ridaforolimus 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| immunosuppressants, rapamycin derivatives | 4778 | 572924-54-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an mTOR inhibitor for the treatment of cancer
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 3.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 46.30 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01EG03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PROTEIN KINASE INHIBITORS Mammalian target of rapamycin (mTOR) kinase inhibitors |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:68481 | mTOR inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.5 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase mTOR | Kinase | INHIBITOR | IC50 | 9.70 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Kinase | Kd | 5.90 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08900 | KEGG_DRUG |
| CHEBI:82677 | CHEBI |
| CHEMBL2103839 | ChEMBL_ID |
| C515074 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7884 | IUPHAR_LIGAND_ID |
| 8822 | INN_ID |
| DB06233 | DRUGBANK_ID |
| 48Z35KB15K | UNII |
| C2713007 | UMLSCUI |
| 11520894 | PUBCHEM_CID |
Pharmaceutical products:
None