diquafosol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4900 | 59985-21-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
purinoceptor P2Y(2) receptor agonist
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 9, 2010 | PMDA | Santen Pharmaceutical |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:53142 | P2Y2 receptor agonists |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tear film insufficiency | indication | 46152009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.71 | acidic |
| pKa2 | 2.32 | acidic |
| pKa3 | 8.93 | acidic |
| pKa4 | 9.53 | acidic |
| pKa5 | 11.46 | acidic |
| pKa6 | 12.06 | acidic |
| pKa7 | 13.51 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| P2Y purinoceptor 2 | GPCR | AGONIST | EC50 | 7.47 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| P2Y purinoceptor 4 | GPCR | AGONIST | EC50 | 6.40 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 7828VC80FJ | UNII |
| D03864 | KEGG_DRUG |
| 211427-08-6 | SECONDARY_CAS_RN |
| C1955479 | UMLSCUI |
| CHEBI:27791 | CHEBI |
| CHEMBL221326 | ChEMBL_ID |
| 148197 | PUBCHEM_CID |
| DB15919 | DRUGBANK_ID |
| CHEMBL1767408 | ChEMBL_ID |
| 8326 | INN_ID |
| C403315 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1736 | IUPHAR_LIGAND_ID |
| 018489 | NDDF |
| 018490 | NDDF |
Pharmaceutical products:
None