEOUS | BLA | 29 sections |
| Nivestym | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0294 | INJECTION, SOLUTION | 480 ug | SUBCUTANEOUS | BLA | 29 sections |
| Neupogen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-2522 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 14 sections |
| Neupogen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-3050 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 14 sections |
| Neupogen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5020 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 14 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-209 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-209 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-209 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-209 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-530 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-530 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-530 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-530 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-546 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-546 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-546 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-546 | INJECTION, SOLUTION | 480 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-924 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-924 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |
| NEUPOGEN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-924 | INJECTION, SOLUTION | 300 ug | INTRAVENOUS | BLA | 32 sections |