strontium ranelate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4714 135459-87-9

Description:

MoleculeDescription

Synonyms:

  • strontium ranelate
  • osseor
  • bivalos
  • distrontium renelate
  • protelos
an uncoupling agent containing strontium prevents bone loss by depressing bone resorption & maintaining bone formation in estrogen-deficient rats
  • Molecular weight: 513.49
  • Formula: C12H6N2O8SSr2
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 187.55
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 21, 2004 EMA Les Laboratoires Servier

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Metaphyseal corner fracture 80.76 52.97 8 189 32 63488793

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Metaphyseal corner fracture 83.18 50.61 8 175 32 79744173
Atypical fracture 51.74 50.61 7 176 699 79743506

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BX03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
ATC M05BX53 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
MeSH PA D050071 Bone Density Conservation Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postmenopausal osteoporosis indication 102447009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEMBL3707306 ChEMBL_ID
C081587 MESH_SUPPLEMENTAL_RECORD_UI
DB09267 DRUGBANK_ID
04NQ160FRU UNII
010550 NDDF
432727001 SNOMEDCT_US
441487000 SNOMEDCT_US
C0936139 UMLSCUI
6918182 PUBCHEM_CID

Pharmaceutical products:

None