acemetacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, indometacin derivatives 47 53164-05-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Bay f 4975
  • TVX 1322
  • acemetacin
  • acemet
  • acemethacin
  • acemethazine
  • rantudil
  • Molecular weight: 415.83
  • Formula: C21H18ClNO6
  • CLOGP: 4.20
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 94.83
  • ALOGS: -5.26
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.12 g O

ADMET properties:

PropertyValueReference
S (Water solubility) 0.06 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Axial spondyloarthritis 55.06 53.36 8 495 376 63488143

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ankylosing spondylitis 63.32 53.32 12 135 5592 34951192
Uveitis 53.80 53.32 11 136 7524 34949260

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Axial spondyloarthritis 75.49 42.02 11 571 575 79743231
Residual urine volume increased 42.85 42.02 5 577 43 79743763

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB11 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatism indication 396332003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.15 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR KEGG DRUG KEGG DRUG
Lactoylglutathione lyase Enzyme Ki 4.89 CHEMBL

External reference:

IDSource
D01582 KEGG_DRUG
16695 RXNORM
C0050409 UMLSCUI
CHEBI:31162 CHEBI
CHEMBL189171 ChEMBL_ID
DB13783 DRUGBANK_ID
C026784 MESH_SUPPLEMENTAL_RECORD_UI
1981 PUBCHEM_CID
C519896 MESH_SUPPLEMENTAL_RECORD_UI
3664 INN_ID
5V141XK28X UNII
329906008 SNOMEDCT_US
391704009 SNOMEDCT_US
003916 NDDF

Pharmaceutical products:

None