canakinumab indications/contra

Stem definitionDrug idCAS RN
human origin 4952 914613-48-2

Description:

MoleculeDescription

Synonyms:

  • canakinumab
  • ilaris
  • ACZ885
a human anti-interleukin-1beta monoclonal antibody for treatment of cryopyrin-associated periodic syndrome
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.70 mg P

Approvals:

DateAgencyCompanyOrphan
Oct. 23, 2009 EMA
June 17, 2009 FDA NOVARTIS PHARMS

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pyrexia 509.20 38.50 184 1127 80931 3303617
Inappropriate schedule of drug administration 398.16 38.50 102 1209 13651 3370897
Histiocytosis haematophagic 397.31 38.50 73 1238 2003 3382545
Juvenile idiopathic arthritis 326.35 38.50 51 1260 501 3384047
Drug ineffective 161.29 38.50 93 1218 115997 3268551
Pneumonia 147.01 38.50 74 1237 70069 3314479
Malaise 143.14 38.50 71 1240 65106 3319442
Incorrect dose administered 121.69 38.50 41 1270 13873 3370675
Condition aggravated 117.39 38.50 53 1258 39180 3345368
C-reactive protein increased 111.92 38.50 35 1276 9348 3375200
Rash 106.51 38.50 60 1251 70761 3313787
Apparent death 105.62 38.50 19 1292 452 3384096
Cryopyrin associated periodic syndrome 101.73 38.50 12 1299 4 3384544
Pain 100.53 38.50 58 1253 71499 3313049
Muckle-Wells syndrome 93.00 38.50 11 1300 4 3384544
Product use issue 89.96 38.50 34 1277 15967 3368581
Arthralgia 84.47 38.50 49 1262 60812 3323736
Bronchitis 74.31 38.50 29 1282 14816 3369732
Cough 74.23 38.50 39 1272 39819 3344729
Diverticulitis 73.29 38.50 22 1289 5103 3379445
Joint swelling 70.41 38.50 29 1282 17028 3367520
Familial mediterranean fever 67.75 38.50 9 1302 22 3384526
Upper respiratory tract infection 67.09 38.50 24 1287 9631 3374917
Infection 65.41 38.50 31 1280 25371 3359177
Nasopharyngitis 63.37 38.50 29 1282 21918 3362630
Headache 59.30 38.50 46 1265 91934 3292614
Vomiting 58.19 38.50 45 1266 89486 3295062
Cellulitis 53.96 38.50 22 1289 12553 3371995
Concomitant disease progression 53.73 38.50 12 1299 865 3383683
Serum ferritin increased 52.53 38.50 13 1298 1461 3383087

Pharmacologic Action:

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SourceCodeDescription
ATC L04AC08 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Familial Mediterranean fever indication 12579009 DOID:2987
Articular gout indication 48440001 DOID:13189
Deficiency of mevalonate kinase indication 124327008 DOID:0050452
Systemic onset juvenile chronic arthritis indication 201796004
TNF receptor-associated periodic fever syndrome (TRAPS) indication 403833009
Cryopyrin associated periodic syndrome indication 430079001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-1 beta Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

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IDSource
6773 IUPHAR_LIGAND_ID
D09315 KEGG_DRUG
4028805 VUID
N0000178497 NUI
C2718773 UMLSCUI
37CQ2C7X93 UNII
8836 INN_ID
853491 RXNORM
4028805 VANDF
26503 MMSL
d07451 MMSL
N0000178497 NDFRT
013212 NDDF
698091001 SNOMEDCT_US
703376008 SNOMEDCT_US
CHEMBL1201834 ChEMBL_ID
DB06168 DRUGBANK_ID
C541220 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Ilaris HUMAN PRESCRIPTION DRUG LABEL 1 0078-0582 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 150 mg SUBCUTANEOUS BLA 18 sections
Ilaris HUMAN PRESCRIPTION DRUG LABEL 1 0078-0734 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 18 sections