carbetocin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| oxytocin derivatives | 495 | 37025-55-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
carbetocin selectively binds to oxytocin receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the tone of the uterus musculature
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | mg | P |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 5, 2007 | UK Medicines and Healthcare Products Regulatory Agency (MHRA) | Ferring Pharmaceuticals Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H01BB03 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES POSTERIOR PITUITARY LOBE HORMONES Oxytocin and analogues |
| MeSH PA | D003692 | Delayed-Action Preparations |
| MeSH PA | D010120 | Oxytocics |
| MeSH PA | D012102 | Reproductive Control Agents |
| CHEBI has role | CHEBI:36063 | oxytocic agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atony of uterus | indication | 9293002 | |
| Prader-Willi syndrome | indication | 89392001 | DOID:11983 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.59 | acidic |
| pKa2 | 13.2 | acidic |
| pKa3 | 13.33 | acidic |
| pKa4 | 13.57 | acidic |
| pKa5 | 13.94 | acidic |
| pKa6 | 13.98 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Oxytocin receptor | GPCR | AGONIST | Ki | 8.15 | SCIENTIFIC LITERATURE | DRUG LABEL | |||
| Vasopressin V1a receptor | GPCR | EC50 | 7.39 | CHEMBL | |||||
| Vasopressin V2 receptor | GPCR | Ki | 5.23 | SCIENTIFIC LITERATURE | |||||
| Oxytocin receptor | GPCR | AGONIST | EC50 | 7.21 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D07229 | KEGG_DRUG |
| C0054670 | UMLSCUI |
| CHEBI:59204 | CHEBI |
| CHEMBL3301668 | ChEMBL_ID |
| DB01282 | DRUGBANK_ID |
| C020731 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11169 | IUPHAR_LIGAND_ID |
| 5014 | INN_ID |
| 88TWF8015Y | UNII |
| 16681432 | PUBCHEM_CID |
| 423594000 | SNOMEDCT_US |
| 425003007 | SNOMEDCT_US |
| 006738 | NDDF |
Pharmaceutical products:
None