carbimazole indications/contra

Stem definitionDrug idCAS RN
497 22232-54-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbimazole
  • athyromazole
  • carbethoxymethimazole
  • carbimazol
  • neomercazole
An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.
  • Molecular weight: 186.23
  • Formula: C7H10N2O2S
  • CLOGP: 1.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 32.78
  • ALOGS: -1.77
  • ROTB: 2

Drug dosage:

DoseUnitRoute
15 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1959 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 131.39 78.62 20 73 2814 3382952

Pharmacologic Action:

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SourceCodeDescription
ATC H03BB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
ANTITHYROID PREPARATIONS
Sulfur-containing imidazole derivatives
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50671 antithyroid drug
MeSH PA D013956 Antithyroid Agents
MeSH PA D006727 Hormone Antagonists
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hyperthyroidism indication 34486009 DOID:7998
Graves' disease indication 353295004 DOID:12361

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thyroid peroxidase Enzyme INHIBITOR WOMBAT-PK SCIENTIFIC LITERATURE
Lactoperoxidase Enzyme IC50 4.98 CHEMBL

External reference:

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IDSource
CHEBI:617099 CHEBI
DB00389 DRUGBANK_ID
N0000167064 NUI
C0006983 UMLSCUI
D07616 KEGG_DRUG
31072 PUBCHEM_CID
N0000167064 NDFRT
002140 NDDF
2020 RXNORM
325325006 SNOMEDCT_US
395831005 SNOMEDCT_US
8KQ660G60G UNII
323 INN_ID
CHEMBL508102 ChEMBL_ID
D002231 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None