tacalcitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
Vitamin D analogues/derivatives	4727	57333-96-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tacalcitol

Molecular weight: 416.65
Formula: C27H44O3
CLOGP: 6.04
LIPINSKI: 1
HAC: 3
HDO: 3
TPSA: 60.69
ALOGS: -4.60
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D05AX04	DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Other antipsoriatics for topical use
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D003879	Dermatologic Agents
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50748	antipsoriatic drug
CHEBI has role	CHEBI:139503	vitamin D nuclear receptor agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Plaque psoriasis	indication	200965009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.7	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vitamin D3 receptor	Nuclear hormone receptor	P11473	VDR_HUMAN	AGONIST	Kd	8.50		IUPHAR

External reference:

ID	Source
D08554	KEGG_DRUG
CHEBI:32176	CHEBI
CHEMBL2105611	ChEMBL_ID
C023850	MESH_SUPPLEMENTAL_RECORD_UI
2780	IUPHAR_LIGAND_ID
6822	INN_ID
DB13689	DRUGBANK_ID
C2W72OJ5ZU	UNII
291204	RXNORM
005930	NDDF
332214000	SNOMEDCT_US
395893005	SNOMEDCT_US
C0953467	UMLSCUI
5283734	PUBCHEM_CID

Pharmaceutical products:

None