captopril ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 484 62571-86-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • captopril
  • (-)-Captopril
  • L-Captopril
  • lopirin
  • S-Captopril
  • SQ14225
  • SQ-14225
  • SQ 14225
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
  • Molecular weight: 217.28
  • Formula: C9H15NO3S
  • CLOGP: 0.89
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 57.61
  • ALOGS: -1.68
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 160 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 38 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.72 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 69 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.75 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.73 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 6, 1981 FDA PAR PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Segmental diverticular colitis 96.41 14.85 18 11414 156 63477434
Pedal pulse abnormal 95.60 14.85 18 11414 164 63477426
Toxic epidermal necrolysis 86.60 14.85 55 11377 25279 63452311
Calcium ionised decreased 86.10 14.85 18 11414 291 63477299
Blood pressure abnormal 75.50 14.85 42 11390 15156 63462434
Cardiac failure congestive 75.41 14.85 88 11344 92345 63385245
Insulin autoimmune syndrome 70.89 14.85 13 11419 101 63477489
Feeding intolerance 69.65 14.85 18 11414 756 63476834
Reduced facial expression 65.12 14.85 21 11411 1945 63475645
Multiple organ dysfunction syndrome 60.12 14.85 62 11370 56690 63420900
Restlessness 56.60 14.85 45 11387 29408 63448182
Listless 53.72 14.85 20 11412 2840 63474750
Dermatitis exfoliative 53.69 14.85 24 11408 5435 63472155
Head discomfort 50.57 14.85 31 11401 13384 63464206
Self-injurious ideation 47.78 14.85 18 11414 2641 63474949
Labile hypertension 42.27 14.85 11 11421 475 63477115
Left ventricular hypertrophy 41.77 14.85 20 11412 5295 63472295
Myocardial infarction 40.53 14.85 68 11364 99825 63377765
Gastrointestinal sounds abnormal 40.45 14.85 18 11414 4033 63473557
Hyponatraemia 39.96 14.85 72 11360 111828 63365762
Prescription drug used without a prescription 38.73 14.85 15 11417 2371 63475219
Cardiac failure 37.93 14.85 62 11370 89080 63388510
Apathy 37.49 14.85 22 11410 8772 63468818
Electrolyte imbalance 37.13 14.85 30 11402 20046 63457544
Hyperthyroidism 36.12 14.85 26 11406 14647 63462943
Foreign body 35.49 14.85 14 11418 2324 63475266
Dehydration 34.56 14.85 88 11344 173266 63304324
Haemodynamic instability 34.03 14.85 21 11411 9169 63468421
Immobile 33.89 14.85 18 11414 5925 63471665
Drug interaction 33.58 14.85 104 11328 229027 63248563
Cholecystitis 32.80 14.85 25 11407 15352 63462238
Joint swelling 31.36 14.85 10 11422 327656 63149934
Affect lability 30.32 14.85 21 11411 11130 63466460
Hypokalaemia 29.92 14.85 61 11371 103743 63373847
Fatigue 29.21 14.85 74 11358 887954 62589636
Skin test positive 29.15 14.85 9 11423 723 63476867
Renal failure 29.14 14.85 65 11367 117587 63360003
Arthralgia 29.08 14.85 36 11396 569674 62907916
Abdominal discomfort 28.63 14.85 11 11421 320874 63156716
Atrial fibrillation 28.40 14.85 64 11368 116572 63361018
Systemic lupus erythematosus 27.08 14.85 3 11429 208915 63268675
Acute myocardial infarction 26.86 14.85 31 11401 32093 63445497
Cognitive disorder 26.74 14.85 41 11391 55774 63421816
Hypertensive crisis 26.50 14.85 22 11410 15264 63462326
Blood urea increased 26.45 14.85 28 11404 26351 63451239
Hypotension 26.40 14.85 108 11324 272496 63205094
Infusion related reaction 26.29 14.85 6 11426 245515 63232075
Metabolic acidosis 25.78 14.85 36 11396 45033 63432557
Respiratory disorder 25.06 14.85 33 11399 39049 63438541
Cholelithiasis 25.00 14.85 35 11397 43890 63433700
Alopecia 24.88 14.85 15 11417 337521 63140069
Pain 24.88 14.85 61 11371 740567 62737023
Therapeutic product effect decreased 24.48 14.85 3 11429 193184 63284406
Acute kidney injury 23.66 14.85 102 11330 263313 63214277
Circulatory collapse 23.27 14.85 24 11408 21914 63455676
Occupational exposure to product 23.24 14.85 10 11422 2068 63475522
Cross sensitivity reaction 22.85 14.85 10 11422 2152 63475438
Vascular stent thrombosis 22.72 14.85 8 11424 969 63476621
Abnormal behaviour 21.94 14.85 23 11409 21403 63456187
Urinary retention 21.65 14.85 27 11405 30274 63447316
Renal injury 21.58 14.85 16 11416 9423 63468167
Bedridden 21.47 14.85 17 11415 11034 63466556
Hyperkalaemia 20.78 14.85 36 11396 54167 63423423
Off label use 20.76 14.85 58 11374 674404 62803186
Cyanosis 20.68 14.85 20 11412 16915 63460675
Rheumatoid arthritis 20.56 14.85 10 11422 253809 63223781
Contraindicated product administered 20.18 14.85 7 11425 217641 63259949
Sudden death 20.14 14.85 16 11416 10433 63467157
Blood sodium decreased 19.60 14.85 23 11409 24229 63453361
Progressive supranuclear palsy 19.29 14.85 4 11428 62 63477528
Cardiac failure acute 19.25 14.85 15 11417 9508 63468082
Blood creatinine increased 18.96 14.85 46 11386 87798 63389792
Maternal exposure during pregnancy 18.87 14.85 8 11424 220054 63257536
Musculoskeletal stiffness 18.81 14.85 5 11427 184613 63292977
Bradycardia 18.73 14.85 41 11391 73186 63404404
Coronary artery disease 18.72 14.85 26 11406 32351 63445239
Pelvic fracture 18.67 14.85 17 11415 13331 63464259
Elastosis perforans 18.47 14.85 3 11429 10 63477580
Posterior reversible encephalopathy syndrome 18.44 14.85 19 11413 17326 63460264
Nodal rhythm 18.22 14.85 8 11424 1735 63475855
Artery dissection 18.14 14.85 4 11428 84 63477506
Encephalopathy 17.97 14.85 28 11404 38592 63438998
Arthropathy 17.91 14.85 10 11422 234782 63242808
Cerebrovascular accident 17.66 14.85 51 11381 107973 63369617
Blood potassium decreased 17.55 14.85 29 11403 41997 63435593
Lymphocytosis 17.55 14.85 9 11423 2758 63474832
Stevens-Johnson syndrome 17.46 14.85 22 11410 24928 63452662
Extrasystoles 17.12 14.85 11 11421 5149 63472441
Scleroderma renal crisis 17.08 14.85 5 11427 335 63477255
Shock 16.91 14.85 21 11411 23442 63454148
Sinusitis 16.79 14.85 10 11422 226643 63250947
Renal impairment 16.70 14.85 44 11388 88311 63389279
Potentiating drug interaction 16.24 14.85 10 11422 4346 63473244
Angiopathy 15.72 14.85 10 11422 4603 63472987
Nasopharyngitis 15.24 14.85 14 11418 254243 63223347
Occupational dermatitis 14.89 14.85 3 11429 40 63477550
Hepatic enzyme increased 14.88 14.85 9 11423 202319 63275271
Hypoacusis 14.88 14.85 20 11412 24131 63453459

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood ketone body increased 35.55 14.69 10 8385 433 34948103
Cyanosis 32.68 14.69 26 8369 12738 34935798
Angioedema 28.81 14.69 40 8355 37334 34911202
Hypertensive crisis 27.18 14.69 20 8375 8731 34939805
Cardiac failure congestive 27.13 14.69 61 8334 83209 34865327
Scleroderma renal crisis 26.08 14.69 7 8388 254 34948282
Renal failure 24.57 14.69 78 8317 130479 34818057
Kidney small 23.86 14.69 5 8390 60 34948476
Myocardial infarction 23.39 14.69 73 8322 121012 34827524
Cerebrovascular accident 23.15 14.69 58 8337 84753 34863783
Coronary artery disease 22.42 14.69 41 8354 48264 34900272
Blood creatinine increased 20.92 14.69 60 8335 94916 34853620
Long QT syndrome 20.41 14.69 11 8384 2792 34945744
Indifference 19.51 14.69 5 8390 151 34948385
Hypokalaemia 19.34 14.69 43 8352 58171 34890365
Pulmonary hypertensive crisis 19.00 14.69 5 8390 168 34948368
Pulmonary hypoplasia 17.63 14.69 6 8389 491 34948045
Reaction to excipient 17.42 14.69 6 8389 509 34948027
Vitamin B12 deficiency 16.71 14.69 11 8384 4020 34944516
Vascular resistance systemic decreased 16.33 14.69 4 8391 100 34948436
Arrhythmia 16.11 14.69 30 8365 35778 34912758
Renal failure neonatal 15.83 14.69 4 8391 114 34948422
Bronchospasm 15.80 14.69 16 8379 10715 34937821
Drug reaction with eosinophilia and systemic symptoms 15.28 14.69 28 8367 32984 34915552
Cardiac failure 14.90 14.69 52 8343 91196 34857340
Renal impairment 14.70 14.69 53 8342 94460 34854076

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Segmental diverticular colitis 92.96 12.81 18 17372 156 79726842
Pedal pulse abnormal 91.01 12.81 18 17372 176 79726822
Cardiac failure congestive 88.91 12.81 131 17259 142271 79584727
Calcium ionised decreased 71.17 12.81 18 17372 569 79726429
Feeding intolerance 64.35 12.81 18 17372 842 79726156
Myocardial infarction 60.77 12.81 128 17262 184001 79542997
Toxic epidermal necrolysis 58.99 12.81 60 17330 44521 79682477
Insulin autoimmune syndrome 51.15 12.81 13 17377 419 79726579
Reduced facial expression 50.65 12.81 20 17370 2745 79724253
Cyanosis 46.95 12.81 41 17349 25141 79701857
Renal failure 45.88 12.81 121 17269 200847 79526151
Hypertensive crisis 45.27 12.81 37 17353 20733 79706265
Blood pressure abnormal 42.59 12.81 33 17357 17136 79709862
Cardiac failure 42.46 12.81 100 17290 154742 79572256
Self-injurious ideation 42.15 12.81 19 17371 3619 79723379
Head discomfort 40.68 12.81 30 17360 14472 79712526
Multiple organ dysfunction syndrome 40.11 12.81 84 17306 120162 79606836
Labile hypertension 38.85 12.81 11 17379 538 79726460
Cerebrovascular accident 38.01 12.81 96 17294 155196 79571802
Listless 37.97 12.81 18 17372 3843 79723155
Gastrointestinal sounds abnormal 37.71 12.81 20 17370 5415 79721583
Apathy 36.75 12.81 27 17363 12950 79714048
Dermatitis exfoliative 36.37 12.81 25 17365 10804 79716194
Coronary artery disease 36.24 12.81 57 17333 65417 79661581
Restlessness 35.27 12.81 47 17343 46445 79680553
Joint swelling 34.63 12.81 10 17380 288636 79438362
Blood creatinine increased 34.00 12.81 92 17298 154965 79572033
Angioedema 33.80 12.81 60 17330 75975 79651023
Scleroderma renal crisis 33.48 12.81 10 17380 591 79726407
Electrolyte imbalance 32.80 12.81 37 17353 30844 79696154
Off label use 32.72 12.81 96 17294 907119 78819879
Drug interaction 32.41 12.81 177 17213 415006 79311992
Completed suicide 32.41 12.81 7 17383 245760 79481238
Occupational exposure to product 31.98 12.81 10 17380 690 79726308
Hypotension 31.91 12.81 184 17206 440133 79286865
Hyponatraemia 30.80 12.81 97 17293 177751 79549247
Hypokalaemia 29.14 12.81 83 17307 143957 79583041
Prescription drug used without a prescription 28.25 12.81 15 17375 4070 79722928
Blood ketone body increased 27.57 12.81 9 17381 713 79726285
Acute myocardial infarction 27.07 12.81 55 17335 76981 79650017
Foreign body 26.96 12.81 13 17377 2881 79724117
Immobile 25.57 12.81 17 17373 6956 79720042
Renal impairment 25.45 12.81 84 17306 157699 79569299
Pulmonary hypoplasia 24.83 12.81 5 17385 54 79726944
Arthralgia 24.82 12.81 55 17335 571748 79155250
Bradycardia 24.45 12.81 75 17315 135482 79591516
Hyperthyroidism 24.25 12.81 27 17363 22182 79704816
Cholecystitis 24.25 12.81 27 17363 22185 79704813
Cross sensitivity reaction 23.91 12.81 13 17377 3699 79723299
Posterior reversible encephalopathy syndrome 23.77 12.81 29 17361 26252 79700746
Rheumatoid arthritis 23.60 12.81 8 17382 208462 79518536
Skin test positive 23.30 12.81 9 17381 1165 79725833
Abdominal discomfort 23.05 12.81 13 17377 250714 79476284
Fatigue 22.76 12.81 115 17275 929612 78797386
Cholelithiasis 22.69 12.81 41 17349 52623 79674375
Left ventricular hypertrophy 22.44 12.81 19 17371 11172 79715826
Affect lability 22.34 12.81 19 17371 11240 79715758
Respiratory disorder 22.03 12.81 37 17353 44819 79682179
Drug reaction with eosinophilia and systemic symptoms 21.55 12.81 45 17345 64199 79662799
Dehydration 21.52 12.81 109 17281 248078 79478920
Indifference 21.12 12.81 6 17384 297 79726701
Infusion related reaction 21.08 12.81 12 17378 230225 79496773
Renal injury 20.97 12.81 22 17368 16905 79710093
Nasopharyngitis 20.82 12.81 15 17375 253866 79473132
Pulmonary oedema 19.97 12.81 53 17337 88201 79638797
Atrial fibrillation 19.37 12.81 90 17300 197796 79529202
Bedridden 19.23 12.81 18 17372 12061 79714937
Cognitive disorder 18.97 12.81 45 17345 69881 79657117
Alopecia 18.54 12.81 14 17376 231341 79495657
Blood urea increased 18.54 12.81 36 17354 48754 79678244
COVID-19 treatment 18.52 12.81 6 17384 464 79726534
Lower respiratory tract infection 18.48 12.81 3 17387 129217 79597781
Long QT syndrome 18.25 12.81 13 17377 5942 79721056
Ventricular extrasystoles 18.24 12.81 22 17368 19682 79707316
Elastosis perforans 17.67 12.81 3 17387 11 79726987
Arrhythmia 17.24 12.81 40 17350 61232 79665766
Kidney small 17.23 12.81 5 17385 267 79726731
Pelvic fracture 17.19 12.81 17 17373 12187 79714811
Haemodynamic instability 17.06 12.81 20 17370 17362 79709636
Hypertension 17.03 12.81 127 17263 330865 79396133
Blood potassium increased 16.91 12.81 26 17364 29249 79697749
Oligohydramnios 16.73 12.81 10 17380 3402 79723596
Laryngeal oedema 16.71 12.81 14 17376 8115 79718883
Tongue oedema 16.19 12.81 13 17377 7104 79719894
Pain 16.10 12.81 89 17301 703713 79023285
Blood potassium decreased 16.09 12.81 33 17357 46479 79680519
Hyperplasia 16.03 12.81 7 17383 1236 79725762
Stomatitis 15.98 12.81 6 17384 146751 79580247
Wound 15.95 12.81 3 17387 116176 79610822
Hyperkalaemia 15.91 12.81 58 17332 114340 79612658
Progressive supranuclear palsy 15.89 12.81 4 17386 124 79726874
Pulmonary hypertensive crisis 15.85 12.81 5 17385 355 79726643
Circulatory collapse 15.81 12.81 29 17361 37639 79689359
Therapeutic product effect decreased 15.78 12.81 8 17382 163855 79563143
Extrasystoles 15.71 12.81 13 17377 7406 79719592
Cardiac failure acute 15.69 12.81 20 17370 18909 79708089
Drug ineffective 15.51 12.81 156 17234 1080757 78646241
Congenital anomaly 15.51 12.81 5 17385 381 79726617
Klebsiella infection 15.29 12.81 18 17372 15702 79711296
Shock 15.19 12.81 31 17359 43517 79683481
Haemorrhagic necrotic pancreatitis 15.03 12.81 4 17386 155 79726843
Nodal rhythm 14.88 12.81 9 17381 3126 79723872
Musculoskeletal stiffness 14.79 12.81 10 17380 174998 79552000
Lactic acidosis 14.66 12.81 41 17349 70318 79656680
Scleroedema 14.46 12.81 3 17387 38 79726960
Sinusitis 14.22 12.81 13 17377 195488 79531510
Pulmonary hypertension 14.20 12.81 32 17358 48048 79678950
Maternal exposure during pregnancy 14.18 12.81 6 17384 136532 79590466
Angiopathy 14.15 12.81 12 17378 7070 79719928
Vascular resistance systemic decreased 13.65 12.81 4 17386 221 79726777
Cardio-respiratory arrest 13.43 12.81 53 17337 108457 79618541
Rhabdomyolysis 13.27 12.81 51 17339 103080 79623918
Rhythm idioventricular 13.16 12.81 5 17385 619 79726379
Apraxia 13.02 12.81 8 17382 2859 79724139
Injection site pain 13.02 12.81 6 17384 129832 79597166
Acute interstitial pneumonitis 12.95 12.81 6 17384 1217 79725781
Artery dissection 12.82 12.81 4 17386 274 79726724

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
FDA MoA N0000000181 Angiotensin-converting Enzyme Inhibitors
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
CHEBI has role CHEBI:35457 ACE inhibitor
CHEBI has role CHEBI:35674 antihypertensive drugs
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Diabetic renal disease indication 127013003
Left ventricular cardiac dysfunction indication 429589006
Atrial fibrillation off-label use 49436004 DOID:0060224
Cystinuria off-label use 85020001 DOID:9266
Diastolic heart failure off-label use 418304008 DOID:9775
Cystine Renal Calculi off-label use
Nondiabetic Proteinuric Nephropathy off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Cough contraindication 49727002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Aortic valve stenosis contraindication 60573004 DOID:1712
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Transplantation contraindication 77465005
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Azotemia contraindication 445009001
Hemodialysis with High-Flux Membrane contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.85 acidic
pKa2 9.56 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR Ki 8.70 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme Ki 4.77 CHEMBL
Prothrombin Enzyme Ki 7.32 CHEMBL
Renin Enzyme Ki 8.77 CHEMBL
Leukotriene A-4 hydrolase Enzyme IC50 7.15 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 4.92 CHEMBL
Angiotensin-converting enzyme Enzyme Ki 8.77 CHEMBL
Angiotensin-converting enzyme Enzyme Ki 8.70 CHEMBL
Succinyl-diaminopimelate desuccinylase Enzyme Ki 5.74 CHEMBL
Beta-lactamase Enzyme Ki 5.62 CHEMBL
Beta-lactamase II Enzyme Ki 4.75 CHEMBL
Beta-lactamase class B VIM-2 Unclassified Kd 6.22 CHEMBL
Beta-lactamase NDM-1 Enzyme Kd 4.85 CHEMBL

External reference:

IDSource
4017614 VUID
N0000145994 NUI
D00251 KEGG_DRUG
1998 RXNORM
C0006938 UMLSCUI
CHEBI:3380 CHEBI
X8Z PDB_CHEM_ID
CHEMBL1560 ChEMBL_ID
DB01197 DRUGBANK_ID
D002216 MESH_DESCRIPTOR_UI
44093 PUBCHEM_CID
5158 IUPHAR_LIGAND_ID
4373 INN_ID
9G64RSX1XD UNII
4347 MMSL
455 MMSL
d00006 MMSL
29439004 SNOMEDCT_US
387160004 SNOMEDCT_US
4017614 VANDF
000656 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1171 TABLET 12.50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1171 TABLET 12.50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1172 TABLET 25 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1172 TABLET 25 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1173 TABLET 50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1173 TABLET 50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1174 TABLET 100 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0143-1174 TABLET 100 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-4519 TABLET 12.50 mg ORAL ANDA 21 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-4520 TABLET 25 mg ORAL ANDA 21 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0615-4521 TABLET 50 mg ORAL ANDA 21 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0781-8052 TABLET 12.50 mg ORAL ANDA 16 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0781-8061 TABLET 25 mg ORAL ANDA 16 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0781-8075 TABLET 50 mg ORAL ANDA 16 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0781-8080 TABLET 100 mg ORAL ANDA 16 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-5045 TABLET 12.50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-5046 TABLET 25 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-5047 TABLET 50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-7105 TABLET 12.50 mg ORAL ANDA 12 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 0904-7106 TABLET 25 mg ORAL ANDA 12 sections
CAPTOPRIL HUMAN PRESCRIPTION DRUG LABEL 1 10544-175 TABLET 50 mg ORAL ANDA 19 sections
CAPTOPRIL AND HYDROCHLOROTHIAZIDE Human Prescription Drug Label 2 16571-827 TABLET 25 mg ORAL ANDA 22 sections
CAPTOPRIL AND HYDROCHLOROTHIAZIDE Human Prescription Drug Label 2 16571-828 TABLET 25 mg ORAL ANDA 22 sections
CAPTOPRIL AND HYDROCHLOROTHIAZIDE Human Prescription Drug Label 2 16571-829 TABLET 50 mg ORAL ANDA 22 sections
CAPTOPRIL AND HYDROCHLOROTHIAZIDE Human Prescription Drug Label 2 16571-830 TABLET 50 mg ORAL ANDA 22 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 21695-477 TABLET 25 mg ORAL ANDA 24 sections
Captopril HUMAN PRESCRIPTION DRUG LABEL 1 21695-478 TABLET 50 mg ORAL ANDA 24 sections
Captopril Human Prescription Drug Label 1 27241-160 TABLET 12.50 mg ORAL ANDA 12 sections
Captopril Human Prescription Drug Label 1 27241-161 TABLET 25 mg ORAL ANDA 12 sections
Captopril Human Prescription Drug Label 1 27241-162 TABLET 50 mg ORAL ANDA 12 sections