carbetocin indications/contra

Stem definitionDrug idCAS RN
oxytocin derivatives 495 37025-55-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pabal
  • carbetocin
  • depotocin
  • duratocin
carbetocin selectively binds to oxytocin receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the tone of the uterus musculature
  • Molecular weight: 988.17
  • Formula: C45H69N11O12S
  • CLOGP: 0.11
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 10
  • TPSA: 362.51
  • ALOGS: -4.57
  • ROTB: 18

Drug dosage:

DoseUnitRoute
0.10 mg P

Approvals:

DateAgencyCompanyOrphan
Nov. 5, 2007 UK Medicines and Healthcare Products Regulatory Agency (MHRA) Ferring Pharmaceuticals Ltd

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 20.69 0 4 2 49679 3336174

Pharmacologic Action:

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SourceCodeDescription
ATC H01BB03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
POSTERIOR PITUITARY LOBE HORMONES
Oxytocin and analogues
MeSH PA D003692 Delayed-Action Preparations
MeSH PA D010120 Oxytocics
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:36063 oxytocic

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Atony of uterus indication 9293002
Prader-Willi syndrome indication 89392001 DOID:11983

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Oxytocin receptor GPCR AGONIST Ki 8.15 SCIENTIFIC LITERATURE DRUG LABEL
Vasopressin V2 receptor GPCR Ki 5.23 SCIENTIFIC LITERATURE
Vasopressin V1a receptor GPCR EC50 7.39 CHEMBL

External reference:

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IDSource
D07229 KEGG_DRUG
423594000 SNOMEDCT_US
425003007 SNOMEDCT_US
006738 NDDF
88TWF8015Y UNII
5014 INN_ID
C020731 MESH_SUPPLEMENTAL_RECORD_UI
DB01282 DRUGBANK_ID
CHEMBL3301668 ChEMBL_ID
16681432 PUBCHEM_CID
CHEBI:59204 CHEBI

Pharmaceutical products:

None