potassium canrenoate indications/contra

Stem definitionDrug idCAS RN
477 2181-04-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • potassium canrenoate
  • aldadiene kalium
  • aldadiene potassium
  • canrenoate potassium
  • canrenoate
  • kanrenol
  • canrenoic acid
  • canrenoic acid potassium
  • canrenoic acid potassium salt
A synthetic pregnadiene derivative with anti-aldosterone activity.
  • Molecular weight: 358.48
  • Formula: C22H30O4
  • CLOGP: 3.16
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -3.91
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.40 g P

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 117.90 63.05 22 66 11272 3374499
Dehydration 67.67 63.05 17 71 33632 3352139

Pharmacologic Action:

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SourceCodeDescription
ATC C03DA02 CARDIOVASCULAR SYSTEM
DIURETICS
POTASSIUM-SPARING AGENTS
Aldosterone antagonists
MeSH PA D004232 Diuretics
MeSH PA D006727 Hormone Antagonists
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
MeSH PA D000451 Mineralocorticoid Receptor Antagonists
MeSH PA D045283 Natriuretic Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.78 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
C0006881 UMLSCUI
D01943 KEGG_DRUG
419615001 SNOMEDCT_US
003944 NDDF
1981 RXNORM
318053000 SNOMEDCT_US
87UG89VA9K UNII
2571 INN_ID
4138-96-9 SECONDARY_CAS_RN
23671691 PUBCHEM_CID
CHEMBL1371200 ChEMBL_ID
D002191 MESH_DESCRIPTOR_UI
DB09015 DRUGBANK_ID
CHEMBL1616951 ChEMBL_ID

Pharmaceutical products:

None