camostat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| proteolytic enzyme inhibitors | 471 | 59721-28-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | B02AB04 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS ANTIFIBRINOLYTICS Proteinase inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D015842 | Serine Proteinase Inhibitors |
| MeSH PA | D014361 | Trypsin Inhibitors |
| CHEBI has role | CHEBI:22587 | antiviral agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:48675 | antifibrinolytic agent |
| CHEBI has role | CHEBI:64926 | serine protease inhibitors |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
| CHEBI has role | CHEBI:149553 | anticoronaviral drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Gastro-esophageal reflux disease with esophagitis | indication | 266433003 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.66 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Trypsin-1 | Enzyme | INHIBITOR | IC50 | 7.30 | CHEMBL | IUPHAR | |||
| Kallikrein-1 | Enzyme | IC50 | 5.83 | CHEMBL | |||||
| Solute carrier family 22 member 2 | Transporter | IC50 | 4.78 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 5.54 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 4.90 | CHEMBL | |||||
| Serine protease hepsin | Enzyme | IC50 | 7.54 | CHEMBL | |||||
| Hepatocyte growth factor activator | Enzyme | IC50 | 4.49 | CHEMBL | |||||
| Prothrombin | Enzyme | IC50 | 4.50 | CHEMBL | |||||
| Transmembrane protease serine 2 | Enzyme | INHIBITOR | IC50 | 6 | IUPHAR | ||||
| Plasminogen | Enzyme | IC50 | 5.58 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01766 | KEGG_DRUG |
| C0129975 | UMLSCUI |
| CHEBI:135632 | CHEBI |
| CHEMBL590799 | ChEMBL_ID |
| DB13729 | DRUGBANK_ID |
| C034532 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6432 | IUPHAR_LIGAND_ID |
| 5068 | INN_ID |
| 59721-29-8 | SECONDARY_CAS_RN |
| 0FD207WKDU | UNII |
| 2536 | PUBCHEM_CID |
| 1179628001 | SNOMEDCT_US |
| 1187213009 | SNOMEDCT_US |
| 1187214003 | SNOMEDCT_US |
| CHEMBL85164 | ChEMBL_ID |
| 018673 | NDDF |
| 018674 | NDDF |
Pharmaceutical products:
None