All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hydroxocobalamin acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4644	22465-48-1

Description:

Molecule	Description
Synonyms: hydroxocobalamin acetate acetatocobalamin hydroxycobalamine acetate	Molecular weight: 1388.41 Formula: C64H91CoN13O16P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 515.01 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	113.87	24.09	74	3573	111826	63373549
Neutropenic sepsis	54.67	24.09	24	3623	16414	63468961
Pneumonia aspiration	48.20	24.09	28	3619	34512	63450863
Forceps delivery	43.63	24.09	8	3639	212	63485163
Lethargy	42.55	24.09	31	3616	55976	63429399
Somnolence	39.65	24.09	50	3597	178635	63306740
Food refusal	39.37	24.09	8	3639	367	63485008
Acute kidney injury	38.06	24.09	60	3587	263355	63222020
Nystagmus	37.74	24.09	14	3633	6206	63479169
Developmental hip dysplasia	33.73	24.09	9	3638	1363	63484012
Urosepsis	31.21	24.09	17	3630	18507	63466868
Inappropriate antidiuretic hormone secretion	31.18	24.09	16	3631	15446	63469929
Haemorrhage in pregnancy	30.72	24.09	9	3638	1916	63483459
Drug ineffective	30.68	24.09	11	3636	1044754	62440621
Pelvic deformity	30.55	24.09	6	3641	231	63485144
Coma	30.46	24.09	27	3620	64337	63421038
Coma scale abnormal	29.08	24.09	11	3636	5142	63480233
Swelling face	28.79	24.09	26	3621	63449	63421926
Underdose	25.03	24.09	17	3630	27439	63457936
Eye swelling	24.68	24.09	16	3631	23902	63461473

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Orthostatic hypotension	39.01	25.66	24	2522	25895	34928490
Acute kidney injury	36.58	25.66	73	2473	304915	34649470
Loss of proprioception	31.41	25.66	7	2539	393	34953992
Confusional state	29.77	25.66	44	2502	144116	34810269
Lower respiratory tract infection	27.78	25.66	21	2525	31616	34922769
Hypomania	26.81	25.66	9	2537	2350	34952035

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	97.11	21.17	91	5926	177757	79560614
Acute kidney injury	77.01	21.17	139	5878	519265	79219106
Neutropenic sepsis	66.58	21.17	35	5982	27029	79711342
Pneumonia aspiration	52.11	21.17	42	5975	66925	79671446
Orthostatic hypotension	47.50	21.17	37	5980	56127	79682244
Confusional state	39.39	21.17	79	5938	317918	79420453
Swelling face	37.93	21.17	36	5981	71176	79667195
Food refusal	34.00	21.17	8	6009	552	79737819
Somnolence	31.53	21.17	61	5956	238920	79499451
Liver function test abnormal	31.33	21.17	31	5986	64444	79673927
Hallucination	30.63	21.17	35	5982	85710	79652661
Dizziness	30.51	21.17	98	5919	526343	79212028
Lip swelling	30.42	21.17	25	5992	40886	79697485
Lethargy	28.72	21.17	33	5984	81259	79657112
Nystagmus	27.79	21.17	14	6003	9890	79728481
Loss of proprioception	26.46	21.17	7	6010	779	79737592
Forceps delivery	26.46	21.17	5	6012	118	79738253
Skin abrasion	26.43	21.17	15	6002	13441	79724930
Coma	26.14	21.17	35	5982	100614	79637757
Lower respiratory tract infection	24.89	21.17	39	5978	129181	79609190
Haemorrhage in pregnancy	22.40	21.17	7	6010	1407	79736964
Eye swelling	21.42	21.17	17	6000	26451	79711920
Urosepsis	21.41	21.17	17	6000	26478	79711893
Malaise	21.28	21.17	83	5934	489786	79248585

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA EPC	N0000175429	Antidote
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:75835	antianaemic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D02707	KEGG_DRUG
4017962	VUID
N0000146312	NUI
4017961	VANDF
4017962	VANDF
CHEBI:27786	CHEBI
I2A	PDB_CHEM_ID
CHEMBL2103737	ChEMBL_ID
S535M27N3Q	UNII
236302	RXNORM
4850	MMSL
7093	MMSL
d03133	MMSL
001044	NDDF
005609	NDDF
1217428002	SNOMEDCT_US
327529002	SNOMEDCT_US
734651006	SNOMEDCT_US
C0771561	UMLSCUI
C0020316	UMLSCUI
DB00200	DRUGBANK_ID
24892771	PUBCHEM_CID
1043	INN_ID
D006879	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Hydroxocobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	0591-2888	INJECTION, SOLUTION	1000 ug	INTRAMUSCULAR	ANDA	16 sections
Hydroxocobalamin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3548	INJECTION, SOLUTION	1000 ug	INTRAMUSCULAR	ANDA	16 sections
ARONAMIN GOLD	HUMAN OTC DRUG LABEL	5	72689-0024	TABLET, FILM COATED	5.22 ug	ORAL	unapproved drug other	7 sections