All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

umifenovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antivirals	4868	131707-25-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: arbidole umifenovir arbidol	an antiviral agent. Although data is limited, in vitro activity against SARS-CoV-1 and SARS-CoV-2 has been reported. The drug has been included in COVID-19 treatment guidelines used in China and Russia. Molecular weight: 477.42 Formula: C22H25BrN2O3S CLOGP: 5.50 LIPINSKI: 1 HAC: 5 HDO: 1 TPSA: 54.70 ALOGS: -4.85 ROTB: 8

Drug dosage:

Dose	Unit	Route
0.80	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	213.89	174.78	62	40	674400	62814520

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	271.78	120.12	79	42	419445	34537365

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	452.52	164.91	136	96	907079	78837077

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J05AX13	ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Other antivirals

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Influenza	indication	6142004	DOID:8469
Coronavirus infection	off-label use	186747009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.81	acidic
pKa2	10.04	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]	Unclassified		HEMA_I34A1		Kd	4.96		CHEMBL

External reference:

ID	Source
93M09WW4RU	UNII
D10558	KEGG_DRUG
C0254211	UMLSCUI
CHEBI:134730	CHEBI
75U	PDB_CHEM_ID
CHEMBL1214598	ChEMBL_ID
131411	PUBCHEM_CID
DB13609	DRUGBANK_ID
9271	INN_ID
C086979	MESH_SUPPLEMENTAL_RECORD_UI
11089	IUPHAR_LIGAND_ID

Pharmaceutical products:

None