carbenoxolone indications/contra

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 493 5697-56-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbenoxolone
  • biogastrone
  • glycyrrhetinic acid hydrogen succinate
  • carbenoxolone disodium salt
  • carbenoxolone disodium
  • carbenoxolone sodium
An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.
  • Molecular weight: 570.77
  • Formula: C34H50O7
  • CLOGP: 7.19
  • LIPINSKI: 2
  • HAC: 7
  • HDO: 2
  • TPSA: 117.97
  • ALOGS: -5.89
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.15 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A02BX01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
ATC A02BX51 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
ATC A02BX71 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Ulcer of esophagus indication 30811009

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.29 acidic
pKa2 5.02 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme INHIBITOR IC50 7.08 CHEMBL KEGG DRUG
Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme IC50 7.09 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 6.97 CHEMBL

External reference:

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IDSource
4151 IUPHAR_LIGAND_ID
N0000166341 NUI
C0006979 UMLSCUI
D01899 KEGG_DRUG
N0000166341 NDFRT
2017 RXNORM
387273006 SNOMEDCT_US
49617001 SNOMEDCT_US
003685 NDDF
636403 PUBCHEM_CID
CHEMBL499915 ChEMBL_ID
D002229 MESH_DESCRIPTOR_UI
DB02329 DRUGBANK_ID
CHEMBL1697717 ChEMBL_ID
F1MP7242Z5 UNII
7421-40-1 SECONDARY_CAS_RN
1789 INN_ID
CHEBI:31351 CHEBI
CBO PDB_CHEM_ID

Pharmaceutical products:

None