ripasudil Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
Rho protein kinase inhibitors 4938 223645-67-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ripasudil
  • ripasudil hydrochloride hydrate
  • ripasudil hydrochloride
  • glanatec
  • glanatec ophthalmic solution
  • ripasudil HCl
Rho-associated kinase inhibitor for the treatment of glaucoma and ocular hypertension
  • Molecular weight: 323.39
  • Formula: C15H18FN3O2S
  • CLOGP: 1.73
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 62.30
  • ALOGS: -3.03
  • ROTB: 1

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 2014 PMDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Glaucoma indication 23986001 DOID:1686

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.12 Basic
pKa2 4.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Rho-associated protein kinase 2 Kinase INHIBITOR IC50 7.72 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Rho-associated protein kinase 1 Kinase INHIBITOR IC50 7.29 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D10463 KEGG_DRUG
11978226XX UNII
9691 INN_ID
CHEBI:136046 CHEBI
DB13165 DRUGBANK_ID
9863672 PUBCHEM_CID
10423 IUPHAR_LIGAND_ID
C584679 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None