Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor antagonists/agonists related to normorphine | 4673 | 152657-84-6 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 21, 2009 | PMDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | V03AX02 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Other therapeutic products |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Severe Pruritus | indication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.64 | acidic |
pKa2 | 7.76 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor | GPCR | AGONIST | Ki | 9.64 | CHEMBL | SCIENTIFIC LITERATURE | |||
Mu-type opioid receptor | GPCR | EC50 | 9.14 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | EC50 | 7.13 | CHEMBL | |||||
Nociceptin receptor | GPCR | Ki | 6.83 | PDSP | |||||
Mitogen-activated protein kinase 3 | Kinase | EC50 | 9.26 | CHEMBL | |||||
Mitogen-activated protein kinase 1 | Kinase | EC50 | 9.26 | CHEMBL | |||||
Orexin receptor type 1 | GPCR | Ki | 6.60 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.37 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 7.29 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 9.43 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 9.75 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | EC50 | 9.30 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 9.75 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.24 | CHEMBL |
ID | Source |
---|---|
D06405 | KEGG_DRUG |
152658-17-8 | SECONDARY_CAS_RN |
CHEBI:136019 | CHEBI |
IVB | PDB_CHEM_ID |
CHEMBL267495 | ChEMBL_ID |
CHEMBL490665 | ChEMBL_ID |
CHEMBL485605 | ChEMBL_ID |
C111212 | MESH_SUPPLEMENTAL_RECORD_UI |
1651 | IUPHAR_LIGAND_ID |
8209 | INN_ID |
DB13471 | DRUGBANK_ID |
XC41AVD567 | UNII |
C2825264 | UMLSCUI |
6445230 | PUBCHEM_CID |
None