carbenicillin indications/contra

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 492 4697-36-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbenicillin
  • carboxybenzylpenicillin
  • carboxybenzylpenicillin acid
  • carbenicillin disodium
  • carbenicillin sodium
  • carbenicillin potassium
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
  • Molecular weight: 378.40
  • Formula: C17H18N2O6S
  • CLOGP: 1.64
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 124.01
  • ALOGS: -2.99
  • ROTB: 5

Drug dosage:

DoseUnitRoute
12 g P

Approvals:

DateAgencyCompanyOrphan
None FDA ROERIG

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01CA03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
FDA EPC N0000175497 Penicillin-class Antibacterial
FDA Chemical/Ingredient N0000011281 Penicillins
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Prostatitis indication 9713002 DOID:14654
Urinary tract infectious disease indication 68566005
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Enterococcus Prostatitis indication
Pseudomonas Aeruginosa Urinary Tract Infection indication
Proteus Prostatitis indication
Enterobacter Prostatitis indication
Morganella Morganii Urinary Tract Infection indication
Enterococcus Urinary Tract Infection indication
Providencia Urinary Tract Infection indication
Kidney disease contraindication 90708001 DOID:2527
Infectious mononucleosis contraindication 271558008 DOID:8568
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.59 acidic
pKa2 3.22 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR IC50 5.37 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR IC50 5 WOMBAT-PK
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL
Penicillin-binding protein 1A Enzyme WOMBAT-PK

External reference:

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IDSource
DB00578 DRUGBANK_ID
4019654 VUID
N0000147746 NUI
C0006976 UMLSCUI
D07614 KEGG_DRUG
3UX6B304L3 UNII
17230-86-3 SECONDARY_CAS_RN
4019654 VANDF
N0000007482 NDFRT
N0000147746 NDFRT
2015 RXNORM
34731007 SNOMEDCT_US
372713001 SNOMEDCT_US
d00092 MMSL
002700 NDDF
CHEMBL1214 ChEMBL_ID
20824 PUBCHEM_CID
CHEMBL606260 ChEMBL_ID
D002228 MESH_DESCRIPTOR_UI
CHEMBL2105992 ChEMBL_ID
2516 INN_ID
CHEBI:3393 CHEBI

Pharmaceutical products:

None