camostat indications/contra

Stem definitionDrug idCAS RN
proteolytic enzyme inhibitors 471 59721-28-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • camostat monomethanesulfonate
  • camostat
  • camostat mesilate
  • camostat mesylate
  • Molecular weight: 398.42
  • Formula: C20H22N4O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 134.81
  • ALOGS: -3.80
  • ROTB: 9

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC B02AB04 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
ANTIFIBRINOLYTICS
Proteinase inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors
MeSH PA D014361 Trypsin Inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Gastro-esophageal reflux disease with esophagitis indication 266433003

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trypsin-1 Enzyme INHIBITOR IC50 7.30 CHEMBL IUPHAR
Solute carrier family 22 member 2 Transporter IC50 4.78 CHEMBL
Kallikrein-1 Enzyme IC50 5.83 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.90 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.54 CHEMBL
Prothrombin Enzyme IC50 4.50 CHEMBL
Hepatocyte growth factor activator Enzyme IC50 4.49 CHEMBL
Plasminogen Enzyme IC50 5.58 CHEMBL

External reference:

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IDSource
6432 IUPHAR_LIGAND_ID
D01766 KEGG_DRUG
0FD207WKDU UNII
5068 INN_ID
59721-29-8 SECONDARY_CAS_RN
2536 PUBCHEM_CID
CHEMBL590799 ChEMBL_ID
C034532 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135632 CHEBI

Pharmaceutical products:

None