bemiparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
heparin derivatives including low molecular mass heparins 4840 9041-08-1

Description:

MoleculeDescription

Synonyms:

  • tinzaparin
  • ardeparin sodium
  • dalteparin sodium
  • tinzaparin sodium
  • bemiparin
  • bemiparin sodium
A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)
  • Molecular weight:
  • Formula: None
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.50 TU P
2.50 TU P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 22, 1994 FDA PFIZER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary embolism 242.57 12.91 269 25966 116415 63346372
Thrombocytopenia 191.48 12.91 272 25963 150885 63311902
Drug ineffective 158.67 12.91 121 26114 1044644 62418143
Hepatocellular injury 153.97 12.91 111 26124 27270 63435517
Acute kidney injury 143.57 12.91 328 25907 263087 63199700
Toxic epidermal necrolysis 138.57 12.91 101 26134 25233 63437554
Anaemia 104.83 12.91 312 25923 293118 63169669
Heparin-induced thrombocytopenia 102.68 12.91 46 26189 4536 63458251
Needle issue 100.03 12.91 59 26176 10317 63452470
General physical health deterioration 100.02 12.91 242 25993 201160 63261627
Drug intolerance 87.44 12.91 12 26223 308649 63154138
Arthralgia 77.45 12.91 73 26162 569637 62893150
Cholestasis 77.34 12.91 77 26158 29357 63433430
Arthropathy 74.48 12.91 6 26229 234786 63228001
Deep vein thrombosis 74.14 12.91 128 26107 83672 63379115
Febrile neutropenia 73.99 12.91 156 26079 118293 63344494
Rheumatoid arthritis 69.25 12.91 11 26224 253808 63208979
Neutropenic sepsis 64.79 12.91 54 26181 16384 63446403
Therapeutic product effect decreased 63.96 12.91 4 26231 193183 63269604
Product dose omission issue 62.04 12.91 11 26224 234302 63228485
Glossodynia 61.40 12.91 3 26232 178873 63283914
Abdominal discomfort 59.72 12.91 29 26206 320856 63141931
Neutropenia 59.46 12.91 183 26052 174822 63287965
Cytokine release syndrome 58.45 12.91 48 26187 14266 63448521
Systemic lupus erythematosus 57.10 12.91 9 26226 208909 63253878
Drug reaction with eosinophilia and systemic symptoms 56.79 12.91 70 26165 33766 63429021
Pancytopenia 55.18 12.91 123 26112 96810 63365977
Sinusitis 55.11 12.91 13 26222 226640 63236147
Blue toe syndrome 52.53 12.91 15 26220 392 63462395
Joint swelling 51.90 12.91 36 26199 327630 63135157
Blood creatine increased 51.77 12.91 31 26204 5570 63457217
Biliary sepsis 51.61 12.91 18 26217 913 63461874
Jaundice 51.50 12.91 62 26173 29189 63433598
Rash maculo-papular 50.36 12.91 64 26171 31832 63430955
Gamma-glutamyltransferase increased 50.16 12.91 66 26169 33965 63428822
Headache 49.29 12.91 119 26116 633122 62829665
Arteriovenous fistula occlusion 49.06 12.91 14 26221 365 63462422
Discomfort 48.57 12.91 6 26229 167368 63295419
Alopecia 47.25 12.91 42 26193 337494 63125293
Treatment failure 47.25 12.91 12 26223 199031 63263756
Venous pressure jugular decreased 46.86 12.91 9 26226 35 63462752
Sepsis 46.41 12.91 154 26081 152969 63309818
Thrombosis 46.00 12.91 90 26145 64665 63398122
Activated partial thromboplastin time prolonged 45.87 12.91 31 26204 6862 63455925
Haemoglobin decreased 45.60 12.91 148 26087 145337 63317450
Melaena 44.92 12.91 59 26176 30306 63432481
Dermatitis exfoliative 44.79 12.91 28 26207 5431 63457356
Haematoma 44.47 12.91 63 26172 34757 63428030
Hyperkalaemia 44.31 12.91 80 26155 54123 63408664
Agranulocytosis 43.80 12.91 53 26182 25081 63437706
Premature delivery 43.51 12.91 58 26177 30223 63432564
Hyperthyroidism 43.45 12.91 41 26194 14632 63448155
Drug hypersensitivity 43.07 12.91 39 26196 310648 63152139
Normal newborn 42.77 12.91 32 26203 8309 63454478
Pericarditis 42.73 12.91 3 26232 131576 63331211
Vessel puncture site bruise 42.40 12.91 13 26222 437 63462350
Blood creatinine increased 40.81 12.91 103 26132 87741 63375046
Adrenal suppression 40.45 12.91 15 26220 909 63461878
Wound 40.40 12.91 9 26226 163254 63299533
Pain 40.12 12.91 164 26071 740464 62722323
Pituitary tumour 40.07 12.91 15 26220 933 63461854
Premature baby 39.90 12.91 46 26189 20689 63442098
Abdominal wall haematoma 39.31 12.91 21 26214 3034 63459753
Ascites 37.03 12.91 63 26172 40665 63422122
Body dysmorphic disorder 36.98 12.91 11 26224 333 63462454
Musculoskeletal stiffness 36.96 12.91 15 26220 184603 63278184
Ovarian hyperstimulation syndrome 36.54 12.91 22 26213 3992 63458795
Gastrointestinal haemorrhage 36.48 12.91 94 26141 81082 63381705
Blood loss anaemia 36.36 12.91 30 26205 8971 63453816
Diarrhoea haemorrhagic 36.24 12.91 30 26205 9012 63453775
Hypothalamo-pituitary disorder 35.84 12.91 13 26222 740 63462047
Malignant neoplasm progression 35.78 12.91 94 26141 82027 63380760
Epistaxis 35.59 12.91 87 26148 72638 63390149
Abdominal wall haemorrhage 35.18 12.91 9 26226 153 63462634
Constipation 34.07 12.91 183 26052 224760 63238027
Contraindicated product administered 33.01 12.91 25 26210 217623 63245164
Pyrexia 32.20 12.91 316 25919 470162 62992625
Depression 31.87 12.91 21 26214 196471 63266316
Cardiac failure 30.96 12.91 94 26141 89048 63373739
Haematoma muscle 30.64 12.91 13 26222 1124 63461663
Pneumothorax traumatic 30.14 12.91 8 26227 158 63462629
Perforation 30.14 12.91 13 26222 1170 63461617
Electrolyte imbalance 29.68 12.91 39 26196 20037 63442750
Infusion related reaction 29.29 12.91 35 26200 245486 63217301
Acute generalised exanthematous pustulosis 29.08 12.91 29 26206 11070 63451717
Intra-abdominal haemorrhage 29.07 12.91 16 26219 2453 63460334
Impaired healing 28.96 12.91 4 26231 102538 63360249
Fatigue 28.93 12.91 232 26003 887796 62574991
Cerebral haemorrhage 28.55 12.91 48 26187 30681 63432106
Drug interaction 28.55 12.91 177 26058 228954 63233833
Joint ankylosis 28.32 12.91 12 26223 1034 63461753
Hypersensitivity 27.77 12.91 49 26186 292636 63170151
Gastric antral vascular ectasia 26.79 12.91 10 26225 617 63462170
Exposure during pregnancy 26.64 12.91 131 26104 155416 63307371
Cardiomyopathy acute 26.50 12.91 8 26227 255 63462532
Neoplasm progression 26.31 12.91 51 26184 36377 63426410
Cholecystitis 26.10 12.91 32 26203 15345 63447442
Eosinophilia 25.90 12.91 39 26196 22717 63440070
Leukopenia 25.44 12.91 80 26155 77210 63385577
Muscle haemorrhage 25.31 12.91 16 26219 3163 63459624
Catheter site thrombosis 25.12 12.91 7 26228 167 63462620
Blood alkaline phosphatase increased 24.97 12.91 55 26180 42912 63419875
Psychiatric decompensation 24.96 12.91 12 26223 1389 63461398
Fracture blisters 24.81 12.91 6 26229 80 63462707
Multiple organ dysfunction syndrome 24.75 12.91 65 26170 56687 63406100
International normalised ratio increased 24.28 12.91 57 26178 46368 63416419
Pleural effusion 24.11 12.91 89 26146 93121 63369666
Bone marrow eosinophilic leukocyte count increased 23.97 12.91 5 26230 32 63462755
Feeling abnormal 23.86 12.91 16 26219 148376 63314411
Diarrhoea 23.78 12.91 421 25814 714945 62747842
Femoral neck fracture 23.69 12.91 23 26212 8500 63454287
Blood cholesterol increased 23.63 12.91 5 26230 94027 63368760
Ill-defined disorder 23.54 12.91 3 26232 81752 63381035
Caesarean section 23.51 12.91 32 26203 17000 63445787
Hypokalaemia 23.49 12.91 95 26140 103709 63359078
Cerebellar haematoma 23.30 12.91 8 26227 387 63462400
Embolism 23.23 12.91 22 26213 7884 63454903
Cerebral infarction 23.10 12.91 38 26197 23855 63438932
Allergic hepatitis 23.10 12.91 5 26230 39 63462748
Haemoptysis 22.96 12.91 42 26193 28684 63434103
Renal tubular acidosis 22.82 12.91 12 26223 1680 63461107
Bronchopulmonary dysplasia 22.58 12.91 8 26227 425 63462362
Pneumobilia 22.35 12.91 6 26229 124 63462663
Foetal growth restriction 22.16 12.91 21 26214 7532 63455255
Retroperitoneal haemorrhage 22.08 12.91 14 26221 2783 63460004
Erythema 22.02 12.91 136 26099 175615 63287172
Haemorrhagic erosive gastritis 21.89 12.91 8 26227 465 63462322
Hepatitis cholestatic 21.87 12.91 20 26215 6858 63455929
Skin warm 21.60 12.91 18 26217 5458 63457329
Granulomatous liver disease 21.31 12.91 9 26226 769 63462018
Gastrointestinal disorder 21.30 12.91 14 26221 131225 63331562
Therapeutic product effect incomplete 20.76 12.91 13 26222 125043 63337744
Haemorrhagic thyroid cyst 20.74 12.91 4 26231 16 63462771
Thrombophlebitis 20.72 12.91 16 26219 4352 63458435
Rash 20.35 12.91 142 26093 560729 62902058
Phlebitis 20.31 12.91 19 26216 6705 63456082
Limbal swelling 20.18 12.91 4 26231 19 63462768
Hypoaesthesia 20.08 12.91 24 26211 168369 63294418
Disease progression 20.03 12.91 102 26133 122656 63340131
Product use issue 19.94 12.91 38 26197 220482 63242305
Subcutaneous haematoma 19.86 12.91 11 26224 1707 63461080
Swelling 19.61 12.91 54 26181 275324 63187463
Gastric ulcer 19.03 12.91 35 26200 24002 63438785
Anaemia folate deficiency 18.97 12.91 6 26229 224 63462563
Toxicity to various agents 18.73 12.91 47 26188 247203 63215584
Hyperlipasaemia 18.71 12.91 8 26227 705 63462082
Restlessness 18.60 12.91 39 26196 29414 63433373
Haemangioma congenital 18.55 12.91 7 26228 445 63462342
Gestational diabetes 18.51 12.91 20 26215 8376 63454411
Protein S decreased 18.39 12.91 4 26231 32 63462755
Autoimmune heparin-induced thrombocytopenia 18.30 12.91 3 26232 3 63462784
Mobility decreased 18.25 12.91 14 26221 121145 63341642
Maternal drugs affecting foetus 18.16 12.91 16 26219 5226 63457561
Haemorrhage 18.13 12.91 61 26174 60961 63401826
Pericardial effusion 18.06 12.91 39 26196 30019 63432768
Abdominal pain 18.06 12.91 193 26042 293263 63169524
Cell death 18.03 12.91 12 26223 2589 63460198
Cholestatic liver injury 17.99 12.91 12 26223 2598 63460189
Protein C decreased 17.78 12.91 4 26231 38 63462749
Mucosal inflammation 17.73 12.91 51 26184 46877 63415910
Faecaloma 17.65 12.91 19 26216 7922 63454865
Chemotherapeutic drug level increased 17.32 12.91 5 26230 136 63462651
Rectal haemorrhage 17.29 12.91 52 26183 48978 63413809
Respiratory disorder 17.28 12.91 45 26190 39037 63423750
Subcutaneous abscess 17.27 12.91 16 26219 5580 63457207
Lordosis 17.15 12.91 6 26229 307 63462480
Insomnia 17.03 12.91 40 26195 215212 63247575
Acidosis 16.88 12.91 22 26213 11211 63451576
Alanine aminotransferase increased 16.77 12.91 86 26149 103684 63359103
Intra-abdominal haematoma 16.71 12.91 10 26225 1795 63460992
Gastrointestinal tract adenoma 16.70 12.91 6 26229 332 63462455
Hepatic function abnormal 16.66 12.91 43 26192 37099 63425688
Sudden death 16.54 12.91 21 26214 10428 63452359
Asthma 16.50 12.91 17 26218 127544 63335243
Haemolysis 16.48 12.91 17 26218 6751 63456036
Anterior segment ischaemia 16.43 12.91 4 26231 55 63462732
Visual acuity reduced transiently 16.43 12.91 5 26230 164 63462623
Cerebral haematoma 16.41 12.91 13 26222 3670 63459117
Liver iron concentration abnormal 16.23 12.91 4 26231 58 63462729
Antibiotic level above therapeutic 16.11 12.91 6 26229 368 63462419
Pharyngeal haematoma 16.04 12.91 4 26231 61 63462726
Therapeutic response decreased 16.02 12.91 3 26232 61522 63401265
Chest X-ray abnormal 15.99 12.91 14 26221 4535 63458252
Varices oesophageal 15.97 12.91 12 26223 3136 63459651
Respiratory distress 15.95 12.91 40 26195 33911 63428876
Interstitial lung disease 15.91 12.91 59 26176 61849 63400938
Cholelithiasis 15.88 12.91 47 26188 43878 63418909
Cardiac hypertrophy 15.79 12.91 8 26227 1037 63461750
Magnetic resonance imaging head abnormal 15.70 12.91 10 26225 2003 63460784
Upper gastrointestinal haemorrhage 15.62 12.91 28 26207 18824 63443963
Hepatic cytolysis 15.57 12.91 25 26210 15382 63447405
Migraine 15.49 12.91 12 26223 103334 63359453
Therapy non-responder 15.45 12.91 6 26229 75895 63386892
Gait disturbance 15.33 12.91 33 26202 183145 63279642
Infantile haemangioma 15.22 12.91 4 26231 76 63462711
Adverse drug reaction 15.11 12.91 7 26228 79707 63383080
Thyroid haemorrhage 15.07 12.91 4 26231 79 63462708
Persecutory delusion 14.97 12.91 11 26224 2779 63460008
Peritonitis 14.89 12.91 26 26209 17128 63445659
Type 2 diabetes mellitus 14.85 12.91 4 26231 63864 63398923
Cardiac failure congestive 14.81 12.91 10 26225 92423 63370364
Hydronephrosis 14.67 12.91 20 26215 10642 63452145
Stevens-Johnson syndrome 14.56 12.91 32 26203 24918 63437869
Upper respiratory tract infection 14.36 12.91 8 26227 82039 63380748
Intracranial pressure increased 14.33 12.91 14 26221 5213 63457574
Adverse event 14.33 12.91 5 26230 67554 63395233
Shock haemorrhagic 14.28 12.91 19 26216 9876 63452911
Arteriovenous fistula site complication 14.27 12.91 6 26229 507 63462280
Peripheral swelling 14.25 12.91 59 26176 265883 63196904
Humerus fracture 14.24 12.91 18 26217 8898 63453889
Post procedural haematoma 14.23 12.91 8 26227 1277 63461510
Catheter site injury 14.18 12.91 5 26230 262 63462525
CSF white blood cell count decreased 14.15 12.91 3 26232 21 63462766
Thrombosis prophylaxis 14.02 12.91 3 26232 22 63462765
Clostridium difficile colitis 13.89 12.91 28 26207 20541 63442246
Polyneuropathy 13.83 12.91 23 26212 14566 63448221
Right ventricular dilatation 13.72 12.91 8 26227 1368 63461419
Loss of personal independence in daily activities 13.71 12.91 12 26223 97278 63365509
Muscle strain 13.69 12.91 17 26218 8257 63454530
Nasal congestion 13.69 12.91 5 26230 65655 63397132
Purulent discharge 13.65 12.91 13 26222 4693 63458094
Dizziness 13.61 12.91 113 26122 429812 63032975
Vascular occlusion 13.51 12.91 7 26228 950 63461837
Reticulocyte count increased 13.42 12.91 7 26228 963 63461824
Injection site erythema 13.32 12.91 9 26226 83165 63379622
Thrombotic microangiopathy 13.32 12.91 19 26216 10542 63452245
Anxiety disorder 13.32 12.91 12 26223 4038 63458749
Renal pain 13.30 12.91 15 26220 6584 63456203
Strabismus 13.26 12.91 9 26226 2005 63460782
Cardiac arrest 13.12 12.91 74 26161 92471 63370316
Varicophlebitis 13.11 12.91 3 26232 31 63462756
Rectosigmoid cancer metastatic 13.11 12.91 3 26232 31 63462756
Thrombocytosis 13.07 12.91 14 26221 5804 63456983
Malnutrition 13.03 12.91 23 26212 15275 63447512
Injury 13.03 12.91 7 26228 73240 63389547
Anaphylactic reaction 13.01 12.91 58 26177 66042 63396745
Mucosal erosion 13.01 12.91 8 26227 1508 63461279
Disseminated intravascular coagulation 12.94 12.91 26 26209 19025 63443762
Congenital genitourinary abnormality 12.94 12.91 3 26232 33 63462754
Gastrointestinal stoma output increased 12.92 12.91 5 26230 341 63462446

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 319.90 13.87 147 25976 8454 34922354
Appendicitis 252.46 13.87 150 25973 14657 34916151
General physical health deterioration 233.89 13.87 375 25748 127894 34802914
Cardiogenic shock 204.38 13.87 165 25958 26453 34904355
Stress 156.38 13.87 150 25973 30197 34900611
Ascites 139.59 13.87 173 25950 46398 34884410
Multiple organ dysfunction syndrome 134.02 13.87 220 25903 76346 34854462
Ventricular fibrillation 132.75 13.87 121 26002 22833 34907975
Drug ineffective 131.24 13.87 91 26032 456660 34474148
Blood phosphorus increased 128.39 13.87 77 26046 7644 34923164
Hyponatraemia 122.91 13.87 221 25902 82470 34848338
Abdominal distension 118.83 13.87 180 25943 58312 34872496
Pulmonary embolism 112.47 13.87 223 25900 89523 34841285
Sepsis 107.37 13.87 320 25803 166241 34764567
Abdominal pain 94.87 13.87 303 25820 163315 34767493
Toxic epidermal necrolysis 77.33 13.87 88 26035 21558 34909250
Hepatocellular injury 73.82 13.87 87 26036 22124 34908684
Dry mouth 70.15 13.87 99 26024 30066 34900742
Thrombocytopenia 65.30 13.87 260 25863 155987 34774821
Heparin-induced thrombocytopenia 59.11 13.87 42 26081 5553 34925255
Toxicity to various agents 58.50 13.87 39 26084 200323 34730485
Drug abuse 58.47 13.87 4 26119 99092 34831716
Lymph node calcification 57.79 13.87 15 26108 143 34930665
Acute kidney injury 49.01 13.87 392 25731 304596 34626212
Constipation 48.66 13.87 217 25906 136765 34794043
Blood uric acid increased 46.58 13.87 46 26077 9578 34921230
Myasthenia gravis 44.89 13.87 39 26084 6901 34923907
Respiratory tract infection bacterial 43.87 13.87 23 26100 1759 34929049
Respiratory tract infection viral 39.00 13.87 24 26099 2493 34928315
Pulmonary sarcoidosis 34.72 13.87 14 26109 582 34930226
Haemorrhage 34.20 13.87 100 26023 51270 34879538
Shock haemorrhagic 33.68 13.87 42 26081 11312 34919496
Feeling abnormal 33.41 13.87 4 26119 63231 34867577
Vomiting 33.24 13.87 306 25817 247315 34683493
Haematemesis 32.42 13.87 67 26056 27644 34903164
Aplasia 32.16 13.87 27 26096 4561 34926247
Drug therapy 31.77 13.87 16 26107 1125 34929683
Respiratory tract infection 30.91 13.87 54 26069 19658 34911150
Dizziness 30.88 13.87 74 26049 218447 34712361
Cardiac failure congestive 30.53 13.87 12 26111 83258 34847550
Suspected product quality issue 29.85 13.87 9 26114 154 34930654
Splenic vein thrombosis 29.64 13.87 12 26111 504 34930304
Depression 29.53 13.87 18 26105 97080 34833728
Bronchial obstruction 29.17 13.87 17 26106 1599 34929209
Hepatic haematoma 28.70 13.87 11 26112 399 34930409
Neutropenia 28.14 13.87 207 25916 156571 34774237
Metastatic malignant melanoma 27.85 13.87 18 26105 2037 34928771
Analgesic therapy 27.80 13.87 14 26109 984 34929824
Peritoneal haematoma 27.43 13.87 7 26116 62 34930746
Hyperkalaemia 26.95 13.87 113 26010 69276 34861532
Lower respiratory tract infection 26.47 13.87 67 26056 31570 34899238
Bronchial disorder 25.96 13.87 15 26108 1388 34929420
Death 25.81 13.87 183 25940 397866 34532942
Hyperphosphataemia 24.87 13.87 23 26100 4414 34926394
Product dose omission issue 24.63 13.87 32 26091 119679 34811129
Sleep disorder therapy 24.60 13.87 13 26110 1010 34929798
Cholestasis 24.59 13.87 59 26064 26889 34903919
Insomnia 24.37 13.87 25 26098 103882 34826926
Portal vein thrombosis 23.92 13.87 21 26102 3767 34927041
Anastomotic infection 23.54 13.87 7 26116 114 34930694
Floppy infant 23.54 13.87 7 26116 114 34930694
Pancytopenia 23.38 13.87 136 25987 95021 34835787
Genitalia external ambiguous 22.86 13.87 8 26115 223 34930585
Therapeutic product effect incomplete 22.68 13.87 5 26118 50536 34880272
Rash maculo-papular 22.51 13.87 59 26064 28392 34902416
Febrile neutropenia 22.47 13.87 177 25946 136672 34794136
Muscle haemorrhage 22.26 13.87 20 26103 3698 34927110
Haematoma 22.23 13.87 55 26068 25550 34905258
Arthralgia 22.13 13.87 60 26063 169981 34760827
Mucosal inflammation 21.81 13.87 71 26052 38551 34892257
Anaemia 21.73 13.87 268 25855 233067 34697741
Embolism 21.70 13.87 28 26095 7801 34923007
Oesophagitis 21.67 13.87 37 26086 13224 34917584
Chondrocalcinosis 21.56 13.87 9 26114 409 34930399
Hypertrophic osteoarthropathy 21.35 13.87 6 26117 79 34930729
Congenital bladder anomaly 21.28 13.87 8 26115 275 34930533
Myalgia 21.16 13.87 19 26104 84091 34846717
Iron deficiency 21.14 13.87 23 26100 5358 34925450
Lung cancer metastatic 20.78 13.87 17 26106 2770 34928038
Drug reaction with eosinophilia and systemic symptoms 20.76 13.87 63 26060 32949 34897859
Mucosal disorder 20.68 13.87 14 26109 1712 34929096
Hepatic cytolysis 20.54 13.87 38 26085 14458 34916350
Haemorrhagic disorder 20.18 13.87 10 26113 679 34930129
Eosinophil percentage decreased 20.16 13.87 6 26117 98 34930710
Neutropenic infection 20 13.87 13 26110 1485 34929323
Diastasis recti abdominis 19.93 13.87 5 26118 41 34930767
Fall 19.93 13.87 81 26042 202804 34728004
Incorrect route of product administration 19.89 13.87 38 26085 14807 34916001
Septic shock 19.18 13.87 105 26018 71729 34859079
Coagulation factor VII level decreased 19.07 13.87 6 26117 119 34930689
Respiratory disorder neonatal 19 13.87 13 26110 1617 34929191
Epistaxis 18.94 13.87 90 26033 58161 34872647
Foetal hypokinesia 18.91 13.87 8 26115 376 34930432
Blood cholesterol increased 18.76 13.87 45 26078 20498 34910310
Vascular device infection 18.41 13.87 19 26104 4166 34926642
Treatment failure 18.35 13.87 6 26117 46691 34884117
Pulmonary infarction 18.26 13.87 12 26111 1396 34929412
Therapeutic product effect prolonged 18.26 13.87 7 26116 254 34930554
Neonatal respiratory depression 18.13 13.87 8 26115 417 34930391
Anxiety 18.06 13.87 29 26094 99399 34831409
Prothrombin time shortened 17.84 13.87 12 26111 1452 34929356
Gamma-glutamyltransferase increased 17.65 13.87 55 26068 29176 34901632
Headache 17.35 13.87 84 26039 200551 34730257
Suicide attempt 17.29 13.87 4 26119 39112 34891696
Myocardial infarction 17.08 13.87 41 26082 121044 34809764
Abdominal discomfort 16.95 13.87 12 26111 59823 34870985
Klebsiella infection 16.93 13.87 26 26097 8505 34922303
Pulmonary artery thrombosis 16.57 13.87 9 26114 739 34930069
Therapeutic product effect decreased 16.50 13.87 3 26120 34740 34896068
Thrombosis 16.43 13.87 78 26045 50380 34880428
Abdominal sepsis 16.37 13.87 10 26113 1025 34929783
Jaundice cholestatic 16.29 13.87 19 26104 4775 34926033
Bladder tamponade 16.27 13.87 8 26115 534 34930274
Butterfly rash 15.71 13.87 5 26118 103 34930705
Compartment syndrome 15.68 13.87 15 26108 3003 34927805
Wrong strength 15.67 13.87 5 26118 104 34930704
Blood pressure diastolic increased 15.57 13.87 19 26104 5006 34925802
Foetal exposure during delivery 15.53 13.87 5 26118 107 34930701
Haemolytic anaemia 15.51 13.87 28 26095 10451 34920357
Needle issue 15.47 13.87 21 26102 6144 34924664
Cardiac flutter 15.30 13.87 12 26111 1841 34928967
Bacterial infection 15.18 13.87 37 26086 17026 34913782
Thrombocytosis 15.16 13.87 17 26106 4095 34926713
Nausea 15.11 13.87 346 25777 339562 34591246
Mental status changes 14.77 13.87 5 26118 38078 34892730
Hypophosphataemia 14.50 13.87 28 26095 10998 34919810
Hospitalisation 14.13 13.87 13 26110 56889 34873919
Penile necrosis 14.08 13.87 4 26119 55 34930753
Pyrexia 13.88 13.87 336 25787 332677 34598131

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 345.10 11.79 146 48766 8405 79687071
General physical health deterioration 322.69 11.79 593 48319 274645 79420831
Pulmonary embolism 313.09 11.79 452 48460 171202 79524274
Drug ineffective 242.93 11.79 186 48726 1080727 78614749
Appendicitis 235.13 11.79 151 48761 20643 79674833
Thrombocytopenia 222.97 11.79 498 48414 264761 79430715
Cardiogenic shock 204.10 11.79 184 48728 41730 79653746
Hepatocellular injury 201.01 11.79 193 48719 47400 79648076
Toxic epidermal necrolysis 190.57 11.79 182 48730 44399 79651077
Ascites 170.86 11.79 221 48691 75341 79620135
Acute kidney injury 158.59 11.79 684 48228 518720 79176756
Multiple organ dysfunction syndrome 158.45 11.79 273 48639 119973 79575503
Sepsis 157.90 11.79 441 48471 268987 79426489
Heparin-induced thrombocytopenia 144.55 11.79 84 48828 9598 79685878
Blood phosphorus increased 126.60 11.79 79 48833 10268 79685208
Ventricular fibrillation 120.88 11.79 122 48790 31804 79663672
Anaemia 108.38 11.79 549 48363 444466 79251010
Arthralgia 98.33 11.79 124 48788 571679 79123797
Abdominal distension 97.35 11.79 222 48690 119428 79576048
Hyponatraemia 97.14 11.79 284 48628 177564 79517912
Toxicity to various agents 94.87 11.79 72 48840 421468 79274008
Constipation 91.72 11.79 380 48532 282670 79412806
Cholestasis 91.57 11.79 135 48777 51974 79643502
Abdominal pain 86.09 11.79 468 48444 389101 79306375
Drug abuse 79.91 11.79 5 48907 162686 79532790
Arthropathy 79.87 11.79 8 48904 177103 79518373
Therapeutic product effect decreased 77.69 11.79 6 48906 163857 79531619
Stress 70.68 11.79 153 48759 79459 79616017
Febrile neutropenia 69.27 11.79 303 48609 230696 79464780
Headache 68.05 11.79 192 48720 653580 79041896
Pancytopenia 68.02 11.79 240 48672 165505 79529971
Neutropenia 67.84 11.79 352 48560 287358 79408118
Hyperkalaemia 67.60 11.79 188 48724 114210 79581266
Drug reaction with eosinophilia and systemic symptoms 64.66 11.79 130 48782 64114 79631362
Abdominal discomfort 64.21 11.79 37 48875 250690 79444786
Sinusitis 64.19 11.79 20 48892 195481 79499995
Joint swelling 63.99 11.79 50 48862 288596 79406880
Drug intolerance 63.45 11.79 42 48870 264077 79431399
Neutropenic sepsis 62.45 11.79 80 48832 26984 79668492
Rash maculo-papular 61.93 11.79 118 48794 55960 79639516
Blood uric acid increased 61.78 11.79 57 48855 13303 79682173
Gamma-glutamyltransferase increased 60.31 11.79 115 48797 54565 79640911
Haematoma 59.09 11.79 111 48801 52084 79643392
Product dose omission issue 58.60 11.79 40 48872 247497 79447979
Deep vein thrombosis 57.48 11.79 184 48728 120735 79574741
Treatment failure 56.77 11.79 17 48895 170469 79525007
Rheumatoid arthritis 55.94 11.79 29 48883 208441 79487035
Thrombosis 54.48 11.79 143 48769 83957 79611519
Discomfort 53.31 11.79 7 48905 125610 79569866
Epistaxis 53.28 11.79 170 48742 111345 79584131
Depression 52.70 11.79 34 48878 216756 79478720
Systemic lupus erythematosus 50.82 11.79 7 48905 121142 79574334
Malignant neoplasm progression 50.77 11.79 191 48721 135799 79559677
Lymph node calcification 50.51 11.79 16 48896 399 79695077
Pemphigus 49.07 11.79 3 48909 99579 79595897
Shock haemorrhagic 48.99 11.79 61 48851 19999 79675477
Musculoskeletal stiffness 48.98 11.79 23 48889 174985 79520491
Glossodynia 48.37 11.79 4 48908 103333 79592143
Respiratory tract infection bacterial 47.74 11.79 24 48888 2053 79693423
Feeling abnormal 47.61 11.79 19 48893 159180 79536296
Cytokine release syndrome 46.40 11.79 81 48831 35917 79659559
Embolism 44.99 11.79 49 48863 13933 79681543
Haemoglobin decreased 44.43 11.79 260 48652 221859 79473617
Blood loss anaemia 42.53 11.79 50 48862 15448 79680028
Aplasia 41.37 11.79 36 48876 7784 79687692
Blue toe syndrome 41.21 11.79 15 48897 576 79694900
Jaundice 41.17 11.79 97 48815 53252 79642224
Respiratory tract infection viral 41.03 11.79 28 48884 4231 79691245
Cardiac failure congestive 40.96 11.79 18 48894 142384 79553092
Haemorrhage 40.90 11.79 136 48776 90982 79604494
Therapeutic product effect incomplete 40.59 11.79 18 48894 141627 79553849
Agranulocytosis 40.48 11.79 87 48825 44943 79650533
Alopecia 39.83 11.79 50 48862 231305 79464171
Myasthenia gravis 39.83 11.79 40 48872 10359 79685117
Muscle haemorrhage 39.52 11.79 32 48880 6268 79689208
Cerebral haemorrhage 39.34 11.79 100 48812 57573 79637903
Arteriovenous fistula occlusion 38.45 11.79 14 48898 538 79694938
Infusion related reaction 38.36 11.79 51 48861 230186 79465290
Hyperthyroidism 38.23 11.79 57 48855 22152 79673324
Biliary sepsis 38.10 11.79 19 48893 1598 79693878
Hypersensitivity 37.96 11.79 64 48848 262175 79433301
Melaena 37.87 11.79 102 48810 60788 79634688
Hepatic cytolysis 37.50 11.79 63 48849 27088 79668388
Blood creatine increased 37.38 11.79 37 48875 9418 79686058
Venous pressure jugular decreased 36.80 11.79 9 48903 82 79695394
Dizziness 36.76 11.79 182 48730 526259 79169217
Pyrexia 36.71 11.79 602 48310 678107 79017369
Insomnia 36.26 11.79 59 48853 245111 79450365
Wound 36.18 11.79 13 48899 116166 79579310
Haematemesis 36.04 11.79 91 48821 52173 79643303
Vessel puncture site bruise 35.72 11.79 13 48899 499 79694977
Pain 34.31 11.79 272 48640 703530 78991946
Normal newborn 34.31 11.79 31 48881 7041 79688435
Drug therapy 33.99 11.79 16 48896 1185 79694291
Psoriatic arthropathy 33.94 11.79 4 48908 77995 79617481
Body dysmorphic disorder 33.32 11.79 11 48901 314 79695162
Fatigue 33.19 11.79 388 48524 929339 78766137
Premature delivery 33.14 11.79 55 48857 23412 79672064
Gastrointestinal haemorrhage 32.88 11.79 178 48734 147541 79547935
Activated partial thromboplastin time prolonged 32.73 11.79 42 48870 14186 79681290
Phlebitis 32.06 11.79 33 48879 8797 79686679
Hepatitis cholestatic 32.04 11.79 41 48871 13811 79681665
Blood alkaline phosphatase increased 31.26 11.79 98 48814 63566 79631910
Ovarian hyperstimulation syndrome 30.95 11.79 22 48890 3549 79691927
Nasal congestion 30.77 11.79 5 48907 76547 79618929
Needle issue 30.73 11.79 39 48873 13029 79682447
Pituitary tumour 30.70 11.79 15 48897 1207 79694269
Gait disturbance 30.62 11.79 50 48862 207456 79488020
Mucosal inflammation 30.59 11.79 109 48803 75471 79620005
Analgesic therapy 30.29 11.79 14 48898 995 79694481
Therapeutic response decreased 30.17 11.79 3 48909 66850 79628626
Duodenal ulcer perforation 29.81 11.79 3 48909 66208 79629268
Ill-defined disorder 29.62 11.79 3 48909 65872 79629604
Haematoma muscle 29.58 11.79 19 48893 2596 79692880
Hyperphosphataemia 29.08 11.79 27 48885 6349 79689127
Pulmonary sarcoidosis 29.00 11.79 15 48897 1362 79694114
Abdominal wall haematoma 28.99 11.79 24 48888 4849 79690627
Adrenal suppression 28.78 11.79 15 48897 1384 79694092
Neoplasm progression 28.62 11.79 83 48829 51599 79643877
Intra-abdominal haemorrhage 28.35 11.79 23 48889 4517 79690959
Vomiting 28.04 11.79 568 48344 665260 79030216
Asthma 27.94 11.79 25 48887 135070 79560406
Mobility decreased 27.25 11.79 21 48891 122154 79573322
Pericarditis 27.21 11.79 15 48897 104221 79591255
Sleep disorder therapy 27.02 11.79 13 48899 1011 79694465
Splenic vein thrombosis 26.71 11.79 12 48900 798 79694678
Intentional overdose 26.59 11.79 16 48896 105944 79589532
Dermatitis exfoliative 26.55 11.79 33 48879 10796 79684680
Bronchial obstruction 26.20 11.79 18 48894 2750 79692726
Peritonitis 26.16 11.79 55 48857 27981 79667495
Hepatic haematoma 26.01 11.79 12 48900 849 79694627
Peripheral swelling 25.92 11.79 82 48830 269535 79425941
Hypokalaemia 25.85 11.79 164 48748 143876 79551600
Lung cancer metastatic 25.80 11.79 20 48892 3679 79691797
Suspected product quality issue 25.71 11.79 9 48903 308 79695168
Diarrhoea 25.44 11.79 713 48199 879776 78815700
Thrombophlebitis 25.43 11.79 25 48887 6310 79689166
Septic shock 25.34 11.79 145 48767 122656 79572820
Portal vein thrombosis 25.28 11.79 24 48888 5803 79689673
Dry mouth 25.23 11.79 114 48798 87905 79607571
Hypothalamo-pituitary disorder 25.13 11.79 13 48899 1181 79694295
Limbal swelling 24.16 11.79 5 48907 19 79695457
Haemolytic anaemia 24.14 11.79 41 48871 17779 79677697
Nasopharyngitis 23.86 11.79 78 48834 253803 79441673
Subcutaneous haematoma 23.82 11.79 17 48895 2760 79692716
Migraine 23.71 11.79 12 48900 87481 79607995
Anastomotic infection 23.70 11.79 7 48905 137 79695339
Cell death 23.59 11.79 21 48891 4678 79690798
Rash 23.53 11.79 234 48678 578124 79117352
Rectal haemorrhage 23.52 11.79 101 48811 76199 79619277
Metastatic malignant melanoma 23.35 11.79 17 48895 2846 79692630
Pneumothorax traumatic 23.25 11.79 8 48904 260 79695216
Adverse drug reaction 23.24 11.79 6 48906 66386 79629090
Bronchial disorder 23.12 11.79 16 48896 2473 79693003
Oesophagitis 23.07 11.79 48 48864 24241 79671235
Pulmonary infarction 22.99 11.79 19 48893 3830 79691646
Retroperitoneal haemorrhage 22.73 11.79 22 48890 5448 79690028
Acute generalised exanthematous pustulosis 22.46 11.79 39 48873 17215 79678261
Fracture blisters 22.46 11.79 6 48906 80 79695396
Loss of personal independence in daily activities 22.41 11.79 18 48894 102562 79592914
Catheter site thrombosis 22.34 11.79 8 48904 293 79695183
Drug hypersensitivity 22.19 11.79 101 48811 298815 79396661
Clostridium difficile colitis 22.03 11.79 56 48856 32227 79663249
Myalgia 21.94 11.79 51 48861 185590 79509886
Bone marrow eosinophilic leukocyte count increased 21.87 11.79 5 48907 33 79695443
Gastric antral vascular ectasia 21.81 11.79 11 48901 947 79694529
Cardiomyopathy acute 21.79 11.79 8 48904 315 79695161
Leukopenia 21.74 11.79 134 48778 116379 79579097
Folliculitis 21.42 11.79 4 48908 55376 79640100
Neutropenic infection 21.14 11.79 15 48897 2412 79693064
Klebsiella infection 21.08 11.79 36 48876 15684 79679792
Peritoneal haematoma 21.06 11.79 7 48905 204 79695272
Allergic hepatitis 20.81 11.79 5 48907 42 79695434
Haemolysis 20.80 11.79 32 48880 12780 79682696
Iron deficiency 20.76 11.79 29 48883 10625 79684851
Injury 20.45 11.79 11 48901 77485 79617991
Gastrointestinal disorder 20.41 11.79 27 48885 122178 79573298
Perforation 20.30 11.79 12 48900 1414 79694062
Compartment syndrome 20.30 11.79 20 48892 5062 79690414
Hypertrophic osteoarthropathy 20.10 11.79 6 48906 122 79695354
Hyperthermia 19.96 11.79 38 48874 17999 79677477
Gastrointestinal stoma output increased 19.91 11.79 8 48904 403 79695073
Hypoaesthesia 19.84 11.79 51 48861 179301 79516175
Treatment noncompliance 19.74 11.79 4 48908 52264 79643212
Retroperitoneal haematoma 19.60 11.79 20 48892 5277 79690199
Thrombocytosis 19.35 11.79 25 48887 8501 79686975
Weight increased 19.26 11.79 96 48816 277290 79418186
Haemorrhagic thyroid cyst 19.16 11.79 4 48908 16 79695460
Blood creatinine increased 18.90 11.79 161 48751 154896 79540580
Abdominal wall haemorrhage 18.89 11.79 9 48903 685 79694791
Suicide attempt 18.82 11.79 14 48898 82918 79612558
Diarrhoea haemorrhagic 18.66 11.79 31 48881 13203 79682273
Reading disorder 18.51 11.79 10 48902 992 79694484
Balance disorder 18.47 11.79 20 48892 98837 79596639
Eosinophil percentage decreased 18.39 11.79 7 48905 305 79695171
Pleural effusion 18.33 11.79 152 48760 145110 79550366
Chondrocalcinosis 18.02 11.79 10 48902 1046 79694430
Livedo reticularis 17.99 11.79 17 48895 4086 79691390
Pulmonary artery thrombosis 17.97 11.79 11 48901 1381 79694095
Upper gastrointestinal haemorrhage 17.88 11.79 61 48851 41319 79654157
Respiratory distress 17.81 11.79 77 48835 58262 79637214
Hospitalisation 17.68 11.79 19 48893 94217 79601259
Basilar artery occlusion 17.26 11.79 6 48906 201 79695275
Impaired healing 17.20 11.79 17 48895 87638 79607838
Bladder tamponade 17.10 11.79 8 48904 584 79694892
International normalised ratio increased 16.80 11.79 99 48813 84622 79610854
Injection site erythema 16.74 11.79 14 48898 78183 79617293
Adverse event 16.70 11.79 8 48904 60206 79635270
Influenza 16.64 11.79 34 48878 129572 79565904
Coagulation factor VII level decreased 16.59 11.79 6 48906 226 79695250
Cerebellar haematoma 16.56 11.79 8 48904 628 79694848
Drug resistance 16.43 11.79 3 48909 42210 79653266
Pneumobilia 16.42 11.79 6 48906 233 79695243
Dysgraphia 16.35 11.79 16 48896 4016 79691460
Transaminases increased 16.34 11.79 69 48843 51674 79643802
Pain in extremity 16.30 11.79 144 48768 364394 79331082
Femoral neck fracture 16.30 11.79 25 48887 9959 79685517
Erysipelas 16.09 11.79 26 48886 10824 79684652
Cerebral haematoma 16.04 11.79 22 48890 7920 79687556
Suicidal ideation 15.93 11.79 14 48898 76326 79619150
Alanine aminotransferase increased 15.89 11.79 161 48751 162409 79533067
International normalised ratio decreased 15.77 11.79 22 48890 8048 79687428
Throat irritation 15.75 11.79 3 48909 40943 79654533
Joint ankylosis 15.67 11.79 12 48900 2168 79693308
Drug dependence 15.65 11.79 3 48909 40766 79654710
Disseminated intravascular coagulation 15.63 11.79 53 48859 35789 79659687
Fall 15.63 11.79 208 48704 487421 79208055
Renal failure 15.52 11.79 190 48722 200778 79494698
Haemorrhagic erosive gastritis 15.42 11.79 8 48904 731 79694745
Adenocarcinoma of colon 15.41 11.79 18 48894 5523 79689953
Engraftment syndrome 15.35 11.79 10 48902 1399 79694077
Acute polyneuropathy 15.34 11.79 7 48905 483 79694993
Intracranial pressure increased 15.25 11.79 22 48890 8300 79687176
Hepatic enzyme increased 15.22 11.79 59 48853 182551 79512925
Penile necrosis 15.21 11.79 4 48908 50 79695426
Influenza like illness 15.15 11.79 13 48899 71694 79623782
Gestational diabetes 15.15 11.79 19 48893 6274 79689202
Febrile bone marrow aplasia 15.12 11.79 28 48884 12992 79682484
Injection site pain 15.07 11.79 36 48876 129802 79565674
Overdose 15.04 11.79 60 48852 184146 79511330
Beta-2 glycoprotein antibody positive 15.04 11.79 3 48909 9 79695467
Platelet count decreased 15.02 11.79 184 48728 194480 79500996
Knee arthroplasty 14.96 11.79 4 48908 43244 79652232
Bone marrow disorder 14.95 11.79 14 48898 3329 79692147
Anaemia folate deficiency 14.92 11.79 6 48906 303 79695173
Product use issue 14.91 11.79 72 48840 209750 79485726
Decubitus ulcer 14.90 11.79 31 48881 15656 79679820
Anterior segment ischaemia 14.86 11.79 4 48908 55 79695421
Viral infection 14.84 11.79 4 48908 43012 79652464
Liver iron concentration abnormal 14.66 11.79 4 48908 58 79695418
Pain in jaw 14.64 11.79 5 48907 46146 79649330
Cholecystitis 14.61 11.79 38 48874 22174 79673302
Burning sensation 14.50 11.79 9 48903 58623 79636853
Vascular device infection 14.40 11.79 24 48888 10252 79685224
Haemorrhagic disorder 14.32 11.79 10 48902 1568 79693908
Mental status changes 14.31 11.79 12 48900 66947 79628529
Varices oesophageal 14.28 11.79 18 48894 5973 79689503
Malaise 14.26 11.79 213 48699 489656 79205820
Sedation 14.24 11.79 7 48905 51888 79643588
Therapeutic product effect prolonged 14.22 11.79 7 48905 572 79694904
Chemotherapeutic drug level increased 14.08 11.79 6 48906 351 79695125
C-reactive protein abnormal 14.08 11.79 6 48906 48361 79647115
Arthritis 14.03 11.79 31 48881 114849 79580627
Superior vena cava syndrome 13.94 11.79 9 48903 1240 79694236
Wrong strength 13.94 11.79 5 48907 184 79695292
Therapy cessation 13.93 11.79 3 48909 37559 79657917
Cardiolipin antibody positive 13.89 11.79 5 48907 186 79695290
Therapy non-responder 13.83 11.79 22 48890 92283 79603193
Wheezing 13.82 11.79 32 48880 116632 79578844
Type 2 diabetes mellitus 13.81 11.79 9 48903 57113 79638363
Hypovolaemic shock 13.75 11.79 26 48886 12250 79683226
Haemoperitoneum 13.59 11.79 15 48897 4328 79691148
Device related thrombosis 13.49 11.79 12 48900 2671 79692805
Injection site swelling 13.48 11.79 6 48906 47126 79648350
Protein C decreased 13.46 11.79 4 48908 80 79695396
Magnetic resonance imaging head abnormal 13.32 11.79 12 48900 2714 79692762
Venous thrombosis 13.31 11.79 19 48893 7097 79688379
Malnutrition 13.29 11.79 37 48875 22465 79673011
Venous thrombosis limb 13.27 11.79 15 48897 4442 79691034
Emotional distress 13.27 11.79 4 48908 39965 79655511
Staphylococcal scalded skin syndrome 13.24 11.79 6 48906 407 79695069
Antinuclear antibody positive 13.22 11.79 20 48892 7870 79687606
Eosinophilia 13.19 11.79 59 48853 45286 79650190
Illness 13.18 11.79 6 48906 46505 79648971
Fluid retention 13.18 11.79 14 48898 69795 79625681
Lymphopenia 13.16 11.79 45 48867 30512 79664964
Cardiac failure 13.11 11.79 149 48763 154693 79540783
Hypophosphataemia 13.03 11.79 34 48878 19879 79675597
Hip arthroplasty 12.97 11.79 3 48909 35753 79659723
Injection site haemorrhage 12.86 11.79 42 48870 27828 79667648
Varicophlebitis 12.84 11.79 3 48909 22 79695454
Skin warm 12.84 11.79 18 48894 6614 79688862
Myositis 12.82 11.79 33 48879 19135 79676341
Haemoptysis 12.80 11.79 68 48844 55931 79639545
Lordosis 12.74 11.79 6 48906 445 79695031
Intra-abdominal haematoma 12.72 11.79 12 48900 2879 79692597
Device related infection 12.64 11.79 48 48864 34246 79661230
CSF white blood cell count decreased 12.62 11.79 3 48909 24 79695452
Antibiotic level above therapeutic 12.61 11.79 7 48905 733 79694743
Palpitations 12.51 11.79 38 48874 126572 79568904
Prostatitis Escherichia coli 12.51 11.79 3 48909 25 79695451
Mucosal disorder 12.47 11.79 13 48899 3515 79691961
Thyroid haemorrhage 12.47 11.79 4 48908 104 79695372
Death 12.45 11.79 259 48653 566255 79129221
Drug withdrawal syndrome 12.42 11.79 3 48909 34715 79660761
Faecaloma 12.35 11.79 24 48888 11540 79683936
Sudden hearing loss 12.35 11.79 10 48902 1959 79693517
Hypercoagulation 12.34 11.79 12 48900 2988 79692488
Exposure during pregnancy 12.32 11.79 105 48807 101027 79594449
Catheter site injury 12.31 11.79 5 48907 259 79695217
Autoimmune heparin-induced thrombocytopenia 12.30 11.79 3 48909 27 79695449
Mean cell volume increased 12.15 11.79 17 48895 6236 79689240
Gastrointestinal tract adenoma 12.14 11.79 6 48906 495 79694981
Somnolence 12.12 11.79 210 48702 238771 79456705
Haematuria 12.11 11.79 78 48834 68758 79626718
Visual acuity reduced transiently 12.10 11.79 5 48907 271 79695205
Protein S decreased 12.09 11.79 4 48908 115 79695361
IIIrd nerve disorder 12.09 11.79 4 48908 115 79695361
Electrolyte imbalance 12.03 11.79 44 48868 30837 79664639
Osteoarthritis 11.99 11.79 22 48890 87287 79608189
Abdominal sepsis 11.94 11.79 10 48902 2052 79693424
Post procedural pulmonary embolism 11.91 11.79 5 48907 282 79695194
Peripheral ischaemia 11.82 11.79 21 48891 9436 79686040
Large intestine perforation 11.80 11.79 27 48885 14540 79680936

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AB10 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC B01AB12 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
FDA CS M0010191 Heparin, Low-Molecular-Weight
FDA EPC N0000175586 Low Molecular Weight Heparin
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
CHEBI has role CHEBI:50249 anticoagulants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pulmonary embolism indication 59282003 DOID:9477
Deep venous thrombosis indication 128053003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
PUE0TO3XDR UNII
4020894 VANDF
4021054 VANDF
4021237 VANDF
4024199 VANDF
C0916062 UMLSCUI
CHEBI:28304 CHEBI
CHEMBL3707365 ChEMBL_ID
772 PUBCHEM_CID
DB09258 DRUGBANK_ID
CHEMBL1201414 ChEMBL_ID
CHEMBL1201448 ChEMBL_ID
CHEMBL1201460 ChEMBL_ID
CHEMBL2108806 ChEMBL_ID
C411345 MESH_SUPPLEMENTAL_RECORD_UI
C093450 MESH_SUPPLEMENTAL_RECORD_UI
6846 IUPHAR_LIGAND_ID
DB06822 DRUGBANK_ID
104466 RXNORM
15471 MMSL
4531 MMSL
d04659 MMSL
005078 NDDF
007911 NDDF
008338 NDDF
108987000 SNOMEDCT_US
108990006 SNOMEDCT_US
350469004 SNOMEDCT_US
395908006 SNOMEDCT_US
410964003 SNOMEDCT_US
410965002 SNOMEDCT_US
410967005 SNOMEDCT_US
412608008 SNOMEDCT_US
D000078222 MESH_DESCRIPTOR_UI
D017985 MESH_DESCRIPTOR_UI
6985 INN_ID
5688 INN_ID
6764 INN_ID
7501 INN_ID
9005-49-6 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0195 INJECTION 2500 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0195 INJECTION 2500 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0196 INJECTION 5000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0196 INJECTION 5000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0206 INJECTION 7500 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0206 INJECTION 7500 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0217 INJECTION 10000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0217 INJECTION 10000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0220 INJECTION 12500 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0220 INJECTION 12500 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0223 INJECTION 15000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0223 INJECTION 15000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0228 INJECTION 18000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0228 INJECTION 18000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0232 INJECTION 25000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0232 INJECTION 25000 [iU] SUBCUTANEOUS NDA 28 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0253 INJECTION 2500 [iU] SUBCUTANEOUS NDA 28 sections