canrenone indications/contra

Stem definitionDrug idCAS RN
aldosterone antagonists, spironolactone derivates 478 976-71-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • canrenone
  • aldadiene
  • phanurane
A synthetic pregnadiene compound with anti-aldosterone activity.
  • Molecular weight: 340.46
  • Formula: C22H28O3
  • CLOGP: 2.91
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -4.91
  • ROTB: 0

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C03DA03 CARDIOVASCULAR SYSTEM
DIURETICS
POTASSIUM-SPARING AGENTS
Aldosterone antagonists
MeSH PA D004232 Diuretics
MeSH PA D006727 Hormone Antagonists
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
MeSH PA D000451 Mineralocorticoid Receptor Antagonists
MeSH PA D045283 Natriuretic Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor ANTAGONIST IC50 6.52 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
N0000167426 NUI
C0006882 UMLSCUI
D03363 KEGG_DRUG
78O20X9J0U UNII
2445 INN_ID
96291007 SNOMEDCT_US
1982 RXNORM
N0000167426 NDFRT
005943 NDDF
13789 PUBCHEM_CID
CHEMBL1463345 ChEMBL_ID
D002192 MESH_DESCRIPTOR_UI
DB12221 DRUGBANK_ID
CHEBI:135445 CHEBI

Pharmaceutical products:

None