carazolol indications/contra

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 487 57775-29-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carazolol
  • DL-Carazolol
  • racemic carazolol
  • Molecular weight: 298.39
  • Formula: C18H22N2O2
  • CLOGP: 3.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 57.28
  • ALOGS: -3.98
  • ROTB: 6

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-3 adrenergic receptor GPCR AGONIST Ki 8.70 IUPHAR
Beta-2 adrenergic receptor GPCR Ki 9.94 CHEMBL
Beta-3 adrenergic receptor Unclassified AGONIST Ki 7.70 IUPHAR
Beta-3 adrenergic receptor Unclassified AGONIST Ki 7.70 IUPHAR

External reference:

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IDSource
569 IUPHAR_LIGAND_ID
C0054636 UMLSCUI
D07608 KEGG_DRUG
29PW75S82A UNII
4036 INN_ID
71739 PUBCHEM_CID
20192 RXNORM
006896 NDDF
CHEMBL324665 ChEMBL_ID
CHEBI:135261 CHEBI
C014382 MESH_SUPPLEMENTAL_RECORD_UI
CAU PDB_CHEM_ID

Pharmaceutical products:

None