metamizole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory analgesics, phenylbutazone derivatives	4659	68-89-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: algocalmin metamizole metamizole sodium metamizol metapyrin methampyrone dipyrone dipyrone monohydrate sulpyrine metamizole magnesium metamizole calcium	A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Molecular weight: 311.36 Formula: C13H17N3O4S CLOGP: -1.20 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 81.16 ALOGS: -2.09 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

algocalmin
metamizole
metamizole sodium
metamizol
metapyrin
methampyrone
dipyrone
dipyrone monohydrate
sulpyrine
metamizole magnesium
metamizole calcium

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.

Molecular weight: 311.36
Formula: C13H17N3O4S
CLOGP: -1.20
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 81.16
ALOGS: -2.09
ROTB: 4

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	P
3	g	R

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1507.27	12.66	1229	46541	200173	63241079
Product prescribing error	639.37	12.66	337	47433	25952	63415300
Systemic infection	383.59	12.66	141	47629	4519	63436733
Haematochezia	365.67	12.66	311	47459	53233	63388019
Anaemia	340.30	12.66	708	47062	292722	63148530
Agranulocytosis	326.96	12.66	215	47555	24919	63416333
Product monitoring error	325.59	12.66	124	47646	4392	63436860
Drug ineffective	253.90	12.66	249	47521	1044516	62396736
Labelled drug-drug interaction medication error	217.75	12.66	132	47638	13267	63427985
Fracture	201.45	12.66	145	47625	19439	63421813
Haematemesis	178.16	12.66	162	47608	30250	63411002
Joint swelling	162.57	12.66	26	47744	327640	63113612
Polyneuropathy	161.56	12.66	113	47657	14476	63426776
Fall	157.21	12.66	647	47123	391687	63049565
Leukopenia	144.71	12.66	230	47540	77060	63364192
Abdominal discomfort	133.61	12.66	38	47732	320847	63120405
Aspirin-exacerbated respiratory disease	132.28	12.66	42	47728	853	63440399
Systemic lupus erythematosus	131.84	12.66	6	47764	208912	63232340
Toxic epidermal necrolysis	127.38	12.66	124	47646	25210	63416042
Infusion related reaction	125.11	12.66	18	47752	245503	63195749
Abdominal pain lower	122.26	12.66	122	47648	25556	63415696
Pemphigus	120.26	12.66	4	47766	183722	63257530
Synovitis	119.15	12.66	5	47765	186913	63254339
Treatment failure	118.54	12.66	8	47762	199035	63242217
Product dose omission issue	117.49	12.66	18	47752	234295	63206957
Pallor	108.02	12.66	124	47646	30444	63410808
Renal impairment	105.25	12.66	216	47554	88139	63353113
Arthropathy	105.00	12.66	24	47746	234768	63206484
Swelling	100.06	12.66	41	47729	275337	63165915
Drug intolerance	99.80	12.66	54	47716	308607	63132645
Therapeutic product effect decreased	98.78	12.66	14	47756	193173	63248079
Dyspnoea	97.63	12.66	838	46932	660475	62780777
Restlessness	96.61	12.66	115	47655	29338	63411914
Sinusitis	93.99	12.66	27	47743	226626	63214626
Arrhythmia	93.69	12.66	129	47641	38011	63403241
Tachypnoea	93.24	12.66	88	47682	17214	63424038
Stevens-Johnson syndrome	92.90	12.66	104	47666	24846	63416406
Apathy	90.16	12.66	65	47705	8729	63432523
Vomiting	89.90	12.66	723	47047	558894	62882358
Erysipelas	84.66	12.66	60	47710	7845	63433407
Nausea	83.78	12.66	995	46775	853476	62587776
Upper gastrointestinal haemorrhage	83.23	12.66	86	47684	18766	63422486
Alopecia	83.04	12.66	79	47691	337457	63103795
Malaise	82.25	12.66	116	47654	415838	63025414
Product administration error	81.07	12.66	92	47678	22305	63418947
Abdominal pain	79.21	12.66	432	47338	293024	63148228
Pericarditis	76.27	12.66	6	47764	131573	63309679
Drug hypersensitivity	76.08	12.66	73	47697	310614	63130638
Drug-induced liver injury	74.28	12.66	119	47651	40103	63401149
Tachycardia	73.96	12.66	226	47544	117930	63323322
Abdominal pain upper	72.06	12.66	327	47443	206117	63235135
Electrolyte imbalance	70.18	12.66	81	47689	19995	63421257
Pancytopenia	69.86	12.66	195	47575	96738	63344514
Atrial fibrillation	69.21	12.66	219	47551	116417	63324835
Product use issue	69.18	12.66	40	47730	220480	63220772
Lower respiratory tract infection	69.01	12.66	9	47761	132298	63308954
Haematoma	68.42	12.66	106	47664	34714	63406538
Cardiac failure	67.89	12.66	183	47587	88959	63352293
Hypokalaemia	67.26	12.66	201	47569	103603	63337649
Jaundice	66.00	12.66	95	47675	29156	63412096
Ascites	65.17	12.66	113	47657	40615	63400637
Completed suicide	64.87	12.66	15	47755	145658	63295594
Rheumatoid arthritis	64.04	12.66	58	47712	253761	63187491
Oedema peripheral	63.77	12.66	297	47473	189214	63252038
Contraindicated product administered	62.09	12.66	44	47726	217604	63223648
Musculoskeletal stiffness	61.54	12.66	31	47739	184587	63256665
Dysuria	61.18	12.66	99	47671	33639	63407613
Acute kidney injury	60.11	12.66	371	47399	263044	63178208
Acute hepatic failure	59.18	12.66	71	47699	18256	63422996
Maternal exposure during pregnancy	58.29	12.66	48	47722	220014	63221238
Gastritis erosive	58.20	12.66	43	47727	5996	63435256
Dehydration	57.81	12.66	271	47499	173083	63268169
Disturbance in attention	53.50	12.66	100	47670	38089	63403163
Cachexia	53.46	12.66	40	47730	5686	63435566
Nasopharyngitis	53.13	12.66	68	47702	254189	63187063
Therapeutic drug monitoring analysis not performed	52.89	12.66	24	47746	1328	63439924
Drug interaction	52.43	12.66	323	47447	228808	63212444
Helicobacter infection	51.68	12.66	5	47765	92780	63348472
Headache	50.75	12.66	275	47495	632966	62808286
Arthralgia	50.41	12.66	239	47531	569471	62871781
Discomfort	50.19	12.66	32	47738	167342	63273910
Gamma-glutamyltransferase increased	48.78	12.66	90	47680	33941	63407311
Musculoskeletal pain	48.22	12.66	166	47604	92111	63349141
Hyponatraemia	48.14	12.66	189	47581	111711	63329541
Thrombocytopenia	47.99	12.66	233	47537	150924	63290328
Off label use	46.60	12.66	307	47463	674155	62767097
Osteochondrosis	46.26	12.66	22	47748	1355	63439897
Injection site pain	46.01	12.66	20	47750	129780	63311472
Listless	46.00	12.66	28	47742	2832	63438420
Spontaneous haemorrhage	45.17	12.66	17	47753	582	63440670
Reduced facial expression	44.36	12.66	24	47746	1942	63439310
Pyrexia	43.68	12.66	543	47227	469935	62971317
Nasal disorder	43.42	12.66	27	47743	2837	63438415
Concomitant disease aggravated	42.82	12.66	43	47727	9069	63432183
Syncope	42.45	12.66	188	47582	117197	63324055
Weight increased	41.94	12.66	83	47687	260709	63180543
Urosepsis	41.55	12.66	60	47710	18464	63422788
Haemorrhagic erosive gastritis	41.48	12.66	15	47755	458	63440794
Malignant neoplasm progression	41.41	12.66	146	47624	81975	63359277
Rash	40.38	12.66	252	47518	560619	62880633
Cardiac failure congestive	40.19	12.66	10	47760	92423	63348829
Hepatorenal failure	39.28	12.66	16	47754	678	63440574
Stenosis	39.22	12.66	20	47750	1434	63439818
Pelvic fracture	38.72	12.66	49	47721	13299	63427953
Mucosal haemorrhage	37.94	12.66	18	47752	1103	63440149
Psoriatic arthropathy	37.72	12.66	11	47759	91509	63349743
Therapy non-responder	37.62	12.66	6	47764	75895	63365357
Hypersensitivity	37.59	12.66	105	47665	292580	63148672
Hypoaesthesia	37.31	12.66	43	47727	168350	63272902
Urogenital haemorrhage	36.85	12.66	12	47758	265	63440987
Tumour pain	36.55	12.66	19	47751	1418	63439834
Subileus	36.07	12.66	25	47745	3154	63438098
Suspected product quality issue	35.09	12.66	11	47759	214	63441038
Therapeutic product effect incomplete	34.70	12.66	26	47744	125030	63316222
Constipation	34.49	12.66	288	47482	224655	63216597
Gallbladder polyp	34.08	12.66	15	47755	772	63440480
Dizziness	33.57	12.66	481	47289	429444	63011808
Hepatitis toxic	33.24	12.66	24	47746	3229	63438023
Psoriasis	33.11	12.66	12	47758	86945	63354307
Spinal pain	33.10	12.66	45	47725	13094	63428158
Nasal congestion	32.97	12.66	5	47765	65655	63375597
Prescription drug used without a prescription	32.45	12.66	21	47749	2365	63438887
Peripheral swelling	32.25	12.66	98	47672	265844	63175408
Hospitalisation	31.95	12.66	12	47758	85069	63356183
Facial nerve disorder	31.80	12.66	13	47757	556	63440696
Angina pectoris	31.70	12.66	70	47700	30008	63411244
Injury	31.70	12.66	8	47762	73239	63368013
Feeling abnormal	31.69	12.66	39	47731	148353	63292899
Drug reaction with eosinophilia and systemic symptoms	31.52	12.66	75	47695	33761	63407491
Medication error	30.82	12.66	98	47672	52186	63389066
Injection site erythema	30.79	12.66	12	47758	83162	63358090
Type I hypersensitivity	30.74	12.66	22	47748	2920	63438332
Gastrointestinal disorder	30.74	12.66	32	47738	131207	63310045
Ileus	30.58	12.66	46	47724	14679	63426573
Somatic symptom disorder	30.37	12.66	21	47749	2639	63438613
Hepatic enzyme increased	30.32	12.66	67	47703	202261	63238991
Diverticulum intestinal	30.31	12.66	31	47739	6682	63434570
Dyspnoea exertional	30.21	12.66	107	47663	60195	63381057
Circulatory collapse	30.16	12.66	57	47713	21881	63419371
Pleural effusion	29.79	12.66	144	47626	93066	63348186
Heart rate increased	29.66	12.66	17	47753	94221	63347031
Hepatic cyst	29.28	12.66	27	47743	5127	63436125
Delirium	29.13	12.66	94	47676	50447	63390805
Intentional product use issue	29.04	12.66	32	47738	127860	63313392
Paresis	28.95	12.66	20	47750	2510	63438742
Chromaturia	28.88	12.66	48	47722	16669	63424583
Gastrointestinal sounds abnormal	28.58	12.66	24	47746	4027	63437225
Adverse event	28.06	12.66	8	47762	67551	63373701
Therapeutic response decreased	28.05	12.66	6	47764	61519	63379733
Head discomfort	27.99	12.66	42	47728	13373	63427879
Hepatitis cholestatic	27.90	12.66	30	47740	6848	63434404
Immobile	27.84	12.66	28	47742	5915	63435337
Respiratory alkalosis	27.77	12.66	20	47750	2681	63438571
Faecaloma	27.68	12.66	32	47738	7909	63433343
Oliguria	27.34	12.66	34	47736	9067	63432185
Irritable bowel syndrome	27.20	12.66	14	47756	82398	63358854
Electrocardiogram abnormal	27.11	12.66	34	47736	9145	63432107
Bradycardia	27.01	12.66	118	47652	73109	63368143
Psychotic symptom	26.97	12.66	16	47754	1545	63439707
Hepatic failure	26.92	12.66	73	47697	35583	63405669
Bicytopenia	26.79	12.66	19	47751	2486	63438766
Nail toxicity	26.66	12.66	10	47760	339	63440913
Muscle tone disorder	26.52	12.66	8	47762	136	63441116
Illness	26.40	12.66	3	47767	49056	63392196
Amnesia	26.22	12.66	5	47765	55580	63385672
Migraine	25.58	12.66	24	47746	103322	63337930
Painful respiration	25.05	12.66	19	47751	2755	63438497
Acute generalised exanthematous pustulosis	24.96	12.66	36	47734	11063	63430189
Insomnia	24.90	12.66	81	47689	215171	63226081
Thirst decreased	24.88	12.66	9	47761	275	63440977
Blood pressure increased	24.83	12.66	53	47717	162009	63279243
Post-traumatic pain	24.64	12.66	10	47760	420	63440832
Lethargy	24.46	12.66	6	47764	56001	63385251
Vascular encephalopathy	24.39	12.66	10	47760	431	63440821
Hypertensive emergency	24.21	12.66	16	47754	1866	63439386
Decreased appetite	24.19	12.66	292	47478	250760	63190492
Injection site reaction	24.18	12.66	7	47763	58517	63382735
Hepatitis acute	24.14	12.66	32	47738	9088	63432164
Antineutrophil cytoplasmic antibody positive	24.06	12.66	11	47759	619	63440633
Pseudarthrosis	24.00	12.66	10	47760	449	63440803
Type 2 diabetes mellitus	24.00	12.66	9	47761	63859	63377393
Death	23.99	12.66	174	47596	374207	63067045
Gastric mucosa erythema	23.94	12.66	9	47761	307	63440945
Injection site pruritus	23.68	12.66	3	47767	45113	63396139
Disease progression	23.44	12.66	35	47735	122723	63318529
Duodenal ulcer	23.34	12.66	29	47741	7727	63433525
Haematuria	23.34	12.66	61	47709	29096	63412156
Urinary retention	22.84	12.66	62	47708	30239	63411013
Myocardial infarction	22.67	12.66	25	47745	99868	63341384
Device stimulation issue	22.64	12.66	6	47764	62	63441190
Pain in jaw	22.57	12.66	3	47767	43493	63397759
Rheumatic fever	22.30	12.66	3	47767	43108	63398144
Gastric ulcer	22.08	12.66	53	47717	23984	63417268
Suspected product contamination	22.03	12.66	5	47765	25	63441227
Fibromyalgia	21.95	12.66	17	47753	80403	63360849
Febrile infection	21.90	12.66	14	47756	1543	63439709
Patent ductus arteriosus	21.73	12.66	21	47749	4229	63437023
Heart rate decreased	21.70	12.66	4	47766	45556	63395696
Gastroenteritis	21.66	12.66	56	47714	26534	63414718
Cholestatic liver injury	21.66	12.66	17	47753	2593	63438659
Humerus fracture	21.65	12.66	30	47740	8886	63432366
Lividity	21.59	12.66	8	47762	262	63440990
Adverse drug reaction	21.56	12.66	17	47753	79697	63361555
Unevaluable event	21.50	12.66	6	47764	51380	63389872
Inappropriate schedule of product administration	21.48	12.66	28	47742	103937	63337315
Metastatic malignant melanoma	21.47	12.66	13	47757	1302	63439950
Knee arthroplasty	21.46	12.66	7	47763	54199	63387053
Ill-defined disorder	21.41	12.66	18	47752	81737	63359515
Loss of personal independence in daily activities	21.37	12.66	25	47745	97265	63343987
Depressed level of consciousness	21.36	12.66	98	47672	61980	63379272
C-reactive protein increased	21.30	12.66	133	47637	94574	63346678
Thirst	21.22	12.66	38	47732	14003	63427249
Helicobacter gastritis	21.15	12.66	14	47756	1638	63439614
Neuropathy peripheral	21.13	12.66	33	47737	113634	63327618
Foreign body	21.09	12.66	16	47754	2322	63438930
Localised infection	20.98	12.66	60	47710	30150	63411102
Vertigo	20.95	12.66	95	47675	59792	63381460
Hyperkinesia	20.75	12.66	14	47756	1690	63439562
Sensory disturbance	20.66	12.66	37	47733	13635	63427617
Chills	20.58	12.66	151	47619	113227	63328025
Cellulitis	20.32	12.66	19	47751	81939	63359313
Aortic valve stenosis	20.15	12.66	18	47752	3281	63437971
Paranasal sinus inflammation	20.04	12.66	9	47761	486	63440766
Transaminases increased	19.60	12.66	60	47710	31307	63409945
Coombs negative haemolytic anaemia	19.50	12.66	7	47763	209	63441043
Arthritis	19.39	12.66	36	47734	115885	63325367
Necrotising fasciitis	19.38	12.66	17	47753	3024	63438228
Hyperaemia	19.37	12.66	15	47755	2244	63439008
Acute abdomen	19.34	12.66	13	47757	1560	63439692
Peritoneal perforation	18.98	12.66	6	47764	120	63441132
Pneumobilia	18.80	12.66	6	47764	124	63441128
Fluid intake reduced	18.63	12.66	18	47752	3623	63437629
Medication overuse headache	18.34	12.66	10	47760	822	63440430
Peripheral arterial occlusive disease	18.24	12.66	19	47751	4182	63437070
Flank pain	18.21	12.66	39	47731	16371	63424881
Pregnancy	18.05	12.66	3	47767	36833	63404419
Liver function test increased	17.98	12.66	60	47710	32751	63408501
Catheter site inflammation	17.93	12.66	10	47760	859	63440393
Left ventricular hypertrophy	17.83	12.66	21	47749	5294	63435958
Sensory level abnormal	17.80	12.66	6	47764	148	63441104
Gastritis	17.67	12.66	65	47705	37238	63404014
Rhonchi	17.63	12.66	15	47755	2561	63438691
Neutropenia	17.48	12.66	205	47565	174800	63266452
Reactive gastropathy	17.45	12.66	8	47762	453	63440799
Spinal osteoarthritis	17.43	12.66	38	47732	16148	63425104
Hyperglycaemia	17.41	12.66	70	47700	41797	63399455
Mucosal erosion	17.38	12.66	12	47758	1504	63439748
Mesenteric arterial occlusion	17.29	12.66	6	47764	162	63441090
Conjunctivitis	17.15	12.66	44	47726	20752	63420500
Acute respiratory failure	17.10	12.66	61	47709	34424	63406828
Diverticulum intestinal haemorrhagic	17.06	12.66	12	47758	1549	63439703
No adverse event	17.01	12.66	5	47765	41400	63399852
Lordosis	16.98	12.66	7	47763	306	63440946
Stoma site inflammation	16.94	12.66	8	47762	485	63440767
Sepsis	16.94	12.66	183	47587	152940	63288312
Peripheral circulatory failure	16.93	12.66	10	47760	958	63440294
Dermatitis bullous	16.85	12.66	26	47744	8482	63432770
Oesophageal candidiasis	16.76	12.66	21	47749	5642	63435610
Normochromic normocytic anaemia	16.70	12.66	19	47751	4617	63436635
Vasculitis	16.57	12.66	40	47730	18169	63423083
Coronavirus test positive	16.55	12.66	9	47761	736	63440516
C-reactive protein abnormal	16.49	12.66	7	47763	46089	63395163
Adrenal calcification	16.48	12.66	4	47766	28	63441224
Nail avulsion	16.35	12.66	6	47764	191	63441061
Breast cancer metastatic	16.24	12.66	31	47739	11987	63429265
Prerenal failure	16.17	12.66	12	47758	1684	63439568
Upper respiratory tract infection	16.04	12.66	23	47747	82024	63359228
Faeces pale	16.04	12.66	12	47758	1705	63439547
Exposure during pregnancy	15.68	12.66	62	47708	155485	63285767
Brain contusion	15.64	12.66	8	47762	577	63440675
Pulmonary vein occlusion	15.54	12.66	5	47765	106	63441146
Anaemia folate deficiency	15.45	12.66	6	47764	224	63441028
Affective disorder	15.40	12.66	21	47749	6125	63435127
Surgery	15.39	12.66	4	47766	35908	63405344
Adrenomegaly	15.33	12.66	5	47765	111	63441141
Product use in unapproved indication	15.26	12.66	76	47694	179004	63262248
Cardiac murmur functional	15.21	12.66	4	47766	40	63441212
Gastrointestinal infection	15.17	12.66	26	47744	9255	63431997
Internal haemorrhage	15.04	12.66	19	47751	5146	63436106
Urogenital infection bacterial	15.03	12.66	4	47766	42	63441210
Abdominal wall cyst	15.03	12.66	4	47766	42	63441210
Urinary tract infection enterococcal	15.00	12.66	14	47756	2699	63438553
Aortic valve sclerosis	14.98	12.66	10	47760	1186	63440066
Dyschezia	14.98	12.66	13	47757	2281	63438971
Dysphagia	14.95	12.66	116	47654	88469	63352783
Disorientation	14.87	12.66	64	47706	39388	63401864
Lumbar vertebral fracture	14.79	12.66	20	47750	5790	63435462
Cardio-respiratory arrest	14.74	12.66	14	47756	59945	63381307
Leukocytosis	14.73	12.66	48	47722	25887	63415365
Gastric ulcer perforation	14.68	12.66	10	47760	1226	63440026
Myoclonus	14.59	12.66	35	47735	15833	63425419
Bone marrow oedema	14.57	12.66	10	47760	1242	63440010
Spinal instability	14.44	12.66	5	47765	134	63441118
Necrolytic migratory erythema	14.43	12.66	3	47767	9	63441243
Contusion	14.37	12.66	61	47709	149983	63291269
Reticulocyte count increased	14.34	12.66	9	47761	961	63440291
Merycism	14.29	12.66	6	47764	275	63440977
Pericardial drainage	14.20	12.66	6	47764	279	63440973
Thalamus haemorrhage	14.20	12.66	8	47762	701	63440551
Bulimia nervosa	14.20	12.66	7	47763	467	63440785
VIIIth nerve injury	14.19	12.66	3	47767	10	63441242
Shock haemorrhagic	13.96	12.66	26	47744	9869	63431383
Liver injury	13.89	12.66	15	47755	60505	63380747
Ileal stenosis	13.88	12.66	11	47759	1702	63439550
Kyphosis	13.84	12.66	13	47757	2527	63438725
Systemic inflammatory response syndrome	13.78	12.66	19	47751	5602	63435650
Nocturia	13.56	12.66	23	47747	8118	63433134
Blister	13.56	12.66	51	47719	129763	63311489
Fatigue	13.55	12.66	539	47231	887489	62553763
CD8 lymphocytes decreased	13.52	12.66	5	47765	163	63441089
Metastatic gastric cancer	13.46	12.66	5	47765	165	63441087
Product used for unknown indication	13.43	12.66	7	47763	525	63440727
Sinobronchitis	13.43	12.66	5	47765	166	63441086
Anaemia of malignant disease	13.39	12.66	7	47763	528	63440724
Feeling cold	13.37	12.66	44	47726	23844	63417408
Respiratory arrest	13.31	12.66	4	47766	32641	63408611
Vision blurred	13.30	12.66	31	47739	91893	63349359
Autoimmune colitis	13.22	12.66	7	47763	542	63440710
Gastrointestinal tract adenoma	13.22	12.66	6	47764	332	63440920
Chronic fatigue syndrome	13.17	12.66	9	47761	1109	63440143
Petechiae	13.15	12.66	31	47739	13866	63427386
Hyperresponsive to stimuli	13.10	12.66	4	47766	71	63441181
Nutritional condition abnormal	13.09	12.66	8	47762	815	63440437
Mucosal dryness	12.99	12.66	13	47757	2731	63438521
Stress	12.96	12.66	19	47751	67148	63374104
SARS-CoV-2 antibody test negative	12.94	12.66	5	47765	184	63441068
Hyperuricaemia	12.94	12.66	18	47752	5352	63435900
Pulmonary atypical adenomatous hyperplasia	12.85	12.66	4	47766	76	63441176
Femoral neck fracture	12.79	12.66	23	47747	8500	63432752
Body fat disorder	12.74	12.66	5	47765	192	63441060

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1576.94	13.58	1228	37530	127041	34791132
Product prescribing error	406.07	13.58	275	38483	22652	34895521
Systemic infection	299.55	13.58	136	38622	5076	34913097
Product monitoring error	228.87	13.58	107	38651	4274	34913899
Anaemia	202.13	13.58	642	38116	232693	34685480
Drug ineffective	181.78	13.58	145	38613	456606	34461567
Haematochezia	176.38	13.58	237	38521	46297	34871876
Appendicolith	144.65	13.58	100	38658	8501	34909672
Abdominal pain	140.25	13.58	449	38309	163169	34755004
Appendicitis	110.10	13.58	107	38651	14700	34903473
Musculoskeletal pain	102.03	13.58	150	38608	31813	34886360
Death	100.79	13.58	180	38578	397869	34520304
Blood phosphorus increased	96.39	13.58	75	38683	7646	34910527
Completed suicide	95.21	13.58	3	38755	98165	34820008
Labelled drug-drug interaction medication error	94.66	13.58	99	38659	14840	34903333
Agranulocytosis	94.30	13.58	124	38634	23697	34894476
Vomiting	93.34	13.58	529	38229	247092	34671081
Malaise	86.98	13.58	49	38709	185776	34732397
Nausea	85.48	13.58	656	38102	339252	34578921
Abdominal pain upper	85.13	13.58	221	38537	71269	34846904
Constipation	83.92	13.58	337	38421	136645	34781528
Tachypnoea	82.86	13.58	102	38656	18250	34899923
Dyspnoea	79.08	13.58	698	38060	376084	34542089
Product dose omission issue	73.17	13.58	21	38737	119690	34798483
Pallor	71.99	13.58	113	38645	25367	34892806
Cardiac failure congestive	70.02	13.58	6	38752	83264	34834909
Ventricular fibrillation	66.52	13.58	103	38655	22851	34895322
Leukopenia	66.46	13.58	186	38572	62670	34855503
Hyponatraemia	65.34	13.58	221	38537	82470	34835703
Tachycardia	63.01	13.58	222	38536	84550	34833623
Ascites	62.80	13.58	151	38607	46420	34871753
Cardiogenic shock	61.70	13.58	108	38650	26510	34891663
Stress	58.84	13.58	114	38644	30233	34887940
Abdominal distension	57.86	13.58	169	38589	58323	34859850
Electrolyte imbalance	56.99	13.58	75	38683	14337	34903836
Micturition disorder	54.75	13.58	33	38725	2215	34915958
Restlessness	54.72	13.58	100	38658	25382	34892791
Paresis	53.01	13.58	32	38726	2154	34916019
Polyneuropathy	52.05	13.58	73	38685	14823	34903350
Fracture	51.85	13.58	50	38708	6799	34911374
Acute abdomen	51.01	13.58	30	38728	1925	34916248
Neuropathy peripheral	50.14	13.58	15	38743	83248	34834925
Toxicity to various agents	49.27	13.58	92	38666	200270	34717903
Electrocardiogram abnormal	47.67	13.58	55	38703	9192	34908981
Blood uric acid increased	47.54	13.58	56	38702	9568	34908605
Myocardial infarction	47.16	13.58	39	38719	121046	34797127
Dyschezia	44.77	13.58	25	38733	1453	34916720
Condition aggravated	44.28	13.58	364	38394	191832	34726341
Multiple organ dysfunction syndrome	44.13	13.58	185	38573	76381	34841792
Drug abuse	43.68	13.58	28	38730	99068	34819105
Hyperventilation	43.21	13.58	31	38727	2793	34915380
Hospitalisation	43.02	13.58	6	38752	56896	34861277
Respiratory tract haemorrhage	42.66	13.58	23	38735	1247	34916926
Negative pressure pulmonary oedema	42.16	13.58	14	38744	219	34917954
Blood pressure measurement	41.50	13.58	13	38745	167	34918006
Platelet count decreased	41.37	13.58	43	38715	119674	34798499
Interstitial lung disease	40.71	13.58	11	38747	65271	34852902
Pyrexia	40.05	13.58	553	38205	332460	34585713
Mucosal haemorrhage	39.95	13.58	24	38734	1601	34916572
Osteochondrosis	39.81	13.58	21	38737	1089	34917084
Oedema peripheral	39.21	13.58	247	38511	119565	34798608
Neuromuscular block prolonged	38.33	13.58	16	38742	485	34917688
C-reactive protein increased	37.89	13.58	139	38619	53959	34864214
Dry mouth	37.67	13.58	95	38663	30070	34888103
Haematemesis	37.50	13.58	90	38668	27621	34890552
Therapeutic drug monitoring analysis not performed	36.47	13.58	16	38742	549	34917624
Blood pressure increased	36.03	13.58	27	38731	88075	34830098
Hepatic cyst	36.03	13.58	27	38731	2602	34915571
Disease progression	36.02	13.58	40	38718	108037	34810136
Wound	35.34	13.58	61	38697	14803	34903370
Myasthenia gravis	35.30	13.58	41	38717	6899	34911274
Treatment failure	35.12	13.58	5	38753	46692	34871481
Product administration error	34.90	13.58	64	38694	16280	34901893
Cardiac arrest	33.83	13.58	34	38724	96125	34822048
Feeling abnormal	33.60	13.58	14	38744	63221	34854952
Gamma-glutamyltransferase increased	33.36	13.58	89	38669	29142	34889031
Infusion related reaction	32.96	13.58	9	38749	53048	34865125
Cachexia	32.52	13.58	40	38718	7146	34911027
Fall	32.14	13.58	355	38403	202530	34715643
Platelet dysfunction	32.09	13.58	12	38746	270	34917903
Impaired healing	31.44	13.58	59	38699	15275	34902898
Urosepsis	29.74	13.58	52	38706	12747	34905426
Hypertensive crisis	29.26	13.58	42	38716	8709	34909464
Joint swelling	29.12	13.58	15	38743	59875	34858298
Abdominal discomfort	29.07	13.58	15	38743	59820	34858353
Medication error	28.33	13.58	77	38681	25488	34892685
Leptotrichia infection	27.81	13.58	8	38750	75	34918098
Lack of application site rotation	27.81	13.58	8	38750	75	34918098
Therapy non-responder	27.62	13.58	5	38753	39141	34879032
Drug reaction with eosinophilia and systemic symptoms	27.61	13.58	90	38668	32922	34885251
Disturbance in attention	27.61	13.58	77	38681	25868	34892305
Accessory spleen	26.91	13.58	9	38749	144	34918029
Erysipelas	26.89	13.58	30	38728	4833	34913340
Internal fixation of fracture	26.75	13.58	8	38750	87	34918086
Weight bearing difficulty	26.48	13.58	16	38742	1079	34917094
Cold sweat	26.42	13.58	43	38715	9944	34908229
Polyneuropathy in malignant disease	26.33	13.58	10	38748	235	34917938
Drug therapy	25.87	13.58	16	38742	1125	34917048
Osteoma	25.52	13.58	8	38750	103	34918070
Therapeutic product effect decreased	25.48	13.58	4	38754	34739	34883434
Polycystic liver disease	25.45	13.58	8	38750	104	34918069
Analgesic therapy	25.21	13.58	15	38743	983	34917190
Toxic epidermal necrolysis	24.79	13.58	66	38692	21580	34896593
Splenic necrosis	24.65	13.58	8	38750	116	34918057
Dizziness	24.63	13.58	359	38399	218162	34700011
Gastrointestinal adenocarcinoma	24.49	13.58	7	38751	64	34918109
White blood cell count decreased	24.15	13.58	43	38715	95402	34822771
Haemoglobin urine present	23.92	13.58	8	38750	128	34918045
Renal impairment	23.90	13.58	183	38575	94330	34823843
Splenic cyst	23.81	13.58	8	38750	130	34918043
Suspected product contamination	23.67	13.58	7	38751	73	34918100
Activated partial thromboplastin time abnormal	22.90	13.58	8	38750	147	34918026
Coma	22.87	13.58	11	38747	45667	34872506
Iron deficiency	22.83	13.58	29	38729	5352	34912821
Heart rate decreased	22.51	13.58	4	38754	31741	34886432
Iris adhesions	22.46	13.58	9	38749	245	34917928
Cardiovascular insufficiency	22.39	13.58	17	38741	1670	34916503
Gastritis	22.38	13.58	64	38694	21809	34896364
Sleep disorder therapy	22.32	13.58	14	38744	1009	34917164
Cardiac disorder	22.19	13.58	10	38748	43116	34875057
Pulmonary sepsis	21.96	13.58	19	38739	2246	34915927
Loss of personal independence in daily activities	21.82	13.58	5	38753	33174	34884999
Malignant neoplasm progression	21.44	13.58	169	38589	87877	34830296
Implant site inflammation	21.29	13.58	7	38751	106	34918067
Urinary sediment present	21.28	13.58	9	38749	282	34917891
Unevaluable event	21.26	13.58	5	38753	32585	34885588
Hepatorenal failure	21.13	13.58	11	38747	555	34917618
Metastases to soft tissue	20.78	13.58	10	38748	426	34917747
Spinal pain	20.78	13.58	29	38729	5860	34912313
Haematoma	20.69	13.58	69	38689	25536	34892637
Disorientation	20.53	13.58	82	38676	33106	34885067
Lower respiratory tract infection	20.35	13.58	5	38753	31632	34886541
Adenocarcinoma of appendix	20.17	13.58	7	38751	126	34918047
Intestinal haemorrhage	20.08	13.58	22	38736	3474	34914699
Hydrocholecystis	20.07	13.58	10	38748	460	34917713
Musculoskeletal stiffness	19.47	13.58	14	38744	46666	34871507
Lordosis	19.44	13.58	9	38749	351	34917822
Anxiety disorder	19.35	13.58	16	38742	1778	34916395
White blood cells urine positive	19.35	13.58	14	38744	1278	34916895
Pseudarthrosis	19.30	13.58	6	38752	75	34918098
Drug resistance	18.98	13.58	3	38755	25924	34892249
Orthostatic hypotension	18.97	13.58	3	38755	25916	34892257
Spinal osteoarthritis	18.88	13.58	32	38726	7651	34910522
Chills	18.88	13.58	154	38604	80889	34837284
Tracheal atresia	18.84	13.58	4	38754	8	34918165
Suspected product quality issue	18.78	13.58	7	38751	156	34918017
Splenic lesion	18.67	13.58	8	38750	259	34917914
Long QT syndrome	18.51	13.58	19	38739	2784	34915389
Immobile	18.49	13.58	18	38740	2476	34915697
Unresponsive to stimuli	18.44	13.58	4	38754	27565	34890608
Toxic neuropathy	18.43	13.58	10	38748	549	34917624
Febrile infection	18.38	13.58	17	38741	2194	34915979
Blood pressure decreased	18.35	13.58	18	38740	51497	34866676
Thirst	18.24	13.58	32	38726	7863	34910310
Upper gastrointestinal haemorrhage	18.22	13.58	66	38692	25452	34892721
Haematocrit abnormal	18.14	13.58	11	38747	746	34917427
Influenza	18.11	13.58	17	38741	49649	34868524
Flank pain	18.09	13.58	29	38729	6622	34911551
Mineral supplementation	18.06	13.58	6	38752	94	34918079
Muscle spasms	17.90	13.58	35	38723	74966	34843207
Arthropathy	17.80	13.58	4	38754	26903	34891270
Wrong dose	17.78	13.58	10	38748	589	34917584
Depressed level of consciousness	17.69	13.58	94	38664	42747	34875426
Psychotic disorder	17.51	13.58	3	38755	24449	34893724
Flushing	17.50	13.58	7	38751	32413	34885760
Genitourinary tract infection	17.50	13.58	6	38752	104	34918069
Fluid intake reduced	17.39	13.58	21	38737	3680	34914493
Administration site discomfort	17.28	13.58	5	38753	48	34918125
Psoriasis	17.04	13.58	11	38747	38801	34879372
Labelled drug-drug interaction issue	16.98	13.58	8	38750	325	34917848
Dysdiadochokinesis	16.93	13.58	7	38751	207	34917966
Rectal haemorrhage	16.88	13.58	12	38746	40237	34877936
Drug-induced liver injury	16.85	13.58	70	38688	28762	34889411
Haematuria	16.84	13.58	104	38654	49962	34868211
Cardio-respiratory arrest	16.77	13.58	22	38736	55251	34862922
Platelet function test abnormal	16.61	13.58	6	38752	122	34918051
Primary biliary cholangitis	16.59	13.58	7	38751	218	34917955
Urogenital infection bacterial	16.58	13.58	5	38753	56	34918117
Reflux nephropathy	16.35	13.58	5	38753	59	34918114
Chronic fatigue syndrome	16.15	13.58	8	38750	363	34917810
Quality of life decreased	16.09	13.58	21	38737	3980	34914193
Rash	15.92	13.58	164	38594	222588	34695585
Cerebrovascular accident	15.90	13.58	45	38713	84766	34833407
Hyperphosphataemia	15.88	13.58	22	38736	4415	34913758
Sepsis	15.83	13.58	266	38492	166295	34751878
Gastritis haemorrhagic	15.77	13.58	13	38745	1438	34916735
Incorrect route of product administration	15.73	13.58	44	38714	14801	34903372
Contraindicated product administered	15.71	13.58	56	38702	21425	34896748
Encephalopathy	15.52	13.58	10	38748	35309	34882864
Red blood cell abnormality	15.51	13.58	8	38750	396	34917777
Angioedema	15.43	13.58	82	38676	37292	34880881
Papillary renal cell carcinoma	15.41	13.58	7	38751	261	34917912
Spinal cord injury cauda equina	15.38	13.58	6	38752	152	34918021
Breath sounds normal	15.34	13.58	3	38755	3	34918170
Lower gastrointestinal haemorrhage	15.34	13.58	33	38725	9419	34908754
Respiratory arrest	15.23	13.58	6	38752	28037	34890136
Cellulitis	15.13	13.58	22	38736	52929	34865244
Contusion	15.04	13.58	11	38747	36353	34881820
Autoimmune nephritis	15.03	13.58	7	38751	277	34917896
Lung disorder	15.01	13.58	10	38748	34686	34883487
Somatosensory evoked potentials abnormal	14.92	13.58	6	38752	165	34918008
Blood folate increased	14.91	13.58	7	38751	282	34917891
Product prescribing issue	14.81	13.58	15	38743	2164	34916009
Therapeutic response decreased	14.76	13.58	7	38751	29306	34888867
Paraparesis	14.69	13.58	14	38744	1875	34916298
Nail bed inflammation	14.69	13.58	6	38752	172	34918001
Haemorrhagic necrotic pancreatitis	14.69	13.58	6	38752	172	34918001
Adrenocortical insufficiency acute	14.67	13.58	13	38745	1587	34916586
Tremor	14.63	13.58	45	38713	82542	34835631
Jaundice	14.59	13.58	72	38686	31810	34886363
Fear of disease	14.53	13.58	7	38751	299	34917874
Mycobacterium fortuitum infection	14.52	13.58	6	38752	177	34917996
Suicidal ideation	14.51	13.58	14	38744	40374	34877799
Anxiety	14.39	13.58	59	38699	99369	34818804
Blood pressure fluctuation	14.39	13.58	5	38753	25244	34892929
Immune effector cell-associated neurotoxicity syndrome	14.18	13.58	19	38739	3694	34914479
Off label use	14.10	13.58	356	38402	419168	34499005
Therapeutic drug monitoring analysis incorrectly performed	14.07	13.58	7	38751	321	34917852
Coronavirus test positive	14.06	13.58	8	38750	482	34917691
Atheroembolism	14.03	13.58	7	38751	323	34917850
Dehydration	14.01	13.58	212	38546	129757	34788416
Oedematous pancreatitis	13.96	13.58	8	38750	489	34917684
Preternatural anus	13.92	13.58	5	38753	100	34918073
Somnolence	13.87	13.58	186	38572	110930	34807243
Vitamin B6 deficiency	13.87	13.58	6	38752	199	34917974
Basal ganglia haemorrhage	13.79	13.58	10	38748	916	34917257
Fear of falling	13.69	13.58	7	38751	340	34917833
Dermatitis allergic	13.65	13.58	26	38732	6804	34911369
Product packaging confusion	13.59	13.58	4	38754	41	34918132
Upper respiratory tract irritation	13.59	13.58	4	38754	41	34918132

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	3065.61	12.06	2365	75866	272873	79393284
Product prescribing error	1021.97	12.06	603	77628	44210	79621947
Systemic infection	658.59	12.06	275	77956	9477	79656680
Anaemia	550.01	12.06	1291	76940	443724	79222433
Product monitoring error	534.54	12.06	231	78000	8675	79657482
Haematochezia	528.49	12.06	534	77697	87111	79579046
Agranulocytosis	332.79	12.06	307	77924	44723	79621434
Drug ineffective	321.25	12.06	354	77877	1080559	78585598
Labelled drug-drug interaction medication error	291.18	12.06	231	78000	27419	79638738
Fracture	237.87	12.06	186	78045	21615	79644542
Haematemesis	194.44	12.06	248	77983	52016	79614141
Abdominal pain	190.96	12.06	822	77409	388747	79277410
Tachypnoea	179.74	12.06	188	78043	31875	79634282
Completed suicide	179.34	12.06	17	78214	245750	79420407
Pallor	179.10	12.06	233	77998	49829	79616328
Malaise	176.21	12.06	134	78097	489735	79176422
Joint swelling	175.39	12.06	35	78196	288611	79377546
Dyspnoea	173.59	12.06	1432	76799	855593	78810564
Leukopenia	172.33	12.06	364	77867	116149	79550008
Vomiting	172.24	12.06	1179	77052	664649	79001508
Nausea	157.21	12.06	1528	76703	955668	78710489
Appendicolith	153.80	12.06	99	78132	8452	79657705
Restlessness	151.88	12.06	207	78024	46285	79619872
Polyneuropathy	148.77	12.06	149	78082	24002	79642155
Abdominal pain upper	146.74	12.06	518	77713	223301	79442856
Fall	145.15	12.06	895	77336	486734	79179423
Infusion related reaction	141.77	12.06	27	78204	230210	79435947
Musculoskeletal pain	141.29	12.06	311	77920	102043	79564114
Abdominal discomfort	137.28	12.06	38	78193	250689	79415468
Tachycardia	136.52	12.06	434	77797	177334	79488823
Product dose omission issue	136.50	12.06	37	78194	247500	79418657
Aspirin-exacerbated respiratory disease	134.62	12.06	49	78182	1158	79664999
Electrolyte imbalance	125.17	12.06	153	78078	30728	79635429
Constipation	124.00	12.06	578	77653	282472	79383685
Treatment failure	123.79	12.06	12	78219	170474	79495683
Synovitis	122.78	12.06	6	78225	150728	79515429
Renal impairment	121.85	12.06	386	77845	157397	79508760
Product administration error	121.41	12.06	153	78078	31693	79634464
Ascites	121.01	12.06	244	77987	75318	79590839
Arthropathy	119.75	12.06	16	78215	177095	79489062
Toxic epidermal necrolysis	111.51	12.06	175	78056	44406	79621751
Therapeutic product effect decreased	107.97	12.06	16	78215	163847	79502310
Oedema peripheral	102.35	12.06	504	77727	251784	79414373
Hyponatraemia	99.29	12.06	391	77840	177457	79488700
Appendicitis	99.19	12.06	112	78119	20682	79645475
Sinusitis	99.13	12.06	34	78197	195467	79470690
Abdominal pain lower	98.53	12.06	138	78093	31644	79634513
Cardiac failure congestive	91.33	12.06	15	78216	142387	79523770
Musculoskeletal stiffness	89.48	12.06	30	78201	174978	79491179
Blood phosphorus increased	85.17	12.06	75	78156	10272	79655885
Pyrexia	84.74	12.06	1027	77204	677682	78988475
Erysipelas	84.07	12.06	76	78155	10774	79655383
Therapeutic drug monitoring analysis not performed	83.81	12.06	40	78191	1896	79664261
Drug intolerance	82.97	12.06	82	78149	264037	79402120
Cachexia	82.68	12.06	76	78155	11007	79655150
Osteochondrosis	82.64	12.06	40	78191	1956	79664201
Injection site pain	82.54	12.06	14	78217	129824	79536333
Blood pressure increased	82.20	12.06	53	78178	211307	79454850
Lower respiratory tract infection	82.00	12.06	14	78217	129206	79536951
Pemphigus	80.97	12.06	4	78227	99578	79566579
Paresis	80.77	12.06	51	78180	4210	79661947
Dehydration	79.65	12.06	465	77766	247722	79418435
Disturbance in attention	78.89	12.06	162	78069	50639	79615518
Electrocardiogram abnormal	77.88	12.06	89	78142	16648	79649509
Systemic lupus erythematosus	77.15	12.06	13	78218	121136	79545021
Upper gastrointestinal haemorrhage	75.22	12.06	141	78090	41239	79624918
Haematoma	73.58	12.06	160	78071	52035	79614122
Jaundice	72.33	12.06	161	78070	53188	79612969
Nasopharyngitis	71.78	12.06	86	78145	253795	79412362
Drug-induced liver injury	71.76	12.06	183	78048	65934	79600223
Pericarditis	71.44	12.06	9	78222	104227	79561930
Abdominal distension	70.78	12.06	268	77963	119382	79546775
Dysuria	70.47	12.06	155	78076	50796	79615361
Arthralgia	68.71	12.06	308	77923	571495	79094662
Gamma-glutamyltransferase increased	68.57	12.06	160	78071	54520	79611637
Mucosal haemorrhage	67.40	12.06	38	78193	2548	79663609
Death	65.18	12.06	310	77921	566204	79099953
Lethargy	63.82	12.06	4	78227	81288	79584869
Feeling abnormal	63.16	12.06	39	78192	159160	79506997
Alopecia	61.62	12.06	82	78149	231273	79434884
Rheumatoid arthritis	60.66	12.06	69	78162	208401	79457756
Medication error	60.51	12.06	176	78055	68466	79597691
Toxicity to various agents	59.48	12.06	213	78018	421327	79244830
Hypokalaemia	59.23	12.06	289	77942	143751	79522406
Multiple organ dysfunction syndrome	58.89	12.06	254	77977	119992	79546165
Apathy	58.68	12.06	68	78163	12909	79653248
Therapy non-responder	58.56	12.06	10	78221	92295	79573862
Swelling	58.54	12.06	76	78155	216635	79449522
Product use issue	58.32	12.06	72	78159	209750	79456407
Acute abdomen	58.10	12.06	37	78194	3100	79663057
Interstitial lung disease	58.07	12.06	19	78212	112581	79553576
Hepatorenal failure	57.00	12.06	27	78204	1258	79664899
Drug reaction with eosinophilia and systemic symptoms	55.93	12.06	164	78067	64080	79602077
Ventricular fibrillation	55.81	12.06	107	78124	31819	79634338
Myocardial infarction	55.71	12.06	59	78172	184070	79482087
Urosepsis	55.45	12.06	96	78135	26399	79639758
Suspected product quality issue	55.36	12.06	18	78213	299	79665858
Maternal exposure during pregnancy	54.78	12.06	33	78198	136505	79529652
Disease progression	54.75	12.06	60	78171	184302	79481855
Acute hepatic failure	53.97	12.06	102	78129	30011	79636146
Mental status changes	53.45	12.06	3	78228	66956	79599201
Off label use	53.18	12.06	602	77629	906613	78759544
Malignant neoplasm progression	53.17	12.06	269	77962	135721	79530436
Drug hypersensitivity	52.91	12.06	136	78095	298780	79367377
Stevens-Johnson syndrome	52.86	12.06	118	78113	39048	79627109
Dizziness	52.41	12.06	765	77466	525676	79140481
Dyschezia	52.27	12.06	34	78197	2954	79663203
Blood uric acid increased	52.21	12.06	65	78166	13295	79652862
Helicobacter infection	50.33	12.06	5	78226	69699	79596458
Arrhythmia	48.25	12.06	151	78080	61121	79605036
Psoriasis	48.20	12.06	14	78217	89573	79576584
Neuropathy peripheral	47.74	12.06	41	78190	141264	79524893
Gastritis erosive	47.65	12.06	56	78175	10791	79655366
Nasal disorder	47.37	12.06	35	78196	3734	79662423
Nasal congestion	47.03	12.06	9	78222	76543	79589614
Hospitalisation	46.70	12.06	17	78214	94219	79571938
Syncope	46.21	12.06	318	77913	179131	79487026
Hepatic cyst	45.90	12.06	42	78189	6047	79660110
Therapeutic product effect incomplete	45.58	12.06	43	78188	141602	79524555
Suspected product contamination	45.31	12.06	12	78219	92	79666065
Chills	44.90	12.06	290	77941	159944	79506213
Thrombocytopenia	44.87	12.06	427	77804	264832	79401325
Immobile	44.75	12.06	44	78187	6929	79659228
Haematuria	44.74	12.06	159	78072	68677	79597480
Psoriatic arthropathy	44.21	12.06	11	78220	77988	79588169
Negative pressure pulmonary oedema	43.55	12.06	14	78217	224	79665933
Cardiogenic shock	43.40	12.06	114	78117	41800	79624357
Micturition disorder	43.13	12.06	34	78197	3994	79662163
Folliculitis	42.66	12.06	3	78228	55377	79610780
Subileus	42.62	12.06	39	78192	5615	79660542
Hypoaesthesia	42.43	12.06	69	78162	179283	79486874
Rash	42.08	12.06	364	77867	577994	79088163
Lordosis	41.85	12.06	16	78215	435	79665722
Heart rate decreased	41.68	12.06	9	78222	70307	79595850
Cellulitis	41.50	12.06	28	78203	109032	79557125
Irritable bowel syndrome	41.16	12.06	6	78225	62235	79603922
Peripheral swelling	40.87	12.06	132	78099	269485	79396672
Loss of personal independence in daily activities	40.86	12.06	25	78206	102555	79563602
Disorientation	40.80	12.06	145	78086	62631	79603526
Fibromyalgia	40.75	12.06	7	78224	64333	79601824
Hypersensitivity	40.72	12.06	127	78104	262112	79404045
Spinal pain	40.69	12.06	62	78169	15330	79650827
Gastrointestinal disorder	40.62	12.06	36	78195	122169	79543988
Platelet count decreased	40.58	12.06	81	78150	194583	79471574
Sepsis	40.38	12.06	423	77808	269005	79397152
Adverse drug reaction	40.38	12.06	8	78223	66384	79599773
Hyperventilation	40.17	12.06	44	78187	7855	79658302
Respiratory tract haemorrhage	40.11	12.06	24	78207	1799	79664358
Tumour pain	39.82	12.06	26	78205	2273	79663884
Migraine	39.75	12.06	18	78213	87475	79578682
Discomfort	39.41	12.06	39	78192	125578	79540579
Drug abuse	39.04	12.06	62	78169	162629	79503528
Spontaneous haemorrhage	38.81	12.06	18	78213	799	79665358
Heart rate increased	38.43	12.06	37	78194	120687	79545470
Febrile infection	37.47	12.06	29	78202	3317	79662840
Haemorrhagic erosive gastritis	37.36	12.06	17	78214	722	79665435
Atrial fibrillation	37.23	12.06	326	77905	197560	79468597
Bradycardia	37.16	12.06	244	77987	135313	79530844
Pancytopenia	35.97	12.06	282	77949	165463	79500694
Inappropriate schedule of product administration	35.93	12.06	47	78184	133581	79532576
Listless	35.88	12.06	30	78201	3831	79662326
Fluid intake reduced	35.46	12.06	37	78194	6251	79659906
Injection site swelling	35.04	12.06	3	78228	47129	79619028
Weight increased	34.70	12.06	147	78084	277239	79388918
Thirst	34.53	12.06	64	78167	18555	79647602
Type I hypersensitivity	34.45	12.06	31	78200	4367	79661790
Acute kidney injury	34.35	12.06	707	77524	518697	79147460
Pain in jaw	34.14	12.06	3	78228	46148	79620009
Injection site erythema	34.12	12.06	17	78214	78180	79587977
Gastritis	33.92	12.06	114	78117	47879	79618278
Intentional product use issue	33.71	12.06	61	78170	152051	79514106
Acute generalised exanthematous pustulosis	32.87	12.06	60	78171	17194	79648963
Flank pain	32.85	12.06	65	78166	19779	79646378
Urogenital haemorrhage	32.85	12.06	17	78214	960	79665197
Respiratory arrest	32.84	12.06	8	78223	57542	79608615
Drug interaction	32.51	12.06	580	77651	414603	79251554
Depressed level of consciousness	32.20	12.06	183	78048	96469	79569688
Exposure during pregnancy	32.18	12.06	31	78200	101101	79565056
Therapeutic response decreased	31.56	12.06	13	78218	66840	79599317
Cardio-respiratory arrest	31.45	12.06	36	78195	108474	79557683
Cardiac arrest	31.43	12.06	77	78154	172019	79494138
Oliguria	31.43	12.06	57	78174	16252	79649905
Blood pressure measurement	31.33	12.06	13	78218	440	79665717
Faecaloma	31.16	12.06	47	78184	11517	79654640
Urogenital infection bacterial	31.00	12.06	9	78222	100	79666057
Type 2 diabetes mellitus	30.59	12.06	9	78222	57113	79609044
Coronavirus test positive	30.54	12.06	17	78214	1112	79665045
C-reactive protein increased	30.50	12.06	224	78007	128803	79537354
Depression	30.22	12.06	110	78121	216680	79449477
White blood cell count decreased	30.06	12.06	90	78141	188198	79477959
Hepatitis cholestatic	30.05	12.06	51	78180	13801	79652356
Cardiac failure	29.59	12.06	256	77975	154586	79511571
Hepatitis acute	29.55	12.06	54	78177	15488	79650669
Unresponsive to stimuli	29.50	12.06	9	78222	55779	79610378
Pelvic fracture	29.26	12.06	47	78184	12157	79654000
Contusion	29.23	12.06	64	78167	148712	79517445
Neuromuscular block prolonged	29.21	12.06	16	78215	1014	79665143
Cardiac disorder	29.14	12.06	14	78217	65743	79600414
Angina pectoris	29.03	12.06	114	78117	51618	79614539
Reduced facial expression	28.88	12.06	23	78208	2742	79663415
Blood pressure fluctuation	28.69	12.06	15	78216	67130	79599027
Headache	28.35	12.06	461	77770	653311	79012846
Platelet dysfunction	28.28	12.06	12	78219	430	79665727
Lack of application site rotation	27.97	12.06	8	78223	84	79666073
Adverse event	27.96	12.06	12	78219	60202	79605955
Blood pressure decreased	27.76	12.06	34	78197	99432	79566725
Chronic fatigue syndrome	27.75	12.06	17	78214	1330	79664827
Unevaluable event	27.58	12.06	10	78221	55575	79610582
Psychotic disorder	27.35	12.06	4	78227	41398	79624759
Injection site reaction	26.94	12.06	10	78221	54775	79611382
Drug therapy	26.92	12.06	16	78215	1185	79664972
Analgesic therapy	26.77	12.06	15	78216	994	79665163
Full blood count abnormal	26.53	12.06	4	78227	40470	79625687
Condition aggravated	26.49	12.06	661	77570	500463	79165694
Somnolence	26.41	12.06	354	77877	238627	79427530
Orthostatic hypotension	26.39	12.06	11	78220	56153	79610004
Dry mouth	26.32	12.06	162	78069	87857	79578300
Osteoma	26.14	12.06	8	78223	108	79666049
Polyneuropathy in malignant disease	25.95	12.06	10	78221	278	79665879
Drug resistance	25.85	12.06	5	78226	42208	79623949
Product used for unknown indication	25.62	12.06	17	78214	1527	79664630
Amnesia	25.62	12.06	15	78216	63042	79603115
Decreased appetite	25.60	12.06	475	77756	341943	79324214
Facial nerve disorder	25.54	12.06	13	78218	709	79665448
Gastritis haemorrhagic	25.43	12.06	21	78210	2636	79663521
Pulmonary sepsis	24.90	12.06	24	78207	3688	79662469
Myasthenia gravis	24.86	12.06	40	78191	10359	79655798
Accessory spleen	24.63	12.06	9	78222	215	79665942
Hypertensive crisis	24.11	12.06	59	78172	20711	79645446
Therapy cessation	23.97	12.06	4	78227	37558	79628599
Sleep disorder therapy	23.89	12.06	14	78217	1010	79665147
Flushing	23.77	12.06	31	78200	88237	79577920
Nail toxicity	23.71	12.06	10	78221	353	79665804
Polycystic liver disease	23.00	12.06	8	78223	165	79665992
Iron deficiency	22.81	12.06	39	78192	10615	79655542
Splenic necrosis	22.73	12.06	8	78223	171	79665986
Vertigo	22.48	12.06	130	78101	68952	79597205
Lower gastrointestinal haemorrhage	22.23	12.06	49	78182	16076	79650081
Bicytopenia	22.01	12.06	25	78206	4645	79661512
C-reactive protein abnormal	21.89	12.06	10	78221	48357	79617800
Delirium	21.78	12.06	150	78081	84477	79581680
Duodenal ulcer	21.73	12.06	49	78182	16320	79649837
Thirst decreased	21.71	12.06	9	78222	304	79665853
Gallbladder polyp	21.70	12.06	13	78218	977	79665180
Rash pruritic	21.60	12.06	23	78208	71606	79594551
Flatulence	21.48	12.06	91	78140	42633	79623524
Post-traumatic pain	21.41	12.06	10	78221	451	79665706
Transaminases increased	21.37	12.06	104	78127	51639	79614518
Arthritis	21.29	12.06	51	78180	114829	79551328
Ill-defined disorder	21.18	12.06	20	78211	65855	79600302
Knee arthroplasty	21.09	12.06	8	78223	43240	79622917
Ileus	21.00	12.06	65	78166	26146	79640011
Joint stiffness	20.85	12.06	7	78224	40823	79625334
Dysdiadochokinesis	20.81	12.06	9	78222	338	79665819
Therapy interrupted	20.77	12.06	3	78228	31338	79634819
Gastric ulcer perforation	20.69	12.06	17	78214	2118	79664039
Rhinorrhoea	20.19	12.06	27	78204	76047	79590110
Long QT syndrome	20.18	12.06	27	78204	5928	79660229
Hyperglycaemia	20.12	12.06	128	78103	70207	79595950
Anxiety	20.04	12.06	152	78079	248360	79417797
Allodynia	20.03	12.06	15	78216	1633	79664524
Hydrocholecystis	20.03	12.06	10	78221	523	79665634
Blood folate increased	19.98	12.06	10	78221	526	79665631
Therapeutic drug monitoring analysis incorrectly performed	19.97	12.06	11	78220	705	79665452
Coombs negative haemolytic anaemia	19.89	12.06	9	78222	377	79665780
Haemorrhagic necrotic pancreatitis	19.78	12.06	7	78224	152	79666005
Angioedema	19.70	12.06	135	78096	75900	79590257
Splenic cyst	19.70	12.06	8	78223	256	79665901
Muscle tone disorder	19.70	12.06	7	78224	154	79666003
Drug ineffective for unapproved indication	19.69	12.06	13	78218	51225	79614932
Aortic arteriosclerosis	19.56	12.06	33	78198	8885	79657272
Hypervolaemia	19.05	12.06	9	78222	42681	79623476
Cerebrovascular accident	18.97	12.06	83	78148	155209	79510948
Hyperaemia	18.80	12.06	19	78212	3091	79663066
Metastases to soft tissue	18.78	12.06	10	78221	599	79665558
Pseudarthrosis	18.77	12.06	8	78223	290	79665867
Peripheral arterial occlusive disease	18.71	12.06	31	78200	8227	79657930
Vascular encephalopathy	18.56	12.06	10	78221	613	79665544
Influenza	18.56	12.06	65	78166	129541	79536616
Anaemia of malignant disease	18.51	12.06	11	78220	814	79665343
Spinal osteoarthritis	18.51	12.06	47	78184	16880	79649277
Hip arthroplasty	18.49	12.06	6	78225	35750	79630407
Rheumatic fever	18.29	12.06	3	78228	28522	79637635
International normalised ratio increased	17.86	12.06	35	78196	84686	79581471
Throat tightness	17.75	12.06	3	78228	27904	79638253
Head discomfort	17.70	12.06	42	78189	14460	79651697
Coma	17.62	12.06	46	78185	100603	79565554
Activated partial thromboplastin time abnormal	17.62	12.06	8	78223	338	79665819
Gastrointestinal sounds abnormal	17.44	12.06	24	78207	5411	79660746
Vision blurred	17.34	12.06	50	78181	105848	79560309
Iron deficiency anaemia	17.28	12.06	60	78171	25612	79640545
Circulatory collapse	17.23	12.06	78	78153	37590	79628567
Disease recurrence	17.21	12.06	11	78220	44098	79622059
Painful respiration	17.15	12.06	19	78212	3434	79662723
Subacute hepatic failure	17.07	12.06	7	78224	230	79665927
Pneumobilia	17.01	12.06	7	78224	232	79665925
Internal fixation of fracture	17.00	12.06	8	78223	367	79665790
Hepatitis toxic	16.93	12.06	23	78208	5124	79661033
Wrong technique in product usage process	16.92	12.06	29	78202	73846	79592311
Road traffic accident	16.89	12.06	11	78220	43653	79622504
Pregnancy	16.83	12.06	3	78228	26848	79639309
Reactive gastropathy	16.72	12.06	9	78222	551	79665606
Rhabdomyolysis	16.67	12.06	49	78182	103082	79563075
Gait inability	16.58	12.06	20	78211	58897	79607260
Rectal haemorrhage	16.54	12.06	31	78200	76269	79589888
Product packaging confusion	16.52	12.06	7	78224	250	79665907
Head injury	16.49	12.06	8	78223	37361	79628796
Hepatic function abnormal	16.47	12.06	29	78202	73078	79593079
Bulimia nervosa	16.39	12.06	7	78224	255	79665902
Lung disorder	16.36	12.06	34	78197	80523	79585634
Fluid retention	16.36	12.06	27	78204	69782	79596375
Wound	16.26	12.06	180	78051	115999	79550158
Cyanosis	16.21	12.06	58	78173	25124	79641033
Pulmonary hypertension	16.17	12.06	14	78217	48066	79618091
Prescription drug used without a prescription	16.16	12.06	20	78211	4065	79662092
Spinal cord injury cauda equina	16.09	12.06	6	78225	152	79666005
Papillary renal cell carcinoma	16.06	12.06	7	78224	268	79665889
Dementia	16.05	12.06	57	78174	24602	79641555
Colitis	16.04	12.06	125	78106	73182	79592975
Hypoxia	16.01	12.06	50	78181	103193	79562964
Implant site inflammation	15.99	12.06	7	78224	271	79665886
Concomitant disease aggravated	15.92	12.06	38	78193	13129	79653028
Breath sounds normal	15.71	12.06	3	78228	3	79666154
Paraparesis	15.66	12.06	19	78212	3784	79662373
Lividity	15.57	12.06	8	78223	445	79665712
Basal ganglia haemorrhage	15.56	12.06	13	78218	1658	79664499
Necrotising fasciitis	15.47	12.06	24	78207	6026	79660131
Peritoneal perforation	15.46	12.06	6	78225	170	79665987
Prostatic specific antigen abnormal	15.44	12.06	8	78223	453	79665704
Adrenal calcification	15.42	12.06	4	78227	28	79666129
Localised infection	15.14	12.06	75	78156	37500	79628657
Visual acuity reduced	15.14	12.06	5	78226	29464	79636693
Viral infection	15.12	12.06	12	78219	43004	79623153
Gastroenteritis viral	15.08	12.06	3	78228	24828	79641329
Medication overuse headache	15.03	12.06	10	78221	902	79665255
Hypertensive emergency	15.01	12.06	16	78215	2769	79663388
Nocturia	14.97	12.06	38	78193	13643	79652514
Tonsillitis	14.94	12.06	25	78206	6689	79659468
Product impurity	14.90	12.06	5	78226	92	79666065
No adverse event	14.89	12.06	9	78222	37183	79628974
Helicobacter gastritis	14.88	12.06	15	78216	2434	79663723
Suicidal ideation	14.86	12.06	33	78198	76307	79589850
Rash erythematous	14.83	12.06	21	78210	57748	79608409
Weight bearing difficulty	14.77	12.06	17	78214	3204	79662953
Somatosensory evoked potentials abnormal	14.72	12.06	6	78225	194	79665963
Incisional hernia	14.69	12.06	15	78216	2471	79663686
Dyspnoea exertional	14.61	12.06	140	78091	86933	79579224
Atheroembolism	14.56	12.06	7	78224	337	79665820
Vitamin B6 deficiency	14.52	12.06	7	78224	339	79665818
Preternatural anus	14.52	12.06	5	78226	100	79666057
Autoimmune nephritis	14.40	12.06	9	78222	730	79665427
Toxic neuropathy	14.38	12.06	10	78221	970	79665187
Peritoneal adhesions	14.35	12.06	7	78224	348	79665809
Pleural effusion	14.35	12.06	211	78020	145051	79521106
Cardiac murmur functional	14.25	12.06	4	78227	39	79666118
Mycobacterium fortuitum infection	14.17	12.06	6	78225	214	79665943
Hepatic enzyme increased	14.10	12.06	113	78118	182497	79483660
Seizure	14.06	12.06	118	78113	188716	79477441
Muscle spasms	14.02	12.06	107	78124	174623	79491534
Diverticulum intestinal	14.02	12.06	28	78203	8577	79657580
Nightmare	13.98	12.06	4	78227	25857	79640300
Antineutrophil cytoplasmic antibody positive	13.93	12.06	11	78220	1295	79664862
Contraindicated product administered	13.83	12.06	94	78137	157444	79508713
Petechiae	13.79	12.06	48	78183	20517	79645640
Respiratory alkalosis	13.78	12.06	19	78212	4292	79661865
Urinary retention	13.76	12.06	99	78132	56531	79609626
Oropharyngeal discomfort	13.75	12.06	25	78206	7141	79659016
Neoplasm malignant	13.75	12.06	7	78224	31803	79634354
Splenic lesion	13.74	12.06	8	78223	570	79665587
Asthma	13.74	12.06	77	78154	135018	79531139
Abdominal wall cyst	13.73	12.06	4	78227	45	79666112
Gastric disorder	13.72	12.06	10	78221	37423	79628734
Tracheal pain	13.65	12.06	4	78227	46	79666111
Cytomegalovirus infection	13.65	12.06	13	78218	42631	79623526
Necrolytic migratory erythema	13.63	12.06	3	78228	9	79666148
Sensory disturbance	13.61	12.06	39	78192	15038	79651119
Solar dermatitis	13.55	12.06	6	78225	239	79665918
Hyperkinesia	13.53	12.06	15	78216	2714	79663443
Urine uric acid decreased	13.47	12.06	5	78226	125	79666032
Acute respiratory distress syndrome	13.45	12.06	14	78217	44053	79622104
Deep vein thrombosis	13.37	12.06	67	78164	120852	79545305
Mesenteric arterial occlusion	13.36	12.06	6	78225	247	79665910
Non-small cell lung cancer	13.25	12.06	23	78208	6337	79659820
Ventricular tachycardia	13.17	12.06	13	78218	41922	79624235
Skin irritation	13.12	12.06	32	78199	11208	79654949
Administration site discomfort	13.11	12.06	5	78226	135	79666022
Chronic gastritis	13.11	12.06	18	78213	4050	79662107
Conjunctivitis	13.10	12.06	55	78176	25660	79640497
Drug withdrawal syndrome	13.09	12.06	9	78222	34709	79631448
Intestinal haemorrhage	13.08	12.06	23	78208	6403	79659754
Immune-mediated hepatitis	13.04	12.06	17	78214	3639	79662518
Catheter site inflammation	13.02	12.06	10	78221	1131	79665026
Emotional distress	13.01	12.06	12	78219	39957	79626200
Peripheral circulatory failure	12.98	12.06	10	78221	1136	79665021
Leptotrichia infection	12.93	12.06	4	78227	56	79666101
Prerenal failure	12.89	12.06	17	78214	3681	79662476
Swelling face	12.89	12.06	32	78199	71180	79594977
Upper respiratory tract infection	12.86	12.06	46	78185	91122	79575035
Gouty arthritis	12.85	12.06	11	78220	1450	79664707
Cross sensitivity reaction	12.84	12.06	17	78214	3695	79662462
Oedematous pancreatitis	12.81	12.06	10	78221	1158	79664999
Foreign body	12.81	12.06	15	78216	2879	79663278
Pulmonary vein occlusion	12.81	12.06	5	78226	144	79666013
Wound haemorrhage	12.79	12.06	18	78213	4143	79662014
Urinary sediment abnormal	12.74	12.06	5	78226	146	79666011
Wheezing	12.69	12.06	65	78166	116599	79549558
Genitourinary tract infection	12.68	12.06	6	78225	279	79665878
Hepatic failure	12.64	12.06	103	78128	61109	79605048
Insomnia	12.63	12.06	167	78064	245003	79421154
Hyperresponsive to stimuli	12.56	12.06	4	78227	62	79666095
Anal haemorrhage	12.55	12.06	18	78213	4216	79661941
Alpha 2 globulin increased	12.46	12.06	5	78226	155	79666002
Cardiovascular insufficiency	12.45	12.06	15	78216	2966	79663191
Drain site complication	12.42	12.06	3	78228	15	79666142
Product use in unapproved indication	12.37	12.06	172	78059	250187	79415970
Neutropenic colitis	12.36	12.06	21	78210	5686	79660471
Pure white cell aplasia	12.33	12.06	4	78227	66	79666091
Organic brain syndrome	12.31	12.06	7	78224	477	79665680
Haematocrit abnormal	12.30	12.06	11	78220	1537	79664620
Lip erosion	12.23	12.06	11	78220	1549	79664608
Anaemia folate deficiency	12.22	12.06	6	78225	303	79665854
Device malfunction	12.20	12.06	3	78228	21445	79644712
Lung neoplasm malignant	12.18	12.06	6	78225	27786	79638371
Dystonia	12.16	12.06	3	78228	21396	79644761
Dry eye	12.12	12.06	11	78220	36920	79629237
Sensory level abnormal	12.09	12.06	5	78226	168	79665989
Obstructive airways disorder	12.07	12.06	8	78223	31451	79634706

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02BB02	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB52	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
ATC	N02BB72	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Pyrazolones
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D058633	Antipyretics
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35842	anti-rheumatic drugs
CHEBI has role	CHEBI:49110	peripheral nervous system drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:67079	anti-inflammatory agents
CHEBI has role	CHEBI:73263	cyclooxygenase-3 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Zimeta	Kindred Biosciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.21	acidic
pKa2	5.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN	BLOCKER	IC50	4.04		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D08190	KEGG_DRUG
N0000167060	NUI
50567-35-6	SECONDARY_CAS_RN
5907-38-0	SECONDARY_CAS_RN
CHEBI:59033	CHEBI
C024864	MESH_SUPPLEMENTAL_RECORD_UI
10608	IUPHAR_LIGAND_ID
6150-97-6	SECONDARY_CAS_RN
51996-59-9	SECONDARY_CAS_RN
DB04817	DRUGBANK_ID
934T64RMNJ	UNII
1537943	RXNORM
NOCODE	MMSL
001609	NDDF
006029	NDDF
22165008	SNOMEDCT_US
735071007	SNOMEDCT_US
780831000	SNOMEDCT_US
781025005	SNOMEDCT_US
C0012586	UMLSCUI
D004177	MESH_DESCRIPTOR_UI
CHEMBL3989803	ChEMBL_ID
CHEMBL461522	ChEMBL_ID
3111	PUBCHEM_CID
477	INN_ID

Pharmaceutical products:

None