corticorelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| pituitary hormone-release stimulating peptides | 4858 | 86784-80-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V04CD04 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for pituitary function |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diagnosis of Hypercortisolism | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.12 | acidic |
| pKa2 | 3.55 | acidic |
| pKa3 | 3.77 | acidic |
| pKa4 | 3.97 | acidic |
| pKa5 | 4.16 | acidic |
| pKa6 | 4.38 | acidic |
| pKa7 | 4.88 | acidic |
| pKa8 | 12.2 | acidic |
| pKa9 | 12.33 | acidic |
| pKa10 | 12.56 | acidic |
| pKa11 | 12.67 | acidic |
| pKa12 | 12.8 | acidic |
| pKa13 | 12.81 | acidic |
| pKa14 | 13.01 | acidic |
| pKa15 | 13.03 | acidic |
| pKa16 | 13.2 | acidic |
| pKa17 | 13.27 | acidic |
| pKa18 | 13.28 | acidic |
| pKa19 | 13.32 | acidic |
| pKa20 | 13.47 | acidic |
| pKa21 | 13.49 | acidic |
| pKa22 | 13.55 | acidic |
| pKa23 | 13.55 | acidic |
| pKa24 | 13.65 | acidic |
| pKa25 | 13.68 | acidic |
| pKa26 | 13.79 | acidic |
| pKa27 | 13.86 | acidic |
| pKa28 | 13.87 | acidic |
| pKa29 | 11.4 | Basic |
| pKa30 | 10.93 | Basic |
| pKa31 | 10.57 | Basic |
| pKa32 | 10.16 | Basic |
| pKa33 | 7.66 | Basic |
| pKa34 | 6.99 | Basic |
| pKa35 | 6.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | GPCR | AGONIST | Kd | 8.48 | SCIENTIFIC LITERATURE | IUPHAR | |||
| Corticotropin-releasing factor receptor 2 | GPCR | AGONIST | Kd | 7.40 | IUPHAR | ||||
| Corticotropin-releasing factor receptor 2 | GPCR | AGONIST | Ki | 7.80 | IUPHAR | ||||
| Corticotropin-releasing factor receptor 2 | GPCR | AGONIST | Kd | 7.90 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D03591 | KEGG_DRUG |
| N0000007539 | NUI |
| CHEBI:65312 | CHEBI |
| CHEMBL2108182 | ChEMBL_ID |
| 1312542-61-2 | SECONDARY_CAS_RN |
| DB05394 | DRUGBANK_ID |
| DB12915 | DRUGBANK_ID |
| 1927940 | RXNORM |
| d04013 | MMSL |
| 006760 | NDDF |
| 007305 | NDDF |
| 71971001 | SNOMEDCT_US |
| 84986000 | SNOMEDCT_US |
| C0010132 | UMLSCUI |
| CHEMBL2107324 | ChEMBL_ID |
| 6666 | INN_ID |
| 16186200 | PUBCHEM_CID |
| 305OE8862Y | UNII |
Pharmaceutical products:
None