cetilistat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
gastrointestinal lipase inhibitors 4886 282526-98-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetilistat
  • ATL-962
  • oblean
lipase inhibitor in randomized, placebo-controlled study of weight reduction in obese patients (3/2007)
  • Molecular weight: 401.59
  • Formula: C25H39NO3
  • CLOGP: 9.52
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 47.89
  • ALOGS: -7.51
  • ROTB: 16

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IRAK1,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 62
kinase-selectivity-class AXL,CAMK2D,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK12,MAPK7,MARK4,PDK4,PLK1,SIK2,STK33,TEK,TTK 17
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 20, 2013 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019440 Anti-Obesity Agents
MeSH PA D057847 Lipid Regulating Agents
CHEBI has role CHEBI:74518 anti-obesity agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Pancreatic triacylglycerol lipase Enzyme INHIBITOR IC50 8.23 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Pancreatic triacylglycerol lipase Enzyme INHIBITOR IC50 7.26 IUPHAR

External reference:

IDSource
LC5G1JUA39 UNII
D09208 KEGG_DRUG
C1957370 UMLSCUI
CHEBI:134721 CHEBI
CHEMBL2103825 ChEMBL_ID
9952916 PUBCHEM_CID
DB06586 DRUGBANK_ID
8461 INN_ID
C520092 MESH_SUPPLEMENTAL_RECORD_UI
11433 IUPHAR_LIGAND_ID
LC5G1JUA39 INXIGHT DRUGS

Pharmaceutical products:

None