topiroxostat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| xanthine oxydase and xanthine dehydrogenase inhibitor | 4888 | 577778-58-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
xanthine oxidoreductase inhibitor
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 28, 2013 | PMDA | Senwa Kegaku Kenkyushp |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D004791 | Enzyme Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hyperuricemia | indication | 35885006 | DOID:1920 |
| Gout | indication | 90560007 | DOID:13189 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.7 | acidic |
| pKa2 | 4.07 | Basic |
| pKa3 | 2.94 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Xanthine dehydrogenase/oxidase | Enzyme | INHIBITOR | IC50 | 8.28 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| ATP-binding cassette sub-family G member 2 | Transporter | IC50 | 6.75 | CHEMBL | |||||
| Xanthine dehydrogenase/oxidase | Enzyme | IC50 | 8.32 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 0J877412JV | UNII |
| D09786 | KEGG_DRUG |
| C4049065 | UMLSCUI |
| CHEMBL1078685 | ChEMBL_ID |
| 5288320 | PUBCHEM_CID |
| DB01685 | DRUGBANK_ID |
| 9220 | INN_ID |
| C504882 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10592 | IUPHAR_LIGAND_ID |
| FYX | PDB_CHEM_ID |
Pharmaceutical products:
None