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fluorometholone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4647 | 3801-06-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 11, 1986 | FDA | ALCON |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Eye pain | 20.17 | 17.39 | 8 | 496 | 44160 | 90583783 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Eye pain | 30.73 | 23.88 | 11 | 554 | 50088 | 110538646 |
| Corneal opacity | 28.34 | 23.88 | 5 | 560 | 1246 | 110587488 |
| Keratopathy | 27.88 | 23.88 | 5 | 560 | 1368 | 110587366 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D018926 | Anti-Allergic Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Cyclitis | indication | 17657000 | |
| Iritis | indication | 65074000 | DOID:1406 |
| Iridocyclitis | indication | 77971008 | |
| Corneal abrasion | indication | 85848002 | |
| Corneal ulcer | indication | 91514001 | DOID:8463 |
| Uveitis | indication | 128473001 | DOID:13141 |
| Punctate keratopathy | indication | 246936005 | |
| Herpes zoster keratitis | indication | 397573005 | |
| Rosacea | indication | 398909004 | DOID:8881 |
| Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
| Post-Op Ocular Inflammation | indication | ||
| Otitis externa | off-label use | 3135009 | |
| Allergic otitis externa | off-label use | 405821001 | |
| Otitis Externa Eczema | off-label use | ||
| Otitis Externa Seborrhea | off-label use | ||
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Herpes simplex keratitis | contraindication | 9389005 | |
| Herpes simplex dendritic keratitis | contraindication | 29943008 | |
| Fungal infection of eye | contraindication | 31194008 | |
| Severe myopia | contraindication | 34187009 | |
| Tuberculosis of eye | contraindication | 49107007 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Krukenberg spindle | contraindication | 85430004 | |
| Eye infection | contraindication | 128351009 | |
| Bacterial infection of eye | contraindication | 128984004 | |
| Viral eye infection | contraindication | 312132001 | |
| Vaccinia keratitis | contraindication | 397552005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.48 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 8.35 | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D04221 | KEGG_DRUG |
| 4020951 | VUID |
| N0000148429 | NUI |
| 4018212 | VANDF |
| 4020951 | VANDF |
| CHEMBL1201064 | ChEMBL_ID |
| 9I50C3I3OK | UNII |
| 216866 | RXNORM |
| 4120 | MMSL |
| 4743 | MMSL |
| 4744 | MMSL |
| 6193 | MMSL |
| 7403 | MMSL |
| 7420 | MMSL |
| 002194 | NDDF |
| 003646 | NDDF |
| 108851006 | SNOMEDCT_US |
| 2925007 | SNOMEDCT_US |
| 703087006 | SNOMEDCT_US |
| C0724587 | UMLSCUI |
| C0016351 | UMLSCUI |
| DB00324 | DRUGBANK_ID |
| 240767 | PUBCHEM_CID |
| 9878 | PUBCHEM_CID |
| 803 | INN_ID |
| D005469 | MESH_DESCRIPTOR_UI |
| CHEBI:31625 | CHEBI |
| 9I50C3I3OK | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Flarex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71776-100 | SUSPENSION/ DROPS | 1 mg | OPHTHALMIC | NDA | 21 sections |
| Flarex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 82667-010 | SUSPENSION/ DROPS | 1 mg | OPHTHALMIC | NDA | 21 sections |