corticorelin indications/contra

Stem definitionDrug idCAS RN
pituitary hormone-release stimulating peptides 4858 86784-80-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • corticorelin
  • corticotropin-releasing factor (human)
  • corticorelin human
  • corticorelin acetate
  • Molecular weight: 4757.52
  • Formula: C208H344N60O63S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 123
  • HDO: 67
  • TPSA: 1998.99
  • ALOGS:
  • ROTB: 163

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC V04CD04 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for pituitary function

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diagnosis of Hypercortisolism indication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Corticotropin-releasing factor receptor 1 GPCR AGONIST Kd 8.48 SCIENTIFIC LITERATURE IUPHAR
Corticotropin-releasing factor receptor 2 GPCR AGONIST Kd 7.40 IUPHAR
Corticotropin-releasing factor receptor 2 Unclassified AGONIST Kd 7.90 IUPHAR
Corticotropin-releasing factor receptor 2 Unclassified AGONIST Ki 7.80 IUPHAR

External reference:

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IDSource
D03591 KEGG_DRUG
912 IUPHAR_LIGAND_ID
N0000007539 NUI
C0010132 UMLSCUI
2YF82QN5RY UNII
1312542-61-2 SECONDARY_CAS_RN
6666 INN_ID
DB05394 DRUGBANK_ID
CHEMBL2107324 ChEMBL_ID
CHEMBL2108182 ChEMBL_ID
d04013 MMSL
214461 RXNORM
N0000007539 NDFRT
84986000 SNOMEDCT_US
006760 NDDF
71971001 SNOMEDCT_US
16186200 PUBCHEM_CID
CHEBI:136037 CHEBI

Pharmaceutical products:

None