betiatide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4666 103725-47-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betiatide
  • technetium tc-99m mertiatide kit
  • technescan MAG3
Betiatide is the active ingredient in several kits for the preparation of radioactive diagnostic agents, including technetium Tc 99m mertiatide. It is used in the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstruction and calculi.
  • Molecular weight: 367.38
  • Formula: C15H17N3O6S
  • CLOGP: 0.27
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 4
  • TPSA: 141.67
  • ALOGS: -3.54
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PLK3,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 55
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6,MAPK7,STK33,TEK 7
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
June 15, 1990 FDA CURIUM

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Renal scan abnormal 71.79 63.88 6 34 36 110589223

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D007202 Indicators and Reagents
MeSH PA D019275 Radiopharmaceuticals

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diagnosis of congenital and acquired renal abnormalities indication
Diagnosis of renal failure indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.25 acidic
pKa2 12.46 acidic
pKa3 12.9 acidic
pKa4 13.53 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03105 KEGG_DRUG
4039908 VANDF
CHEBI:136015 CHEBI
CHEMBL2109104 ChEMBL_ID
6176 INN_ID
DB14082 DRUGBANK_ID
9NV2SR34P8 UNII
194098 RXNORM
35599 MMSL
d09061 MMSL
C0672188 UMLSCUI
CHEMBL2107488 ChEMBL_ID
185457 PUBCHEM_CID
712599009 SNOMEDCT_US
D017263 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Kit for the Preparation of Technetium Tc99m Mertiatide HUMAN PRESCRIPTION DRUG LABEL 1 45567-0655 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS ANDA 17 sections
TECHNETIUM Tc 99m MERTIATIDE HUMAN PRESCRIPTION DRUG LABEL 1 65174-261 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 23 sections
Technescan MAG3 HUMAN PRESCRIPTION DRUG LABEL 1 69945-096 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 17 sections