luseogliflozin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives 4891 898537-18-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • luseogliflozin
  • lusefi
  • luseogliflozin hydrate
  • TS-071
an antidiabetic agent that inhibits sodium-dependent glucose cotransporter 2 (SGLT2)
  • Molecular weight: 434.55
  • Formula: C23H30O6S
  • CLOGP: 3.35
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 99.38
  • ALOGS: -3.93
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 24, 2014 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BK07 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.22 acidic
pKa2 13.21 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.65 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1 Transporter IC50 5.40 SCIENTIFIC LITERATURE

External reference:

IDSource
C596HWF74Z UNII
D10195 KEGG_DRUG
C2933904 UMLSCUI
CHEBI:134725 CHEBI
11988953 PUBCHEM_CID
DB12214 DRUGBANK_ID
9292 INN_ID
C549343 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None