ipragliflozin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives 4890 761423-87-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ipragliflozin
  • suglat
  • ipragliflozin L-proline
  • ASP1941
  • Molecular weight: 404.45
  • Formula: C21H21FO5S
  • CLOGP: 3.38
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 90.15
  • ALOGS: -4.13
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 2014 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 54.34 38.15 17 445 45659 79698267
Diabetes mellitus inadequate control 41.66 38.15 12 450 24252 79719674

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BK05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D000077203 Sodium-Glucose Transporter 2 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Diabetes mellitus type 1 indication 46635009 DOID:9744




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.62 acidic
pKa2 13.26 acidic
pKa3 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.13 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1 Transporter IC50 5.73 SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.20 IUPHAR
Sodium/glucose cotransporter 1 Transporter INHIBITOR IC50 5.86 IUPHAR
Sodium/glucose cotransporter 1 Transporter INHIBITOR IC50 5.93 IUPHAR
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.25 IUPHAR

External reference:

IDSource
3N2N8OOR7X UNII
D10196 KEGG_DRUG
951382-34-6 SECONDARY_CAS_RN
C3492889 UMLSCUI
CHEBI:134724 CHEBI
CHEMBL2018096 ChEMBL_ID
10453870 PUBCHEM_CID
DB11698 DRUGBANK_ID
CHEMBL4297658 ChEMBL_ID
9258 INN_ID
C572941 MESH_SUPPLEMENTAL_RECORD_UI
9394 IUPHAR_LIGAND_ID

Pharmaceutical products:

None