creatine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4661	57-00-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

creatine
methylguanidoacetic acid

An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.

Molecular weight: 131.14
Formula: C4H9N3O2
CLOGP: -1.51
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 90.41
ALOGS: -1.50
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	48
kinase-selectivity-class	ACVR2B,AXL,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,STK33,TEK,TGFBR1	11
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	255.89	69.96	57	495	40883	90587012
Coma	223.39	69.96	57	495	72575	90555320
Gastrooesophageal reflux disease	180.82	69.96	58	494	166279	90461616
Somnolence	163.87	69.96	57	495	209027	90418868
Underdose	97.46	69.96	28	524	53989	90573906

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Focal segmental glomerulosclerosis	39.99	35.37	8	329	2540	42618458

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	203.65	37.60	58	848	81175	110507218
Coma	178.18	37.60	57	849	117812	110470581
Gastrooesophageal reflux disease	158.26	37.60	58	848	179918	110408475
Somnolence	133.27	37.60	59	847	297390	110291003
Underdose	88.55	37.60	29	877	63525	110524868
Incorrect route of product administration	46.33	37.60	18	888	64043	110524350

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35705	immunosuppressive agent
CHEBI has role	CHEBI:48407	antiparkinson drug
CHEBI has role	CHEBI:50733	nutraceutical
CHEBI has role	CHEBI:63726	neuroprotective agent
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:176497	geroprotector

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.48	acidic
pKa2	11.13	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4024927	VUID
N0000170276	NUI
4024927	VANDF
CHEBI:16919	CHEBI
CRN	PDB_CHEM_ID
CHEMBL283800	ChEMBL_ID
4496	IUPHAR_LIGAND_ID
DB00148	DRUGBANK_ID
MU72812GK0	UNII
2907	RXNORM
NOCODE	MMSL
d04417	MMSL
008272	NDDF
C0010286	UMLSCUI
D003401	MESH_DESCRIPTOR_UI
586	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ginsamin Energy	HUMAN OTC DRUG LABEL	5	44738-7001	LIQUID	10000 mg	ORAL	unapproved drug other	3 sections