technetium Tc 99m tilmanocept 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4755 746637-33-2

Description:

MoleculeDescription

Synonyms:

  • technetium TC-99m tilmanocept
  • technetium Tc 99m tilmanocept
  • lymphoseek
  • technetium (99mTc) tilmanocept
Tilmanocept is a receptor-targeted radiopharmaceutical that is designed to rapidly transit lymphatic vessels; it biotargets, accumulates, and is retained in primary, key predictive, draining lymph nodes (sentinel lymphnodes). The drug substance, tilmanocept, specifically binds to mannose binding receptor proteins (CD206) that reside on the surface of macrophages and dendritic cells. Macrophages are present in high concentrations in lymph nodes.
  • Molecular weight:
  • Formula: None
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 13, 2013 FDA NAVIDEA BIOPHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 245.65 167.69 80 47 1044685 62444210

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V09IA09 VARIOUS
DIAGNOSTIC RADIOPHARMACEUTICALS
TUMOUR DETECTION
Technetium (99mTc) compounds
FDA MoA N0000000205 Radiopharmaceutical Activity
FDA EPC N0000177914 Radioactive Diagnostic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diagnostic aid indication 2949005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
N/A LYMPHOSEEK KIT CARDINAL HEALTH 414 N202207 March 13, 2013 RX INJECTABLE INJECTION May 19, 2024 NEW PATIENT POPULATION

Bioactivity Summary:

None

External reference:

IDSource
8IHI69PQTC UNII
4038731 VANDF
C3555537 UMLSCUI
CHEMBL2108726 ChEMBL_ID
DB09266 DRUGBANK_ID
C431884 MESH_SUPPLEMENTAL_RECORD_UI
1373391 RXNORM
203086 MMSL
207617 MMSL
1262984-82-6 SECONDARY_CAS_RN

Pharmaceutical products:

None