acotiamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4908 185106-16-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • YM-443
  • Z-338
  • acotiamide
  • acotiamide hydrochloride
  • acotiamide hydrochloride hydrate
  • acofide
  • acotiamide HCl
A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
  • Molecular weight: 450.55
  • Formula: C21H30N4O5S
  • CLOGP: 4.20
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 113.02
  • ALOGS: -4.37
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 25, 2013 PMDA Zeria

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03FA10 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nonulcer dyspepsia indication 3696007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.18 acidic
pKa2 9.82 acidic
pKa3 13.5 acidic
pKa4 10.27 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme INHIBITOR IC50 5.52 DRUG LABEL SCIENTIFIC LITERATURE

External reference:

IDSource
D08838 KEGG_DRUG
CHEBI:34523 CHEBI
CHEMBL2107723 ChEMBL_ID
CHEMBL2107308 ChEMBL_ID
C410959 MESH_SUPPLEMENTAL_RECORD_UI
773092-05-0 SECONDARY_CAS_RN
DB12482 DRUGBANK_ID
C4317155 UMLSCUI
8506 INN_ID
5282338 PUBCHEM_CID
D42OWK5383 UNII

Pharmaceutical products:

None