All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

enoxaparin sodium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
heparin derivatives including low molecular mass heparins	4879	679809-58-6

Description:

Molecule	Description
Synonyms: thorinane enoxaparin sodium enoxaparin lovenox enoxaparine	Low-molecular-weight fragment of heparin, having a 4-enopyranosuronate sodium structure at the non-reducing end of the chain. It is prepared by depolymerization of the benzylic ester of porcine mucosal heparin. Therapeutically, it is used as an antithrombotic agent. (From Merck Index, 11th ed) Molecular weight: Formula: None CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
2	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 15, 2016	EMA	Techdow Pharma Netherlands B.V.
March 29, 1993	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haematoma	639.47	10.77	493	100877	34327	63353325
Heparin-induced thrombocytopenia	553.41	10.77	225	101145	4357	63383295
Thrombocytopenia	530.69	10.77	902	100468	150255	63237397
Abdominal wall haematoma	525.59	10.77	194	101176	2861	63384791
Drug ineffective	482.38	10.77	579	100791	1044186	62343466
Exposure during pregnancy	452.17	10.77	855	100515	154692	63232960
Shock haemorrhagic	429.02	10.77	240	101130	9655	63377997
Pulmonary embolism	420.86	10.77	705	100665	115979	63271673
Cholestasis	396.19	10.77	348	101022	29086	63358566
Retroperitoneal haematoma	368.85	10.77	148	101222	2765	63384887
Deep vein thrombosis	355.06	10.77	545	100825	83255	63304397
Acute generalised exanthematous pustulosis	354.60	10.77	221	101149	10878	63376774
Hepatocellular injury	353.13	10.77	316	101054	27065	63360587
Acute kidney injury	333.20	10.77	1050	100320	262365	63125287
Retroperitoneal haemorrhage	329.74	10.77	135	101235	2662	63384990
Injury associated with device	323.15	10.77	144	101226	3522	63384130
Joint swelling	319.50	10.77	67	101303	327599	63060053
Anaemia	318.87	10.77	1111	100259	292319	63095333
Rheumatoid arthritis	290.18	10.77	33	101337	253786	63133866
Alopecia	268.08	10.77	102	101268	337434	63050218
Drug intolerance	266.40	10.77	81	101289	308580	63079072
Drug reaction with eosinophilia and systemic symptoms	263.49	10.77	297	101073	33539	63354113
Synovitis	258.35	10.77	9	101361	186909	63200743
Therapeutic product effect decreased	248.53	10.77	15	101355	193172	63194480
Abdominal discomfort	243.33	10.77	104	101266	320781	63066871
Arthropathy	239.31	10.77	43	101327	234749	63152903
Systemic lupus erythematosus	234.19	10.77	29	101341	208889	63178763
Rash maculo-papular	229.86	10.77	269	101101	31627	63356025
Premature delivery	227.64	10.77	261	101109	30020	63357632
Muscle haemorrhage	218.22	10.77	105	101265	3074	63384578
Arthralgia	217.43	10.77	360	101010	569350	62818302
Eosinophilia	216.31	10.77	222	101148	22534	63365118
Completed suicide	212.60	10.77	4	101366	145669	63241983
Premature baby	202.02	10.77	205	101165	20530	63367122
Pain	201.38	10.77	566	100804	740062	62647590
Glossodynia	200.05	10.77	25	101345	178851	63208801
Intra-abdominal haematoma	192.13	10.77	81	101289	1724	63385928
Haemorrhage	191.49	10.77	347	101023	60675	63326977
Treatment failure	177.55	10.77	49	101321	198994	63188658
Weight increased	174.24	10.77	100	101270	260692	63126960
Haemoglobin decreased	170.93	10.77	566	100804	144919	63242733
Foetal exposure during pregnancy	168.99	10.77	231	101139	31731	63355921
Infusion related reaction	168.56	10.77	91	101279	245430	63142222
Swelling	168.31	10.77	117	101253	275261	63112391
Nasopharyngitis	163.53	10.77	102	101268	254155	63133497
Neutropenia	158.16	10.77	625	100745	174380	63213272
Thrombosis	152.01	10.77	326	101044	64429	63323223
Sinusitis	151.25	10.77	87	101283	226566	63161086
Pericarditis	148.04	10.77	18	101352	131561	63256091
Wound	147.83	10.77	39	101331	163224	63224428
Hypersensitivity	146.22	10.77	151	101219	292534	63095118
Discomfort	144.11	10.77	44	101326	167330	63220322
Hepatic cytolysis	142.26	10.77	148	101222	15259	63372393
Contraindicated product administered	140.36	10.77	87	101283	217561	63170091
Fatigue	138.74	10.77	842	100528	887186	62500466
Toxic skin eruption	135.86	10.77	133	101237	12752	63374900
Drug interaction	134.62	10.77	721	100649	228410	63159242
International normalised ratio increased	133.11	10.77	254	101116	46171	63341481
Drug hypersensitivity	132.06	10.77	182	101188	310505	63077147
Headache	130.35	10.77	545	100825	632696	62754956
Musculoskeletal stiffness	130.26	10.77	66	101304	184552	63203100
Therapeutic product effect incomplete	129.30	10.77	22	101348	125034	63262618
Pelvic haematoma	128.54	10.77	45	101325	564	63387088
Hypoxia	127.87	10.77	290	101080	59502	63328150
Mixed liver injury	125.86	10.77	84	101286	4651	63383001
Gastrointestinal haemorrhage	122.60	10.77	345	101025	80831	63306821
Psoriatic arthropathy	121.07	10.77	6	101364	91514	63296138
Helicobacter infection	114.03	10.77	9	101361	92776	63294876
Haematuria	112.78	10.77	182	101188	28975	63358677
Duodenal ulcer perforation	111.40	10.77	7	101363	87202	63300450
Cerebral haemorrhage	111.03	10.77	186	101184	30543	63357109
Fibromyalgia	107.25	10.77	5	101365	80415	63307237
Irritable bowel syndrome	107.13	10.77	6	101364	82406	63305246
Foetal growth restriction	107.03	10.77	92	101278	7461	63380191
Hypotension	105.06	10.77	770	100600	271834	63115818
Computerised tomogram thorax abnormal	99.57	10.77	51	101319	1712	63385940
Arterial haemorrhage	97.93	10.77	50	101320	1667	63385985
Pyrexia	96.94	10.77	1162	100208	469316	62918336
Haemoperitoneum	93.70	10.77	57	101313	2684	63384968
Oliguria	92.35	10.77	92	101278	9009	63378643
Folliculitis	91.77	10.77	5	101365	70312	63317340
Sepsis	91.31	10.77	484	100886	152639	63235013
Product dose omission issue	90.99	10.77	146	101224	234167	63153485
Agranulocytosis	90.62	10.77	152	101218	24982	63362670
Blood cholesterol increased	89.90	10.77	20	101350	94012	63293640
Melaena	89.34	10.77	168	101202	30197	63357455
Loss of personal independence in daily activities	88.49	10.77	23	101347	97267	63290385
Pancytopenia	88.12	10.77	347	101023	96586	63291066
Intra-abdominal haemorrhage	86.09	10.77	52	101318	2417	63385235
Febrile neutropenia	85.25	10.77	395	100975	118054	63269598
Compartment syndrome	84.57	10.77	50	101320	2234	63385418
Psoriasis	84.14	10.77	18	101352	86939	63300713
Hypokalaemia	82.85	10.77	357	101013	103447	63284205
Haematoma muscle	82.45	10.77	39	101331	1098	63386554
Low birth weight baby	81.61	10.77	77	101293	7052	63380600
Computerised tomogram thorax	79.02	10.77	29	101341	420	63387232
Renal failure	77.17	10.77	382	100988	117270	63270382
Extradural haematoma	75.26	10.77	42	101328	1680	63385972
Transaminases increased	74.82	10.77	159	101211	31208	63356444
Hyperkalaemia	74.71	10.77	223	101147	53980	63333672
Leukopenia	73.76	10.77	281	101089	77009	63310643
Spinal epidural haematoma	73.66	10.77	36	101334	1091	63386561
Subdural haematoma	71.89	10.77	101	101269	14227	63373425
Product use issue	70.94	10.77	154	101216	220366	63167286
Muscle injury	70.93	10.77	10	101360	65335	63322317
Pleural effusion	70.90	10.77	316	101054	92894	63294758
Hypovolaemic shock	70.66	10.77	67	101303	6174	63381478
Respiratory failure	70.59	10.77	336	101034	101522	63286130
Gamma-glutamyltransferase increased	70.46	10.77	163	101207	33868	63353784
Asthma	70.44	10.77	60	101310	127501	63260151
Paraplegia	70.05	10.77	47	101323	2625	63385027
Ecchymosis	69.21	10.77	87	101283	11007	63376645
Hyponatraemia	68.95	10.77	357	101013	111543	63276109
Hepatic enzyme increased	68.70	10.77	137	101233	202191	63185461
Atelectasis	68.41	10.77	123	101247	21360	63366292
Multiple organ dysfunction syndrome	65.84	10.77	220	101150	56532	63331120
Mobility decreased	65.68	10.77	58	101312	121101	63266551
Atrial fibrillation	65.66	10.77	363	101007	116273	63271379
Peripheral swelling	65.59	10.77	212	101158	265730	63121922
Injection site haematoma	65.54	10.77	67	101303	6765	63380887
Labelled drug-drug interaction medication error	65.08	10.77	93	101277	13306	63374346
Cytokine release syndrome	64.66	10.77	96	101274	14218	63373434
Spinal cord haematoma	64.60	10.77	20	101350	165	63387487
Ischaemic stroke	63.94	10.77	108	101262	17849	63369803
Feeling abnormal	63.89	10.77	86	101284	148306	63239346
Malaise	62.70	10.77	398	100972	415556	62972096
Septic shock	62.55	10.77	241	101129	66388	63321264
Dermatitis bullous	61.68	10.77	72	101298	8436	63379216
Insomnia	61.52	10.77	160	101210	215092	63172560
Toxicity to various agents	61.03	10.77	197	101173	247053	63140599
Dizziness	60.96	10.77	419	100951	429506	62958146
Post procedural haematoma	60.73	10.77	33	101337	1252	63386400
Tachycardia	60.14	10.77	358	101012	117798	63269854
Arthritis	59.86	10.77	58	101312	115863	63271789
Hepatitis acute	59.26	10.77	73	101297	9047	63378605
Wheezing	59.13	10.77	40	101330	95555	63292097
Adverse drug reaction	58.46	10.77	27	101343	79687	63307965
Lymphopenia	58.45	10.77	105	101265	18222	63369430
Thrombocytosis	57.53	10.77	58	101312	5760	63381892
Foetal death	57.48	10.77	79	101291	10901	63376751
Maternal exposure during pregnancy	57.38	10.77	570	100800	219492	63168160
Spontaneous haematoma	56.80	10.77	28	101342	865	63386787
Intentional overdose	56.14	10.77	24	101346	74128	63313524
Stomatitis	55.18	10.77	85	101285	138640	63249012
Haematemesis	54.74	10.77	138	101232	30274	63357378
Cholestatic liver injury	54.64	10.77	40	101330	2570	63385082
Activated partial thromboplastin time prolonged	54.48	10.77	61	101309	6832	63380820
Post procedural haemorrhage	53.78	10.77	65	101305	7899	63379753
Depression	53.18	10.77	150	101220	196342	63191310
Ovarian hyperstimulation syndrome	53.06	10.77	47	101323	3967	63383685
Hepatitis cholestatic	52.88	10.77	60	101310	6818	63380834
Rectal haemorrhage	52.44	10.77	185	101185	48845	63338807
Blood pressure increased	52.24	10.77	113	101257	161949	63225703
Intentional product use issue	52.18	10.77	77	101293	127815	63259837
Hypertransaminasaemia	51.40	10.77	58	101312	6551	63381101
Purpura	50.91	10.77	76	101294	11309	63376343
Electrocardiogram QT prolonged	50.79	10.77	209	101161	59321	63328331
Aplastic anaemia	50.32	10.77	69	101301	9500	63378152
Cell death	50.28	10.77	38	101332	2563	63385089
Cardiac arrest	50.07	10.77	285	101085	92260	63295392
Haemarthrosis	49.94	10.77	41	101329	3120	63384532
Haemorrhage intracranial	49.50	10.77	82	101288	13337	63374315
Haemorrhagic stroke	48.79	10.77	53	101317	5739	63381913
Alveolitis	48.57	10.77	39	101331	2876	63384776
Hypercoagulation	48.34	10.77	34	101336	2051	63385601
Ill-defined disorder	48.21	10.77	36	101334	81719	63305933
Drug abuse	48.08	10.77	28	101342	72490	63315162
Musculoskeletal pain	47.84	10.77	46	101324	92231	63295421
Embolism	47.73	10.77	61	101309	7845	63379807
Vascular pseudoaneurysm	47.62	10.77	30	101340	1504	63386148
Cardiogenic shock	47.59	10.77	95	101275	17837	63369815
Clostridium test positive	47.42	10.77	40	101330	3161	63384491
Sinus bradycardia	47.21	10.77	84	101286	14467	63373185
Tachyarrhythmia	47.03	10.77	46	101324	4404	63383248
International normalised ratio decreased	46.59	10.77	46	101324	4455	63383197
Wound infection pseudomonas	46.38	10.77	28	101342	1300	63386352
Blood pressure fluctuation	46.02	10.77	9	101361	46308	63341344
Hyperglycaemia	45.66	10.77	159	101211	41708	63345944
Needle issue	44.60	10.77	68	101302	10308	63377344
Blood loss anaemia	44.49	10.77	63	101307	8938	63378714
Coagulopathy	44.29	10.77	100	101270	20444	63367208
Hepatitis	44.17	10.77	152	101218	39636	63348016
Rash morbilliform	44.09	10.77	39	101331	3286	63384366
Device expulsion	44.01	10.77	3	101367	34919	63352733
COVID-19 pneumonia	43.52	10.77	80	101290	14129	63373523
Haemodynamic instability	43.48	10.77	63	101307	9127	63378525
Blood alkaline phosphatase increased	43.29	10.77	159	101211	42808	63344844
Encephalopathy	42.41	10.77	147	101223	38473	63349179
Fibrin D dimer increased	42.29	10.77	46	101324	4988	63382664
Lymphatic fistula	42.26	10.77	22	101348	764	63386888
Pain in extremity	42.16	10.77	333	101037	331153	63056499
Type 2 diabetes mellitus	41.86	10.77	25	101345	63843	63323809
COVID-19 treatment	41.81	10.77	13	101357	109	63387543
Erysipelas	41.57	10.77	57	101313	7848	63379804
Circulatory collapse	41.01	10.77	101	101269	21837	63365815
Femoral hernia incarcerated	40.86	10.77	22	101348	819	63386833
General physical health deterioration	40.67	10.77	496	100874	200906	63186746
Respiratory distress	40.61	10.77	133	101237	33818	63353834
Aspartate aminotransferase increased	40.58	10.77	265	101105	90012	63297640
Rash	40.51	10.77	641	100729	560230	62827422
Migraine	40.44	10.77	64	101306	103282	63284370
Thrombophlebitis	40.39	10.77	42	101328	4326	63383326
Vascular device infection	40.39	10.77	54	101316	7258	63380394
Acute respiratory failure	40.27	10.77	134	101236	34351	63353301
Subcutaneous haematoma	39.79	10.77	28	101342	1690	63385962
Pancreatic steatosis	39.61	10.77	23	101347	993	63386659
Toxic epidermal necrolysis	39.52	10.77	109	101261	25225	63362427
Epistaxis	39.35	10.77	224	101146	72501	63315151
Placental insufficiency	39.35	10.77	26	101344	1415	63386237
Therapeutic response decreased	39.05	10.77	25	101345	61500	63326152
Prothrombin time prolonged	38.76	10.77	61	101309	9503	63378149
Syringe issue	38.74	10.77	34	101336	2835	63384817
Seroma	38.71	10.77	30	101340	2101	63385551
Alanine aminotransferase increased	38.66	10.77	291	101079	103479	63284173
Cardiac valve replacement complication	38.58	10.77	13	101357	144	63387508
Weight decreased	38.56	10.77	271	101099	276527	63111125
Suicide attempt	38.33	10.77	25	101345	60893	63326759
Jugular vein thrombosis	38.24	10.77	35	101335	3083	63384569
Cystitis radiation	38.14	10.77	11	101359	69	63387583
Lower respiratory tract infection	38.04	10.77	98	101272	132209	63255443
Bladder tamponade	38.01	10.77	11	101359	70	63387582
Haemorrhagic transformation stroke	37.95	10.77	24	101346	1211	63386441
Suicidal ideation	37.43	10.77	27	101343	62394	63325258
Petechiae	37.33	10.77	74	101296	13823	63373829
Device related infection	36.85	10.77	101	101269	23291	63364361
Gait disturbance	36.66	10.77	159	101211	183019	63204633
Cerebral venous sinus thrombosis	36.34	10.77	28	101342	1944	63385708
Influenza like illness	36.19	10.77	32	101338	66792	63320860
Patent ductus arteriosus	35.99	10.77	39	101331	4211	63383441
Dermatitis exfoliative generalised	35.91	10.77	37	101333	3770	63383882
Caesarean section	35.71	10.77	82	101288	16950	63370702
Stress	35.38	10.77	33	101337	67134	63320518
Normal newborn	34.92	10.77	54	101316	8287	63379365
Chest wall haematoma	34.89	10.77	13	101357	197	63387455
Excessive eye blinking	34.72	10.77	23	101347	1257	63386395
Erythema multiforme	34.67	10.77	60	101310	10109	63377543
Generalised bullous fixed drug eruption	34.59	10.77	11	101359	100	63387552
Hypochromic anaemia	34.54	10.77	27	101343	1915	63385737
Adrenal haemorrhage	34.44	10.77	16	101354	432	63387220
Premature labour	34.10	10.77	67	101303	12437	63375215
Bradycardia	33.55	10.77	216	101154	73011	63314641
Cerebral haematoma	33.32	10.77	35	101335	3648	63384004
Pulmonary thrombosis	33.21	10.77	54	101316	8648	63379004
Intentional product misuse	33.19	10.77	29	101341	60888	63326764
Epidural haemorrhage	33.13	10.77	11	101359	116	63387536
Venous thrombosis	33.09	10.77	40	101330	4862	63382790
Wound dehiscence	33.08	10.77	40	101330	4863	63382789
Nasal congestion	32.58	10.77	34	101336	65626	63322026
Adverse event	32.39	10.77	36	101334	67523	63320129
Vision blurred	32.25	10.77	61	101309	91863	63295789
Haemoptysis	32.11	10.77	110	101260	28616	63359036
Osteoarthritis	31.95	10.77	65	101305	95278	63292374
Device safety feature issue	31.90	10.77	7	101363	10	63387642
Stevens-Johnson syndrome	31.89	10.77	100	101270	24850	63362802
Vitamin K deficiency	31.62	10.77	15	101355	425	63387227
Blister	31.60	10.77	104	101266	129710	63257942
Peritoneal haematoma	31.44	10.77	10	101360	91	63387561
Hip arthroplasty	30.73	10.77	19	101351	47627	63340025
Cardio-respiratory arrest	30.69	10.77	182	101188	59777	63327875
Inappropriate schedule of product administration	30.66	10.77	76	101294	103889	63283763
Therapy non-responder	30.66	10.77	46	101324	75855	63311797
Rhinorrhoea	30.29	10.77	36	101334	65541	63322111
Injection site erythema	30.24	10.77	54	101316	83120	63304532
Influenza	30.13	10.77	82	101288	108640	63279012
Systolic dysfunction	30.11	10.77	23	101347	1576	63386076
Cataract	30.08	10.77	28	101342	57025	63330627
Aortic arteriosclerosis	30.01	10.77	43	101327	6166	63381486
Anticoagulation drug level below therapeutic	29.95	10.77	17	101353	703	63386949
Bullous haemorrhagic dermatosis	29.88	10.77	9	101361	67	63387585
Flushing	29.85	10.77	46	101324	75041	63312611
Postpartum haemorrhage	29.85	10.77	25	101345	1956	63385696
Illness	29.70	10.77	21	101349	49038	63338614
Escherichia infection	29.66	10.77	64	101306	12690	63374962
Ear infection	29.51	10.77	12	101358	38201	63349451
Ascites	29.40	10.77	136	101234	40592	63347060
Memory impairment	29.37	10.77	78	101292	104180	63283472
Erythrodermic psoriasis	29.34	10.77	19	101351	999	63386653
International normalised ratio abnormal	29.18	10.77	31	101339	3273	63384379
Muscle spasms	29.17	10.77	139	101231	156011	63231641
Cerebral artery occlusion	29.03	10.77	18	101352	877	63386775
Pre-eclampsia	28.70	10.77	52	101318	9081	63378571
Congenital central nervous system anomaly	28.68	10.77	13	101357	331	63387321
Peripheral nerve injury	28.27	10.77	14	101356	437	63387215
Hemianopia homonymous	28.18	10.77	16	101354	662	63386990
Anuria	28.07	10.77	62	101308	12489	63375163
Abortion induced	28.07	10.77	55	101315	10187	63377465
Bursitis	28.01	10.77	12	101358	37029	63350623
Hyperleukocytosis	28.00	10.77	16	101354	670	63386982
Condition aggravated	27.88	10.77	463	100907	401754	62985898
Pulmonary hypertension	27.57	10.77	125	101245	36998	63350654
Hypersensitivity myocarditis	27.43	10.77	11	101359	205	63387447
Impaired healing	27.19	10.77	79	101291	102463	63285189
Malnutrition	27.09	10.77	69	101301	15229	63372423
Premature separation of placenta	27.04	10.77	23	101347	1838	63385814
Joint range of motion decreased	27.04	10.77	9	101361	32419	63355233
Dry mouth	27.02	10.77	52	101318	77811	63309841
Duodenal ulcer haemorrhage	27.01	10.77	26	101344	2441	63385211
Tricuspid valve incompetence	26.99	10.77	67	101303	14554	63373098
Neuromyotonia	26.99	10.77	8	101362	56	63387596
Procedural haemorrhage	26.95	10.77	27	101343	2661	63384991
Gastrointestinal disorder	26.81	10.77	113	101257	131126	63256526
Plasma cell myeloma	26.74	10.77	121	101249	35784	63351868
Haematocrit decreased	26.67	10.77	129	101241	39211	63348441
Electrocardiogram ST segment elevation	26.43	10.77	32	101338	3895	63383757
Intraventricular haemorrhage	26.40	10.77	24	101346	2096	63385556
Right ventricular dilatation	26.37	10.77	20	101350	1356	63386296
Hypernatraemia	26.08	10.77	45	101325	7564	63380088
Therapeutic embolisation	26.00	10.77	10	101360	166	63387486
Faecaloma	25.96	10.77	46	101324	7895	63379757
Blood creatinine increased	25.56	10.77	233	101137	87611	63300041
Chest discomfort	25.47	10.77	90	101280	109879	63277773
Vaginal haemorrhage	25.44	10.77	99	101271	27388	63360264
Basal ganglion degeneration	25.42	10.77	13	101357	435	63387217
Target skin lesion	25.41	10.77	9	101361	117	63387535
Joint stiffness	25.25	10.77	18	101352	41851	63345801
Grip strength decreased	25.17	10.77	3	101367	22284	63365368
Disorientation	25.06	10.77	127	101243	39325	63348327
Knee arthroplasty	24.78	10.77	30	101340	54176	63333476
Aphasia	24.41	10.77	111	101259	32889	63354763
Palpitations	24.35	10.77	95	101275	112675	63274977
Infection	24.35	10.77	241	101129	228932	63158720
Hypoaesthesia	24.35	10.77	163	101207	168230	63219422
Infantile apnoea	24.31	10.77	17	101353	1016	63386636
Myalgia	24.23	10.77	136	101234	146393	63241259
Factor XIII deficiency	24.21	10.77	8	101362	83	63387569
Febrile infection	24.19	10.77	20	101350	1537	63386115
Oropharyngeal pain	24.18	10.77	74	101296	94413	63293239
Dehydration	24.15	10.77	400	100970	172954	63214698
HELLP syndrome	24.15	10.77	17	101353	1027	63386625
Neonatal respiratory distress syndrome	24.11	10.77	26	101344	2792	63384860
Aortic valve stenosis	24.05	10.77	28	101342	3271	63384381
Metastases to meninges	24.02	10.77	25	101345	2577	63385075
Gastric disorder	23.97	10.77	15	101355	37354	63350298
Red blood cell sedimentation rate increased	23.89	10.77	21	101349	43961	63343691
Vena cava thrombosis	23.85	10.77	23	101347	2164	63385488
Device related sepsis	23.79	10.77	31	101339	4063	63383589
Rash pustular	23.57	10.77	42	101328	7240	63380412
Product administered at inappropriate site	23.41	10.77	27	101343	3122	63384530
Fluid retention	23.31	10.77	37	101333	59649	63328003
Abdominal pain upper	23.25	10.77	214	101156	206230	63181422
Inflammatory marker increased	22.86	10.77	40	101330	6799	63380853
Spinal cord haemorrhage	22.84	10.77	10	101360	234	63387418
Developmental glaucoma	22.80	10.77	7	101363	56	63387596
Small for dates baby	22.74	10.77	29	101341	3722	63383930
Spinal epidural haemorrhage	22.73	10.77	8	101362	102	63387550
Abortion spontaneous	22.72	10.77	141	101229	47054	63340598
Pulmonary haemorrhage	22.71	10.77	41	101329	7140	63380512
Nonreassuring foetal heart rate pattern	22.69	10.77	7	101363	57	63387595
Incubator therapy	22.69	10.77	7	101363	57	63387595
Protein total decreased	22.69	10.77	37	101333	5940	63381712
Arrhythmogenic right ventricular dysplasia	22.65	10.77	6	101364	26	63387626
Syncope	22.34	10.77	286	101084	117099	63270553
Foetal arrhythmia	22.33	10.77	9	101361	170	63387482
Protein S deficiency	22.29	10.77	6	101364	28	63387624
Disseminated intravascular coagulation	22.22	10.77	74	101296	18977	63368675
Wrong technique in product usage process	22.19	10.77	41	101329	62299	63325353
Haemothorax	22.00	10.77	22	101348	2163	63385489
Neurological decompensation	21.98	10.77	24	101346	2614	63385038
Acute respiratory distress syndrome	21.97	10.77	85	101285	23449	63364203
Tachypnoea	21.80	10.77	69	101301	17233	63370419
Upper gastrointestinal haemorrhage	21.78	10.77	73	101297	18779	63368873
Antiphospholipid syndrome	21.77	10.77	20	101350	1770	63385882
Administration site necrosis	21.77	10.77	4	101366	0	63387652
Prescribed overdose	21.50	10.77	14	101356	34139	63353513
Vaccination site reaction	21.48	10.77	8	101362	121	63387531
Clostridium difficile colitis	21.46	10.77	77	101293	20492	63367160
Product prescribing error	21.40	10.77	91	101279	26198	63361454
Toxic encephalopathy	21.37	10.77	38	101332	6541	63381111
Acidosis	21.29	10.77	52	101318	11181	63376471
Small intestinal obstruction	21.18	10.77	71	101299	18266	63369386
Ear pain	21.16	10.77	16	101354	36102	63351550
Neutropenic sepsis	21.12	10.77	66	101304	16372	63371280
Injection site swelling	21.04	10.77	27	101343	47545	63340107
Subarachnoid haemorrhage	20.85	10.77	60	101310	14223	63373429
Purple glove syndrome	20.82	10.77	9	101361	204	63387448
Diverticulum intestinal	20.82	10.77	38	101332	6675	63380977
Herpes zoster	20.80	10.77	65	101305	82397	63305255
Polyserositis	20.77	10.77	11	101359	396	63387256
Brain compression	20.69	10.77	11	101359	399	63387253
Hypoalbuminaemia	20.65	10.77	53	101317	11752	63375900
Electrocardiogram repolarisation abnormality	20.63	10.77	17	101353	1300	63386352
Amnesia	20.28	10.77	36	101334	55549	63332103
Anxiety	20.19	10.77	236	101134	217305	63170347
Groin pain	20.17	10.77	48	101322	10155	63377497
Anaesthesia	20.08	10.77	11	101359	424	63387228
Blood pressure systolic increased	19.85	10.77	28	101342	47369	63340283
Foetal monitoring abnormal	19.47	10.77	9	101361	240	63387412
Renal tubular necrosis	19.42	10.77	52	101318	11826	63375826
Intracranial pressure increased	19.36	10.77	32	101338	5195	63382457
Mitral valve incompetence	19.31	10.77	72	101298	19522	63368130
Skin candida	19.18	10.77	18	101352	1637	63386015
Uterine enlargement	19.10	10.77	16	101354	1252	63386400
Jaundice neonatal	18.97	10.77	14	101356	911	63386741
Shock	18.93	10.77	81	101289	23382	63364270
Vascular purpura	18.93	10.77	17	101353	1461	63386191
Breast cancer	18.89	10.77	30	101340	48353	63339299
Tissue infiltration	18.77	10.77	12	101358	617	63387035
Oral pain	18.76	10.77	11	101359	28383	63359269
Dysaesthesia	18.76	10.77	29	101341	4449	63383203
Ejection fraction decreased	18.72	10.77	78	101292	22254	63365398
Haemorrhage in pregnancy	18.69	10.77	19	101351	1906	63385746
Language disorder	18.60	10.77	20	101350	2140	63385512
Urticaria	18.60	10.77	172	101198	165630	63222022
Brain herniation	18.56	10.77	26	101344	3651	63384001
Coronary artery thrombosis	18.47	10.77	15	101355	1124	63386528
Off label use	18.43	10.77	1281	100089	673181	62714471
Hepatic cyst	18.35	10.77	31	101339	5123	63382529
Gastric haemorrhage	18.32	10.77	35	101335	6363	63381289
Haemolytic anaemia	18.27	10.77	46	101324	10079	63377573
Purpura non-thrombocytopenic	18.27	10.77	7	101363	115	63387537
Hepatitis fulminant	18.25	10.77	25	101345	3439	63384213
Impaired work ability	18.21	10.77	3	101367	17472	63370180
Urosepsis	18.20	10.77	68	101302	18456	63369196
Dermo-hypodermitis	18.17	10.77	9	101361	281	63387371
Microembolism	18.11	10.77	4	101366	6	63387646
Hepatic failure	18.10	10.77	108	101262	35548	63352104
Twin pregnancy	18.08	10.77	15	101355	1158	63386494
Bronchitis	18.02	10.77	121	101249	124814	63262838
Rash erythematous	18.02	10.77	123	101247	42387	63345265
Hyperbilirubinaemia	17.97	10.77	49	101321	11265	63376387
Gastrooesophageal reflux disease	17.93	10.77	85	101285	95554	63292098
Hepatic infarction	17.92	10.77	12	101358	668	63386984
Thymus disorder	17.85	10.77	9	101361	292	63387360
Cardiac failure	17.73	10.77	219	101151	88923	63298729
Metabolic acidosis	17.69	10.77	128	101242	44941	63342711
Lower gastrointestinal haemorrhage	17.67	10.77	39	101331	7851	63379801
Transfusion	17.65	10.77	59	101311	15158	63372494
Hypercholesterolaemia	17.65	10.77	6	101364	21328	63366324
Protein deficiency	17.63	10.77	9	101361	300	63387352
Crystalluria	17.63	10.77	10	101360	413	63387239
Spinal cord compression	17.57	10.77	27	101343	4121	63383531
Bronchopulmonary dysplasia	17.41	10.77	10	101360	423	63387229
Anticoagulation drug level above therapeutic	17.39	10.77	16	101354	1419	63386233
Splenic injury	17.36	10.77	8	101362	212	63387440
Panic attack	17.26	10.77	7	101363	22324	63365328
Product monitoring error	17.20	10.77	28	101342	4488	63383164
Generalised oedema	17.18	10.77	60	101310	15758	63371894
Diabetes mellitus	17.08	10.77	40	101330	55770	63331882
Tinnitus	17.06	10.77	19	101351	35609	63352043
Soft tissue infection	17.04	10.77	19	101351	2118	63385534
Road traffic accident	17.03	10.77	20	101350	36612	63351040
Throat irritation	17.03	10.77	21	101349	37626	63350026
Blood phosphorus increased	17.02	10.77	23	101347	3122	63384530
Spinal subdural haematoma	17.00	10.77	7	101363	140	63387512
Radiation fibrosis	16.99	10.77	5	101365	34	63387618
Peripheral sensory neuropathy	16.88	10.77	37	101333	7414	63380238
Central nervous system injury	16.82	10.77	7	101363	144	63387508
Eye irritation	16.80	10.77	7	101363	21964	63365688
Oesophageal compression	16.77	10.77	4	101366	10	63387642
Hypertension	16.65	10.77	330	101040	278973	63108679
Scintillating scotoma	16.60	10.77	7	101363	149	63387503
Abdominal pain	16.52	10.77	598	100772	292858	63094794
Hepatitis toxic	16.42	10.77	23	101347	3230	63384422
Epstein-Barr virus test positive	16.40	10.77	11	101359	614	63387038
Cystitis	16.37	10.77	40	101330	54951	63332701
Abdominal wall haemorrhage	16.35	10.77	7	101363	155	63387497
Microphthalmos	16.35	10.77	7	101363	155	63387497
Ultrasound Doppler abnormal	16.35	10.77	7	101363	155	63387497
Bacterascites	16.32	10.77	3	101367	0	63387652
Skin neoplasm bleeding	16.32	10.77	3	101367	0	63387652
Factor Xa activity increased	16.32	10.77	3	101367	0	63387652
Anti factor X antibody positive	16.32	10.77	3	101367	0	63387652
Heparin-induced thrombocytopenia test positive	16.24	10.77	4	101366	12	63387640
Carbohydrate antigen 15-3	16.22	10.77	6	101364	89	63387563
Post procedural complication	16.21	10.77	62	101308	17012	63370640
Foetal heart rate abnormal	16.21	10.77	11	101359	626	63387026
Bicytopenia	16.19	10.77	20	101350	2485	63385167
Febrile bone marrow aplasia	16.17	10.77	36	101334	7289	63380363
Feeling cold	16.15	10.77	9	101361	23879	63363773
Cerebral artery embolism	16.14	10.77	13	101357	963	63386689
Unmasking of previously unidentified disease	16.14	10.77	13	101357	963	63386689
Vascular stent thrombosis	16.13	10.77	13	101357	964	63386688
Skin necrosis	16.10	10.77	54	101316	13896	63373756
Carcinoembryonic antigen	16.04	10.77	6	101364	92	63387560
Hygroma colli	16.00	10.77	4	101366	13	63387639
Stoma site candida	16.00	10.77	4	101366	13	63387639
Myelosuppression	15.92	10.77	9	101361	23694	63363958
Vitiligo	15.89	10.77	15	101355	1374	63386278
Eye pruritus	15.89	10.77	5	101365	18666	63368986
Urine output decreased	15.87	10.77	47	101323	11323	63376329
Cerebral venous thrombosis	15.79	10.77	18	101352	2056	63385596
Pruritus	15.74	10.77	448	100922	361005	63026647
Necrosis	15.69	10.77	30	101340	5457	63382195
Myocarditis	15.68	10.77	44	101326	10281	63377371
Dandy-Walker syndrome	15.52	10.77	6	101364	101	63387551
Epidural analgesia	15.48	10.77	5	101365	48	63387604
Laryngitis	15.44	10.77	4	101366	16963	63370689
Coagulation time prolonged	15.36	10.77	15	101355	1433	63386219
Carpal tunnel syndrome	15.34	10.77	7	101363	20810	63366842
Aspiration	15.28	10.77	45	101325	10806	63376846
Coronary artery embolism	15.21	10.77	7	101363	185	63387467
Intracardiac thrombus	15.19	10.77	19	101351	2391	63385261
Sinus congestion	15.16	10.77	5	101365	18118	63369534
Musculoskeletal disorder	15.12	10.77	7	101363	20637	63367015
Frequent bowel movements	15.10	10.77	9	101361	23013	63364639
Escherichia sepsis	15.09	10.77	28	101342	4979	63382673
Sleep disorder	14.99	10.77	73	101297	81493	63306159
Pneumonitis	14.98	10.77	102	101268	35120	63352532
Necrotising panniculitis	14.98	10.77	4	101366	18	63387634
Renal artery thrombosis	14.95	10.77	6	101364	112	63387540
Injection site pruritus	14.91	10.77	31	101339	45085	63342567
Localised oedema	14.88	10.77	29	101341	5349	63382303
Pharyngeal haemorrhage	14.85	10.77	10	101360	562	63387090
Skin test positive	14.83	10.77	11	101359	721	63386931
Arm amputation	14.80	10.77	4	101366	19	63387633
Myelomalacia	14.79	10.77	5	101365	56	63387596
Folate deficiency	14.79	10.77	19	101351	2456	63385196
International normalised ratio fluctuation	14.77	10.77	19	101351	2459	63385193
Sciatica	14.65	10.77	20	101350	34304	63353348
Placental infarction	14.64	10.77	8	101362	307	63387345
Subcapsular splenic haematoma	14.63	10.77	4	101366	20	63387632
Sputum discoloured	14.60	10.77	4	101366	16343	63371309
Nephrolithiasis	14.60	10.77	28	101342	41956	63345696
Talipes	14.59	10.77	15	101355	1525	63386127
Lymphorrhoea	14.48	10.77	5	101365	60	63387592
Heart rate decreased	14.47	10.77	32	101338	45528	63342124
Polyhydramnios	14.47	10.77	18	101352	2253	63385399
Breast haematoma	14.42	10.77	7	101363	209	63387443
Diffuse large B-cell lymphoma stage II	14.40	10.77	5	101365	61	63387591
Cardiomyopathy alcoholic	14.31	10.77	4	101366	22	63387630
Blood bilirubin increased	14.30	10.77	105	101265	37035	63350617
Empyema	14.29	10.77	17	101353	2032	63385620
Vascular pseudoaneurysm ruptured	14.26	10.77	5	101365	63	63387589
Myocardial rupture	14.26	10.77	5	101365	63	63387589
Bilirubin conjugated abnormal	14.25	10.77	3	101367	3	63387649
Injection site bruising	14.20	10.77	115	101255	41795	63345857
Adrenal haematoma	14.16	10.77	4	101366	23	63387629
Protein C deficiency	14.16	10.77	4	101366	23	63387629
Liver function test abnormal	14.11	10.77	128	101242	48053	63339599
Cognitive disorder	14.07	10.77	44	101326	55771	63331881
Seasonal allergy	14.01	10.77	8	101362	20942	63366710
Vessel puncture site haematoma	14.01	10.77	6	101364	133	63387519
Cerebellar haemorrhage	13.97	10.77	14	101356	1380	63386272
Pericardial effusion	13.97	10.77	89	101281	29969	63357683
Duodenal polyp	13.96	10.77	6	101364	134	63387518
Osteoporosis	13.90	10.77	46	101324	57292	63330360
Nail toxicity	13.87	10.77	8	101362	341	63387311
Fat embolism	13.80	10.77	7	101363	230	63387422
Monoplegia	13.79	10.77	21	101349	3180	63384472
Iliac vein occlusion	13.75	10.77	4	101366	26	63387626
Cough	13.73	10.77	359	101011	292384	63095268
Blood lactate dehydrogenase increased	13.70	10.77	73	101297	23043	63364609
Sneezing	13.62	10.77	6	101364	18212	63369440
Hypertonia neonatal	13.61	10.77	7	101363	237	63387415
Deafness bilateral	13.58	10.77	14	101356	1428	63386224
Intestinal ischaemia	13.55	10.77	34	101336	7434	63380218
Bradypnoea	13.51	10.77	22	101348	3528	63384124
Klebsiella infection	13.50	10.77	37	101333	8529	63379123
Injection site reaction	13.48	10.77	48	101322	58476	63329176
Anaphylactic reaction	13.44	10.77	57	101313	66043	63321609
Pleural neoplasm	13.42	10.77	8	101362	363	63387289
Night sweats	13.38	10.77	37	101333	48777	63338875
Swelling face	13.36	10.77	54	101316	63421	63324231
Eye disorder	13.35	10.77	10	101360	22675	63364977
Gastroduodenal haemorrhage	13.29	10.77	5	101365	78	63387574
Cerebrovascular accident	13.15	10.77	244	101126	107780	63279872
Intentional self-injury	13.08	10.77	13	101357	25674	63361978
Metabolic alkalosis	13.07	10.77	20	101350	3041	63384611
Polyneuropathy	13.06	10.77	52	101318	14537	63373115
Foetal exposure during delivery	13.05	10.77	6	101364	158	63387494
Tricuspid valve stenosis	13.04	10.77	3	101367	6	63387646
Heparin-induced thrombocytopenia test	13.04	10.77	3	101367	6	63387646
Sinus disorder	13	10.77	12	101358	24541	63363111
Gestational diabetes	12.97	10.77	36	101334	8360	63379292
Pelvic venous thrombosis	12.97	10.77	15	101355	1740	63385912
Drug dependence	12.92	10.77	12	101358	24471	63363181
Hip fracture	12.92	10.77	86	101284	29388	63358264
Chemical burns of eye	12.89	10.77	5	101365	85	63387567
Thrombectomy	12.88	10.77	6	101364	163	63387489
Photosensitivity reaction	12.79	10.77	4	101366	14990	63372662
Device related thrombosis	12.76	10.77	15	101355	1770	63385882
Factor XIII Inhibition	12.71	10.77	4	101366	35	63387617
Pituitary haemorrhage	12.68	10.77	5	101365	89	63387563
Quadriplegia	12.66	10.77	15	101355	1785	63385867
Infective glossitis	12.61	10.77	4	101366	36	63387616
Pneumonia mycoplasmal	12.57	10.77	11	101359	914	63386738
Coloboma	12.43	10.77	5	101365	94	63387558
Prosthetic cardiac valve thrombosis	12.42	10.77	4	101366	38	63387614
Hydrocholecystis	12.33	10.77	4	101366	39	63387613
Tumour inflammation	12.33	10.77	4	101366	39	63387613
Autoimmune disorder	12.31	10.77	6	101364	17171	63370481
Anterior chamber cleavage syndrome	12.27	10.77	6	101364	182	63387470
Basal cell carcinoma	12.26	10.77	16	101354	27975	63359677
Uterine hypertonus	12.25	10.77	7	101363	293	63387359
Injection site thrombosis	12.24	10.77	5	101365	98	63387554
Brain oedema	12.23	10.77	50	101320	14145	63373507
Subcapsular renal haematoma	12.21	10.77	7	101363	295	63387357
Liver function test increased	12.20	10.77	92	101278	32719	63354933
Blood urea increased	12.19	10.77	78	101292	26301	63361351
Parenteral nutrition associated liver disease	12.18	10.77	3	101367	9	63387643
Tongue fungal infection	12.18	10.77	3	101367	9	63387643
Leukocytosis	12.18	10.77	77	101293	25858	63361794
Supraventricular tachycardia	12.08	10.77	50	101320	14221	63373431
Orbital oedema	12.06	10.77	7	101363	302	63387350
Hepatic cirrhosis	12.05	10.77	13	101357	24721	63362931
Metastases to heart	12.01	10.77	5	101365	103	63387549
Intra-abdominal fluid collection	12.00	10.77	17	101353	2412	63385240
Bone lesion	11.98	10.77	28	101342	5853	63381799
Metastases to central nervous system	11.96	10.77	47	101323	13058	63374594
Muscle oedema	11.94	10.77	3	101367	10	63387642
Blood albumin decreased	11.93	10.77	51	101319	14715	63372937
Gastritis	11.91	10.77	101	101269	37202	63350450
Acute myocardial infarction	11.91	10.77	90	101280	32034	63355618
Scar pain	11.89	10.77	6	101364	195	63387457
Epilepsy	11.88	10.77	79	101291	26986	63360666
Immobilisation prolonged	11.88	10.77	5	101365	106	63387546
Disease progression	11.88	10.77	268	101102	122490	63265162
Hyperpyrexia	11.82	10.77	21	101349	3611	63384041
Pulmonary infarction	11.80	10.77	18	101352	2729	63384923
Left ventricular dysfunction	11.77	10.77	44	101326	11944	63375708
Stupor	11.77	10.77	23	101347	4252	63383400
Otitis media acute	11.73	10.77	11	101359	999	63386653
Peripheral artery thrombosis	11.72	10.77	15	101355	1931	63385721
Pneumonia	11.66	10.77	863	100507	455904	62931748
Hydrocephalus	11.65	10.77	26	101344	5274	63382378
Ventricular hypokinesia	11.61	10.77	24	101346	4620	63383032
Placenta praevia	11.60	10.77	11	101359	1013	63386639
Myocardial infarction	11.59	10.77	224	101146	99669	63287983
Oligohydramnios	11.57	10.77	29	101341	6337	63381315
Upper respiratory tract infection	11.56	10.77	80	101290	81967	63305685
Dyspepsia	11.46	10.77	106	101264	102090	63285562
Blood disorder	11.43	10.77	30	101340	6741	63380911
Face oedema	11.42	10.77	63	101307	20149	63367503
Right ventricular failure	11.39	10.77	56	101314	17132	63370520
Inguinal hernia	11.36	10.77	15	101355	1992	63385660
Anti factor X activity increased	11.32	10.77	3	101367	13	63387639
Liver abscess	11.29	10.77	18	101352	2836	63384816
Anti-platelet antibody positive	11.22	10.77	4	101366	53	63387599
Hypochromasia	11.22	10.77	7	101363	345	63387307
Gingival erosion	11.20	10.77	6	101364	221	63387431
Symmetrical drug-related intertriginous and flexural exanthema	11.18	10.77	8	101362	496	63387156
Catheter site haemorrhage	11.17	10.77	19	101351	3156	63384496
Subileus	11.16	10.77	19	101351	3160	63384492
Hemivertebra	11.15	10.77	5	101365	124	63387528
Feeling hot	11.13	10.77	42	101328	50312	63337340
Gingival discomfort	11.13	10.77	7	101363	350	63387302
Tendonitis	11.10	10.77	9	101361	19606	63368046
Pelvic fluid collection	11.07	10.77	10	101360	866	63386786
Device malfunction	11.00	10.77	57	101313	17800	63369852
Portal vein thrombosis	10.97	10.77	17	101353	2613	63385039
Pathological fracture	10.92	10.77	35	101335	8799	63378853
Disability	10.91	10.77	8	101362	18339	63369313
Superior vena cava syndrome	10.90	10.77	9	101361	690	63386962
Alkalosis	10.88	10.77	7	101363	364	63387288
Pseudomonas infection	10.88	10.77	41	101329	11172	63376480
Colitis	10.88	10.77	122	101248	48406	63339246
Pulmonary sepsis	10.87	10.77	13	101357	1563	63386089
Poor venous access	10.85	10.77	5	101365	14780	63372872
Splenic rupture	10.85	10.77	12	101358	1326	63386326
Endoscopic retrograde cholangiopancreatography	10.83	10.77	4	101366	59	63387593
Product used for unknown indication	10.79	10.77	8	101362	524	63387128

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	554.38	10.67	276	89514	5319	34861822
Haematoma	430.78	10.67	423	89367	25182	34841959
Thrombocytopenia	388.06	10.67	1075	88715	155172	34711969
Hepatocellular injury	301.41	10.67	327	89463	21884	34845257
Retroperitoneal haemorrhage	275.86	10.67	139	89651	2749	34864392
Haemorrhage	275.08	10.67	482	89308	50888	34816253
Pulmonary embolism	268.98	10.67	663	89127	89083	34778058
Haematoma muscle	251.89	10.67	104	89686	1264	34865877
Retroperitoneal haematoma	244.44	10.67	125	89665	2553	34864588
Abdominal wall haematoma	244.32	10.67	111	89679	1726	34865415
Drug reaction with eosinophilia and systemic symptoms	241.40	10.67	357	89433	32655	34834486
Drug ineffective	224.39	10.67	530	89260	456221	34410920
Toxicity to various agents	219.34	10.67	121	89669	200241	34666900
Deep vein thrombosis	214.74	10.67	500	89290	64748	34802393
Shock haemorrhagic	204.83	10.67	195	89595	11159	34855982
Muscle haemorrhage	203.53	10.67	124	89666	3594	34863547
Drug abuse	194.59	10.67	16	89774	99080	34768061
Eosinophilia	185.13	10.67	279	89511	25943	34841198
Hepatic cytolysis	161.94	10.67	193	89597	14303	34852838
Cholestasis	157.50	10.67	263	89527	26685	34840456
Anaemia	150.74	10.67	1070	88720	232265	34634876
Rash maculo-papular	149.66	10.67	265	89525	28186	34838955
Acute kidney injury	121.55	10.67	1256	88534	303732	34563409
Intra-abdominal haematoma	116.55	10.67	61	89729	1309	34865832
Haematuria	115.54	10.67	336	89454	49730	34817411
Agranulocytosis	105.38	10.67	206	89584	23615	34843526
Product dose omission issue	96.53	10.67	99	89691	119612	34747529
Mixed liver injury	90.41	10.67	68	89722	2805	34864336
Off label use	87.94	10.67	1538	88252	417986	34449155
Haemoglobin decreased	86.76	10.67	569	89221	120203	34746938
Cytokine release syndrome	86.02	10.67	185	89605	22692	34844449
International normalised ratio decreased	83.43	10.67	79	89711	4488	34862653
Hypertransaminasaemia	82.12	10.67	86	89704	5520	34861621
Cerebral haemorrhage	80.13	10.67	234	89556	34703	34832438
Headache	79.91	10.67	257	89533	200378	34666763
Insomnia	78.15	10.67	91	89699	103816	34763325
Haemorrhage intracranial	73.08	10.67	140	89650	15806	34851335
Fatigue	72.97	10.67	606	89184	370047	34497094
Post procedural haemorrhage	68.40	10.67	95	89695	8194	34858947
Death	67.41	10.67	676	89114	397373	34469768
Embolism	66.52	10.67	91	89699	7738	34859403
Therapeutic product effect incomplete	63.70	10.67	25	89765	50516	34816625
Dizziness	63.51	10.67	317	89473	218204	34648937
Rheumatoid arthritis	63.18	10.67	11	89779	38227	34828914
Neutropenia	62.81	10.67	647	89143	156131	34711010
Weight increased	61.20	10.67	90	89700	92943	34774198
Asthma	60.94	10.67	17	89773	42639	34824502
Suicidal ideation	59.78	10.67	15	89775	40373	34826768
Acute generalised exanthematous pustulosis	59.45	10.67	80	89710	6696	34860445
Thrombosis	58.61	10.67	271	89519	50187	34816954
Thrombocytosis	58.31	10.67	62	89728	4050	34863091
Intentional product misuse	56.76	10.67	23	89767	45588	34821553
Joint swelling	56.09	10.67	43	89747	59847	34807294
Toxic epidermal necrolysis	55.52	10.67	151	89639	21495	34845646
Drug intolerance	55.50	10.67	43	89747	59527	34807614
Haematemesis	55.48	10.67	177	89613	27534	34839607
Haemoperitoneum	55.06	10.67	42	89748	1770	34865371
Toxic skin eruption	54.70	10.67	102	89688	11283	34855858
Arthralgia	54.49	10.67	238	89552	169803	34697338
Nasopharyngitis	53.98	10.67	60	89730	69908	34797233
Alanine aminotransferase increased	53.33	10.67	373	89417	80442	34786699
Gastric haemorrhage	53.19	10.67	95	89695	10166	34856975
Melaena	51.91	10.67	204	89586	35176	34831965
Liver function test increased	51.59	10.67	115	89675	14450	34852691
Intentional overdose	51.22	10.67	24	89766	43650	34823491
General physical health deterioration	51.18	10.67	529	89261	127740	34739401
COVID-19 treatment	50.72	10.67	21	89769	257	34866884
Gastrointestinal haemorrhage	50.22	10.67	394	89396	88083	34779058
Myalgia	48.21	10.67	89	89701	84021	34783120
Blood pressure increased	48.07	10.67	96	89694	88006	34779135
Post procedural haematoma	47.76	10.67	36	89754	1490	34865651
International normalised ratio increased	46.95	10.67	243	89547	47084	34820057
Leukopenia	46.20	10.67	298	89492	62558	34804583
Chest wall haematoma	45.85	10.67	18	89772	190	34866951
Erysipelas	45.10	10.67	59	89731	4804	34862337
Hepatitis	44.54	10.67	149	89641	23755	34843386
Premature baby	44.52	10.67	131	89659	19502	34847639
Malaise	44.01	10.67	288	89502	185537	34681604
Injury associated with device	43.14	10.67	30	89760	1093	34866048
Hypovolaemic shock	42.52	10.67	70	89720	7015	34860126
Blood pressure fluctuation	42.29	10.67	7	89783	25242	34841899
COVID-19 pneumonia	42.15	10.67	117	89673	16850	34850291
Blood loss anaemia	41.37	10.67	75	89715	8119	34859022
Therapeutic product effect decreased	40.88	10.67	19	89771	34724	34832417
Spinal cord haemorrhage	40.77	10.67	19	89771	314	34866827
Hypoxia	40.36	10.67	261	89529	54834	34812307
Cerebral haematoma	39.75	10.67	54	89736	4561	34862580
Heparin-induced thrombocytopenia test positive	39.51	10.67	14	89776	108	34867033
Hypotension	39.38	10.67	793	88997	220856	34646285
Treatment failure	38.30	10.67	38	89752	46659	34820482
Haemodynamic instability	38.10	10.67	79	89711	9444	34857697
Ischaemic stroke	37.84	10.67	118	89672	18132	34849009
Depression	37.46	10.67	126	89664	96972	34770169
Upper gastrointestinal haemorrhage	37.31	10.67	147	89643	25371	34841770
Venous thrombosis	37.15	10.67	45	89745	3390	34863751
Musculoskeletal stiffness	37.14	10.67	39	89751	46641	34820500
Transaminases increased	36.42	10.67	151	89639	26672	34840469
Splenic infarction	36.21	10.67	35	89755	2040	34865101
Respiratory failure	36.08	10.67	432	89358	108140	34759001
Dermatitis bullous	35.76	10.67	64	89726	6858	34860283
Abdominal discomfort	35.45	10.67	62	89728	59773	34807368
Feeling abnormal	35.27	10.67	68	89722	63167	34803974
Anticoagulation drug level below therapeutic	35.26	10.67	24	89766	844	34866297
Compartment syndrome	35.05	10.67	41	89749	2977	34864164
International normalised ratio abnormal	34.95	10.67	43	89747	3292	34863849
Vascular device infection	34.58	10.67	48	89742	4137	34863004
Haematocrit decreased	34.47	10.67	169	89621	32047	34835094
Electrocardiogram QT prolonged	34.40	10.67	201	89589	40751	34826390
Hepatitis cholestatic	34.25	10.67	68	89722	7879	34859262
Petechiae	34.07	10.67	75	89715	9343	34857798
Symmetrical drug-related intertriginous and flexural exanthema	33.56	10.67	17	89773	340	34866801
Heart rate decreased	33.45	10.67	20	89770	31725	34835416
Palpitations	33.42	10.67	32	89758	39954	34827187
Hypocoagulable state	33.40	10.67	24	89766	922	34866219
Septic shock	32.89	10.67	305	89485	71529	34795612
Weight decreased	32.42	10.67	293	89497	176008	34691133
Hypofibrinogenaemia	32.40	10.67	30	89760	1656	34865485
Inappropriate schedule of product administration	32.19	10.67	70	89720	62226	34804915
Drug dependence	32.16	10.67	11	89779	24206	34842935
Hospitalisation	31.90	10.67	61	89729	56841	34810300
Heparin-induced thrombocytopenia test	31.87	10.67	12	89778	112	34867029
Rash morbilliform	31.06	10.67	39	89751	3048	34864093
Hypercapnic coma	31.05	10.67	13	89777	164	34866977
Vascular purpura	31.04	10.67	30	89760	1748	34865393
Long QT syndrome	30.77	10.67	37	89753	2766	34864375
Abdominal mass	30.39	10.67	27	89763	1412	34865729
Arterial haemorrhage	30.28	10.67	22	89768	860	34866281
Hypokalaemia	30.17	10.67	254	89536	57960	34809181
Subdural haematoma	30.15	10.67	118	89672	20303	34846838
Suicide attempt	29.66	10.67	34	89756	39082	34828059
Purpura	29.57	10.67	75	89715	10236	34856905
Alveolar lung disease	29.49	10.67	16	89774	370	34866771
Drug hypersensitivity	29.37	10.67	107	89683	80422	34786719
Activated partial thromboplastin time abnormal	29.27	10.67	12	89778	143	34866998
Nausea	28.68	10.67	660	89130	339248	34527893
Atrial fibrillation	28.08	10.67	456	89334	121937	34745204
Erectile dysfunction	28.06	10.67	9	89781	20628	34846513
Urinary tract infection pseudomonal	27.80	10.67	22	89768	979	34866162
Scrotal haematoma	27.48	10.67	10	89780	84	34867057
Pulmonary interstitial emphysema syndrome	27.46	10.67	17	89773	507	34866634
Loss of personal independence in daily activities	27.21	10.67	27	89763	33152	34833989
Haemothorax	27.19	10.67	41	89749	3811	34863330
Catheter site haemorrhage	27.15	10.67	31	89759	2193	34864948
Clostridium test positive	27.12	10.67	38	89752	3304	34863837
Psoriasis	27.05	10.67	36	89754	38776	34828365
Fibrin D dimer increased	26.92	10.67	43	89747	4201	34862940
Hepatitis acute	26.90	10.67	60	89730	7541	34859600
Haemarthrosis	26.36	10.67	37	89753	3222	34863919
Pelvic haematoma	26.33	10.67	12	89778	188	34866953
Blood glucose increased	25.43	10.67	87	89703	66631	34800510
Ureteric compression	25.35	10.67	13	89777	267	34866874
Aspartate aminotransferase increased	25.33	10.67	276	89514	67507	34799634
Product use issue	25.08	10.67	81	89709	63135	34804006
Paraplegia	24.97	10.67	34	89756	2877	34864264
Acute respiratory failure	24.81	10.67	150	89640	30778	34836363
Catheter site haematoma	24.81	10.67	11	89779	161	34866980
Diabetes mellitus	24.77	10.67	52	89738	46821	34820320
Influenza	24.68	10.67	57	89733	49609	34817532
Memory impairment	24.66	10.67	46	89744	43272	34823869
Prostate cancer	24.48	10.67	40	89750	39609	34827532
Wrong technique in product usage process	24.45	10.67	34	89756	35952	34831189
Splenic haemorrhage	24.42	10.67	15	89775	441	34866700
Venous thrombosis limb	24.40	10.67	28	89762	1991	34865150
Pain	24.16	10.67	375	89415	204300	34662841
Pancytopenia	23.89	10.67	360	89430	94797	34772344
Herpes zoster	23.87	10.67	32	89758	34367	34832774
Therapeutic response decreased	23.87	10.67	24	89766	29289	34837852
Splenic cyst	23.75	10.67	10	89780	128	34867013
Patient restraint	23.71	10.67	9	89781	86	34867055
Peripheral swelling	23.35	10.67	109	89681	76432	34790709
Bronchial haemorrhage	22.80	10.67	17	89773	692	34866449
Haemoptysis	22.73	10.67	161	89629	34845	34832296
Underdose	22.68	10.67	4	89786	13776	34853365
Extradural haematoma	22.55	10.67	21	89769	1168	34865973
Cholestatic liver injury	22.42	10.67	29	89761	2335	34864806
Foetal exposure during pregnancy	22.33	10.67	171	89619	37930	34829211
Rectal haemorrhage	22.13	10.67	178	89612	40071	34827070
Injection site haematoma	21.99	10.67	25	89765	1760	34865381
Immobilisation prolonged	21.91	10.67	5	89785	4	34867137
Blood blister	21.75	10.67	24	89766	1635	34865506
Muscle spasms	21.61	10.67	109	89681	74892	34792249
Pyelocaliectasis	21.51	10.67	20	89770	1110	34866031
Splenic necrosis	21.39	10.67	9	89781	115	34867026
Diet refusal	21.35	10.67	12	89778	298	34866843
Sinusitis	20.99	10.67	47	89743	41355	34825786
Phlebitis infective	20.98	10.67	9	89781	121	34867020
Thrombophlebitis	20.92	10.67	33	89757	3189	34863952
Spinal cord compression	20.85	10.67	37	89753	3938	34863203
Febrile neutropenia	20.83	10.67	479	89311	136370	34730771
Bronchopleural fistula	20.65	10.67	14	89776	489	34866652
Bladder cancer	20.59	10.67	8	89782	16270	34850871
Intra-abdominal haemorrhage	20.51	10.67	28	89762	2376	34864765
Cough	20.19	10.67	268	89522	149872	34717269
Chest discomfort	20.18	10.67	72	89718	54458	34812683
Gait disturbance	20.09	10.67	132	89658	85008	34782133
Ecchymosis	20.05	10.67	50	89740	6753	34860388
Prothrombin time prolonged	19.66	10.67	61	89729	9345	34857796
Urethral valves	19.51	10.67	11	89779	275	34866866
Epistaxis	19.42	10.67	232	89558	58019	34809122
Jugular vein thrombosis	19.42	10.67	23	89767	1692	34865449
Interstitial lung disease	19.31	10.67	94	89696	65188	34801953
Haemorrhagic stroke	19.20	10.67	48	89742	6491	34860650
Suture rupture	19.20	10.67	12	89778	364	34866777
Dyspepsia	19.20	10.67	41	89749	36691	34830450
Acetabulum fracture	19.08	10.67	11	89779	287	34866854
Vascular stent thrombosis	18.98	10.67	30	89760	2905	34864236
Osteoma	18.96	10.67	8	89782	103	34867038
Polycystic liver disease	18.89	10.67	8	89782	104	34867037
Drug withdrawal syndrome	18.87	10.67	14	89776	19820	34847321
Vision blurred	18.86	10.67	58	89732	45905	34821236
Respiratory distress	18.68	10.67	156	89634	35509	34831632
Spinal cord haematoma	18.62	10.67	8	89782	108	34867033
Therapy non-responder	18.59	10.67	46	89744	39100	34828041
Anger	18.40	10.67	4	89786	11880	34855261
Intentional product use issue	18.35	10.67	85	89705	59731	34807410
Hepatic haematoma	18.25	10.67	12	89778	398	34866743
Neck pain	18.19	10.67	23	89767	25326	34841815
Traumatic haematoma	18.18	10.67	15	89775	709	34866432
Antibiotic level above therapeutic	18.06	10.67	10	89780	241	34866900
Hyperthermia	18.01	10.67	64	89726	10513	34856628
Cardiac tamponade	18.00	10.67	41	89749	5225	34861916
Injection site thrombosis	17.94	10.67	5	89785	15	34867126
Peripheral artery thrombosis	17.92	10.67	26	89764	2334	34864807
Prothrombin time abnormal	17.75	10.67	15	89775	733	34866408
Bicytopenia	17.72	10.67	26	89764	2358	34864783
Subcutaneous haematoma	17.71	10.67	17	89773	982	34866159
Plasma cell myeloma	17.51	10.67	175	89615	41862	34825279
Splenic lesion	17.48	10.67	10	89780	257	34866884
Multiple organ dysfunction syndrome	17.44	10.67	285	89505	76281	34790860
Haemoglobin urine present	17.40	10.67	8	89782	128	34867013
Hypoaldosteronism	17.37	10.67	9	89781	189	34866952
Wound haemorrhage	17.36	10.67	24	89766	2061	34865080
Coagulation time prolonged	17.35	10.67	19	89771	1283	34865858
Prostatic specific antigen increased	17.31	10.67	8	89782	14672	34852469
Procedural site reaction	17.28	10.67	9	89781	191	34866950
Pituitary haemorrhage	17.28	10.67	9	89781	191	34866950
Subclavian vein thrombosis	17.25	10.67	16	89774	885	34866256
Glycosylated haemoglobin increased	17.23	10.67	4	89786	11356	34855785
Amnesia	17.16	10.67	26	89764	26537	34840604
Intentional self-injury	17.04	10.67	7	89783	13764	34853377
Hypersensitivity	16.85	10.67	90	89700	60945	34806196
Respiratory gas exchange disorder	16.72	10.67	12	89778	460	34866681
Anxiety	16.65	10.67	169	89621	99259	34767882
Vascular pseudoaneurysm	16.64	10.67	24	89766	2143	34864998
Coagulopathy	16.53	10.67	97	89693	19692	34847449
Eye pain	16.40	10.67	7	89783	13455	34853686
Renal disorder	16.40	10.67	25	89765	25455	34841686
Arthritis	16.37	10.67	35	89755	31311	34835830
Flushing	16.27	10.67	37	89753	32383	34834758
Incision site haematoma	16.26	10.67	7	89783	95	34867046
Puncture site haemorrhage	16.19	10.67	10	89780	297	34866844
Pulmonary infarction	16.14	10.67	19	89771	1389	34865752
Pruritus	16.11	10.67	262	89528	141719	34725422
Adverse drug reaction	15.97	10.67	32	89758	29310	34837831
Hyperlipasaemia	15.95	10.67	12	89778	495	34866646
Diabetic bullosis	15.94	10.67	5	89785	25	34867116
Psychotic symptom	15.94	10.67	21	89769	1722	34865419
Spinal epidural haematoma	15.84	10.67	10	89780	309	34866832
Needle issue	15.80	10.67	43	89747	6122	34861019
Procedural haemorrhage	15.73	10.67	25	89765	2432	34864709
Soft tissue disorder	15.70	10.67	14	89776	736	34866405
Tachycardia	15.57	10.67	305	89485	84467	34782674
Pneumonitis	15.57	10.67	144	89646	33734	34833407
Cerebral artery occlusion	15.54	10.67	14	89776	746	34866395
Pleural effusion	15.52	10.67	295	89495	81251	34785890
Heart sounds abnormal	15.51	10.67	15	89775	875	34866266
Balance disorder	15.50	10.67	53	89737	40601	34826540
Tachypnoea	15.35	10.67	90	89700	18262	34848879
Body temperature abnormal	15.20	10.67	13	89777	646	34866495
Incision site haemorrhage	15.18	10.67	12	89778	533	34866608
Ischaemic hepatitis	15.15	10.67	21	89769	1807	34865334
Periportal sinus dilatation	15.15	10.67	8	89782	175	34866966
Creatinine renal clearance abnormal	15.14	10.67	9	89781	249	34866892
Pulmonary fibrosis	15.05	10.67	15	89775	18381	34848760
Intestinal infarction	14.99	10.67	12	89778	543	34866598
Spinal subdural haematoma	14.98	10.67	6	89784	67	34867074
Peripheral ischaemia	14.91	10.67	40	89750	5647	34861494
Sepsis	14.83	10.67	545	89245	166016	34701125
Overdose	14.75	10.67	156	89634	90903	34776238
Generalised oedema	14.66	10.67	67	89723	12341	34854800
Gynaecomastia	14.64	10.67	4	89786	10176	34856965
Product prescribing error	14.62	10.67	105	89685	22822	34844319
Paraparesis	14.62	10.67	21	89769	1868	34865273
Urinary retention	14.60	10.67	150	89640	36138	34831003
Swelling face	14.55	10.67	23	89767	23082	34844059
Pulmonary sepsis	14.43	10.67	23	89767	2242	34864899
Gastric disorder	14.33	10.67	7	89783	12434	34854707
Labelled drug-drug interaction medication error	14.32	10.67	76	89714	14863	34852278
Vitamin B6 deficiency	14.29	10.67	8	89782	197	34866944
Irritability	14.24	10.67	26	89764	24664	34842477
Infusion related reaction	14.22	10.67	79	89711	52978	34814163
Axillary vein thrombosis	14.22	10.67	8	89782	199	34866942
Skin necrosis	14.18	10.67	40	89750	5813	34861328
Cardiac failure congestive	14.16	10.67	141	89649	83129	34784012
White blood cells urine positive	14.09	10.67	17	89773	1275	34865866
Urticarial vasculitis	14.06	10.67	5	89785	39	34867102
Mucosal haemorrhage	13.97	10.67	19	89771	1606	34865535
Rhinorrhoea	13.96	10.67	28	89762	25640	34841501
Dry skin	13.91	10.67	38	89752	31249	34835892
Ocular hyperaemia	13.88	10.67	6	89784	11446	34855695
Dermatitis exfoliative	13.83	10.67	43	89747	6596	34860545
Wheezing	13.81	10.67	57	89733	41345	34825796
Intraventricular haemorrhage	13.78	10.67	29	89761	3502	34863639
Pneumobilia	13.77	10.67	6	89784	84	34867057
Neuropathy peripheral	13.74	10.67	142	89648	83121	34784020
Postoperative respiratory failure	13.73	10.67	7	89783	142	34866999
Decreased appetite	13.72	10.67	324	89466	166068	34701073
Cyanosis	13.68	10.67	67	89723	12697	34854444
Prothrombin level abnormal	13.64	10.67	6	89784	86	34867055
Ventricular flutter	13.64	10.67	6	89784	86	34867055
Confusional state	13.64	10.67	475	89315	143685	34723456
Adrenal haemorrhage	13.60	10.67	8	89782	217	34866924
Accidental exposure to product	13.58	10.67	8	89782	12794	34854347
Tumour haemorrhage	13.56	10.67	26	89764	2936	34864205
Foetal heart rate deceleration abnormality	13.51	10.67	11	89779	510	34866631
Diplopia	13.47	10.67	14	89776	16829	34850312
Hemiplegia	13.47	10.67	44	89746	6928	34860213
Obstructive airways disorder	13.42	10.67	12	89778	15482	34851659
Neonatal infection	13.41	10.67	10	89780	407	34866734
Drug interaction	13.40	10.67	709	89081	225237	34641904
Haemorrhagic transformation stroke	13.39	10.67	18	89772	1505	34865636
Serotonin syndrome	13.37	10.67	19	89771	19914	34847227
Gamma-glutamyltransferase increased	13.31	10.67	124	89666	29107	34838034
Renal infarct	13.24	10.67	17	89773	1359	34865782
Hypertension	13.18	10.67	259	89531	136184	34730957
Psoriatic arthropathy	13.15	10.67	19	89771	19779	34847362
Autoimmune heparin-induced thrombocytopenia	13.10	10.67	4	89786	18	34867123
Device toxicity	13.10	10.67	4	89786	18	34867123
Acne	13.09	10.67	6	89784	11060	34856081
Oropharyngeal pain	13.03	10.67	47	89743	35438	34831703
Rash	12.99	10.67	455	89335	222297	34644844
Abnormal behaviour	12.94	10.67	28	89762	24941	34842200
Mitral perforation	12.92	10.67	4	89786	19	34867122
Bullous impetigo	12.83	10.67	3	89787	3	34867138
Visual impairment	12.76	10.67	48	89742	35754	34831387
Low birth weight baby	12.76	10.67	47	89743	7858	34859283
Oesophageal carcinoma	12.75	10.67	4	89786	9300	34857841
Diffuse alveolar damage	12.74	10.67	22	89768	2292	34864849
Tooth disorder	12.72	10.67	6	89784	10876	34856265
Product monitoring error	12.70	10.67	32	89758	4349	34862792
Antithrombin III deficiency	12.67	10.67	6	89784	103	34867038
Urticaria	12.64	10.67	101	89689	62276	34804865
Hypoacusis	12.54	10.67	14	89776	16287	34850854
Arthropathy	12.48	10.67	32	89758	26875	34840266
Fluid retention	12.45	10.67	32	89758	26855	34840286
Red blood cell sedimentation rate increased	12.45	10.67	4	89786	9158	34857983
Cell death	12.44	10.67	22	89768	2335	34864806
Mechanical ventilation complication	12.44	10.67	4	89786	22	34867119
Lymphoedema	12.41	10.67	30	89760	3973	34863168
Anaphylactic reaction	12.38	10.67	42	89748	32259	34834882
Device safety feature issue	12.37	10.67	3	89787	4	34867137
Road traffic accident	12.35	10.67	16	89774	17434	34849707
Lymphopenia	12.33	10.67	78	89712	16257	34850884
Myelosuppression	12.30	10.67	19	89771	19246	34847895
Visual acuity reduced	12.28	10.67	14	89776	16135	34851006
Type 2 diabetes mellitus	12.08	10.67	14	89776	16018	34851123
Infective exacerbation of chronic obstructive airways disease	12.08	10.67	19	89771	1832	34865309
Tumour lysis syndrome	11.98	10.67	80	89710	16979	34850162
Empyema	11.96	10.67	26	89764	3210	34863931
Influenza like illness	11.96	10.67	34	89756	27600	34839541
Mitral valve replacement	11.90	10.67	7	89783	190	34866951
Hallucination, auditory	11.88	10.67	8	89782	11909	34855232
White blood cell count decreased	11.88	10.67	173	89617	95272	34771869
Catheter site oedema	11.88	10.67	4	89786	26	34867115
Pyrexia	11.87	10.67	1001	88789	332012	34535129
Tri-iodothyronine increased	11.81	10.67	5	89785	65	34867076
Gastrointestinal disorder	11.79	10.67	46	89744	33902	34833239
Platelet function test abnormal	11.75	10.67	6	89784	122	34867019
Pneumatosis intestinalis	11.73	10.67	29	89761	3894	34863247
Injection site haemorrhage	11.73	10.67	53	89737	9715	34857426
Urinary sediment present	11.71	10.67	8	89782	283	34866858
Superinfection bacterial	11.67	10.67	13	89777	895	34866246
Dry eye	11.63	10.67	5	89785	9570	34857571
Aortic embolus	11.62	10.67	3	89787	6	34867135
Sleep disorder	11.61	10.67	42	89748	31646	34835495
Tremor	11.61	10.67	146	89644	82441	34784700
Vena cava thrombosis	11.60	10.67	15	89775	1207	34865934
Meningorrhagia	11.49	10.67	6	89784	128	34867013
Thrombosis in device	11.49	10.67	26	89764	3299	34863842
Red blood cell abnormality	11.48	10.67	9	89781	395	34866746
Morganella infection	11.43	10.67	10	89780	512	34866629
Schizophrenia	11.40	10.67	4	89786	8662	34858479
Hepatic function abnormal	11.38	10.67	67	89723	44296	34822845
Granulocyte count increased	11.36	10.67	9	89781	401	34866740
Dysdiadochokinesis	11.36	10.67	7	89783	207	34866934
Blood disorder	11.34	10.67	26	89764	3328	34863813
Embolism arterial	11.31	10.67	11	89779	646	34866495
Spontaneous haematoma	11.27	10.67	10	89780	522	34866619
Administration site erythema	11.23	10.67	5	89785	74	34867067
Injection site bruising	11.16	10.67	48	89742	8615	34858526
Product substitution issue	11.15	10.67	6	89784	10089	34857052
Drug resistance	11.15	10.67	32	89758	25895	34841246
Treatment noncompliance	11.14	10.67	36	89754	28064	34839077
Osteochondrosis	11.13	10.67	14	89776	1096	34866045
Lip swelling	11.11	10.67	15	89775	16065	34851076
Angle closure glaucoma	11.11	10.67	13	89777	944	34866197
Seizure	11.07	10.67	196	89594	104661	34762480
Hypospadias	11.03	10.67	25	89765	3176	34863965
Paresis	11.02	10.67	20	89770	2166	34864975
Therapeutic embolisation	11.00	10.67	8	89782	313	34866828
Constipation	10.94	10.67	268	89522	136714	34730427
Blood pressure systolic increased	10.88	10.67	27	89763	22925	34844216
Pustule	10.88	10.67	10	89780	547	34866594
Klebsiella infection	10.78	10.67	47	89743	8484	34858657
Acute respiratory distress syndrome	10.76	10.67	108	89682	25861	34841280
Restless legs syndrome	10.74	10.67	4	89786	8350	34858791
Nutritional condition abnormal	10.72	10.67	9	89781	436	34866705
Throat irritation	10.69	10.67	7	89783	10578	34856563
Gastrointestinal stoma complication	10.68	10.67	15	89775	1307	34865834

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heparin-induced thrombocytopenia	1044.82	9.90	475	166221	9207	79568485
Haematoma	983.17	9.90	839	165857	51356	79526336
Thrombocytopenia	828.22	9.90	1757	164939	263502	79314190
Abdominal wall haematoma	701.65	9.90	293	166403	4580	79573112
Hepatocellular injury	642.38	9.90	635	166061	46958	79530734
Shock haemorrhagic	569.46	9.90	411	166285	19649	79558043
Pulmonary embolism	552.44	9.90	1152	165544	170502	79407190
Retroperitoneal haematoma	549.86	9.90	253	166443	5044	79572648
Cholestasis	514.70	9.90	589	166107	51520	79526172
Drug reaction with eosinophilia and systemic symptoms	492.82	9.90	639	166057	63605	79514087
Completed suicide	491.11	9.90	4	166692	245763	79331929
Retroperitoneal haemorrhage	483.96	9.90	234	166462	5236	79572456
Drug ineffective	480.32	9.90	963	165733	1079950	78497742
Anaemia	461.52	9.90	1996	164700	443019	79134673
Deep vein thrombosis	427.42	9.90	844	165852	120075	79457617
Acute kidney injury	423.34	9.90	2172	164524	517232	79060460
Haemorrhage	418.12	9.90	712	165984	90406	79487286
Eosinophilia	406.92	9.90	488	166208	44857	79532835
Muscle haemorrhage	368.29	9.90	204	166492	6096	79571596
Joint swelling	358.54	9.90	82	166614	288564	79289128
Acute generalised exanthematous pustulosis	357.04	9.90	293	166403	16961	79560731
Rash maculo-papular	348.75	9.90	504	166192	55574	79522118
Haematoma muscle	332.58	9.90	144	166552	2471	79575221
Rheumatoid arthritis	326.00	9.90	30	166666	208440	79369252
Drug intolerance	290.55	9.90	95	166601	264024	79313668
Hepatic cytolysis	286.97	9.90	318	166378	26833	79550859
Synovitis	277.99	9.90	8	166688	150726	79426966
Intra-abdominal haematoma	271.94	9.90	129	166567	2762	79574930
Toxicity to various agents	271.05	9.90	289	166407	421251	79156441
Arthralgia	268.05	9.90	492	166204	571311	79006381
Exposure during pregnancy	252.55	9.90	614	166082	100518	79477174
Therapeutic product effect decreased	247.24	9.90	27	166669	163836	79413856
Haemoglobin decreased	243.26	9.90	1014	165682	221105	79356587
Haematuria	235.29	9.90	474	166222	68362	79509330
Weight increased	231.67	9.90	147	166549	277239	79300453
Nasopharyngitis	228.38	9.90	123	166573	253758	79323934
Arthropathy	226.54	9.90	47	166649	177064	79400628
Alopecia	212.64	9.90	109	166587	231246	79346446
Drug abuse	212.61	9.90	41	166655	162650	79415042
Pain	204.81	9.90	769	165927	703033	78874659
Mixed liver injury	203.10	9.90	150	166546	7428	79570264
Abdominal discomfort	202.41	9.90	138	166558	250589	79327103
Neutropenia	197.13	9.90	1149	165547	286561	79291131
Headache	194.32	9.90	708	165988	653064	78924628
Pemphigus	192.57	9.90	3	166693	99579	79478113
Premature delivery	183.89	9.90	236	166460	23231	79554461
Agranulocytosis	178.26	9.90	330	166366	44700	79532992
Therapeutic product effect incomplete	176.22	9.90	40	166656	141605	79436087
Fatigue	174.96	9.90	1183	165513	928544	78649148
Sinusitis	173.90	9.90	96	166600	195405	79382287
Toxic skin eruption	168.13	9.90	220	166476	22073	79555619
Gastrointestinal haemorrhage	167.61	9.90	682	166014	147037	79430655
Systemic lupus erythematosus	165.96	9.90	27	166669	121122	79456570
Cerebral haemorrhage	160.07	9.90	365	166331	57308	79520384
Musculoskeletal stiffness	159.96	9.90	83	166613	174925	79402767
Drug hypersensitivity	152.79	9.90	243	166453	298673	79279019
Treatment failure	151.21	9.90	84	166612	170402	79407290
Hypoxia	149.87	9.90	516	166180	102727	79474965
Product dose omission issue	149.85	9.90	178	166518	247359	79330333
Cytokine release syndrome	146.50	9.90	267	166429	35731	79541961
International normalised ratio increased	146.03	9.90	449	166247	84272	79493420
Infusion related reaction	144.29	9.90	161	166535	230076	79347616
Hypersensitivity	142.89	9.90	204	166492	262035	79315657
Melaena	140.69	9.90	359	166337	60531	79517161
Glossodynia	135.07	9.90	26	166670	103311	79474381
Hypertransaminasaemia	130.04	9.90	142	166554	11782	79565910
Thrombosis	129.71	9.90	429	166267	83671	79494021
Haemoperitoneum	127.85	9.90	91	166605	4252	79573440
Hypotension	127.08	9.90	1443	165253	438874	79138818
Insomnia	126.49	9.90	198	166498	244972	79332720
Post procedural haemorrhage	123.38	9.90	148	166548	13596	79564096
Off label use	122.85	9.90	2614	164082	904601	78673091
Pelvic haematoma	121.76	9.90	51	166645	803	79576889
Asthma	120.60	9.90	66	166630	135029	79442663
Drug interaction	120.41	9.90	1362	165334	413821	79163871
Arterial haemorrhage	117.90	9.90	71	166625	2490	79575202
Dizziness	114.76	9.90	639	166057	525802	79051890
Intentional overdose	113.13	9.90	40	166656	105920	79471772
Swelling	112.75	9.90	174	166522	216537	79361155
Discomfort	111.21	9.90	62	166634	125555	79452137
Loss of personal independence in daily activities	110.77	9.90	38	166658	102542	79475150
Haematemesis	109.38	9.90	297	166399	51967	79525725
Malaise	109.28	9.90	590	166106	489279	79088413
Irritable bowel syndrome	108.86	9.90	5	166691	62236	79515456
Leukopenia	107.01	9.90	505	166191	116008	79461684
Transaminases increased	105.26	9.90	291	166405	51452	79526240
Blood pressure increased	104.97	9.90	175	166521	211185	79366507
International normalised ratio decreased	103.88	9.90	105	166591	7965	79569727
Respiratory failure	103.39	9.90	690	166006	180221	79397471
Duodenal ulcer perforation	102.18	9.90	10	166686	66201	79511491
Thrombocytosis	100.84	9.90	106	166590	8420	79569272
Psoriatic arthropathy	99.07	9.90	21	166675	77978	79499714
Feeling abnormal	95.73	9.90	115	166581	159084	79418608
Contraindicated product administered	95.59	9.90	113	166583	157425	79420267
Hypovolaemic shock	95.46	9.90	123	166573	12153	79565539
Atrial fibrillation	95.21	9.90	724	165972	197162	79380530
Haemorrhage intracranial	95.05	9.90	185	166511	26008	79551684
Embolism	94.77	9.90	131	166565	13851	79563841
COVID-19 treatment	94.63	9.90	36	166660	434	79577258
Pancytopenia	94.61	9.90	632	166064	165113	79412579
Helicobacter infection	94.41	9.90	16	166680	69688	79508004
Dermatitis bullous	94.36	9.90	132	166564	14113	79563579
Compartment syndrome	92.16	9.90	80	166616	5002	79572690
Pericarditis	91.47	9.90	52	166644	104184	79473508
Alanine aminotransferase increased	90.46	9.90	616	166080	161954	79415738
Blood loss anaemia	90.10	9.90	135	166561	15363	79562329
Toxic epidermal necrolysis	89.97	9.90	250	166446	44331	79533361
Blood pressure fluctuation	89.66	9.90	16	166680	67129	79510563
Hepatitis	89.26	9.90	288	166408	55439	79522253
Febrile neutropenia	88.59	9.90	803	165893	230196	79347496
Subdural haematoma	88.38	9.90	200	166496	31234	79546458
C-reactive protein abnormal	87.58	9.90	3	166693	48364	79529328
Intentional product misuse	87.12	9.90	45	166651	95120	79482572
Electrocardiogram QT prolonged	86.84	9.90	397	166299	89989	79487703
Sepsis	86.84	9.90	903	165793	268525	79309167
Ischaemic stroke	86.78	9.90	205	166491	32926	79544766
Wound	85.87	9.90	70	166626	116109	79461583
Pyrexia	85.67	9.90	1937	164759	676772	78900920
Paraplegia	84.55	9.90	76	166620	4977	79572715
Septic shock	84.30	9.90	491	166205	122310	79455382
COVID-19 pneumonia	83.85	9.90	186	166510	28663	79549029
Peripheral swelling	82.47	9.90	288	166408	269329	79308363
Extradural haematoma	81.76	9.90	59	166637	2817	79574875
Gastric haemorrhage	81.71	9.90	127	166569	14923	79562769
Folliculitis	81.31	9.90	10	166686	55370	79522322
Post procedural haematoma	80.86	9.90	55	166641	2387	79575305
Spinal epidural haematoma	79.96	9.90	45	166651	1387	79576305
Renal failure	79.81	9.90	704	165992	200264	79377428
Ecchymosis	79.35	9.90	126	166570	15080	79562612
Computerised tomogram thorax abnormal	78.95	9.90	54	166642	2365	79575327
Hepatitis acute	78.65	9.90	127	166569	15415	79562277
Hypokalaemia	78.47	9.90	543	166153	143497	79434195
General physical health deterioration	77.89	9.90	899	165797	274339	79303353
Product use issue	77.85	9.90	205	166491	209617	79368075
Sleep disorder due to general medical condition, insomnia type	77.83	9.90	3	166693	43553	79534139
Injury associated with device	77.73	9.90	62	166634	3444	79574248
Hepatitis cholestatic	76.76	9.90	118	166578	13734	79563958
Purpura	75.88	9.90	142	166554	19385	79558307
Psoriasis	75.36	9.90	47	166649	89540	79488152
Chest wall haematoma	74.88	9.90	30	166666	419	79577273
Computerised tomogram thorax	74.81	9.90	30	166666	420	79577272
Haemodynamic instability	74.65	9.90	132	166564	17250	79560442
Blood cholesterol increased	74.56	9.90	41	166655	83679	79494013
Arthritis	74.51	9.90	78	166618	114802	79462890
Depression	74.35	9.90	220	166476	216570	79361122
Clostridium test positive	74.13	9.90	79	166617	6375	79571317
Suicidal ideation	73.06	9.90	34	166662	76306	79501386
Injection site haematoma	71.84	9.90	68	166628	4759	79572933
Cholestatic liver injury	70.49	9.90	68	166628	4873	79572819
Weight decreased	70.46	9.90	444	166252	354754	79222938
Cerebral haematoma	70.43	9.90	85	166611	7857	79569835
Erysipelas	69.59	9.90	99	166597	10751	79566941
Intra-abdominal haemorrhage	69.57	9.90	65	166631	4475	79573217
Wheezing	69.36	9.90	85	166611	116579	79461113
Adverse drug reaction	69.28	9.90	26	166670	66366	79511326
Haemarthrosis	68.28	9.90	72	166624	5740	79571952
Multiple organ dysfunction syndrome	67.08	9.90	456	166240	119790	79457902
Rash morbilliform	66.64	9.90	73	166623	6077	79571615
Mobility decreased	66.52	9.90	95	166601	122080	79455612
Gamma-glutamyltransferase increased	65.59	9.90	257	166439	54423	79523269
Oliguria	65.13	9.90	120	166576	16189	79561503
Fibrin D dimer increased	64.62	9.90	85	166611	8569	79569123
Upper gastrointestinal haemorrhage	64.59	9.90	212	166484	41168	79536524
Rectal haemorrhage	64.50	9.90	323	166373	75977	79501715
Pain in extremity	63.71	9.90	473	166223	364065	79213627
Petechiae	63.65	9.90	136	166560	20429	79557263
Stomatitis	63.55	9.90	132	166564	146625	79431067
Suicide attempt	62.49	9.90	49	166647	82883	79494809
Intentional product use issue	62.40	9.90	141	166555	151971	79425721
Tachycardia	62.14	9.90	606	166090	177162	79400530
Aspartate aminotransferase increased	62.09	9.90	499	166197	138142	79439550
Vascular device infection	61.87	9.90	91	166605	10185	79567507
Muscle injury	61.82	9.90	13	166683	48548	79529144
Musculoskeletal pain	60.40	9.90	75	166621	102279	79475413
Haemorrhagic stroke	59.67	9.90	93	166603	10953	79566739
Respiratory distress	59.61	9.90	261	166435	58078	79519614
Spontaneous haematoma	59.27	9.90	37	166659	1385	79576307
Haematocrit decreased	58.66	9.90	269	166427	61043	79516649
Myalgia	58.29	9.90	196	166500	185445	79392247
Pleural effusion	58.23	9.90	510	166186	144752	79432940
Muscle spasms	57.98	9.90	180	166516	174550	79403142
Liver function test increased	57.86	9.90	199	166497	39574	79538118
Labelled drug-drug interaction medication error	57.72	9.90	157	166539	27493	79550199
Acute respiratory failure	57.54	9.90	262	166434	59279	79518413
International normalised ratio abnormal	56.57	9.90	65	166631	5703	79571989
Heparin-induced thrombocytopenia test positive	56.06	9.90	18	166678	125	79577567
Influenza	55.76	9.90	117	166579	129489	79448203
Gait disturbance	55.47	9.90	234	166462	207272	79370420
Spinal cord haematoma	55.19	9.90	22	166674	303	79577389
Cell death	54.82	9.90	58	166638	4641	79573051
Epistaxis	54.15	9.90	409	166287	111106	79466586
Venous thrombosis	53.30	9.90	70	166626	7046	79570646
Thrombophlebitis	53.26	9.90	66	166630	6269	79571423
Memory impairment	53.16	9.90	95	166601	111639	79466053
Palpitations	53.05	9.90	116	166580	126494	79451198
Migraine	52.79	9.90	63	166633	87430	79490262
Spinal cord haemorrhage	52.12	9.90	25	166671	549	79577143
Inappropriate schedule of product administration	51.51	9.90	128	166568	133500	79444192
Coagulopathy	51.38	9.90	179	166517	35827	79541865
Vision blurred	51.32	9.90	89	166607	105809	79471883
Atelectasis	51.01	9.90	166	166530	32091	79545601
Haemoptysis	50.86	9.90	242	166454	55757	79521935
Heart rate decreased	49.95	9.90	44	166652	70272	79507420
Lymphopenia	49.91	9.90	159	166537	30398	79547294
Anticoagulation drug level below therapeutic	49.51	9.90	34	166662	1499	79576193
Wrong technique in product usage process	49.21	9.90	49	166647	73826	79503866
Prothrombin time prolonged	49.16	9.90	109	166587	16790	79560902
Therapeutic response decreased	48.50	9.90	41	166655	66812	79510880
Nasal congestion	48.49	9.90	53	166643	76499	79501193
Tachyarrhythmia	48.34	9.90	66	166630	6896	79570796
Sinus bradycardia	47.44	9.90	138	166558	25109	79552583
Rhinorrhoea	46.73	9.90	54	166642	76020	79501672
Injection site erythema	46.44	9.90	57	166639	78140	79499552
Herpes zoster	45.32	9.90	78	166618	93005	79484687
Chest discomfort	45.23	9.90	143	166553	137901	79439791
Ovarian hyperstimulation syndrome	45.12	9.90	46	166650	3525	79574167
Haemothorax	44.34	9.90	56	166640	5422	79572270
Jugular vein thrombosis	44.27	9.90	51	166645	4487	79573205
Haemorrhagic transformation stroke	44.08	9.90	40	166656	2652	79575040
Influenza like illness	43.94	9.90	51	166645	71656	79506036
Flushing	43.86	9.90	73	166623	88195	79489497
Maternal exposure during pregnancy	43.63	9.90	457	166239	136081	79441611
Blood alkaline phosphatase increased	43.30	9.90	254	166442	63410	79514282
Red blood cell sedimentation rate increased	43.13	9.90	21	166675	45921	79531771
Vascular purpura	43.00	9.90	42	166654	3056	79574636
Heparin-induced thrombocytopenia test	42.48	9.90	15	166681	144	79577548
Ear infection	42.25	9.90	10	166686	34422	79543270
Symmetrical drug-related intertriginous and flexural exanthema	41.92	9.90	25	166671	861	79576831
Therapy non-responder	41.68	9.90	81	166615	92224	79485468
Encephalopathy	41.47	9.90	262	166434	67135	79510557
Subcutaneous haematoma	41.10	9.90	39	166657	2738	79574954
Illness	41.09	9.90	23	166673	46488	79531204
Cardiac arrest	40.82	9.90	544	166152	171552	79406140
Long QT syndrome	40.67	9.90	56	166640	5899	79571793
Splenic infarction	40.59	9.90	44	166652	3620	79574072
Type 2 diabetes mellitus	40.26	9.90	36	166660	57086	79520606
Dry mouth	39.95	9.90	77	166619	87942	79489750
Oropharyngeal pain	39.66	9.90	108	166588	109245	79468447
Procedural haemorrhage	39.52	9.90	49	166647	4657	79573035
Seroma	39.29	9.90	35	166661	2265	79575427
Wound infection pseudomonas	38.82	9.90	30	166666	1591	79576101
Adrenal haemorrhage	38.79	9.90	21	166675	599	79577093
Stress	38.49	9.90	67	166629	79545	79498147
Ill-defined disorder	38.10	9.90	49	166647	65826	79511866
Throat irritation	38.01	9.90	19	166677	40927	79536765
Drug dependence	37.72	9.90	19	166677	40750	79536942
Blood pressure systolic increased	37.54	9.90	51	166645	66935	79510757
Hypofibrinogenaemia	37.28	9.90	32	166664	1970	79575722
Hyponatraemia	37.27	9.90	550	166146	177298	79400394
Hypercapnic coma	37.09	9.90	18	166678	406	79577286
Tachypnoea	37.08	9.90	149	166547	31914	79545778
Vascular pseudoaneurysm	36.89	9.90	41	166655	3469	79574223
Gastric disorder	36.86	9.90	16	166680	37417	79540275
Bullous haemorrhagic dermatosis	36.81	9.90	12	166684	88	79577604
Anxiety	36.75	9.90	337	166359	248175	79329517
Vascular stent thrombosis	36.71	9.90	42	166654	3668	79574024
Product prescribing error	36.66	9.90	188	166508	44625	79533067
Hypoaesthesia	36.65	9.90	222	166474	179130	79398562
Amnesia	36.37	9.90	47	166649	63010	79514682
Escherichia infection	36.31	9.90	101	166595	17916	79559776
Lymphatic fistula	36.29	9.90	22	166674	781	79576911
Cataract	36.14	9.90	46	166650	62074	79515618
Activated partial thromboplastin time prolonged	36.13	9.90	87	166609	14141	79563551
Vena cava thrombosis	36.05	9.90	37	166659	2858	79574834
Femoral hernia incarcerated	35.33	9.90	22	166674	820	79576872
Coagulation time prolonged	34.96	9.90	34	166662	2461	79575231
Intraventricular haemorrhage	34.95	9.90	47	166649	4840	79572852
Hypercoagulation	34.95	9.90	37	166659	2963	79574729
Spinal cord compression	34.88	9.90	54	166642	6323	79571369
Plasma cell myeloma	34.63	9.90	210	166486	53049	79524643
Adverse event	34.60	9.90	45	166651	60169	79517523
Cough	34.49	9.90	549	166147	366240	79211452
Swelling face	34.36	9.90	60	166636	71152	79506540
Diabetes mellitus	34.35	9.90	70	166626	78320	79499372
Duodenal ulcer haemorrhage	34.18	9.90	57	166639	7106	79570586
Injection site swelling	34.07	9.90	29	166667	47103	79530589
Urinary tract infection pseudomonal	34.02	9.90	29	166667	1769	79575923
Osteoarthritis	33.36	9.90	84	166612	87225	79490467
Nausea	33.31	9.90	1649	165047	955547	78622145
Bradycardia	33.18	9.90	431	166265	135126	79442566
Foetal death	33.15	9.90	60	166636	7984	79569708
Cerebral artery occlusion	33.04	9.90	28	166668	1694	79575998
Bursitis	32.72	9.90	17	166679	35827	79541865
Alveolitis	32.68	9.90	42	166654	4138	79573554
Fluid retention	32.62	9.90	60	166636	69749	79507943
Venous thrombosis limb	32.08	9.90	43	166653	4414	79573278
Acute respiratory distress syndrome	32.05	9.90	179	166517	43888	79533804
Bicytopenia	32.02	9.90	44	166652	4626	79573066
Foetal growth restriction	31.82	9.90	30	166666	2089	79575603
Rash	31.64	9.90	944	165752	577414	79000278
Disorientation	31.45	9.90	232	166464	62544	79515148
Pancreatic steatosis	31.44	9.90	23	166673	1122	79576570
Gastrooesophageal reflux disease	31.40	9.90	112	166584	104134	79473558
Therapeutic embolisation	31.36	9.90	17	166679	486	79577206
Hepatic enzyme increased	31.35	9.90	238	166458	182372	79395320
Urticaria	31.03	9.90	243	166453	184958	79392734
Ureteric compression	30.89	9.90	14	166682	269	79577423
Neonatal infection	30.85	9.90	8	166688	22	79577670
Pulmonary interstitial emphysema syndrome	30.74	9.90	17	166679	506	79577186
Gastrointestinal disorder	30.70	9.90	141	166555	122064	79455628
Empyema	30.39	9.90	41	166655	4235	79573457
Catheter site haemorrhage	30.35	9.90	45	166651	5072	79572620
Anaphylactic reaction	30.14	9.90	83	166613	83660	79494032
Drug withdrawal syndrome neonatal	29.97	9.90	14	166682	289	79577403
Spinal subdural haematoma	29.87	9.90	13	166683	226	79577466
Cerebral venous sinus thrombosis	29.84	9.90	30	166666	2261	79575431
Pituitary haemorrhage	29.63	9.90	14	166682	297	79577395
Lower respiratory tract infection	29.63	9.90	154	166542	129066	79448626
Knee arthroplasty	29.60	9.90	28	166668	43220	79534472
Blood creatinine increased	29.59	9.90	472	166224	154585	79423107
Hypocoagulable state	29.46	9.90	29	166667	2130	79575562
Pneumonitis	29.41	9.90	223	166473	60637	79517055
Alveolar lung disease	29.19	9.90	17	166679	560	79577132
Road traffic accident	29.04	9.90	29	166667	43635	79534057
Product monitoring error	28.84	9.90	60	166636	8846	79568846
Joint range of motion decreased	28.63	9.90	17	166679	33265	79544427
Pyelocaliectasis	28.51	9.90	20	166676	913	79576779
Haemolytic anaemia	28.44	9.90	92	166604	17728	79559964
Hemianopia homonymous	28.21	9.90	23	166673	1318	79576374
Vitamin K deficiency	27.99	9.90	18	166678	710	79576982
Pruritus	27.72	9.90	621	166075	394027	79183665
Neck pain	27.70	9.90	74	166622	75343	79502349
Hyperkalaemia	27.69	9.90	363	166333	114035	79463657
Rash pustular	27.48	9.90	68	166628	11243	79566449
Placental insufficiency	27.36	9.90	21	166675	1102	79576590
Eye pruritus	27.25	9.90	5	166691	20565	79557127
Immobilisation prolonged	27.19	9.90	10	166686	109	79577583
Hepatic cyst	27.13	9.90	47	166649	6042	79571650
Hip arthroplasty	27.09	9.90	21	166675	35735	79541957
Cardiac valve replacement complication	27.04	9.90	12	166684	219	79577473
Accidental exposure to product	26.94	9.90	16	166680	31306	79546386
Wound dehiscence	26.93	9.90	49	166647	6546	79571146
Hypoaldosteronism	26.76	9.90	14	166682	372	79577320
Wound haemorrhage	26.73	9.90	38	166658	4123	79573569
Catheter site haematoma	26.62	9.90	14	166682	376	79577316
Splenic necrosis	26.57	9.90	11	166685	168	79577524
Myelosuppression	26.52	9.90	27	166669	40269	79537423
Abdominal pain upper	26.38	9.90	320	166376	223499	79354193
Scrotal haematoma	26.30	9.90	9	166687	78	79577614
Acne	26.18	9.90	12	166684	27178	79550514
Circulatory collapse	26.08	9.90	151	166545	37517	79540175
Splenic haemorrhage	26.03	9.90	17	166679	689	79577003
Injection site pruritus	25.98	9.90	30	166666	42253	79535439
Urinary retention	25.97	9.90	205	166491	56425	79521267
Intentional self-injury	25.91	9.90	18	166678	32401	79545291
Stevens-Johnson syndrome	25.82	9.90	155	166541	39011	79538681
Generalised bullous fixed drug eruption	25.66	9.90	11	166685	184	79577508
Blood pressure systolic abnormal	25.60	9.90	3	166693	17244	79560448
Cystitis radiation	25.44	9.90	11	166685	188	79577504
Cerebrovascular accident	25.37	9.90	461	166235	154831	79422861
Dyspepsia	25.21	9.90	129	166567	108558	79469134
Injection site thrombosis	25.20	9.90	10	166686	136	79577556
Infection	25.03	9.90	355	166341	241357	79336335
Target skin lesion	24.94	9.90	10	166686	140	79577552
Hypertension	24.93	9.90	515	166181	330477	79247215
Peritoneal haematoma	24.82	9.90	11	166685	200	79577492
Blood pressure diastolic abnormal	24.73	9.90	5	166691	19197	79558495
Erythrodermic psoriasis	24.71	9.90	24	166672	1734	79575958
Pneumonia	24.67	9.90	1648	165048	658598	78919094
Patient restraint	24.64	9.90	9	166687	96	79577596
Acidosis	24.60	9.90	94	166602	19668	79558024
Pulmonary fibrosis	24.30	9.90	34	166662	44078	79533614
Skin necrosis	24.16	9.90	88	166608	17999	79559693
Peripheral artery thrombosis	24.16	9.90	33	166663	3450	79574242
Frequent bowel movements	24.15	9.90	16	166680	29523	79548169
Epidural haemorrhage	24.10	9.90	11	166685	215	79577477
Poisoning deliberate	24.05	9.90	5	166691	18823	79558869
Ear pain	24.03	9.90	20	166676	32849	79544843
Nodule	23.99	9.90	9	166687	22985	79554707
Abdominal wall haemorrhage	23.86	9.90	16	166680	678	79577014
Aplastic anaemia	23.82	9.90	87	166609	17818	79559874
White blood cell count decreased	23.81	9.90	265	166431	188023	79389669
Abdominal mass	23.70	9.90	33	166663	3512	79574180
Crystalluria	23.65	9.90	18	166678	933	79576759
Small intestinal obstruction	23.42	9.90	116	166580	27156	79550536
Heart rate increased	23.33	9.90	152	166544	120572	79457120
Hyperleukocytosis	23.25	9.90	28	166668	2582	79575110
Electrocardiogram ST segment elevation	23.13	9.90	53	166643	8344	79569348
Eye disorder	23.06	9.90	10	166686	23402	79554290
Musculoskeletal disorder	23.05	9.90	8	166688	21440	79556252
Pulmonary infarction	23.05	9.90	34	166662	3815	79573877
Skin candida	23.01	9.90	25	166671	2062	79575630
Therapeutic response shortened	22.95	9.90	3	166693	15860	79561832
Subclavian vein thrombosis	22.95	9.90	27	166669	2430	79575262
Eye pain	22.73	9.90	27	166669	37551	79540141
Generalised oedema	22.65	9.90	104	166592	23605	79554087
Intestinal ischaemia	22.54	9.90	70	166626	13200	79564492
Uveitis	22.49	9.90	4	166692	16826	79560866
Activated partial thromboplastin time abnormal	22.43	9.90	12	166684	334	79577358
Hot flush	22.39	9.90	51	166645	54826	79522866
Tenosynovitis	22.37	9.90	3	166693	15551	79562141
Hypersensitivity myocarditis	22.31	9.90	11	166685	257	79577435
Klebsiella infection	22.29	9.90	78	166618	15642	79562050
Sciatica	22.16	9.90	22	166674	33200	79544492
Febrile infection	22.15	9.90	31	166665	3315	79574377
Lip dry	22.11	9.90	3	166693	15415	79562277
Factor XIII deficiency	22.10	9.90	8	166688	83	79577609
Hypochromic anaemia	22.07	9.90	28	166668	2723	79574969
Aphasia	21.89	9.90	170	166526	46562	79531130
Superinfection bacterial	21.79	9.90	21	166675	1503	79576189
Bronchopleural fistula	21.79	9.90	15	166681	664	79577028
Eye irritation	21.74	9.90	8	166688	20673	79557019
Tinnitus	21.71	9.90	37	166659	44296	79533396
Excessive eye blinking	21.65	9.90	22	166674	1679	79576013
Antiphospholipid syndrome	21.46	9.90	23	166673	1868	79575824
Autoimmune heparin-induced thrombocytopenia	21.43	9.90	6	166690	24	79577668
Ischaemic hepatitis	21.42	9.90	32	166664	3632	79574060
Spinal epidural haemorrhage	21.30	9.90	9	166687	145	79577547
Hyperlipasaemia	21.26	9.90	19	166677	1235	79576457
Prothrombin time abnormal	21.25	9.90	18	166678	1088	79576604
Intracranial pressure increased	21.25	9.90	51	166645	8271	79569421
Bladder tamponade	21.20	9.90	14	166682	578	79577114
Paraesthesia	21.19	9.90	251	166445	176072	79401620
Protein deficiency	21.17	9.90	11	166685	288	79577404
Factor Xa activity increased	21.10	9.90	5	166691	8	79577684
Pulmonary sepsis	21.10	9.90	32	166664	3680	79574012
Visual impairment	21.00	9.90	110	166586	92021	79485671
Post procedural complication	20.93	9.90	102	166594	23727	79553965
Obstructive airways disorder	20.80	9.90	21	166675	31438	79546254
Breast cancer	20.72	9.90	24	166672	33757	79543935
Shock	20.72	9.90	159	166537	43389	79534303
Osteoporosis	20.71	9.90	52	166644	54060	79523632
Tumour lysis syndrome	20.69	9.90	102	166594	23837	79553855
Neuromyotonia	20.56	9.90	8	166688	103	79577589
Renal tubular necrosis	20.45	9.90	105	166591	24934	79552758
Brain herniation	20.44	9.90	47	166649	7416	79570276
Bronchial haemorrhage	20.42	9.90	19	166677	1301	79576391
Erythema multiforme	20.39	9.90	82	166614	17569	79560123
Protein total decreased	20.36	9.90	53	166643	9039	79568653
Arrhythmogenic right ventricular dysplasia	20.35	9.90	6	166690	30	79577662
Device related infection	20.28	9.90	132	166564	34162	79543530
Dermatitis exfoliative generalised	20.27	9.90	46	166650	7195	79570497
Sleep disorder	20.26	9.90	101	166595	85576	79492116
Poisoning	20.24	9.90	14	166682	25258	79552434
Inflammation	20.23	9.90	114	166582	93639	79484053
Osteoma	20.21	9.90	8	166688	108	79577584
Hyperthermia	20.20	9.90	83	166613	17954	79559738
Blood pressure diastolic decreased	20.17	9.90	20	166676	30196	79547496
Hospitalisation	20.11	9.90	115	166581	94121	79483571
Anuria	20.06	9.90	92	166604	20871	79556821
Schizophrenia	19.93	9.90	4	166692	15436	79562256
Premature labour	19.92	9.90	50	166646	8340	79569352
Hepatic infarction	19.90	9.90	16	166680	899	79576793
Tumour haemorrhage	19.80	9.90	33	166663	4111	79573581
Blood blister	19.76	9.90	28	166668	3029	79574663
Basal ganglion degeneration	19.54	9.90	12	166684	436	79577256
Splenic cyst	19.52	9.90	10	166686	254	79577438
Lower gastrointestinal haemorrhage	19.50	9.90	76	166620	16049	79561643
Dehydration	19.46	9.90	667	166029	247520	79330172
Vaccination site reaction	19.39	9.90	8	166688	121	79577571
Tongue disorder	19.39	9.90	3	166693	13972	79563720
Bronchitis	19.36	9.90	177	166519	130467	79447225
Feeling cold	19.19	9.90	19	166677	28710	79548982
Throat tightness	19.18	9.90	18	166678	27889	79549803
Cystitis	19.17	9.90	52	166644	52680	79525012
Postpartum haemorrhage	19.17	9.90	20	166676	1575	79576117
Joint stiffness	19.16	9.90	35	166661	40795	79536897
Anger	19.15	9.90	6	166690	17156	79560536
Prescribed overdose	19.12	9.90	31	166665	37852	79539840
Peripheral ischaemia	19.04	9.90	53	166643	9404	79568288
Intracardiac thrombus	18.95	9.90	33	166663	4260	79573432
Brain compression	18.89	9.90	13	166683	575	79577117
Subarachnoid haemorrhage	18.88	9.90	101	166595	24364	79553328
Urosepsis	18.86	9.90	107	166589	26388	79551304
Sputum discoloured	18.85	9.90	11	166685	21732	79555960
Peripheral nerve injury	18.83	9.90	14	166682	700	79576992
Malnutrition	18.82	9.90	95	166601	22407	79555285
Sinus congestion	18.82	9.90	9	166687	19887	79557805
Faecaloma	18.72	9.90	60	166636	11504	79566188
Mucosal haemorrhage	18.69	9.90	25	166671	2561	79575131
Needle issue	18.67	9.90	65	166631	13003	79564689
Hepatic haematoma	18.61	9.90	15	166681	846	79576846
Foetal heart rate abnormal	18.60	9.90	11	166685	373	79577319
Suture rupture	18.60	9.90	13	166683	590	79577102
Body temperature decreased	18.49	9.90	24	166672	32121	79545571
Night sweats	18.47	9.90	52	166644	52043	79525649
Sneezing	18.47	9.90	9	166687	19674	79558018
Impaired work ability	18.47	9.90	9	166687	19672	79558020
Puncture site haemorrhage	18.37	9.90	13	166683	602	79577090
Pulmonary haemorrhage	18.32	9.90	70	166626	14647	79563045
Rash erythematous	18.27	9.90	193	166503	57576	79520116
Aspiration	18.22	9.90	87	166609	20071	79557621
Hyperglycaemia	18.21	9.90	226	166470	70109	79507583
Postoperative respiratory failure	18.15	9.90	9	166687	213	79577479
Systemic inflammatory response syndrome	18.12	9.90	59	166637	11406	79566286
Twin pregnancy	18.08	9.90	15	166681	881	79576811
Incision site haematoma	18.03	9.90	8	166688	146	79577546
Subdural haemorrhage	18.02	9.90	39	166657	5909	79571783
Coronary artery thrombosis	17.97	9.90	27	166669	3079	79574613
Febrile bone marrow aplasia	17.94	9.90	64	166632	12956	79564736
Tooth disorder	17.93	9.90	17	166679	26216	79551476
Jaundice neonatal	17.88	9.90	8	166688	149	79577543
Photosensitivity reaction	17.88	9.90	11	166685	21116	79556576
Diabetic bullosis	17.86	9.90	5	166691	20	79577672
Balance disorder	17.84	9.90	127	166569	98730	79478962
Pre-eclampsia	17.82	9.90	43	166653	6998	79570694
Device occlusion	17.81	9.90	60	166636	11806	79565886
Glycosylated haemoglobin increased	17.78	9.90	9	166687	19251	79558441
Neurological decompensation	17.73	9.90	36	166660	5217	79572475
Right ventricular dilatation	17.71	9.90	21	166675	1905	79575787
Normal newborn	17.70	9.90	43	166653	7029	79570663
Kidney infection	17.64	9.90	12	166684	21839	79555853
Incubator therapy	17.63	9.90	6	166690	51	79577641
Basal cell carcinoma	17.57	9.90	32	166664	37343	79540349
Anticoagulation drug level above therapeutic	17.53	9.90	29	166667	3591	79574101
Renal injury	17.49	9.90	76	166620	16851	79560841
Superior vena cava syndrome	17.46	9.90	17	166679	1232	79576460
Hyperbilirubinaemia	17.44	9.90	99	166597	24419	79553273
Panic attack	17.38	9.90	15	166681	24201	79553491
Blood glucose increased	17.38	9.90	155	166541	114820	79462872
HELLP syndrome	17.33	9.90	14	166682	792	79576900
Blood disorder	17.29	9.90	47	166649	8226	79569466
Renal disorder	17.28	9.90	39	166657	42066	79535626
Language disorder	17.28	9.90	27	166669	3187	79574505
Musculoskeletal discomfort	17.24	9.90	10	166686	19825	79557867
Supraventricular tachycardia	17.23	9.90	89	166607	21181	79556511
Polycystic liver disease	17.13	9.90	8	166688	165	79577527
Diverticulum intestinal	17.10	9.90	48	166648	8557	79569135
Drug ineffective for unapproved indication	17.07	9.90	173	166523	51065	79526627
Hydrocephalus	17.06	9.90	49	166647	8851	79568841
Lupus-like syndrome	17.05	9.90	4	166692	13853	79563839
Drug withdrawal syndrome	16.98	9.90	29	166667	34689	79543003
Pulmonary thrombosis	16.92	9.90	60	166636	12111	79565581
Overdose	16.86	9.90	277	166419	183929	79393763
Thrombosis in device	16.85	9.90	36	166660	5406	79572286
Pelvic venous thrombosis	16.84	9.90	22	166674	2203	79575489
Inguinal hernia	16.83	9.90	40	166656	6448	79571244
Splenic rupture	16.82	9.90	23	166673	2406	79575286
Bladder cancer	16.76	9.90	10	166686	19516	79558176
Caesarean section	16.75	9.90	61	166635	12474	79565218
Foetal arrhythmia	16.69	9.90	6	166690	61	79577631
Serotonin syndrome	16.67	9.90	44	166652	44983	79532709
Transplant rejection	16.61	9.90	10	166686	19427	79558265
Pericardial haemorrhage	16.61	9.90	32	166664	4463	79573229
Abortion induced	16.50	9.90	42	166654	7067	79570625
Dermatitis exfoliative	16.47	9.90	55	166641	10774	79566918
Renal infarct	16.45	9.90	24	166672	2667	79575025
Joint injury	16.43	9.90	25	166671	31310	79546382
Purple glove syndrome	16.43	9.90	9	166687	263	79577429
Psychotic symptom	16.40	9.90	24	166672	2673	79575019
Antithrombin III deficiency	16.33	9.90	7	166689	117	79577575
Foetal monitoring abnormal	16.26	9.90	8	166688	186	79577506
Immunodeficiency	16.22	9.90	13	166683	21755	79555937
Cognitive disorder	16.21	9.90	83	166613	69843	79507849
Liver function test abnormal	16.19	9.90	206	166490	64269	79513423
Seasonal allergy	16.17	9.90	7	166689	16399	79561293
Cardiac failure	16.13	9.90	431	166265	154411	79423281
Bone density decreased	16.13	9.90	4	166692	13343	79564349
Fall	16.12	9.90	844	165852	486785	79090907
Sudden death	16.08	9.90	91	166605	22420	79555272
Toothache	16.08	9.90	11	166685	19959	79557733
Necrosis	16.05	9.90	50	166646	9443	79568249
Sinus disorder	16.02	9.90	14	166682	22450	79555242
Placental infarction	16.01	9.90	7	166689	123	79577569
Foot deformity	15.99	9.90	16	166680	24058	79553634
Hypercapnia	15.99	9.90	48	166648	8887	79568805
Acetabulum fracture	15.94	9.90	12	166684	612	79577080
Underdose	15.93	9.90	28	166668	33123	79544569
Subileus	15.92	9.90	36	166660	5618	79572074
Inflammatory marker increased	15.85	9.90	54	166642	10686	79567006
Staphylococcal infection	15.82	9.90	189	166507	58106	79519586
Axillary vein thrombosis	15.75	9.90	12	166684	623	79577069
Confusional state	15.70	9.90	814	165882	317183	79260509
Thymus disorder	15.69	9.90	9	166687	288	79577404
Premature separation of placenta	15.65	9.90	16	166680	1230	79576462
Interstitial lung disease	15.64	9.90	155	166541	112445	79465247
Vessel puncture site haematoma	15.59	9.90	8	166688	204	79577488
Laryngitis	15.56	9.90	7	166689	16032	79561660
Anti factor X antibody positive	15.52	9.90	3	166693	0	79577692
Non-immune heparin associated thrombocytopenia	15.52	9.90	3	166693	0	79577692
Condition aggravated	15.52	9.90	873	165823	500251	79077441
Intracranial haematoma	15.46	9.90	14	166682	926	79576766
Embolism venous	15.45	9.90	30	166666	4209	79573483
Hepatic cirrhosis	15.44	9.90	31	166665	34875	79542817
Diplopia	15.43	9.90	29	166667	33437	79544255
Hemiplegia	15.38	9.90	67	166629	14872	79562820
Gastrointestinal stoma complication	15.37	9.90	23	166673	2614	79575078
Pulmonary toxicity	15.36	9.90	4	166692	12910	79564782
Radiation fibrosis	15.30	9.90	5	166691	37	79577655
Cardio-respiratory arrest	15.29	9.90	315	166381	108195	79469497
Ocular hyperaemia	15.28	9.90	22	166674	28184	79549508
Acute myocardial infarction	15.25	9.90	236	166460	76800	79500892
Viral infection	15.21	9.90	43	166653	42973	79534719
Malignant neoplasm progression	15.18	9.90	382	166314	135608	79442084
Cardiogenic shock	15.17	9.90	144	166552	41770	79535922
Stoma site candida	15.17	9.90	4	166692	12	79577680
Parenteral nutrition associated liver disease	15.17	9.90	4	166692	12	79577680
Eosinophilic pneumonia	15.16	9.90	34	166662	5276	79572416
Blister	15.16	9.90	168	166528	119308	79458384
Upper-airway cough syndrome	15.15	9.90	3	166693	11690	79566002
Aortic arteriosclerosis	15.11	9.90	47	166649	8871	79568821
Injection site reaction	15.11	9.90	61	166635	54724	79522968
Respiratory alkalosis	15.09	9.90	30	166666	4281	79573411
Quadriplegia	15.05	9.90	26	166670	3334	79574358
Metastases to meninges	15.02	9.90	27	166669	3574	79574118
Coronary artery embolism	15.01	9.90	9	166687	313	79577379
Periportal sinus dilatation	15.01	9.90	7	166689	144	79577548
Electrocardiogram repolarisation abnormality	15.00	9.90	21	166675	2246	79575446
Eye swelling	14.98	9.90	20	166676	26448	79551244
Pain in jaw	14.97	9.90	48	166648	46103	79531589
Restless legs syndrome	14.97	9.90	12	166684	20080	79557612
Psychotic disorder	14.92	9.90	41	166655	41361	79536331
Cardiac tamponade	14.90	9.90	48	166648	9228	79568464
Traumatic haematoma	14.90	9.90	20	166676	2056	79575636
Tissue infiltration	14.85	9.90	12	166684	679	79577013
Cerebral artery embolism	14.78	9.90	19	166677	1872	79575820
Lymphorrhoea	14.71	9.90	7	166689	151	79577541
Impaired healing	14.68	9.90	115	166581	87540	79490152
Depressed mood	14.65	9.90	52	166644	48428	79529264
Full blood count abnormal	14.65	9.90	40	166656	40434	79537258
Upper respiratory tract infection	14.63	9.90	121	166575	91047	79486645
Protein S deficiency	14.62	9.90	7	166689	153	79577539
Device related sepsis	14.62	9.90	37	166659	6203	79571489
Poor venous access	14.61	9.90	10	166686	18139	79559553
Contraindicated product prescribed	14.58	9.90	18	166678	1703	79575989
Lordosis	14.56	9.90	10	166686	441	79577251
Splenic lesion	14.51	9.90	11	166685	567	79577125
Groin pain	14.50	9.90	60	166636	13020	79564672
Nervousness	14.50	9.90	30	166666	33385	79544307
Central nervous system injury	14.50	9.90	7	166689	156	79577536
Carcinoembryonic antigen	14.47	9.90	6	166690	92	79577600
Dysdiadochokinesis	14.39	9.90	9	166687	338	79577354
Product administered at inappropriate site	14.38	9.90	28	166668	3937	79573755
Microembolism	14.35	9.90	5	166691	46	79577646
Tooth infection	14.34	9.90	11	166685	18821	79558871
Cyanosis	14.33	9.90	96	166600	25086	79552606
Carbohydrate antigen 15-3	14.29	9.90	6	166690	95	79577597
Adrenal cortex necrosis	14.29	9.90	4	166692	16	79577676
Neoplasm malignant	14.28	9.90	28	166668	31782	79545910
Mechanical ventilation complication	14.25	9.90	5	166691	47	79577645
Cardiac ventricular thrombosis	14.15	9.90	18	166678	1755	79575937
Paresis	14.14	9.90	29	166667	4232	79573460
Carpal tunnel syndrome	14.13	9.90	12	166684	19516	79558176
Deafness bilateral	14.10	9.90	20	166676	2165	79575527
Poor quality sleep	14.09	9.90	16	166680	22706	79554986
Back pain	14.09	9.90	507	166189	303673	79274019
Hepatic vein thrombosis	14.03	9.90	8	166688	253	79577439
Budd-Chiari syndrome	14.01	9.90	6	166690	100	79577592
Epidural analgesia	13.98	9.90	5	166691	50	79577642
Osteochondrosis	13.98	9.90	19	166677	1977	79575715
Pseudomonas infection	13.95	9.90	83	166613	20820	79556872
Uterine enlargement	13.91	9.90	13	166683	895	79576797
Device toxicity	13.91	9.90	4	166692	18	79577674
Peripheral sensory neuropathy	13.84	9.90	59	166637	12974	79564718
Renal embolism	13.80	9.90	7	166689	174	79577518
Pneumothorax	13.80	9.90	104	166592	28219	79549473
Incision site haemorrhage	13.74	9.90	14	166682	1072	79576620
Mitral perforation	13.73	9.90	4	166692	19	79577673
Splenic injury	13.72	9.90	8	166688	264	79577428
Brachiocephalic vein thrombosis	13.69	9.90	8	166688	265	79577427
Bronchiectasis	13.63	9.90	16	166680	22370	79555322
Phlebitis	13.56	9.90	45	166651	8785	79568907
Respiratory tract congestion	13.56	9.90	13	166683	19941	79557751
Vaginal haemorrhage	13.53	9.90	85	166611	21732	79555960
Hypernatraemia	13.52	9.90	63	166633	14388	79563304
Intra-abdominal fluid collection	13.50	9.90	24	166672	3148	79574544
Atrial thrombosis	13.48	9.90	26	166670	3630	79574062
Product quality issue	13.47	9.90	32	166664	33908	79543784
Skin neoplasm bleeding	13.44	9.90	3	166693	3	79577689
Soft tissue infection	13.43	9.90	27	166669	3885	79573807
Erectile dysfunction	13.32	9.90	7	166689	14657	79563035
Prosthetic cardiac valve thrombosis	13.32	9.90	5	166691	58	79577634
International normalised ratio fluctuation	13.27	9.90	25	166671	3429	79574263
Atrial flutter	13.26	9.90	84	166612	21541	79556151
Transfusion	13.17	9.90	83	166613	21247	79556445
Infective glossitis	13.16	9.90	5	166691	60	79577632
Anaesthesia	13.16	9.90	10	166686	517	79577175
Chemical burns of eye	13.16	9.90	6	166690	117	79577575
Procalcitonin increased	13.13	9.90	23	166673	2983	79574709
Infective exacerbation of chronic obstructive airways disease	13.08	9.90	22	166674	2762	79574930
Aortic valve stenosis	13.05	9.90	32	166664	5262	79572430
Disability	13.04	9.90	10	166686	17110	79560582
Limb discomfort	13.02	9.90	31	166665	32819	79544873
Intestinal infarction	13.01	9.90	15	166681	1321	79576371
Creatinine renal clearance abnormal	12.99	9.90	10	166686	527	79577165
Duodenal ulcer	12.92	9.90	68	166628	16301	79561391
Disease recurrence	12.88	9.90	48	166648	44061	79533631
Premature baby	12.87	9.90	26	166670	3754	79573938
Polyserositis	12.86	9.90	11	166685	674	79577018
Clinical trial participant	12.84	9.90	6	166690	124	79577568
Mental disorder	12.84	9.90	29	166667	31273	79546419
Gastroenteritis viral	12.84	9.90	20	166676	24811	79552881
Large intestinal obstruction	12.83	9.90	24	166672	3275	79574417
Dysstasia	12.83	9.90	24	166672	27722	79549970
Post transplant lymphoproliferative disorder	12.80	9.90	4	166692	11460	79566232
Paraparesis	12.76	9.90	26	166670	3777	79573915
Respiratory gas exchange disorder	12.69	9.90	12	166684	839	79576853
Epilepsy	12.68	9.90	136	166560	40724	79536968
Amaurosis	12.67	9.90	14	166682	1177	79576515
Purpura non-thrombocytopenic	12.64	9.90	7	166689	209	79577483
Injection site pain	12.63	9.90	193	166503	129645	79448047
Scintillating scotoma	12.61	9.90	7	166689	210	79577482
Pericardial effusion	12.59	9.90	150	166546	46087	79531605
Hyperaemia	12.56	9.90	23	166673	3087	79574605
Diffuse alveolar damage	12.52	9.90	25	166671	3579	79574113
Irritability	12.52	9.90	44	166652	41100	79536592
Nephrolithiasis	12.50	9.90	63	166633	53228	79524464
Coinfection	12.47	9.90	5	166691	70	79577622
Diet refusal	12.45	9.90	12	166684	859	79576833
Abnormal behaviour	12.44	9.90	37	166659	36384	79541308
Sensory loss	12.42	9.90	57	166639	12934	79564758
Alkalosis	12.40	9.90	10	166686	564	79577128
Arterial thrombosis	12.39	9.90	21	166675	2653	79575039
Thyroid disorder	12.38	9.90	7	166689	14072	79563620
Injection site plaque	12.38	9.90	6	166690	135	79577557
Hallucination, auditory	12.37	9.90	15	166681	20678	79557014
Meningorrhagia	12.36	9.90	8	166688	319	79577373
Cerebellar haemorrhage	12.31	9.90	22	166674	2898	79574794
Hypercreatininaemia	12.29	9.90	13	166683	1040	79576652
Dry eye	12.27	9.90	38	166658	36893	79540799
Pulmonary hypertension	12.23	9.90	154	166542	47926	79529766
Oesophageal carcinoma	12.15	9.90	4	166692	11080	79566612
Antibiotic level above therapeutic	12.13	9.90	11	166685	729	79576963
Duodenal polyp	12.12	9.90	8	166688	330	79577362
Adenocarcinoma of colon	12.10	9.90	32	166664	5509	79572183
Cardiac disorder	12.10	9.90	84	166612	65673	79512019
Coordination abnormal	12.09	9.90	11	166685	17301	79560391
Immune thrombocytopenia	12.08	9.90	71	166625	17734	79559958
Prostatic specific antigen abnormal	12.07	9.90	9	166687	452	79577240
Adrenal haematoma	11.99	9.90	6	166690	145	79577547
Prothrombin time shortened	11.95	9.90	23	166673	3205	79574487
Vitamin B6 deficiency	11.95	9.90	8	166688	338	79577354
Joint effusion	11.94	9.90	12	166684	18002	79559690
Contusion	11.93	9.90	229	166467	148547	79429145
Abdominal distension	11.93	9.90	177	166519	119473	79458219
Bullous impetigo	11.92	9.90	3	166693	7	79577685
Eye infection	11.89	9.90	5	166691	11915	79565777
Oesophageal compression	11.86	9.90	4	166692	33	79577659
Myocarditis	11.86	9.90	82	166614	21651	79556041
Injection site urticaria	11.83	9.90	6	166690	12820	79564872
Rash scarlatiniform	11.77	9.90	7	166689	240	79577452
Spinal cord injury cauda equina	11.73	9.90	6	166690	152	79577540
Product prescribing issue	11.66	9.90	26	166670	4019	79573673
Nail toxicity	11.60	9.90	8	166688	355	79577337
Skin ulcer	11.60	9.90	66	166630	54084	79523608
Hypercholesterolaemia	11.56	9.90	19	166677	23076	79554616
Protein C deficiency	11.56	9.90	4	166692	36	79577656
Toxic encephalopathy	11.54	9.90	51	166645	11389	79566303
Pleural neoplasm	11.50	9.90	8	166688	360	79577332
Anti factor X activity increased	11.48	9.90	5	166691	87	79577605
Gait inability	11.47	9.90	74	166622	58843	79518849
Factor XIII Inhibition	11.46	9.90	4	166692	37	79577655
Tumour inflammation	11.46	9.90	4	166692	37	79577655
Iliac vein occlusion	11.46	9.90	4	166692	37	79577655
Hypocapnia	11.41	9.90	10	166686	633	79577059
Nightmare	11.41	9.90	23	166673	25838	79551854
Withdrawal of life support	11.38	9.90	3	166693	9	79577683
Otitis media acute	11.35	9.90	14	166682	1323	79576369
Coagulation test abnormal	11.29	9.90	14	166682	1331	79576361
Liver abscess	11.29	9.90	33	166663	6021	79571671
Obstructive shock	11.23	9.90	5	166691	92	79577600
Prostate cancer	11.22	9.90	34	166662	33234	79544458
Skin cancer	11.18	9.90	9	166687	15031	79562661
Uterine hypertonus	11.17	9.90	7	166689	264	79577428
Hyperpyrexia	11.16	9.90	33	166663	6059	79571633
Device safety feature issue	11.14	9.90	3	166693	10	79577682
Glaucoma	11.12	9.90	15	166681	19746	79557946
Spinal cord ischaemia	11.09	9.90	6	166690	171	79577521
Abnormal dreams	11.04	9.90	5	166691	11407	79566285
Dysgeusia	11.04	9.90	72	166624	57105	79520587
Drug resistance	11.02	9.90	48	166648	42165	79535527
Dysaesthesia	11.02	9.90	32	166664	5816	79571876
Quality of life decreased	11.00	9.90	4	166692	10416	79567276
Normocytic anaemia	10.98	9.90	26	166670	4181	79573511
Decubitus ulcer	10.93	9.90	63	166633	15624	79562068
Bacterascites	10.92	9.90	3	166693	11	79577681
Duodenitis	10.84	9.90	39	166657	7928	79569764
Injection site warmth	10.84	9.90	9	166687	14798	79562894
Hypoalbuminaemia	10.83	9.90	79	166617	21218	79556474
Cytomegalovirus infection	10.83	9.90	49	166647	42595	79535097
Mitral valve stenosis	10.81	9.90	13	166683	1197	79576495
Intracranial mass	10.81	9.90	18	166678	2241	79575451
Stroke in evolution	10.80	9.90	5	166691	101	79577591
Diffuse large B-cell lymphoma stage II	10.80	9.90	5	166691	101	79577591
Lymphoedema	10.80	9.90	53	166643	12360	79565332
Lower limb fracture	10.80	9.90	20	166676	23195	79554497
Jaundice	10.78	9.90	164	166532	53185	79524507
Product substitution issue	10.77	9.90	16	166680	20240	79557452
Hypoacusis	10.76	9.90	30	166666	30120	79547572
Pulmonary alveolar haemorrhage	10.76	9.90	50	166646	11407	79566285
Lipase increased	10.75	9.90	65	166631	16401	79561291
Chronic sinusitis	10.72	9.90	7	166689	13019	79564673
Pancreatic carcinoma metastatic	10.68	9.90	24	166672	3729	79573963
Mitral valve replacement	10.66	9.90	8	166688	406	79577286
Hepatic rupture	10.63	9.90	5	166691	105	79577587
Thirst	10.61	9.90	14	166682	18605	79559087
Heart sounds abnormal	10.58	9.90	14	166682	1419	79576273
Breast haematoma	10.57	9.90	6	166690	188	79577504
Ventricular hyperkinesia	10.54	9.90	7	166689	292	79577400
Stupor	10.54	9.90	35	166661	6837	79570855
Tricuspid valve incompetence	10.54	9.90	74	166622	19638	79558054
Placental necrosis	10.52	9.90	3	166693	13	79577679
Hepatitis toxic	10.52	9.90	29	166667	5118	79572574
Treatment noncompliance	10.51	9.90	65	166631	52203	79525489
Ventricular flutter	10.50	9.90	5	166691	108	79577584
Increased appetite	10.47	9.90	6	166690	11972	79565720
Tremor	10.44	9.90	273	166423	169810	79407882
Somatosensory evoked potentials abnormal	10.40	9.90	6	166690	194	79577498
Head discomfort	10.39	9.90	9	166687	14493	79563199
Wrist fracture	10.38	9.90	6	166690	11915	79565777
Sensorimotor disorder	10.37	9.90	11	166685	883	79576809
Bradypnoea	10.35	9.90	32	166664	6020	79571672
Hemiparesis	10.34	9.90	112	166584	33621	79544071
Mood swings	10.29	9.90	16	166680	19864	79557828
Gastritis	10.27	9.90	149	166547	47844	79529848
Thrombectomy	10.27	9.90	7	166689	305	79577387
Bone disorder	10.26	9.90	15	166681	19098	79558594
Pneumonia parainfluenzae viral	10.23	9.90	7	166689	307	79577385
Emotional disorder	10.22	9.90	9	166687	14378	79563314
Ascites	10.20	9.90	218	166478	75344	79502348
Burkholderia test positive	10.19	9.90	9	166687	576	79577116
Venoocclusive liver disease	10.14	9.90	6	166690	11765	79565927
Withdrawal syndrome	10.13	9.90	26	166670	26828	79550864
Fat embolism	10.10	9.90	8	166688	440	79577252
Urethral stenosis	10.07	9.90	12	166684	1094	79576598
Quadrantanopia	10.03	9.90	6	166690	208	79577484
Scan abnormal	10.02	9.90	5	166691	120	79577572
Accident	10.01	9.90	3	166693	8828	79568864
COVID-19	10.01	9.90	414	166282	157260	79420432
Anti-platelet antibody positive	9.99	9.90	7	166689	319	79577373
Pulseless electrical activity	9.95	9.90	57	166639	14103	79563589
Product complaint	9.91	9.90	8	166688	13341	79564351
Pharyngitis streptococcal	9.90	9.90	5	166691	10709	79566983

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AB05	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group
MeSH PA	D000925	Anticoagulants
MeSH PA	D006401	Hematologic Agents
FDA CS	M0010191	Heparin, Low-Molecular-Weight
FDA EPC	N0000175586	Low Molecular Weight Heparin
CHEBI has role	CHEBI:50249	anticoagulants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Unstable angina	indication	4557003
Myocardial infarction	indication	22298006	DOID:5844
Pulmonary embolism	indication	59282003	DOID:9477
Deep venous thrombosis	indication	128053003
Prevention of clot formation during haemodialysis	indication
Prevention of venous thromboembolism	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Antithrombin-III	Secreted	P01008	ANT3_HUMAN	ACTIVATOR				WOMBAT-PK	CHEMBL

External reference:

ID	Source
D03674	KEGG_DRUG
4020831	VANDF
CHEBI:28304	CHEBI
CHEMBL1201476	ChEMBL_ID
C000711671	MESH_SUPPLEMENTAL_RECORD_UI
6811	IUPHAR_LIGAND_ID
DB01225	DRUGBANK_ID
221095	RXNORM
1304	MMSL
175440	MMSL
4659	MMSL
d03041	MMSL
004210	NDDF
006123	NDDF
108983001	SNOMEDCT_US
108984007	SNOMEDCT_US
372562003	SNOMEDCT_US
C0724579	UMLSCUI
D017984	MESH_DESCRIPTOR_UI
CHEMBL1201685	ChEMBL_ID
5452	INN_ID
9005-49-6	SECONDARY_CAS_RN
772	PUBCHEM_CID
8NZ41MIK1O	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-0620	INJECTION	40 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-0621	INJECTION	60 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-0622	INJECTION	80 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-0623	INJECTION	100 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-0624	INJECTION	30 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-0626	INJECTION	300 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-2912	INJECTION	120 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-2915	INJECTION	150 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8013	INJECTION	30 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8013	INJECTION	30 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8014	INJECTION	40 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8014	INJECTION	40 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8016	INJECTION	60 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8016	INJECTION	60 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8018	INJECTION	80 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8018	INJECTION	80 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8020	INJECTION	100 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8020	INJECTION	100 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8022	INJECTION	120 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8022	INJECTION	120 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8025	INJECTION	150 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8025	INJECTION	150 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8030	INJECTION	300 mg	SUBCUTANEOUS	NDA	30 sections
Lovenox	HUMAN PRESCRIPTION DRUG LABEL	1	0075-8030	INJECTION	300 mg	SUBCUTANEOUS	NDA	30 sections
Enoxaparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5601	INJECTION	100 mg	SUBCUTANEOUS	ANDA	29 sections
Enoxaparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5601	INJECTION	100 mg	SUBCUTANEOUS	ANDA	29 sections
Enoxaparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5602	INJECTION	100 mg	SUBCUTANEOUS	ANDA	29 sections
Enoxaparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5602	INJECTION	100 mg	SUBCUTANEOUS	ANDA	29 sections
Enoxaparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5603	INJECTION	100 mg	SUBCUTANEOUS	ANDA	29 sections
Enoxaparin Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0548-5603	INJECTION	100 mg	SUBCUTANEOUS	ANDA	29 sections