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iguratimod 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| immunomodulators, both stimulant/suppressive and stimulant | 4894 | 123663-49-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a methanesulfonanilide disease-modifying antirheumatic drug that has been developed exclusively in Japan and China
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 29, 2012 | PMDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumocystis jirovecii pneumonia | 198.35 | 43.17 | 48 | 1171 | 21568 | 90605660 |
| Interstitial lung disease | 130.73 | 43.17 | 46 | 1173 | 76359 | 90550869 |
| Lymphoproliferative disorder | 127.26 | 43.17 | 25 | 1194 | 4237 | 90622991 |
| Adult T-cell lymphoma/leukaemia | 69.48 | 43.17 | 10 | 1209 | 254 | 90626974 |
| Varicella zoster pneumonia | 59.58 | 43.17 | 8 | 1211 | 120 | 90627108 |
| Herpes zoster | 53.96 | 43.17 | 26 | 1193 | 94618 | 90532610 |
| Osteonecrosis of jaw | 53.45 | 43.17 | 20 | 1199 | 39083 | 90588145 |
| Pneumonia bacterial | 47.84 | 43.17 | 14 | 1205 | 12776 | 90614452 |
| Diffuse large B-cell lymphoma | 43.81 | 43.17 | 12 | 1207 | 8633 | 90618595 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 80.57 | 50.72 | 29 | 354 | 78433 | 42542519 |
| Lymphoproliferative disorder | 54.24 | 50.72 | 11 | 372 | 3296 | 42617656 |
| Pneumonia bacterial | 50.77 | 50.72 | 14 | 369 | 15678 | 42605274 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 186.06 | 34.85 | 74 | 1765 | 139260 | 110448200 |
| Pneumocystis jirovecii pneumonia | 181.34 | 34.85 | 54 | 1785 | 42681 | 110544779 |
| Lymphoproliferative disorder | 169.80 | 34.85 | 36 | 1803 | 7182 | 110580278 |
| Pneumonia bacterial | 89.15 | 34.85 | 28 | 1811 | 26233 | 110561227 |
| Adult T-cell lymphoma/leukaemia | 62.75 | 34.85 | 10 | 1829 | 408 | 110587052 |
| Herpes zoster | 59.23 | 34.85 | 31 | 1808 | 108348 | 110479112 |
| Osteonecrosis of jaw | 48.57 | 34.85 | 21 | 1818 | 47996 | 110539464 |
| Varicella zoster pneumonia | 48.49 | 34.85 | 8 | 1831 | 406 | 110587054 |
| Diffuse large B-cell lymphoma | 45.90 | 34.85 | 15 | 1824 | 15883 | 110571577 |
| Atypical mycobacterial infection | 38.71 | 34.85 | 9 | 1830 | 2709 | 110584751 |
| Listeriosis | 38.40 | 34.85 | 9 | 1830 | 2805 | 110584655 |
| Lymphoma | 34.92 | 34.85 | 13 | 1826 | 20158 | 110567302 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.64 | acidic |
| pKa2 | 9.55 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Macrophage migration inhibitory factor | Cytokine | IC50 | 5.17 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4IHY34Y2NV | UNII |
| D01146 | KEGG_DRUG |
| C1872427 | UMLSCUI |
| CHEBI:31689 | CHEBI |
| 7TN | PDB_CHEM_ID |
| CHEMBL2107455 | ChEMBL_ID |
| 124246 | PUBCHEM_CID |
| DB12233 | DRUGBANK_ID |
| 8176 | INN_ID |
| C519076 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9736 | IUPHAR_LIGAND_ID |
| C077313 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4IHY34Y2NV | INXIGHT DRUGS |
Pharmaceutical products:
None