acemetacin indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory, indometacin derivatives 47 53164-05-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Bay f 4975
  • TVX 1322
  • acemetacin
  • acemet
  • acemethacin
  • acemethazine
  • rantudil
  • Molecular weight: 415.83
  • Formula: C21H18ClNO6
  • CLOGP: 4.20
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 94.83
  • ALOGS: -5.26
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.12 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC M01AB11 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatism indication 396332003

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.15 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Prostaglandin G/H synthase 2 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Lactoylglutathione lyase Enzyme Ki 4.89 CHEMBL

External reference:

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IDSource
C0050409 UMLSCUI
D01582 KEGG_DRUG
5V141XK28X UNII
3664 INN_ID
391704009 SNOMEDCT_US
16695 RXNORM
329906008 SNOMEDCT_US
003916 NDDF
CHEMBL189171 ChEMBL_ID
1981 PUBCHEM_CID
C519896 MESH_SUPPLEMENTAL_RECORD_UI
C026784 MESH_SUPPLEMENTAL_RECORD_UI
DB13783 DRUGBANK_ID
DB00328 DRUGBANK_ID
CHEBI:31162 CHEBI

Pharmaceutical products:

None