estrone sulphate indications/contra

Stem definitionDrug idCAS RN
estrogens 4857 7280-37-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • estrone sulphate
  • estrone sodium sulfate
  • estropipate
  • piperazine estrone sulfate
  • sodium estrone sulfate
used therapeutically in menopausal patients
  • Molecular weight: 350.43
  • Formula: C18H22O5S
  • CLOGP: 1.82
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -4.77
  • ROTB: 2

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
May 19, 1977 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperhidrosis 13.35 0 3 11 23607 3362238

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D003270 Contraceptive Agents
MeSH PA D012102 Reproductive Control Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Female hypogonadism syndrome indication 16041008
Atrophic vaginitis indication 52441000 DOID:11968

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 -0.57 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL
Estrogen receptor beta Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL
Steryl-sulfatase Enzyme Ki 4.22 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 4.24 CHEMBL

External reference:

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IDSource
D00948 KEGG_DRUG
4018490 VUID
N0000146812 NUI
C0304783 UMLSCUI
6K6FDA543A UNII
438-67-5 SECONDARY_CAS_RN
CHEMBL494753 ChEMBL_ID
CHEMBL1200980 ChEMBL_ID
DB04574 DRUGBANK_ID
CHEMBL2106240 ChEMBL_ID
C009927 MESH_SUPPLEMENTAL_RECORD_UI
115502007 SNOMEDCT_US
DB00655 DRUGBANK_ID
3001028 PUBCHEM_CID
CHEBI:17474 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0414 TABLET 0.75 mg ORAL ANDA 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0415 TABLET 1.50 mg ORAL ANDA 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0416 TABLET 3 mg ORAL ANDA 13 sections
Esterified Estrogens and Methyltestosterone HUMAN PRESCRIPTION DRUG LABEL 2 50220-001 TABLET, FILM COATED 0.63 mg ORAL Unapproved drug other 13 sections
Esterified Estrogens and Methyltestosterone HUMAN PRESCRIPTION DRUG LABEL 2 50220-002 TABLET, FILM COATED 1.25 mg ORAL Unapproved drug other 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 54868-3114 TABLET 0.75 mg ORAL ANDA 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4149 TABLET 1.50 mg ORAL ANDA 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4761 TABLET 3 mg ORAL ANDA 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 69189-0414 TABLET 0.75 mg ORAL ANDA 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 69189-0416 TABLET 1.50 mg ORAL ANDA 13 sections