All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

omalizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4972	242138-07-4

Description:

Molecule

Description

Synonyms: omalizumab xolair rhuMab-E25 olizumab

An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
16	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 25, 2005	EMA	Novartis Europharm Ltd
June 20, 2003	FDA	GENENTECH
Jan. 21, 2009	PMDA	Novartis Pharma K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria	2814.26	16.35	2359	113076	163443	63210144
Forced expiratory volume decreased	1974.51	16.35	611	114824	4357	63369230
Anaphylactic reaction	1928.86	16.35	1303	114132	64797	63308790
Wheezing	1899.21	16.35	1493	113942	94102	63279485
No adverse event	1491.47	16.35	932	114503	40473	63333114
Cough	1306.02	16.35	2086	113349	290657	63082930
Sputum discoloured	1097.52	16.35	554	114881	15793	63357794
Obstructive airways disorder	1064.49	16.35	587	114848	20112	63353475
Productive cough	882.89	16.35	807	114628	62401	63311186
Dyspnoea	878.99	16.35	2912	112523	658401	62715186
Chest discomfort	717.30	16.35	940	114495	109029	63264558
Middle insomnia	692.72	16.35	374	115061	12269	63361318
Pruritus	559.52	16.35	1681	113754	359772	63013815
Sensitivity to weather change	544.14	16.35	265	115170	6972	63366615
Influenza	526.08	16.35	806	114629	107916	63265671
Angioedema	519.91	16.35	533	114902	47432	63326155
Heart rate increased	509.50	16.35	736	114699	93502	63280085
Blood immunoglobulin E increased	494.53	16.35	205	115230	3644	63369943
Nasal congestion	485.91	16.35	598	114837	65062	63308525
Blood pressure systolic increased	478.41	16.35	507	114928	46890	63326697
Oropharyngeal pain	454.94	16.35	699	114736	93788	63279799
Malaise	426.54	16.35	1687	113748	414267	62959320
Acute kidney injury	416.42	16.35	14	115421	263401	63110186
Toxicity to various agents	402.33	16.35	10	115425	247240	63126347
Asthmatic crisis	399.49	16.35	143	115292	1670	63371917
Infusion related reaction	381.31	16.35	15	115420	245506	63128081
Skin plaque	378.93	16.35	218	115217	8102	63365485
Asthma	373.98	16.35	759	114676	126802	63246785
Throat tightness	365.33	16.35	327	115108	24560	63349027
Nasopharyngitis	356.89	16.35	1144	114291	253113	63120474
Blood pressure increased	356.13	16.35	859	114576	161203	63212384
Bronchitis	318.20	16.35	702	114733	124233	63249354
Pemphigus	312.82	16.35	4	115431	183722	63189865
Hypoventilation	306.95	16.35	157	115278	4597	63368990
Synovitis	302.34	16.35	8	115427	186910	63186677
Respiratory tract congestion	285.14	16.35	246	115189	17586	63356001
Neutropenia	284.90	16.35	7	115428	174998	63198589
Drug intolerance	282.80	16.35	104	115331	308557	63065030
Secretion discharge	281.66	16.35	209	115226	12022	63361565
Rhinorrhoea	280.81	16.35	460	114975	65117	63308470
Drug interaction	278.85	16.35	42	115393	229089	63144498
Nasal polyps	274.38	16.35	158	115277	5881	63367706
Hand deformity	273.57	16.35	3	115432	159454	63214133
Perfume sensitivity	269.89	16.35	87	115348	718	63372869
Bronchospasm	261.44	16.35	231	115204	17049	63356538
Arthropathy	251.72	16.35	59	115376	234733	63138854
Completed suicide	248.72	16.35	3	115432	145670	63227917
Body temperature decreased	242.48	16.35	238	115197	20081	63353506
Upper-airway cough syndrome	240.53	16.35	185	115250	11233	63362354
Glossodynia	239.07	16.35	24	115411	178852	63194735
Diarrhoea	237.04	16.35	602	114833	714764	62658823
Hepatic enzyme increased	235.19	16.35	42	115393	202286	63171301
Systemic lupus erythematosus	235.12	16.35	47	115388	208871	63164716
Seasonal allergy	234.52	16.35	237	115198	20713	63352874
Rales	233.69	16.35	190	115245	12507	63361080
Breath sounds abnormal	231.61	16.35	178	115257	10795	63362792
Treatment failure	223.52	16.35	45	115390	198998	63174589
Pulmonary function test decreased	222.42	16.35	119	115316	3828	63369759
Respiratory rate increased	219.66	16.35	189	115246	13459	63360128
Forced vital capacity decreased	218.64	16.35	80	115355	999	63372588
Rheumatoid arthritis	215.34	16.35	96	115339	253723	63119864
Pulmonary function test abnormal	210.15	16.35	90	115345	1740	63371847
Bronchopulmonary aspergillosis allergic	207.59	16.35	95	115340	2163	63371424
Pneumonia	207.45	16.35	1480	113955	455287	62918300
Joint swelling	205.92	16.35	176	115259	327490	63046097
Peak expiratory flow rate decreased	198.77	16.35	65	115370	564	63373023
Condition aggravated	198.25	16.35	265	115170	401952	62971635
Confusional state	198.01	16.35	91	115344	236289	63137298
Illness	193.79	16.35	332	115103	48727	63324860
Abdominal discomfort	192.46	16.35	180	115255	320705	63052882
Anaemia	191.29	16.35	152	115283	293278	63080309
Eosinophilic granulomatosis with polyangiitis	188.35	16.35	88	115347	2104	63371483
Hyponatraemia	187.98	16.35	3	115432	111897	63261690
Sneezing	187.48	16.35	197	115238	18021	63355566
Inappropriate schedule of product administration	186.66	16.35	511	114924	103454	63270133
Erythema	183.50	16.35	718	114717	175033	63198554
Dysphonia	182.55	16.35	318	115117	47296	63326291
Scratch	180.58	16.35	125	115310	6440	63367147
Stress	178.34	16.35	384	115051	66783	63306804
Throat irritation	177.47	16.35	276	115159	37371	63336216
Respiratory tract infection	174.84	16.35	289	115146	41194	63332393
Hypersensitivity	174.22	16.35	1016	114419	291669	63081918
Dust allergy	172.14	16.35	60	115375	644	63372943
Humidity intolerance	171.52	16.35	51	115384	311	63373276
White blood cell count decreased	167.99	16.35	26	115409	139078	63234509
Full blood count abnormal	162.90	16.35	242	115193	31475	63342112
Stomatitis	160.72	16.35	29	115406	138696	63234891
Anaphylactic shock	159.97	16.35	206	115229	23427	63350160
Pregnancy	158.44	16.35	259	115176	36577	63337010
Pericarditis	155.73	16.35	26	115409	131553	63242034
Eosinophil count increased	155.24	16.35	141	115294	10787	63362800
Platelet count decreased	151.47	16.35	17	115418	116105	63257482
Dehydration	151.03	16.35	63	115372	173291	63200296
Bronchial secretion retention	148.98	16.35	81	115354	2692	63370895
Respiratory disorder	147.18	16.35	259	115176	38823	63334764
Smoke sensitivity	146.63	16.35	48	115387	418	63373169
Helicobacter infection	146.22	16.35	5	115430	92780	63280807
Aphonia	145.22	16.35	131	115304	9932	63363655
Weight decreased	145.14	16.35	930	114505	275868	63097719
Thrombocytopenia	145.06	16.35	47	115388	151110	63222477
Bronchiectasis	144.18	16.35	162	115273	15980	63357607
Hypokalaemia	143.81	16.35	12	115423	103792	63269795
Constipation	143.44	16.35	119	115316	224824	63148763
Allergy to animal	142.16	16.35	61	115374	1185	63372402
Pharyngeal swelling	142.02	16.35	107	115328	6297	63367290
Vital capacity decreased	141.17	16.35	67	115368	1661	63371926
Myalgia	138.06	16.35	580	114855	145949	63227638
Swelling face	137.61	16.35	335	115100	63140	63310447
Lip swelling	135.74	16.35	220	115215	30843	63342744
Dyspnoea exertional	134.74	16.35	322	115113	59980	63313607
Nasal oedema	133.56	16.35	62	115373	1460	63372127
Reversible airways obstruction	131.14	16.35	65	115370	1777	63371810
Eye pruritus	129.91	16.35	165	115270	18506	63355081
Food allergy	129.46	16.35	130	115305	11271	63362316
Psoriatic arthropathy	128.39	16.35	10	115425	91510	63282077
Sinus pain	128.27	16.35	79	115356	3331	63370256
Viral infection	127.44	16.35	231	115204	35432	63338155
Lower respiratory tract congestion	127.10	16.35	74	115361	2812	63370775
Product use issue	125.98	16.35	129	115306	220391	63153196
Disease progression	125.38	16.35	34	115401	122724	63250863
Rhinitis allergic	122.79	16.35	128	115307	11599	63361988
Nausea	121.62	16.35	984	114451	853487	62520100
Sinus congestion	121.13	16.35	157	115278	17966	63355621
Influenza like illness	120.42	16.35	329	115106	66495	63307092
Exposure to allergen	120.25	16.35	38	115397	292	63373295
Swollen tongue	120.04	16.35	222	115213	34578	63339009
Impaired healing	119.70	16.35	21	115414	102521	63271066
Wound	118.88	16.35	75	115360	163188	63210399
Therapeutic product effect decreased	117.32	16.35	107	115328	193080	63180507
Alanine aminotransferase increased	115.30	16.35	24	115411	103746	63269841
Incorrect dose administered	114.87	16.35	302	115133	59666	63313921
Urticaria thermal	113.48	16.35	39	115396	400	63373187
Lower respiratory tract infection	113.36	16.35	509	114926	131798	63241789
Animal scratch	112.85	16.35	54	115381	1364	63372223
Urinary tract discomfort	112.10	16.35	43	115392	617	63372970
Hypotension	111.81	16.35	203	115232	272401	63101186
Paranasal sinus discomfort	110.32	16.35	79	115356	4297	63369290
Sinusitis	107.53	16.35	743	114692	225910	63147677
Injection site pain	105.73	16.35	492	114943	129308	63244279
Sputum culture positive	104.63	16.35	59	115376	2108	63371479
Total lung capacity decreased	104.22	16.35	59	115376	2124	63371463
Aspartate aminotransferase increased	102.13	16.35	20	115415	90257	63283330
Temperature intolerance	99.56	16.35	101	115334	8863	63364724
Nasal discharge discolouration	99.40	16.35	58	115377	2213	63371374
Cardiac failure congestive	95.51	16.35	25	115410	92408	63281179
Rubber sensitivity	95.39	16.35	57	115378	2274	63371313
Overdose	95.20	16.35	45	115390	115033	63258554
Blood pressure decreased	94.95	16.35	297	115138	64725	63308862
Neuropathy peripheral	94.72	16.35	44	115391	113623	63259964
Decreased appetite	94.21	16.35	197	115238	250855	63122732
Gastrointestinal haemorrhage	93.93	16.35	17	115418	81159	63292428
Migraine	93.36	16.35	404	115031	102942	63270645
Alveolar osteitis	92.66	16.35	41	115394	860	63372727
Headache	90.07	16.35	1633	113802	631608	62741979
Leukopenia	89.83	16.35	16	115419	77274	63296313
Serum sickness	89.52	16.35	59	115376	2801	63370786
Sepsis	89.21	16.35	88	115347	153035	63220552
Paraesthesia oral	87.71	16.35	139	115296	19117	63354470
Tunnel vision	86.83	16.35	43	115392	1173	63372414
Feeling abnormal	86.06	16.35	512	114923	147880	63225707
Pharyngeal oedema	85.72	16.35	115	115320	13606	63359981
Ear pruritus	85.16	16.35	65	115370	3900	63369687
Anaphylactoid reaction	84.32	16.35	63	115372	3660	63369927
Bradycardia	83.30	16.35	16	115419	73211	63300376
Lung disorder	83.30	16.35	276	115159	61985	63311602
Atrial fibrillation	82.95	16.35	55	115380	116581	63257006
Vomiting	82.80	16.35	637	114798	558980	62814607
Eczema	82.69	16.35	182	115253	32109	63341478
Septic shock	81.45	16.35	12	115423	66617	63306970
Mechanical urticaria	80.80	16.35	31	115404	445	63373142
Spirometry abnormal	80.61	16.35	26	115409	215	63373372
Neutrophil count decreased	79.57	16.35	6	115429	56400	63317187
Ear congestion	79.35	16.35	54	115381	2705	63370882
Eye swelling	79.26	16.35	150	115285	23768	63349819
Irritable bowel syndrome	78.37	16.35	26	115409	82386	63291201
Musculoskeletal stiffness	77.88	16.35	135	115300	184483	63189104
Multiple organ dysfunction syndrome	77.39	16.35	7	115428	56745	63316842
Feeling hot	77.23	16.35	234	115201	50120	63323467
Renal impairment	77.09	16.35	32	115403	88323	63285264
Respiratory tract inflammation	77.01	16.35	32	115403	572	63373015
Renal failure	76.48	16.35	61	115374	117591	63255996
Adverse event	76.34	16.35	15	115420	67544	63306043
Depressed level of consciousness	76.30	16.35	11	115424	62067	63311520
Hyperkalaemia	75.80	16.35	6	115429	54197	63319390
Bronchial obstruction	75.39	16.35	42	115393	1465	63372122
Mast cell activation syndrome	73.62	16.35	34	115401	791	63372796
Oropharyngeal discomfort	73.01	16.35	67	115368	5193	63368394
Increased bronchial secretion	71.79	16.35	43	115392	1723	63371864
Ear pain	71.31	16.35	184	115251	35934	63337653
Status asthmaticus	70.65	16.35	34	115401	870	63372717
Electrocardiogram QT prolonged	69.88	16.35	12	115423	59518	63314069
Sensation of foreign body	68.92	16.35	62	115373	4683	63368904
Multiple sclerosis relapse	68.83	16.35	5	115430	48473	63325114
Total lung capacity increased	68.31	16.35	46	115389	2264	63371323
International normalised ratio increased	68.24	16.35	4	115431	46421	63327166
Knee arthroplasty	68.05	16.35	9	115426	54197	63319390
Pulmonary mass	67.92	16.35	136	115299	22460	63351127
Mastocytosis	67.88	16.35	29	115406	557	63373030
Conjunctivitis allergic	66.35	16.35	33	115402	909	63372678
Suicide attempt	65.81	16.35	15	115420	60903	63312684
Interstitial lung disease	65.39	16.35	16	115419	61892	63311695
Wound secretion	64.49	16.35	59	115376	4555	63369032
Rhabdomyolysis	63.96	16.35	4	115431	43947	63329640
Frustration tolerance decreased	63.89	16.35	71	115364	6917	63366670
Cold urticaria	63.74	16.35	19	115416	117	63373470
C-reactive protein increased	62.95	16.35	48	115387	94659	63278928
Breast cancer	61.63	16.35	211	115224	48172	63325415
Ascites	61.46	16.35	3	115432	40725	63332862
Bladder pain	61.26	16.35	43	115392	2265	63371322
Lacrimation increased	60.61	16.35	123	115312	20508	63353079
Cardiac arrest	58.87	16.35	49	115386	92496	63281091
Hallucination	58.22	16.35	14	115421	54803	63318784
Liver function test abnormal	58.15	16.35	9	115426	48172	63325415
Polymyalgia rheumatica	55.98	16.35	50	115385	3741	63369846
Hypokinesia	55.91	16.35	95	115340	13841	63359746
Gastrointestinal disorder	55.30	16.35	96	115339	131143	63242444
Rhinitis	54.48	16.35	84	115351	11282	63362305
Death	54.39	16.35	428	115007	373953	62999634
Cognitive disorder	54.14	16.35	17	115418	55798	63317789
Weight increased	53.91	16.35	717	114718	260075	63113512
Mental status changes	53.68	16.35	5	115430	39594	63333993
Delirium	53.50	16.35	13	115422	50528	63323059
Cardio-respiratory arrest	53.46	16.35	21	115414	59938	63313649
Food intolerance	53.40	16.35	46	115389	3279	63370308
Forced expiratory flow decreased	51.98	16.35	15	115420	81	63373506
Auditory neuropathy spectrum disorder	51.64	16.35	12	115423	21	63373566
Lactic acidosis	51.46	16.35	5	115430	38282	63335305
Blood iron decreased	50.87	16.35	94	115341	14627	63358960
Quality of life decreased	50.79	16.35	71	115364	8732	63364855
Papule	50.62	16.35	57	115378	5634	63367953
Psoriasis	50.59	16.35	50	115385	86907	63286680
Skin ulcer	49.82	16.35	9	115426	43036	63330551
Hepatic failure	49.70	16.35	4	115431	35652	63337935
Crepitations	49.63	16.35	67	115368	7973	63365614
Blood bilirubin increased	49.53	16.35	5	115430	37135	63336452
Blood immunoglobulin E decreased	49.24	16.35	14	115421	71	63373516
Chronic spontaneous urticaria	49.19	16.35	29	115406	1128	63372459
Dyspnoea at rest	49.06	16.35	48	115387	4031	63369556
Coma	49.02	16.35	28	115407	64336	63309251
Hepatitis	49.01	16.35	7	115428	39781	63333806
Medication error	48.83	16.35	17	115418	52267	63321320
Wound complication	48.67	16.35	46	115389	3701	63369886
Adverse drug reaction	48.53	16.35	44	115391	79670	63293917
Abortion spontaneous	48.49	16.35	192	115243	47003	63326584
Throat clearing	48.35	16.35	38	115397	2381	63371206
Respiratory failure	48.13	16.35	69	115366	101789	63271798
Pulmonary congestion	47.83	16.35	101	115334	17317	63356270
Lung diffusion test decreased	47.83	16.35	24	115411	674	63372913
General physical health deterioration	47.81	16.35	196	115239	201206	63172381
Hypoacusis	47.63	16.35	123	115312	24028	63349559
Blood alkaline phosphatase increased	47.59	16.35	10	115425	42957	63330630
Pulmonary pain	47.56	16.35	44	115391	3446	63370141
Plasma cell myeloma	47.45	16.35	5	115430	35900	63337687
Drug-induced liver injury	47.45	16.35	8	115427	40214	63333373
Neonatal hypoacusis	47.43	16.35	11	115424	19	63373568
Hypoaesthesia oral	47.29	16.35	85	115350	12948	63360639
Product availability issue	46.80	16.35	47	115388	4074	63369513
Increased viscosity of bronchial secretion	46.54	16.35	19	115416	324	63373263
Chest X-ray abnormal	46.45	16.35	49	115386	4500	63369087
Multiple allergies	46.27	16.35	87	115348	13715	63359872
Pleural effusion	45.18	16.35	62	115373	93148	63280439
Blood creatinine increased	45.07	16.35	56	115379	87788	63285799
Urinary tract infection	44.52	16.35	290	115145	264394	63109193
Prescribed overdose	44.51	16.35	5	115430	34148	63339439
Anxiety	44.49	16.35	597	114838	216944	63156643
Ear discomfort	44.48	16.35	63	115372	7843	63365744
Decompression sickness	44.04	16.35	13	115422	77	63373510
Injection site discomfort	43.98	16.35	48	115387	4582	63369005
Unresponsive to stimuli	43.95	16.35	5	115430	33811	63339776
Hospitalisation	43.90	16.35	54	115381	85027	63288560
Chronic kidney disease	43.72	16.35	14	115421	45384	63328203
Haemoglobin decreased	43.69	16.35	128	115307	145357	63228230
Hypocalcaemia	43	16.35	4	115431	31709	63341878
Nasal pruritus	42.96	16.35	20	115415	474	63373113
Body temperature abnormal	42.83	16.35	33	115402	2008	63371579
Blood cholesterol increased	42.20	16.35	66	115369	93966	63279621
Liver disorder	41.39	16.35	23	115412	53664	63319923
Burning sensation	41.18	16.35	202	115233	54205	63319382
Hyperventilation	40.89	16.35	53	115382	6063	63367524
Melaena	40.72	16.35	4	115431	30361	63343226
Needle issue	40.66	16.35	70	115365	10306	63363281
Myopathy	40.62	16.35	73	115362	11118	63362469
FEV1/FVC ratio decreased	39.94	16.35	13	115422	111	63373476
Mouth swelling	39.66	16.35	46	115389	4694	63368893
Ligament sprain	39.62	16.35	78	115357	12722	63360865
Sinus disorder	39.43	16.35	116	115319	24437	63349150
Expiratory reserve volume decreased	39.06	16.35	10	115425	31	63373556
Cryopyrin associated periodic syndrome	39.03	16.35	17	115418	343	63373244
Laryngeal oedema	38.93	16.35	50	115385	5668	63367919
Otorrhoea	38.64	16.35	27	115408	1412	63372175
Infection	38.58	16.35	251	115184	228922	63144665
Pneumonia aspiration	38.33	16.35	8	115427	34532	63339055
Femur fracture	38.27	16.35	14	115421	41742	63331845
Rhonchi	38.09	16.35	34	115401	2542	63371045
Peak expiratory flow rate abnormal	37.88	16.35	12	115423	93	63373494
Choking	37.86	16.35	66	115369	9813	63363774
Nasal mucosal disorder	37.75	16.35	18	115417	451	63373136
Bronchial wall thickening	37.64	16.35	27	115408	1472	63372115
Dizziness	37.50	16.35	1035	114400	428890	62944697
Urticaria chronic	37.33	16.35	20	115415	645	63372942
Osteonecrosis of jaw	37.24	16.35	9	115426	35114	63338473
Feeling cold	36.61	16.35	111	115324	23777	63349810
Hepatic function abnormal	36.58	16.35	11	115424	37131	63336456
Head deformity	36.51	16.35	12	115423	106	63373481
Gastrooesophageal reflux disease	36.48	16.35	298	115137	95341	63278246
Concomitant disease aggravated	36.40	16.35	62	115373	9050	63364537
Fluid retention	36.26	16.35	33	115402	59653	63313934
Loss of personal independence in daily activities	35.89	16.35	77	115358	97213	63276374
Chills	35.85	16.35	339	115096	113039	63260548
Restrictive pulmonary disease	35.45	16.35	28	115407	1767	63371820
Orthostatic hypotension	35.09	16.35	11	115424	36149	63337438
Cystic fibrosis	34.54	16.35	36	115399	3260	63370327
Pain	34.51	16.35	1055	114380	739573	62634014
Upper respiratory tract infection	34.23	16.35	261	115174	81786	63291801
Urticarial vasculitis	34.18	16.35	19	115416	660	63372927
Limb injury	34.11	16.35	113	115322	25364	63348223
Nasal inflammation	33.44	16.35	17	115418	491	63373096
Nervousness	33.42	16.35	128	115307	30851	63342736
Oral pruritus	33.40	16.35	30	115405	2261	63371326
Osteoarthritis	33.10	16.35	78	115357	95265	63278322
Colitis	33.01	16.35	24	115411	48504	63325083
Live birth	32.79	16.35	4	115431	25626	63347961
Periorbital swelling	32.63	16.35	33	115402	2885	63370702
Laboratory test abnormal	32.54	16.35	5	115430	26907	63346680
Fall	32.39	16.35	510	114925	391824	62981763
Accident	32.37	16.35	47	115388	5985	63367602
Lung opacity	32.13	16.35	34	115401	3134	63370453
Functional residual capacity decreased	31.85	16.35	10	115425	75	63373512
Tryptase increased	31.75	16.35	15	115420	368	63373219
Accidental overdose	31.44	16.35	3	115432	23306	63350281
Eosinophilia	31.43	16.35	102	115333	22654	63350933
Insomnia	31.42	16.35	558	114877	214694	63158893
Flushing	30.84	16.35	238	115197	74849	63298738
Depression	30.68	16.35	220	115215	196272	63177315
Psychotic disorder	30.58	16.35	5	115430	25707	63347880
Serum sickness-like reaction	30.50	16.35	16	115419	494	63373093
Idiopathic urticaria	30.46	16.35	13	115422	249	63373338
Allergy test positive	30.26	16.35	17	115418	603	63372984
Treatment noncompliance	30.23	16.35	15	115420	37310	63336277
Pulmonary arterial hypertension	30.21	16.35	3	115432	22574	63351013
Gamma-glutamyltransferase increased	30.20	16.35	12	115423	34019	63339568
Heart rate abnormal	30.19	16.35	41	115394	4906	63368681
Suicidal ideation	29.76	16.35	42	115393	62379	63311208
Cystic fibrosis pancreatic	29.71	16.35	9	115426	59	63373528
Agranulocytosis	29.64	16.35	5	115430	25129	63348458
Blood calcium decreased	29.61	16.35	6	115429	26445	63347142
Joint range of motion decreased	29.50	16.35	11	115424	32417	63341170
Blood urea increased	29.50	16.35	6	115429	26373	63347214
Blood lactic acid increased	29.35	16.35	49	115386	7037	63366550
Skin lesion	29.19	16.35	122	115313	30599	63342988
Seizure	29.06	16.35	133	115302	132501	63241086
Symptom recurrence	28.99	16.35	25	115410	1785	63371802
Pain in jaw	28.95	16.35	22	115413	43474	63330113
Body temperature increased	28.80	16.35	139	115296	37053	63336534
Rectal haemorrhage	28.74	16.35	28	115407	49002	63324585
Intentional self-injury	28.40	16.35	6	115429	25681	63347906
Tooth disorder	28.35	16.35	8	115427	28149	63345438
Surgery	28.24	16.35	15	115420	35897	63337690
Movement disorder	28.05	16.35	95	115340	21566	63352021
Injection site hypoaesthesia	28.05	16.35	15	115420	482	63373105
Increased upper airway secretion	28.02	16.35	34	115401	3638	63369949
Coronary artery disease	27.79	16.35	12	115423	32365	63341222
Histamine level increased	27.52	16.35	7	115428	21	63373566
Respiration abnormal	27.42	16.35	45	115390	6372	63367215
Haematocrit decreased	27.35	16.35	19	115416	39321	63334266
Stevens-Johnson syndrome	27.23	16.35	6	115429	24944	63348643
Metastases to liver	27.23	16.35	5	115430	23634	63349953
Sense of oppression	27.13	16.35	19	115416	997	63372590
Red blood cell sedimentation rate increased	27.10	16.35	24	115411	43958	63329629
Musculoskeletal disorder	26.96	16.35	3	115432	20641	63352946
Ear infection	26.89	16.35	139	115296	38074	63335513
Exercise tolerance decreased	26.87	16.35	41	115394	5456	63368131
Pancreatitis acute	26.84	16.35	8	115427	27158	63346429
Ear swelling	26.65	16.35	22	115413	1479	63372108
Haematochezia	26.57	16.35	35	115400	53509	63320078
Device dislocation	26.45	16.35	7	115428	25698	63347889
Vocal cord dysfunction	26.45	16.35	15	115420	542	63373045
Discomfort	26.32	16.35	187	115248	167187	63206400
Frequent bowel movements	26.24	16.35	5	115430	23017	63350570
Muscle tension dysphonia	26.15	16.35	11	115424	203	63373384
Injection related reaction	26.08	16.35	17	115418	792	63372795
Therapeutic product effect incomplete	25.87	16.35	128	115307	124928	63248659
Respiratory rate decreased	25.80	16.35	32	115403	3503	63370084
Choking sensation	25.66	16.35	32	115403	3522	63370065
Rash maculo-papular	25.56	16.35	13	115422	31883	63341704
Drug reaction with eosinophilia and systemic symptoms	25.36	16.35	15	115420	33821	63339766
Injury	25.36	16.35	60	115375	73187	63300400
Hypervolaemia	25.25	16.35	10	115425	28403	63345184
Acute respiratory distress syndrome	25.01	16.35	6	115429	23528	63350059
Deep vein thrombosis	24.95	16.35	74	115361	83726	63289861
Sinus headache	24.83	16.35	40	115395	5576	63368011
Urinary retention	24.81	16.35	12	115423	30289	63343298
Lymphocyte count decreased	24.75	16.35	12	115423	30245	63343342
Vascular access site thrombosis	24.54	16.35	7	115428	36	63373551
Asthma-chronic obstructive pulmonary disease overlap syndrome	24.32	16.35	24	115411	2037	63371550
Urinary incontinence	24.27	16.35	14	115421	32000	63341587
Dyskinesia	24.25	16.35	14	115421	31988	63341599
Injection site scab	24.21	16.35	13	115422	421	63373166
Red blood cell count decreased	24.07	16.35	23	115412	40622	63332965
Nocturnal dyspnoea	23.97	16.35	19	115416	1205	63372382
Ehlers-Danlos syndrome	23.90	16.35	10	115425	182	63373405
Vasculitis	23.70	16.35	80	115355	18129	63355458
Forced expiratory volume abnormal	23.64	16.35	8	115427	78	63373509
Sputum culture	23.54	16.35	11	115424	263	63373324
Hypoglycaemia	23.45	16.35	46	115389	60019	63313568
Paraesthesia	23.28	16.35	408	115027	156558	63217029
Upper airway obstruction	23.22	16.35	15	115420	688	63372899
Hyposmia	23.14	16.35	15	115420	692	63372895
Reaction to azo-dyes	23.11	16.35	6	115429	20	63373567
Lymphopenia	23.10	16.35	3	115432	18324	63355263
Local reaction	23.10	16.35	15	115420	694	63372893
Lung hyperinflation	23.03	16.35	19	115416	1276	63372311
Oropharyngeal spasm	23.02	16.35	11	115424	277	63373310
Generalised tonic-clonic seizure	22.99	16.35	12	115423	29004	63344583
Type III immune complex mediated reaction	22.98	16.35	11	115424	278	63373309
Device related infection	22.91	16.35	7	115428	23385	63350202
Sarcoidosis	22.77	16.35	44	115391	7078	63366509
Functional residual capacity increased	22.69	16.35	8	115427	89	63373498
Forced expiratory volume increased	22.67	16.35	6	115429	22	63373565
Wrist fracture	22.59	16.35	65	115370	13522	63360065
Claustrophobia	22.55	16.35	17	115418	1001	63372586
Fear of disease	22.54	16.35	19	115416	1315	63372272
General physical condition abnormal	22.50	16.35	33	115402	4241	63369346
Blister	22.43	16.35	141	115294	129673	63243914
Photosensitivity reaction	22.34	16.35	69	115366	14925	63358662
Suffocation feeling	22.34	16.35	19	115416	1331	63372256
Bronchomalacia	22.08	16.35	10	115425	222	63373365
Vascular access site infection	22.01	16.35	7	115428	55	63373532
Chest pain	22.01	16.35	531	114904	215428	63158159
Colitis ulcerative	21.88	16.35	10	115425	26081	63347506
Pyrexia	21.83	16.35	1055	114380	469423	62904164
Lethargy	21.78	16.35	43	115392	55964	63317623
Osteomyelitis	21.77	16.35	10	115425	26010	63347577
Chronic obstructive pulmonary disease	21.61	16.35	191	115244	62495	63311092
Tongue pruritus	21.61	16.35	13	115422	525	63373062
Mite allergy	21.60	16.35	14	115421	646	63372941
Bacteraemia	21.49	16.35	3	115432	17345	63356242
Pleural rub	21.48	16.35	7	115428	60	63373527
Blood immunoglobulin E abnormal	21.43	16.35	5	115430	9	63373578
Night sweats	21.20	16.35	35	115400	48779	63324808
Pharyngeal paraesthesia	21.16	16.35	22	115413	1987	63371600
Selective IgA immunodeficiency	21.08	16.35	5	115430	10	63373577
Cytomegalovirus infection	21.01	16.35	6	115429	20946	63352641
Blood potassium increased	20.82	16.35	4	115431	18305	63355282
Injection site reaction	20.53	16.35	179	115256	58345	63315242
Coagulopathy	20.39	16.35	6	115429	20538	63353049
Speech disorder	20.29	16.35	135	115300	40494	63333093
Cerebral infarction	20.28	16.35	9	115426	23884	63349703
Sputum retention	20.27	16.35	13	115422	589	63372998
Respiratory fume inhalation disorder	20.23	16.35	8	115427	125	63373462
Respiratory moniliasis	20.16	16.35	9	115426	193	63373394
Flatulence	20.13	16.35	20	115415	34682	63338905
Pulmonary thrombosis	20.00	16.35	47	115388	8655	63364932
Foot deformity	19.97	16.35	13	115422	27840	63345747
Drug eruption	19.76	16.35	14	115421	28680	63344907
Pulmonary hypertension	19.74	16.35	23	115412	37100	63336487
Product quality issue	19.65	16.35	122	115313	35743	63337844
Ventricular tachycardia	19.53	16.35	6	115429	19973	63353614
Ligament pain	19.46	16.35	9	115426	210	63373377
Haematemesis	19.46	16.35	16	115419	30396	63343191
Injection site oedema	19.41	16.35	18	115417	1414	63372173
Disorientation	19.36	16.35	26	115409	39426	63334161
Altered state of consciousness	19.17	16.35	11	115424	25219	63348368
Urosepsis	19.15	16.35	5	115430	18519	63355068
Oropharyngitis fungal	19.11	16.35	6	115429	45	63373542
Pigmentation disorder	19.11	16.35	32	115403	4607	63368980
Lipohypertrophy	19.09	16.35	13	115422	652	63372935
Cardiac infection	19.02	16.35	12	115423	528	63373059
Bronchial disorder	19.02	16.35	17	115418	1273	63372314
Respiratory distress	18.92	16.35	116	115319	33835	63339752
Hyperlipidaemia	18.91	16.35	6	115429	19565	63354022
Croup infectious	18.88	16.35	12	115423	535	63373052
Disability	18.87	16.35	5	115430	18342	63355245
Abdominal pain upper	18.86	16.35	263	115172	206181	63167406
Ligament rupture	18.81	16.35	27	115408	3403	63370184
Acute respiratory failure	18.74	16.35	21	115414	34464	63339123
Hereditary angioedema	18.65	16.35	42	115393	7520	63366067
Sedation	18.61	16.35	26	115409	38783	63334804
Caffeine allergy	18.55	16.35	5	115430	20	63373567
Peripheral venous disease	18.43	16.35	3	115432	15474	63358113
Injection site bruising	18.42	16.35	135	115300	41775	63331812
Laryngospasm	18.34	16.35	25	115410	3003	63370584
Blood creatine phosphokinase increased	18.27	16.35	17	115418	30413	63343174
Allergy to chemicals	18.25	16.35	25	115410	3017	63370570
Vaccination site pain	18.20	16.35	8	115427	165	63373422
Labyrinthitis	18.08	16.35	22	115413	2361	63371226
Acute myocardial infarction	18.08	16.35	19	115416	32105	63341482
Aphasia	18.04	16.35	20	115415	32980	63340607
Sinus tachycardia	17.85	16.35	11	115424	24257	63349330
Blood sodium decreased	17.83	16.35	11	115424	24241	63349346
Red blood cell count increased	17.80	16.35	25	115410	3087	63370500
Lower limb fracture	17.78	16.35	11	115424	24210	63349377
Tubulointerstitial nephritis	17.69	16.35	7	115428	19896	63353691
Blood lactate dehydrogenase increased	17.68	16.35	10	115425	23106	63350481
Blood pressure fluctuation	17.63	16.35	36	115399	46281	63327306
Atopy	17.58	16.35	9	115426	264	63373323
Muscle disorder	17.51	16.35	32	115403	4937	63368650
Cerebral haemorrhage	17.49	16.35	18	115417	30711	63342876
Laryngitis	17.40	16.35	69	115366	16898	63356689
Therapy interrupted	17.38	16.35	20	115415	32435	63341152
Visual acuity reduced	17.33	16.35	9	115426	21817	63351770
Ileus	17.21	16.35	3	115432	14722	63358865
Drug ineffective for unapproved indication	17.17	16.35	22	115413	34041	63339546
Pancreatitis	17.13	16.35	40	115395	49015	63324572
Clostridium difficile colitis	17.07	16.35	8	115427	20561	63353026
Small intestinal obstruction	17.05	16.35	6	115429	18331	63355256
Oral pain	16.89	16.35	16	115419	28378	63345209
Osteonecrosis	16.85	16.35	12	115423	24518	63349069
Blood calcium increased	16.79	16.35	46	115389	9304	63364283
Abnormal behaviour	16.77	16.35	9	115426	21417	63352170
Complication associated with device	16.77	16.35	5	115430	16973	63356614
Tongue oedema	16.75	16.35	30	115405	4556	63369031
Nasal turbinate abnormality	16.75	16.35	5	115430	31	63373556
Macular degeneration	16.65	16.35	12	115423	24364	63349223
Urticaria pressure	16.61	16.35	5	115430	32	63373555
Solar urticaria	16.54	16.35	6	115429	73	63373514
Nasal obstruction	16.54	16.35	18	115417	1713	63371874
Drug dependence	16.50	16.35	88	115347	24395	63349192
Pharyngeal hypoaesthesia	16.45	16.35	9	115426	303	63373284
Eye allergy	16.41	16.35	14	115421	985	63372602
Nasal disorder	16.37	16.35	23	115412	2841	63370746

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Forced expiratory volume decreased	1032.44	20.79	300	38876	2903	34914852
Wheezing	1001.60	20.79	606	38570	40796	34876959
Urticaria	778.57	20.79	607	38569	61770	34855985
No adverse event	756.02	20.79	411	38765	22516	34895239
Cough	495.94	20.79	718	38458	149422	34768333
Nasopharyngitis	492.16	20.79	492	38684	69476	34848279
Obstructive airways disorder	456.33	20.79	258	38918	15236	34902519
Productive cough	413.60	20.79	341	38835	37472	34880283
Blood immunoglobulin E increased	412.04	20.79	141	39035	2405	34915350
Sputum discoloured	406.97	20.79	191	38985	7621	34910134
Nasal congestion	387.81	20.79	269	38907	22788	34894967
Dyspnoea	379.47	20.79	1098	38078	375684	34542071
Blood pressure increased	370.14	20.79	474	38702	87628	34830127
Chest discomfort	362.26	20.79	372	38804	54158	34863597
Middle insomnia	350.28	20.79	165	39011	6637	34911118
Anaphylactic reaction	346.30	20.79	288	38888	32013	34885742
Blood pressure systolic increased	333.54	20.79	245	38931	22707	34895048
Body temperature decreased	327.96	20.79	196	38980	12838	34904917
Asthma	318.22	20.79	310	38866	42346	34875409
Acute kidney injury	263.54	20.79	21	39155	304967	34612788
Influenza	263.47	20.79	301	38875	49365	34868390
Heart rate increased	254.55	20.79	286	38890	46057	34871698
Hypersensitivity	252.30	20.79	326	38850	60709	34857046
Respiratory tract congestion	244.52	20.79	125	39051	6014	34911741
Sensitivity to weather change	220.68	20.79	79	39097	1547	34916208
Drug interaction	211.66	20.79	10	39166	225936	34691819
Respiratory rate increased	211.20	20.79	134	39042	9760	34907995
Nasal polyps	207.85	20.79	85	39091	2418	34915337
Hypoventilation	207.67	20.79	93	39083	3321	34914434
Eosinophilic granulomatosis with polyangiitis	201.68	20.79	78	39098	1909	34915846
Malaise	195.86	20.79	552	38624	185273	34732482
Anaemia	180.90	20.79	24	39152	233311	34684444
Rhinorrhoea	177.30	20.79	179	38997	25489	34892266
Pruritus	168.70	20.79	441	38735	141540	34776215
Bronchopulmonary aspergillosis allergic	160.31	20.79	54	39122	875	34916880
Neutropenia	143.35	20.79	8	39168	156770	34760985
Sinusitis	141.85	20.79	202	38974	41200	34876555
Asthmatic crisis	139.56	20.79	42	39134	462	34917293
Lower respiratory tract infection	138.50	20.79	174	39002	31463	34886292
Oropharyngeal pain	134.84	20.79	182	38994	35303	34882452
Weight increased	134.80	20.79	312	38864	92721	34825034
Seasonal allergy	134.02	20.79	87	39089	6588	34911167
Bronchitis	132.51	20.79	197	38979	41766	34875989
Weight decreased	130.63	20.79	464	38712	175837	34741918
Thrombocytopenia	126.07	20.79	14	39162	156233	34761522
Forced vital capacity decreased	125.63	20.79	43	39133	733	34917022
Sinus congestion	122.32	20.79	77	39099	5528	34912227
Respiratory disorder	118.01	20.79	126	39050	19138	34898617
Dyspnoea exertional	108.73	20.79	183	38993	43096	34874659
Allergy to animal	108.60	20.79	33	39143	376	34917379
Hypotension	107.97	20.79	57	39119	221592	34696163
Diarrhoea	104.57	20.79	173	39003	389739	34528016
Smoke sensitivity	101.07	20.79	25	39151	120	34917635
Pulmonary function test decreased	97.81	20.79	64	39112	4911	34912844
Angioedema	95.16	20.79	159	39017	37215	34880540
Completed suicide	92.90	20.79	4	39172	98164	34819591
Renal failure	90.81	20.79	18	39158	130539	34787216
Confusional state	90.15	20.79	25	39151	144135	34773620
Pancytopenia	89.64	20.79	4	39172	95153	34822602
Disease progression	88.89	20.79	9	39167	108068	34809687
Food allergy	85.62	20.79	39	39137	1449	34916306
Malignant neoplasm progression	85.31	20.79	3	39173	88043	34829712
Eczema	83.22	20.79	103	39073	18333	34899422
Lower respiratory tract congestion	82.93	20.79	36	39140	1191	34916564
Constipation	81.56	20.79	26	39150	136956	34780799
Perfume sensitivity	81.20	20.79	20	39156	94	34917661
Hyponatraemia	79.48	20.79	3	39173	82688	34835067
Headache	78.82	20.79	437	38739	200198	34717557
Platelet count decreased	78.20	20.79	19	39157	119698	34798057
Peak expiratory flow rate decreased	77.26	20.79	20	39156	119	34917636
Nasal discharge discolouration	74.16	20.79	23	39153	282	34917473
Dehydration	73.33	20.79	27	39149	129942	34787813
Bronchospasm	72.53	20.79	74	39102	10657	34907098
Increased viscosity of bronchial secretion	72.40	20.79	21	39155	201	34917554
Throat tightness	72.27	20.79	66	39110	8292	34909463
Haemoglobin decreased	71.75	20.79	23	39153	120749	34797006
Injection site pain	71.52	20.79	144	39032	38861	34878894
Overdose	71.31	20.79	9	39167	91050	34826705
White blood cell count decreased	71.06	20.79	11	39165	95434	34822321
Breath sounds abnormal	70.84	20.79	60	39116	6821	34910934
Dust allergy	69.24	20.79	29	39147	877	34916878
Influenza like illness	68.25	20.79	116	39060	27518	34890237
Rhonchi	67.24	20.79	36	39140	1904	34915851
Multiple organ dysfunction syndrome	66.68	20.79	5	39171	76561	34841194
Stress	66.67	20.79	121	39055	30226	34887529
Sneezing	65.12	20.79	51	39125	5191	34912564
Temperature intolerance	64.79	20.79	43	39133	3379	34914376
Forced expiratory flow decreased	63.15	20.79	18	39158	161	34917594
Increased bronchial secretion	62.66	20.79	34	39142	1847	34915908
Blood creatinine increased	62.15	20.79	15	39161	94961	34822794
Humidity intolerance	61.24	20.79	12	39164	12	34917743
Sepsis	61.08	20.79	58	39118	166503	34751252
Illness	60.11	20.79	75	39101	13454	34904301
Discomfort	59.87	20.79	89	39087	18849	34898906
Eosinophil count increased	59.55	20.79	60	39116	8512	34909243
Rhinitis	58.65	20.79	52	39124	6286	34911469
Rales	57.63	20.79	63	39113	9820	34907935
Erythema	56.67	20.79	223	38953	88557	34829198
Throat irritation	55.77	20.79	64	39112	10521	34907234
Rhabdomyolysis	55.19	20.79	6	39170	68157	34849598
Cardiac arrest	54.18	20.79	20	39156	96139	34821616
Septic shock	54.10	20.79	8	39168	71826	34845929
Gastrointestinal haemorrhage	54.06	20.79	16	39160	88461	34829294
Chronic obstructive pulmonary disease	53.92	20.79	148	39028	48770	34868985
Aspartate aminotransferase increased	50.02	20.79	8	39168	67775	34849980
Renal impairment	49.43	20.79	22	39154	94491	34823264
Swelling face	49.32	20.79	91	39085	23014	34894741
Neuropathy peripheral	49.18	20.79	16	39160	83247	34834508
Acne	48.61	20.79	61	39115	11005	34906750
Eye swelling	48.61	20.79	58	39118	9937	34907818
Spirometry abnormal	48.14	20.79	21	39155	703	34917052
Ear infection	47.52	20.79	58	39118	10173	34907582
Decreased appetite	47.09	20.79	71	39105	166321	34751434
Maternal exposure timing unspecified	45.98	20.79	17	39159	366	34917389
Alanine aminotransferase increased	45.20	20.79	17	39159	80798	34836957
Skin plaque	44.99	20.79	39	39137	4575	34913180
Factor V Leiden mutation	44.20	20.79	12	39164	88	34917667
Drug intolerance	44.02	20.79	7	39169	59563	34858192
Arthralgia	43.69	20.79	333	38843	169708	34748047
Restrictive pulmonary disease	43.58	20.79	23	39153	1181	34916574
FEV1/FVC ratio decreased	43.28	20.79	12	39164	96	34917659
Lip swelling	43.04	20.79	70	39106	16010	34901745
Rhinitis allergic	43.00	20.79	32	39144	3018	34914737
Respiratory tract infection	42.53	20.79	78	39098	19634	34898121
Infusion related reaction	42.12	20.79	5	39171	53052	34864703
Bradycardia	41.95	20.79	16	39160	75402	34842353
Drug ineffective	41.61	20.79	730	38446	456021	34461734
Chronic sinusitis	41.61	20.79	28	39148	2251	34915504
Interstitial lung disease	41.37	20.79	11	39165	65271	34852484
Dermoid cyst	41.01	20.79	13	39163	172	34917583
Secretion discharge	40.41	20.79	41	39135	5864	34911891
Concomitant disease aggravated	39.78	20.79	40	39136	5661	34912094
Total lung capacity decreased	39.67	20.79	20	39156	933	34916822
Hypoglycaemia	39.09	20.79	7	39169	54633	34863122
Delirium	37.93	20.79	3	39173	43988	34873767
Pulmonary congestion	36.95	20.79	60	39116	13705	34904050
Diaphragmatic disorder	36.87	20.79	21	39155	1254	34916501
Asthma-chronic obstructive pulmonary disease overlap syndrome	36.69	20.79	21	39155	1266	34916489
Dermatitis atopic	36.36	20.79	37	39139	5310	34912445
Sinus disorder	35.92	20.79	42	39134	7043	34910712
Gastroenteritis viral	35.73	20.79	42	39134	7082	34910673
Nausea	35.69	20.79	229	38947	339679	34578076
Cardio-respiratory arrest	35.62	20.79	9	39167	55264	34862491
Claustrophobia	35.28	20.79	13	39163	277	34917478
Serum sickness	35.15	20.79	24	39152	1976	34915779
Blood immunoglobulin E decreased	35.14	20.79	9	39167	51	34917704
Blood pressure diastolic decreased	35.05	20.79	47	39129	9047	34908708
Lung hyperinflation	34.88	20.79	18	39158	882	34916873
Increased upper airway secretion	34.88	20.79	23	39153	1787	34915968
Polyp	34.17	20.79	31	39145	3861	34913894
Anaphylactoid reaction	34.14	20.79	25	39151	2300	34915455
Hypereosinophilic syndrome	33.80	20.79	12	39164	229	34917526
Nasal disorder	33.56	20.79	23	39153	1905	34915850
Viral infection	33.41	20.79	66	39110	17557	34900198
Anosmia	33.28	20.79	31	39145	3993	34913762
Throat clearing	32.98	20.79	13	39163	335	34917420
Coronary artery disease	32.84	20.79	7	39169	48298	34869457
Feeling abnormal	32.67	20.79	149	39027	63086	34854669
Dyspnoea at rest	32.65	20.79	30	39146	3798	34913957
Eye pruritus	32.44	20.79	41	39135	7448	34910307
Chronic kidney disease	32.42	20.79	4	39172	41206	34876549
Injection site swelling	31.97	20.79	51	39125	11476	34906279
Blood immunoglobulin E abnormal	31.96	20.79	7	39169	17	34917738
Blood bilirubin increased	31.96	20.79	3	39173	38293	34879462
International normalised ratio increased	31.89	20.79	7	39169	47320	34870435
Body mass index increased	31.88	20.79	18	39158	1057	34916698
Allergy to chemicals	31.52	20.79	9	39167	81	34917674
Sputum increased	31.49	20.79	24	39152	2346	34915409
Respiratory tract irritation	30.74	20.79	11	39165	215	34917540
Maternal exposure during breast feeding	30.72	20.79	20	39156	1521	34916234
Hyposmia	30.69	20.79	11	39165	216	34917539
Upper-airway cough syndrome	30.57	20.79	28	39148	3530	34914225
Coagulation factor deficiency	30.39	20.79	10	39166	150	34917605
Seizure	30.36	20.79	44	39132	104813	34812942
Coma	30.29	20.79	7	39169	45671	34872084
Scratch	30.04	20.79	27	39149	3321	34914434
Status asthmaticus	29.95	20.79	12	39164	323	34917432
Nasal discomfort	29.72	20.79	20	39156	1608	34916147
Sputum retention	29.42	20.79	13	39163	449	34917306
Cardiac failure congestive	29.33	20.79	30	39146	83240	34834515
Bronchiolitis	29.27	20.79	26	39150	3150	34914605
Pleural effusion	29.15	20.79	29	39147	81517	34836238
Urticaria thermal	28.98	20.79	5	39171	0	34917755
Vital capacity decreased	28.13	20.79	12	39164	380	34917375
Injection site urticaria	27.57	20.79	21	39155	2051	34915704
Stomatitis	27.24	20.79	7	39169	42507	34875248
Lung disorder	27.02	20.79	93	39083	34603	34883152
Papule	26.98	20.79	28	39148	4111	34913644
Upper respiratory tract infection	26.97	20.79	90	39086	32969	34884786
Inappropriate schedule of product administration	26.60	20.79	139	39037	62157	34855598
Hyperglycaemia	26.28	20.79	6	39170	39474	34878281
Mast cell activation syndrome	26.03	20.79	10	39166	240	34917515
Lacrimation increased	25.57	20.79	39	39137	8443	34909312
Hepatic function abnormal	25.36	20.79	9	39167	44354	34873401
Pneumonia	25.28	20.79	557	38619	362070	34555685
Oropharyngeal discomfort	25.24	20.79	24	39152	3172	34914583
Endocarditis fibroplastica	25.04	20.79	5	39171	6	34917749
Death	25.00	20.79	306	38870	397743	34520012
Upper respiratory tract congestion	24.66	20.79	14	39162	831	34916924
Haematuria	24.12	20.79	13	39163	50053	34867702
Dysphonia	24.03	20.79	69	39107	23314	34894441
Needle issue	23.97	20.79	32	39144	6133	34911622
Hallucination	23.91	20.79	14	39162	51484	34866271
Aggression	23.87	20.79	7	39169	38957	34878798
Ligament sprain	23.77	20.79	24	39152	3413	34914342
Injection site bruising	23.57	20.79	38	39138	8625	34909130
Procedural pain	23.55	20.79	28	39148	4778	34912977
General physical health deterioration	23.45	20.79	70	39106	128199	34789556
Eosinophilic oesophagitis	23.37	20.79	10	39166	319	34917436
Skin reaction	23.24	20.79	29	39147	5201	34912554
Therapeutic response decreased	23.20	20.79	79	39097	29234	34888521
Animal scratch	23.20	20.79	9	39167	222	34917533
Rubber sensitivity	23.16	20.79	9	39167	223	34917532
Central obesity	22.98	20.79	12	39164	603	34917152
Injection related reaction	22.67	20.79	10	39166	344	34917411
Rosacea	22.60	20.79	15	39161	1178	34916577
Choking	22.59	20.79	28	39148	4987	34912768
Blood test abnormal	22.37	20.79	33	39143	6938	34910817
Myalgia	22.27	20.79	166	39010	83944	34833811
Coagulation factor V level abnormal	22.22	20.79	6	39170	43	34917712
Liver function test abnormal	22.18	20.79	4	39172	31070	34886685
Rib fracture	21.57	20.79	49	39127	14351	34903404
Crepitations	21.52	20.79	22	39154	3174	34914581
Respiratory failure	21.51	20.79	57	39119	108515	34809240
Vomiting	21.50	20.79	176	39000	247445	34670310
Mite allergy	21.49	20.79	12	39164	690	34917065
Haematochezia	21.11	20.79	13	39163	46521	34871234
Pneumonitis	20.91	20.79	6	39170	33872	34883883
Multiple allergies	20.82	20.79	21	39155	2982	34914773
Atrial fibrillation	20.82	20.79	69	39107	122324	34795431

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Forced expiratory volume decreased	2864.79	16.84	877	126922	6937	79609652
Urticaria	2641.95	16.84	2261	125538	182940	79433649
Wheezing	2369.35	16.84	1754	126045	114910	79501679
Cough	1602.77	16.84	2418	125381	364371	79252218
Sputum discoloured	1457.76	16.84	707	127092	21036	79595553
Obstructive airways disorder	1428.15	16.84	787	127012	30672	79585917
Productive cough	1204.85	16.84	1053	126746	87278	79529311
Anaphylactic reaction	1111.41	16.84	983	126816	82760	79533829
Middle insomnia	1024.55	16.84	505	127294	15564	79601025
Dyspnoea	967.59	16.84	3285	124514	853740	78762849
Nasopharyngitis	864.72	16.84	1497	126302	252384	79364205
Chest discomfort	823.25	16.84	1059	126740	136985	79479604
Nasal congestion	802.02	16.84	788	127011	75764	79540825
Blood pressure systolic increased	782.08	16.84	732	127067	66254	79550335
Influenza	769.21	16.84	992	126807	128614	79487975
Heart rate increased	746.32	16.84	943	126856	119781	79496808
Sensitivity to weather change	737.02	16.84	325	127474	7722	79608867
Acute kidney injury	722.33	16.84	25	127774	519379	79097210
Blood pressure increased	705.82	16.84	1236	126563	210124	79406465
No adverse event	701.77	16.84	536	127263	36656	79579933
Blood immunoglobulin E increased	669.10	16.84	277	127522	5605	79610984
Toxicity to various agents	621.00	16.84	11	127788	421529	79195060
Pruritus	619.84	16.84	1702	126097	392946	79223643
Oropharyngeal pain	580.87	16.84	793	127006	108560	79508029
Body temperature decreased	515.46	16.84	421	127378	31724	79584865
Respiratory tract congestion	515.09	16.84	348	127451	19606	79596983
Drug interaction	514.45	16.84	40	127759	415143	79201446
Malaise	512.39	16.84	1835	125964	488034	79128555
Hypoventilation	499.37	16.84	240	127559	6984	79609605
Seasonal allergy	464.26	16.84	303	127496	16103	79600486
Asthma	463.44	16.84	800	126999	134295	79482294
Bronchitis	456.49	16.84	780	127019	129864	79486725
Skin plaque	430.93	16.84	248	127551	10497	79606092
Nasal polyps	427.83	16.84	217	127582	7110	79609479
Rhinorrhoea	427.18	16.84	567	127232	75507	79541082
Neutropenia	421.46	16.84	8	127791	287702	79328887
Respiratory rate increased	391.40	16.84	304	127495	21296	79595293
Asthmatic crisis	384.09	16.84	138	127661	1868	79614721
Hypersensitivity	347.18	16.84	1065	126734	261174	79355415
Forced vital capacity decreased	337.84	16.84	121	127678	1622	79614967
Anaemia	336.87	16.84	146	127653	444869	79171720
Perfume sensitivity	336.24	16.84	102	127697	777	79615812
Secretion discharge	331.54	16.84	238	127561	14784	79601805
Weight decreased	330.88	16.84	1283	126516	353915	79262674
Angioedema	329.72	16.84	501	127298	75534	79541055
Bronchopulmonary aspergillosis allergic	314.17	16.84	134	127665	2927	79613662
Infusion related reaction	309.67	16.84	14	127785	230223	79386366
Thrombocytopenia	305.82	16.84	34	127765	265225	79351364
Throat tightness	300.83	16.84	292	127507	27615	79588974
Breath sounds abnormal	281.01	16.84	221	127578	15763	79600826
Illness	277.06	16.84	357	127442	46154	79570435
Lower respiratory tract infection	272.04	16.84	624	127175	128596	79487993
Pulmonary function test decreased	271.35	16.84	163	127636	7474	79609115
Stress	268.29	16.84	468	127331	79144	79537445
Rales	265.38	16.84	235	127564	19766	79596823
Upper-airway cough syndrome	262.04	16.84	187	127612	11506	79605083
Hyponatraemia	260.11	16.84	5	127794	177843	79438746
Hypotension	255.77	16.84	199	127600	440118	79176471
Respiratory disorder	252.74	16.84	335	127464	44521	79572068
Pancytopenia	249.44	16.84	3	127796	165742	79450847
Drug abuse	244.60	16.84	3	127796	162688	79453901
Diarrhoea	244.21	16.84	670	127129	879819	78736770
Confusional state	244.19	16.84	102	127697	317895	79298694
Peak expiratory flow rate decreased	238.93	16.84	74	127725	609	79615980
Allergy to animal	238.46	16.84	89	127710	1350	79615239
Smoke sensitivity	237.85	16.84	72	127727	544	79616045
Sinusitis	235.61	16.84	769	127030	194732	79421857
Sneezing	235.10	16.84	218	127581	19465	79597124
Eosinophilic granulomatosis with polyangiitis	233.13	16.84	115	127684	3545	79613044
Dust allergy	232.81	16.84	89	127710	1447	79615142
Platelet count decreased	231.96	16.84	22	127777	194642	79421947
Inappropriate schedule of product administration	224.67	16.84	592	127207	133036	79483553
Dyspnoea exertional	223.89	16.84	456	127343	86617	79529972
Bronchospasm	223.83	16.84	236	127563	24623	79591966
Respiratory tract infection	221.26	16.84	328	127471	48361	79568228
Humidity intolerance	221.04	16.84	62	127737	345	79616244
Scratch	213.76	16.84	145	127654	8218	79608371
Synovitis	209.99	16.84	7	127792	150727	79465862
White blood cell count decreased	207.48	16.84	28	127771	188260	79428329
Dehydration	206.56	16.84	70	127729	248117	79368472
Sinus congestion	204.76	16.84	203	127596	19693	79596896
Lower respiratory tract congestion	200.72	16.84	107	127692	3890	79612699
Erythema	197.40	16.84	794	127005	222496	79394093
Disease progression	197.12	16.84	30	127769	184332	79432257
Pneumonia	195.08	16.84	1759	126040	658487	78958102
Drug intolerance	194.38	16.84	90	127709	264029	79352560
Food allergy	191.00	16.84	150	127649	10674	79605915
Condition aggravated	184.99	16.84	325	127474	500799	79115790
Hypokalaemia	183.55	16.84	12	127787	144028	79472561
Temperature intolerance	178.86	16.84	138	127661	9567	79607022
Dysphonia	178.29	16.84	324	127475	56548	79560041
Full blood count abnormal	177.24	16.84	268	127531	40206	79576383
Overdose	175.51	16.84	40	127759	184166	79432423
Throat irritation	174.88	16.84	268	127531	40678	79575911
Multiple organ dysfunction syndrome	173.35	16.84	4	127795	120242	79496347
Death	172.94	16.84	410	127389	566104	79050485
Pulmonary function test abnormal	169.77	16.84	97	127702	4047	79612542
Vital capacity decreased	168.38	16.84	74	127725	1742	79614847
Constipation	167.92	16.84	125	127674	282925	79333664
Headache	167.35	16.84	1690	126109	652082	78964507
Influenza like illness	163.95	16.84	358	127441	71349	79545240
Weight increased	163.48	16.84	876	126923	276510	79340079
Alanine aminotransferase increased	161.64	16.84	32	127767	162538	79454051
Hepatic enzyme increased	159.93	16.84	47	127752	182563	79434026
Swelling face	158.82	16.84	352	127447	70860	79545729
Sepsis	158.52	16.84	120	127679	269308	79347281
Feeling abnormal	158.51	16.84	588	127211	158611	79457978
Injection site pain	157.45	16.84	512	127287	129326	79487263
Nasal discharge discolouration	156.97	16.84	78	127721	2443	79614146
Hyperkalaemia	156.94	16.84	6	127793	114392	79502197
Renal failure	154.92	16.84	64	127735	200904	79415685
Aspartate aminotransferase increased	154.19	16.84	20	127779	138621	79477968
Gastrointestinal haemorrhage	153.48	16.84	26	127773	147693	79468896
Hand deformity	151.60	16.84	3	127796	103916	79512673
Septic shock	148.61	16.84	13	127786	122788	79493801
Stomatitis	147.77	16.84	28	127771	146729	79469860
Rhabdomyolysis	146.50	16.84	4	127795	103127	79513462
Viral infection	146.32	16.84	254	127545	42762	79573827
Eosinophil count increased	146.23	16.84	158	127641	16947	79599642
Aphonia	144.49	16.84	125	127674	10187	79606402
Total lung capacity decreased	143.72	16.84	77	127722	2828	79613761
Eye pruritus	143.54	16.84	171	127628	20399	79596190
Migraine	143.31	16.84	384	127415	87109	79529480
Leukopenia	141.91	16.84	12	127787	116501	79500088
Rhinitis allergic	140.96	16.84	133	127666	12136	79604453
Nasal oedema	139.90	16.84	64	127735	1660	79614929
Bronchial secretion retention	139.12	16.84	85	127714	4019	79612570
Bronchiectasis	136.69	16.84	174	127625	22212	79594377
Incorrect dose administered	136.44	16.84	347	127452	76283	79540306
Sinus pain	135.88	16.84	81	127718	3661	79612928
Cardiac arrest	133.94	16.84	54	127745	172042	79444547
Rubber sensitivity	132.80	16.84	62	127737	1687	79614902
Bradycardia	129.99	16.84	29	127770	135528	79481061
Urticaria thermal	129.90	16.84	42	127757	403	79616186
Exposure to allergen	128.00	16.84	39	127760	302	79616287
Arthropathy	127.71	16.84	62	127737	177049	79439540
Renal impairment	126.94	16.84	47	127752	157736	79458853
Lip swelling	126.85	16.84	232	127567	40679	79575910
Rheumatoid arthritis	126.28	16.84	90	127709	208380	79408209
Reversible airways obstruction	125.73	16.84	64	127735	2112	79614477
Cardiac failure congestive	124.04	16.84	37	127762	142365	79474224
Treatment failure	123.97	16.84	59	127740	170427	79446162
Animal scratch	123.66	16.84	56	127743	1418	79615171
Off label use	119.63	16.84	908	126891	906307	78710282
Pharyngeal swelling	119.30	16.84	99	127700	7620	79608969
Neutrophil count decreased	119.18	16.84	8	127791	93951	79522638
Decreased appetite	119.16	16.84	230	127569	342188	79274401
Eczema	118.47	16.84	225	127574	40593	79575996
Eye swelling	118.35	16.84	177	127622	26291	79590298
Nausea	117.92	16.84	976	126823	956220	78660369
Joint swelling	117.80	16.84	175	127624	288471	79328118
Increased bronchial secretion	115.58	16.84	70	127729	3257	79613332
Interstitial lung disease	114.38	16.84	21	127778	112579	79504010
Neuropathy peripheral	113.83	16.84	42	127757	141263	79475326
Respiratory failure	108.39	16.84	79	127720	180832	79435757
Forced expiratory flow decreased	108.25	16.84	33	127766	256	79616333
Electrocardiogram QT prolonged	108.19	16.84	10	127789	90376	79526213
International normalised ratio increased	108.08	16.84	7	127792	84714	79531875
Atrial fibrillation	107.81	16.84	95	127704	197791	79418798
Paranasal sinus discomfort	106.18	16.84	74	127725	4382	79612207
Lung disorder	106.16	16.84	327	127472	80230	79536359
Urinary tract discomfort	105.40	16.84	41	127758	700	79615889
Systemic lupus erythematosus	104.56	16.84	32	127767	121117	79495472
Cardio-respiratory arrest	104.46	16.84	23	127776	108487	79508102
Increased viscosity of bronchial secretion	100.62	16.84	37	127762	537	79616052
Ascites	100.21	16.84	5	127794	75557	79541032
Lacrimation increased	100.05	16.84	150	127649	22327	79594262
Glossodynia	99.28	16.84	22	127777	103315	79513274
Rhinitis	98.26	16.84	120	127679	14687	79601902
Psoriatic arthropathy	97.88	16.84	7	127792	77992	79538597
Blood creatinine increased	96.46	16.84	65	127734	154992	79461597
Spirometry abnormal	95.18	16.84	41	127758	918	79615671
Ear pruritus	94.94	16.84	67	127732	4048	79612541
Myalgia	94.53	16.84	564	127235	185077	79431512
Depressed level of consciousness	94.03	16.84	20	127779	96632	79519957
Multiple allergies	93.61	16.84	99	127700	10361	79606228
Alveolar osteitis	93.41	16.84	39	127760	806	79615783
Blood bilirubin increased	92.49	16.84	3	127796	66229	79550360
Lactic acidosis	92.22	16.84	5	127794	70354	79546235
Rhonchi	91.47	16.84	65	127734	3971	79612618
Frustration tolerance decreased	91.34	16.84	84	127715	7418	79609171
Swollen tongue	91.06	16.84	207	127592	42363	79574226
Oropharyngeal discomfort	90.69	16.84	82	127717	7084	79609505
Anaphylactic shock	90.68	16.84	187	127612	35809	79580780
Pericarditis	89.12	16.84	28	127771	104208	79512381
Ear pain	89.05	16.84	176	127623	32693	79583896
Drug-induced liver injury	88.89	16.84	4	127795	66113	79550476
Haemoglobin decreased	88.34	16.84	137	127662	221982	79394607
Delirium	87.65	16.84	15	127784	84612	79531977
Product use issue	86.75	16.84	126	127673	209696	79406893
Sinus disorder	86.18	16.84	140	127659	22324	79594265
Feeling hot	85.81	16.84	250	127549	59484	79557105
Vomiting	84.94	16.84	672	127127	665156	78951433
Mental status changes	84.05	16.84	6	127793	66953	79549636
Insomnia	84.03	16.84	676	127123	244494	79372095
Mechanical urticaria	83.29	16.84	30	127769	409	79616180
Ear congestion	82.78	16.84	54	127745	2865	79613724
Helicobacter infection	82.66	16.84	8	127791	69696	79546893
Hepatic failure	81.34	16.84	4	127795	61208	79555381
Coma	80.91	16.84	30	127769	100619	79515970
Papule	80.73	16.84	78	127721	7329	79609260
FEV1/FVC ratio decreased	80.58	16.84	25	127774	207	79616382
Dyspnoea at rest	79.79	16.84	77	127722	7225	79609364
Suicide attempt	78.97	16.84	18	127781	82914	79533675
Blood pressure decreased	77.84	16.84	341	127458	99125	79517464
Melaena	77.76	16.84	5	127794	60885	79555704
Therapeutic product effect decreased	77.43	16.84	89	127710	163774	79452815
C-reactive protein increased	76.42	16.84	57	127742	128970	79487619
Respiratory tract inflammation	76.07	16.84	34	127765	834	79615755
Hallucination	75.16	16.84	22	127777	85723	79530866
Liver function test abnormal	74.90	16.84	8	127791	64467	79552122
Product availability issue	74.65	16.84	57	127742	3890	79612699
Serum sickness	73.90	16.84	55	127744	3611	79612978
Hepatic function abnormal	73.46	16.84	14	127785	73093	79543496
Tunnel vision	72.98	16.84	40	127759	1538	79615051
Crepitations	72.74	16.84	85	127714	9932	79606657
Sputum culture positive	72.38	16.84	55	127744	3726	79612863
Folliculitis	72.38	16.84	4	127795	55376	79561213
Cholestasis	70.56	16.84	3	127796	52106	79564483
Chronic kidney disease	70.13	16.84	11	127788	66143	79550446
Hypoglycaemia	69.59	16.84	38	127761	101556	79515033
Total lung capacity increased	68.83	16.84	44	127755	2254	79614335
Restrictive pulmonary disease	68.72	16.84	46	127753	2549	79614040
Pulmonary congestion	68.51	16.84	141	127658	26959	79589630
Throat clearing	67.78	16.84	46	127753	2608	79613981
Ligament sprain	67.41	16.84	95	127704	13369	79603220
Paraesthesia oral	67.17	16.84	119	127680	20352	79596237
Hepatitis	67.13	16.84	6	127793	55721	79560868
Cognitive disorder	66.94	16.84	15	127784	69911	79546678
Mastocytosis	66.66	16.84	27	127772	515	79616074
Pulmonary mass	66.38	16.84	145	127654	28889	79587700
Pleural effusion	66.38	16.84	81	127718	145181	79471408
Concomitant disease aggravated	66.06	16.84	93	127706	13074	79603515
Blood iron decreased	65.86	16.84	101	127698	15333	79601256
Abdominal discomfort	65.28	16.84	196	127603	250531	79366058
Coronary artery disease	64.81	16.84	13	127786	65461	79551128
Blood immunoglobulin E decreased	64.81	16.84	18	127781	96	79616493
Unresponsive to stimuli	64.60	16.84	7	127792	55781	79560808
Ear infection	64.49	16.84	159	127640	34273	79582316
Blood alkaline phosphatase increased	64.38	16.84	12	127787	63652	79552937
Cold urticaria	64.35	16.84	18	127781	99	79616490
Hypocalcaemia	64.05	16.84	4	127795	49920	79566669
General physical health deterioration	63.48	16.84	227	127572	275011	79341578
Nervousness	63.32	16.84	155	127644	33260	79583329
Chronic obstructive pulmonary disease	63.19	16.84	288	127511	85131	79531458
Choking	63.00	16.84	87	127712	12014	79604575
Impaired healing	62.68	16.84	31	127768	87624	79528965
Breast cancer	62.22	16.84	155	127644	33626	79582963
Muscle injury	61.97	16.84	4	127795	48557	79568032
Adverse event	61.64	16.84	11	127788	60203	79556386
Plasma cell myeloma	60.87	16.84	7	127792	53252	79563337
Bladder pain	60.87	16.84	41	127758	2296	79614293
Sensation of foreign body	59.90	16.84	58	127741	5464	79611125
Seizure	59.57	16.84	134	127665	188700	79427889
Mast cell activation syndrome	59.28	16.84	27	127772	693	79615896
Anxiety	59.25	16.84	634	127165	247878	79368711
Intentional product misuse	59.03	16.84	40	127759	95125	79521464
Colitis	58.66	16.84	22	127777	73285	79543304
Limb injury	58.13	16.84	139	127660	29389	79587200
Drug reaction with eosinophilia and systemic symptoms	57.20	16.84	16	127783	64228	79552361
Hypoaesthesia oral	56.88	16.84	90	127709	14034	79602555
Agranulocytosis	56.61	16.84	4	127795	45026	79571563
Pharyngeal oedema	56.52	16.84	97	127702	16175	79600414
Burning sensation	56.16	16.84	214	127585	58418	79558171
Orthostatic hypotension	55.91	16.84	11	127788	56153	79560436
Liver disorder	55.86	16.84	23	127776	72394	79544195
Injection site discomfort	55.55	16.84	54	127745	5112	79611477
Cardiogenic shock	54.86	16.84	3	127796	41911	79574678
Lung diffusion test decreased	54.57	16.84	31	127768	1279	79615310
Wound secretion	52.61	16.84	57	127742	6131	79610458
Gamma-glutamyltransferase increased	51.79	16.84	12	127787	54668	79561921
Lung hyperinflation	51.76	16.84	34	127765	1825	79614764
Hyposmia	51.61	16.84	25	127774	740	79615849
Hypokinesia	51.55	16.84	102	127697	18958	79597631
Nasal disorder	51.42	16.84	45	127754	3724	79612865
Asthma-chronic obstructive pulmonary disease overlap syndrome	51.21	16.84	42	127757	3179	79613410
Food intolerance	50.61	16.84	45	127754	3803	79612786
Haematochezia	50.26	16.84	40	127759	87605	79528984
Bronchial obstruction	50.22	16.84	39	127760	2729	79613860
Medication error	49.50	16.84	24	127775	68618	79547971
Gastrooesophageal reflux disease	49.40	16.84	311	127488	103935	79512654
Increased upper airway secretion	49.36	16.84	46	127753	4131	79612458
Hospitalisation	49.20	16.84	47	127752	94189	79522400
Urinary retention	48.78	16.84	15	127784	56615	79559974
Periorbital swelling	48.66	16.84	39	127760	2857	79613732
Treatment noncompliance	48.47	16.84	12	127787	52256	79564333
Cystic fibrosis	48.32	16.84	44	127755	3836	79612753
Ear discomfort	48.16	16.84	64	127735	8519	79608070
Injection site bruising	48.13	16.84	160	127639	40842	79575747
Blood urea increased	47.64	16.84	10	127789	48780	79567809
Acute respiratory distress syndrome	47.46	16.84	7	127792	44060	79572529
Claustrophobia	47.44	16.84	28	127771	1242	79615347
Nasal mucosal disorder	46.98	16.84	19	127780	361	79616228
Acute myocardial infarction	46.95	16.84	33	127766	77003	79539586
Ventricular tachycardia	46.72	16.84	6	127793	41929	79574660
Hypercalcaemia	46.67	16.84	4	127795	38426	79578163
Blood creatine phosphokinase increased	46.31	16.84	24	127775	66066	79550523
Fatigue	46.29	16.84	1874	125925	927853	78688736
Rash maculo-papular	46.28	16.84	16	127783	56062	79560527
Therapeutic response decreased	46.20	16.84	221	127578	66632	79549957
Anaphylactoid reaction	46.19	16.84	50	127749	5372	79611217
Rectal haemorrhage	46.09	16.84	33	127766	76267	79540322
Hyperventilation	46.03	16.84	60	127739	7839	79608750
Prescribed overdose	45.85	16.84	4	127795	37879	79578710
Upper respiratory tract infection	45.73	16.84	276	127523	90892	79525697
Quality of life decreased	45.60	16.84	69	127730	10351	79606238
Cardiac failure	45.55	16.84	114	127685	154728	79461861
Wrist fracture	45.32	16.84	74	127725	11847	79604742
Decompression sickness	45.10	16.84	13	127786	81	79616508
Pulmonary pain	44.84	16.84	45	127754	4428	79612161
Pancreatitis acute	44.82	16.84	12	127787	49592	79566997
Irritable bowel syndrome	44.52	16.84	22	127777	62219	79554370
Polymyalgia rheumatica	44.30	16.84	45	127754	4492	79612097
Osteonecrosis of jaw	44.02	16.84	8	127791	43218	79573371
Accident	43.75	16.84	62	127737	8769	79607820
Hypervolaemia	43.26	16.84	8	127791	42682	79573907
Haematemesis	42.98	16.84	15	127784	52249	79564340
Acute respiratory failure	42.65	16.84	21	127778	59520	79557069
Body temperature increased	42.43	16.84	162	127637	44258	79572331
Lethargy	41.91	16.84	41	127758	81251	79535338
Cerebral haemorrhage	41.83	16.84	20	127779	57653	79558936
Pneumonia aspiration	41.73	16.84	28	127771	66939	79549650
Mouth swelling	41.71	16.84	50	127749	6001	79610588
Otorrhoea	41.63	16.84	29	127770	1716	79614873
Dizziness	41.58	16.84	1121	126678	525320	79091269
Psychotic disorder	41.44	16.84	8	127791	41394	79575195
Nasal inflammation	40.89	16.84	21	127778	706	79615883
Hallucination, visual	40.88	16.84	3	127796	32726	79583863
Wound complication	40.72	16.84	45	127754	4948	79611641
Deep vein thrombosis	40.46	16.84	83	127716	120836	79495753
Skin lesion	40.29	16.84	153	127646	41691	79574898
Body temperature abnormal	39.94	16.84	32	127767	2343	79614246
Musculoskeletal stiffness	39.88	16.84	145	127654	174863	79441726
Nasal pruritus	39.83	16.84	19	127780	543	79616046
Jaundice	39.47	16.84	18	127781	53331	79563258
Neonatal hypoacusis	39.42	16.84	9	127790	17	79616572
Cryopyrin associated periodic syndrome	39.41	16.84	17	127782	382	79616207
Status asthmaticus	39.16	16.84	23	127776	1011	79615578
Cytomegalovirus infection	39.14	16.84	10	127789	42634	79573955
Tubulointerstitial nephritis	39.10	16.84	7	127792	38228	79578361
Respiration abnormal	39.06	16.84	55	127744	7733	79608856
Skin ulcer	38.94	16.84	19	127780	54131	79562458
Respiratory rate decreased	38.92	16.84	45	127754	5198	79611391
Myopathy	38.55	16.84	95	127704	20468	79596121
Auditory neuropathy spectrum disorder	38.44	16.84	9	127790	20	79616569
Circulatory collapse	38.30	16.84	7	127792	37661	79578928
Head deformity	38.15	16.84	10	127789	41	79616548
Disorientation	38.11	16.84	27	127772	62749	79553840
Sputum retention	37.90	16.84	23	127776	1074	79615515
Cerebral infarction	37.75	16.84	13	127786	45663	79570926
Lymphopenia	37.60	16.84	3	127796	30554	79586035
Pulmonary hypertension	37.52	16.84	15	127784	48065	79568524
Myelodysplastic syndrome	37.22	16.84	3	127796	30298	79586291
Blood immunoglobulin E abnormal	37.02	16.84	9	127790	25	79616564
Heart rate abnormal	36.85	16.84	47	127752	6010	79610579
Needle issue	36.64	16.84	71	127728	12997	79603592
Injection related reaction	36.51	16.84	22	127777	1014	79615575
Haematocrit decreased	36.40	16.84	27	127772	61285	79555304
Stevens-Johnson syndrome	36.30	16.84	9	127790	39157	79577432
Coagulopathy	35.95	16.84	7	127792	35999	79580590
Gastroenteritis viral	35.72	16.84	104	127695	24727	79591862
Urticaria chronic	35.53	16.84	18	127781	588	79616001
Mite allergy	35.48	16.84	23	127776	1207	79615382
Generalised tonic-clonic seizure	35.43	16.84	13	127786	43897	79572692
Pneumocystis jirovecii pneumonia	35.39	16.84	5	127794	32503	79584086
Altered state of consciousness	35.31	16.84	13	127786	43809	79572780
Intentional self-injury	35.26	16.84	5	127794	32414	79584175
Allergy test positive	35.18	16.84	19	127780	709	79615880
Conjunctivitis allergic	35.11	16.84	26	127773	1694	79614895
Clostridium difficile colitis	35.06	16.84	5	127794	32278	79584311
Psoriasis	34.88	16.84	56	127743	89531	79527058
Acne	34.53	16.84	109	127690	27081	79589508
Laboratory test abnormal	33.84	16.84	3	127796	28045	79588544
Peritonitis	33.82	16.84	3	127796	28033	79588556
Pulmonary embolism	33.58	16.84	151	127648	171503	79445086
Hip arthroplasty	33.56	16.84	8	127791	35748	79580841
Device related infection	33.54	16.84	7	127792	34287	79582302
Dyskinesia	33.29	16.84	15	127784	44758	79571831
Urticarial vasculitis	33.23	16.84	17	127782	567	79616022
Bronchial wall thickening	32.99	16.84	30	127769	2611	79613978
Functional residual capacity decreased	32.87	16.84	10	127789	77	79616512
Intentional product use issue	32.73	16.84	129	127670	151983	79464606
Aphasia	32.70	16.84	17	127782	46715	79569874
Pancreatitis	32.64	16.84	37	127762	68538	79548051
Forced expiratory volume abnormal	32.59	16.84	11	127788	122	79616467
Movement disorder	32.55	16.84	107	127692	27152	79589437
Myocardial infarction	32.52	16.84	168	127631	183961	79432628
Factor V Leiden mutation	32.46	16.84	12	127787	177	79616412
Expiratory reserve volume decreased	32.21	16.84	10	127789	83	79616506
Respiratory tract irritation	32.14	16.84	17	127782	608	79615981
Therapy non-responder	32.04	16.84	62	127737	92243	79524346
Full blood count decreased	32	16.84	3	127796	26816	79589773
Sedation	31.93	16.84	22	127777	51873	79564716
Fluid retention	31.80	16.84	39	127760	69770	79546819
Allergy to chemicals	31.42	16.84	29	127770	2573	79614016
Adverse drug reaction	31.41	16.84	36	127763	66356	79550233
Functional residual capacity increased	31.40	16.84	10	127789	91	79616498
Feeling cold	30.99	16.84	109	127690	28620	79587969
Injection site scab	30.89	16.84	14	127785	355	79616234
Urinary tract infection	30.87	16.84	286	127513	274226	79342363
Cystic fibrosis pancreatic	30.83	16.84	9	127790	59	79616530
Chronic spontaneous urticaria	30.75	16.84	21	127778	1203	79615386
Symptom recurrence	30.31	16.84	27	127772	2287	79614302
Ventricular fibrillation	30.25	16.84	7	127792	31919	79584670
Chest X-ray abnormal	30.06	16.84	49	127750	7834	79608755
Knee arthroplasty	29.87	16.84	16	127783	43232	79573357
Dermoid cyst	29.86	16.84	13	127786	299	79616290
Nocturnal dyspnoea	29.70	16.84	23	127776	1603	79614986
Upper limb fracture	29.54	16.84	79	127720	17888	79598701
Abnormal behaviour	29.02	16.84	11	127788	36410	79580179
Frequent bowel movements	28.95	16.84	6	127793	29533	79587056
Pain in extremity	28.94	16.84	777	127022	363761	79252828
Femur fracture	28.66	16.84	13	127786	38639	79577950
Bronchial disorder	28.62	16.84	27	127772	2462	79614127
Injection site hypoaesthesia	28.55	16.84	15	127784	529	79616060
Pharyngeal paraesthesia	28.43	16.84	28	127771	2693	79613896
Ligament rupture	28.39	16.84	31	127768	3363	79613226
Body mass index increased	28.24	16.84	24	127775	1909	79614680
Diaphragmatic disorder	28.20	16.84	23	127776	1727	79614862
Blood calcium decreased	28.18	16.84	8	127791	31811	79584778
Agitation	28.10	16.84	75	127724	99640	79516949
Hypoacusis	28.01	16.84	109	127690	30041	79586548
Procedural pain	27.91	16.84	91	127708	22993	79593596
Drug eruption	27.87	16.84	18	127781	43917	79572672
Administration site erythema	27.70	16.84	13	127786	358	79616231
Upper respiratory tract congestion	27.60	16.84	27	127772	2576	79614013
Exercise tolerance decreased	27.55	16.84	51	127748	9020	79607569
Ear swelling	27.48	16.84	22	127777	1609	79614980
Chronic sinusitis	27.47	16.84	63	127736	12963	79603626
Respiratory arrest	27.45	16.84	31	127768	57519	79559070
Shock	27.41	16.84	18	127781	43530	79573059
Forced expiratory volume increased	27.21	16.84	8	127791	54	79616535
Pigmentation disorder	27.18	16.84	39	127760	5579	79611010
Oral pruritus	27.10	16.84	26	127773	2422	79614167
Injection site erythema	26.95	16.84	216	127583	77981	79538608
Electrolyte imbalance	26.92	16.84	8	127791	30873	79585716
Peak expiratory flow rate abnormal	26.90	16.84	9	127790	97	79616492
Ejection fraction decreased	26.64	16.84	11	127788	34566	79582023
Joint range of motion decreased	26.61	16.84	10	127789	33272	79583317
Pain in jaw	26.53	16.84	21	127778	46130	79570459
Sinus tachycardia	26.46	16.84	13	127786	36895	79579694
Hyperlipidaemia	26.20	16.84	5	127794	26088	79590501
Depression	26.06	16.84	222	127577	216568	79400021
Glomerular filtration rate decreased	25.90	16.84	3	127796	22699	79593890
Gastric ulcer	25.77	16.84	11	127788	33894	79582695
Injection site swelling	25.77	16.84	146	127653	46986	79569603
Hypereosinophilic syndrome	25.64	16.84	14	127785	534	79616055
Malnutrition	25.61	16.84	3	127796	22499	79594090
Reaction to azo-dyes	25.43	16.84	6	127793	14	79616575
Lymphocyte count decreased	25.37	16.84	23	127776	47266	79569323
Toxic skin eruption	25.30	16.84	3	127796	22290	79594299
Red blood cell count decreased	25.29	16.84	33	127766	57480	79559109
Sputum increased	25.27	16.84	34	127765	4579	79612010
Vascular access site thrombosis	25.26	16.84	7	127792	37	79616552
Fear of disease	25.19	16.84	19	127780	1273	79615316
Lung opacity	25.15	16.84	36	127763	5138	79611451
Drug ineffective for unapproved indication	25.10	16.84	27	127772	51211	79565378
Poisoning	25.05	16.84	5	127794	25267	79591322
Blood lactate dehydrogenase increased	24.91	16.84	16	127783	39154	79577435
Laryngitis	24.85	16.84	69	127730	15970	79600619
Injection site urticaria	24.84	16.84	60	127739	12766	79603823
Urosepsis	24.73	16.84	6	127793	26489	79590100
Wound	24.69	16.84	99	127700	116080	79500509
Tachycardia	24.66	16.84	175	127624	177593	79438996
Infection	24.58	16.84	258	127541	241454	79375135
Drug resistance	24.53	16.84	19	127780	42194	79574395
Osteomyelitis	24.45	16.84	11	127788	32854	79583735
Pulmonary oedema	24.40	16.84	67	127732	88187	79528402
Respiratory depression	24.37	16.84	7	127792	27623	79588966
Atrial flutter	24.32	16.84	3	127796	21622	79594967
Respiratory fume inhalation disorder	24.25	16.84	10	127789	200	79616389
Skin swelling	24.19	16.84	31	127768	3983	79612606
Sense of oppression	24.02	16.84	20	127779	1546	79615043
Drug hypersensitivity	23.96	16.84	638	127161	298278	79318311
Subarachnoid haemorrhage	23.92	16.84	5	127794	24460	79592129
Small intestinal obstruction	23.89	16.84	7	127792	27265	79589324
Flatulence	23.87	16.84	20	127779	42704	79573885
Injection site pruritus	23.80	16.84	132	127667	42151	79574438
Abdominal pain	23.62	16.84	461	127338	389108	79227481
Metastases to liver	23.50	16.84	8	127791	28306	79588283
Withdrawal syndrome	23.33	16.84	7	127792	26847	79589742
Choking sensation	23.27	16.84	30	127769	3876	79612713
Urinary incontinence	23.04	16.84	19	127780	40890	79575699
Coagulation factor deficiency	22.96	16.84	9	127790	157	79616432
Panic attack	22.86	16.84	88	127711	24128	79592461
Surgery	22.80	16.84	12	127787	32754	79583835
Atopy	22.72	16.84	12	127787	428	79616161
Right ventricular failure	22.57	16.84	5	127794	23492	79593097
Muscle tension dysphonia	22.55	16.84	9	127790	165	79616424
Blood test abnormal	22.49	16.84	71	127728	17639	79598950
Mycotic allergy	22.48	16.84	19	127780	1500	79615089
Unevaluable event	22.35	16.84	34	127765	55551	79561038
Mitral valve incompetence	22.14	16.84	9	127790	28556	79588033
Pericardial effusion	21.95	16.84	25	127774	46212	79570377
Metastases to bone	21.90	16.84	6	127793	24421	79592168
Muscle rigidity	21.78	16.84	3	127796	19879	79596710
Occupational exposure to dust	21.76	16.84	6	127793	31	79616558
Visual acuity reduced	21.71	16.84	10	127789	29459	79587130
Blood pressure diastolic decreased	21.68	16.84	101	127698	30115	79586474
Local reaction	21.68	16.84	13	127786	594	79615995
Bronchomalacia	21.59	16.84	10	127789	267	79616322
Hereditary angioedema	21.49	16.84	34	127765	5301	79611288
Blood potassium increased	21.46	16.84	10	127789	29265	79587324
Polyp	21.46	16.84	43	127756	8064	79608525
Sinus headache	21.33	16.84	33	127766	5047	79611542
Epistaxis	21.26	16.84	99	127700	111416	79505173
Sputum abnormal	21.18	16.84	17	127782	1248	79615341
Vaccination site pain	21.16	16.84	9	127790	195	79616394
Injection site eczema	21.04	16.84	7	127792	74	79616515
Skin reaction	20.94	16.84	65	127734	16003	79600586
Ataxia	20.91	16.84	7	127792	25032	79591557
Tryptase increased	20.80	16.84	13	127786	640	79615949
Abortion spontaneous	20.71	16.84	98	127701	29409	79587180
Asthma exercise induced	20.65	16.84	8	127791	135	79616454
Device dislocation	20.43	16.84	8	127791	25962	79590627
Ehlers-Danlos syndrome	20.28	16.84	8	127791	142	79616447
Sputum culture	20.28	16.84	9	127790	217	79616372
Laryngeal oedema	20.20	16.84	42	127757	8087	79608502
Chromaturia	20.14	16.84	8	127791	25738	79590851
Live birth	20.13	16.84	3	127796	18741	79597848
Eosinophilia	20.07	16.84	133	127666	45212	79571377
Endocarditis fibroplastica	20.04	16.84	5	127794	16	79616573
Joint injury	19.80	16.84	101	127698	31234	79585355
Cardiac infection	19.79	16.84	11	127788	435	79616154
Allergic sinusitis	19.73	16.84	14	127785	853	79615736
Gastrointestinal disorder	19.65	16.84	115	127684	122090	79494499
Hypothermia	19.63	16.84	6	127793	22740	79593849
Red blood cell sedimentation rate increased	19.55	16.84	27	127772	45915	79570674
Eye allergy	19.51	16.84	13	127786	715	79615874
Sarcoidosis	19.48	16.84	42	127757	8293	79608296
COVID-19 pneumonia	19.45	16.84	11	127788	28838	79587751
Dermatitis atopic	19.43	16.84	47	127752	10009	79606580
Ulcer	19.40	16.84	12	127787	29960	79586629
Upper airway obstruction	19.38	16.84	17	127782	1411	79615178
Sudden death	19.32	16.84	6	127793	22505	79594084
Metastases to lung	19.29	16.84	3	127796	18160	79598429
Therapy cessation	19.29	16.84	19	127780	37543	79579046
Blood sodium decreased	19.28	16.84	15	127784	33240	79583349
Head discomfort	19.21	16.84	59	127740	14443	79602146
Caffeine allergy	19.17	16.84	5	127794	20	79616569
Ileus	19.15	16.84	9	127790	26202	79590387
Ligament pain	19.14	16.84	9	127790	249	79616340
Escherichia infection	19.08	16.84	3	127796	18014	79598575
Croup infectious	19.06	16.84	13	127786	743	79615846
Leukocytosis	19.04	16.84	25	127774	43430	79573159
Bronchial irritation	19.00	16.84	6	127793	53	79616536
Physiotherapy chest	18.99	16.84	4	127795	4	79616585
Suicidal ideation	18.91	16.84	61	127738	76279	79540310
General physical condition abnormal	18.82	16.84	36	127763	6527	79610062
Skin laceration	18.76	16.84	94	127705	28868	79587721
Arthropod sting	18.62	16.84	16	127783	1292	79615297
Speech disorder	18.54	16.84	150	127649	54295	79562294
Suffocation feeling	18.53	16.84	18	127781	1702	79614887
Colitis ulcerative	18.52	16.84	17	127782	34725	79581864
Coagulation factor V level abnormal	18.43	16.84	6	127793	59	79616530
Proteinuria	18.42	16.84	15	127784	32487	79584102
Hydronephrosis	18.28	16.84	3	127796	17451	79599138
Myocardial ischaemia	18.28	16.84	9	127790	25510	79591079
Injection site reaction	18.15	16.84	150	127649	54635	79561954
Nasal discomfort	18.15	16.84	32	127767	5451	79611138
Bruxism	18.10	16.84	27	127772	3999	79612590
Polyneuropathy	18.10	16.84	8	127791	24143	79592446
Oxygen saturation decreased	18.07	16.84	299	127500	128748	79487841
Pleural rub	17.99	16.84	6	127793	64	79616525
Brain oedema	17.96	16.84	9	127790	25254	79591335
Paraesthesia	17.96	16.84	389	127410	175934	79440655
Musculoskeletal disorder	17.90	16.84	6	127793	21442	79595147
Device malfunction	17.90	16.84	6	127793	21442	79595147
Dystonia	17.84	16.84	6	127793	21393	79595196
Extrapyramidal disorder	17.82	16.84	7	127792	22672	79593917
Disability	17.80	16.84	3	127796	17117	79599472
Swelling of eyelid	17.77	16.84	26	127773	3785	79612804
Vascular access site infection	17.76	16.84	7	127792	124	79616465
Haematuria	17.75	16.84	54	127745	68782	79547807
Allergy to metals	17.74	16.84	11	127788	534	79616055
Pneumonitis	17.74	16.84	45	127754	60815	79555774
Tooth disorder	17.69	16.84	10	127789	26223	79590366
Dermatitis contact	17.62	16.84	48	127751	10985	79605604
Arthralgia	17.60	16.84	1101	126698	570702	79045887
Dialysis	17.59	16.84	4	127795	18458	79598131
Pharyngitis streptococcal	17.50	16.84	47	127752	10667	79605922
Acute coronary syndrome	17.49	16.84	6	127793	21127	79595462
Overweight	17.48	16.84	27	127772	4123	79612466
Product prescribing error	17.45	16.84	28	127771	44785	79571804
COVID-19	17.39	16.84	165	127634	157509	79459080
Tongue pruritus	17.29	16.84	11	127788	559	79616030
Lipohypertrophy	17.23	16.84	13	127786	871	79615718
Oropharyngeal spasm	17.23	16.84	10	127789	430	79616159
Red blood cell count increased	17.20	16.84	27	127772	4181	79612408
Urticaria pressure	17.10	16.84	5	127794	33	79616556
Skin necrosis	17.07	16.84	4	127795	18083	79598506
Iron deficiency anaemia	17.00	16.84	10	127789	25662	79590927
Paranoia	17.00	16.84	5	127794	19427	79597162
Urine output decreased	16.98	16.84	4	127795	18018	79598571
Breath sounds	16.93	16.84	7	127792	141	79616448
Flushing	16.91	16.84	216	127583	88052	79528537
Left ventricular dysfunction	16.90	16.84	5	127794	19356	79597233
Eosinophilic oesophagitis	16.87	16.84	11	127788	583	79616006

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03DX05	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Other systemic drugs for obstructive airway diseases
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D019141	Respiratory System Agents
FDA MoA	N0000175792	IgE-directed Antibody Interactions
FDA PE	N0000175793	Decreased IgE Activity
FDA EPC	N0000175794	Anti-IgE

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Asthma	indication	195967001	DOID:2841
Chronic idiopathic urticaria	indication	302162004
Seasonal allergic rhinitis	indication	367498001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Ig epsilon chain C region	Antibody	P01854	IGHE_HUMAN	ANTIBODY BINDING	Kd	8.16		IUPHAR	DRUG LABEL

External reference:

ID	Source
D05251	KEGG_DRUG
4021399	VUID
N0000148817	NUI
4021399	VANDF
CHEMBL1201589	ChEMBL_ID
C401983	MESH_SUPPLEMENTAL_RECORD_UI
6890	IUPHAR_LIGAND_ID
DB00043	DRUGBANK_ID
302379	RXNORM
17379	MMSL
46992	MMSL
d04881	MMSL
000571	NDDF
406442003	SNOMEDCT_US
406443008	SNOMEDCT_US
D000069444	MESH_DESCRIPTOR_UI
C0966225	UMLSCUI
8039	INN_ID
2P471X1Z11	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
XOLAIR	HUMAN PRESCRIPTION DRUG LABEL	1	50242-040	INJECTION, SOLUTION	202.50 mg	SUBCUTANEOUS	BLA	32 sections
XOLAIR	HUMAN PRESCRIPTION DRUG LABEL	1	50242-040	INJECTION, SOLUTION	150 mg	SUBCUTANEOUS	BLA	32 sections
Xolair PFS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-214	INJECTION, SOLUTION	75 mg	SUBCUTANEOUS	BLA	32 sections
Xolair PFS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-214	INJECTION, SOLUTION	75 mg	SUBCUTANEOUS	BLA	32 sections
Xolair PFS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-215	INJECTION, SOLUTION	150 mg	SUBCUTANEOUS	BLA	32 sections
Xolair PFS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-215	INJECTION, SOLUTION	150 mg	SUBCUTANEOUS	BLA	32 sections
Xolair	HUMAN PRESCRIPTION DRUG LABEL	1	50242-227	INJECTION, SOLUTION	300 mg	SUBCUTANEOUS	BLA	32 sections