phenylacetic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4624	103-82-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzeneacetic acid phenylacetic acid phenylethanoic acid sodium phenylacetate	Molecular weight: 136.15 Formula: C8H8O2 CLOGP: 1.41 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -1.58 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzeneacetic acid
phenylacetic acid
phenylethanoic acid
sodium phenylacetate

Molecular weight: 136.15
Formula: C8H8O2
CLOGP: 1.41
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -1.58
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 1987	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A16AX30	ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products
MeSH PA	D000963	Antimetabolites
MeSH PA	D000964	Antimetabolites, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D009676	Noxae
FDA MoA	N0000175806	Ammonium Ion Binding Activity
FDA EPC	N0000175807	Nitrogen Binding Agent
CHEBI has role	CHEBI:22676	auxins
CHEBI has role	CHEBI:27026	toxins
CHEBI has role	CHEBI:35219	plant growth inhibitors
CHEBI has role	CHEBI:50904	alergeno
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:76956	Aspergillus metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:90318	EC 6.4.1.1 (pyruvate carboxylase) inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperammonemia	indication	9360008
Hypokalemia	contraindication	43339004
Body fluid retention	contraindication	43498006
Chronic heart failure	contraindication	48447003
Acute nephropathy	contraindication	58574008
Metabolic acidosis	contraindication	59455009
Hyperglycemia	contraindication	80394007	DOID:4195
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Disease of liver	contraindication	235856003	DOID:409
Edema	contraindication	267038008
CNS Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Aldose reductase	Enzyme	P15121	ALDR_HUMAN		IC50	4.02		CHEMBL

External reference:

ID	Source
D05867	KEGG_DRUG
114-70-5	SECONDARY_CAS_RN
4019576	VANDF
CHEBI:30745	CHEBI
CHEMBL1044	ChEMBL_ID
CHEMBL1200358	ChEMBL_ID
C025136	MESH_SUPPLEMENTAL_RECORD_UI
DB09269	DRUGBANK_ID
ER5I1W795A	UNII
33332	RXNORM
19292	MMSL
d05460	MMSL
001244	NDDF
004954	NDDF
125705007	SNOMEDCT_US
398818001	SNOMEDCT_US
C0070620	UMLSCUI
PAC	PDB_CHEM_ID
999	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ammonul	HUMAN PRESCRIPTION DRUG LABEL	2	0187-0010	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	26 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	13811-705	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
Ammonul	HUMAN PRESCRIPTION DRUG LABEL	2	62592-720	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA	28 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	67457-844	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	27 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	68382-396	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	68382-396	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
Sodium Phenylacetate and sodium benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	68475-001	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
Sodium Phenylacetate and sodium benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	68475-001	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	24 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	68682-001	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	NDA authorized generic	26 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	69784-810	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	69784-810	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	69784-811	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	69784-811	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	70511-101	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	70511-101	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	70511-102	INJECTION	100 mg	INTRAVENOUS	NDA	29 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	70511-102	INJECTION	100 mg	INTRAVENOUS	NDA	29 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE	HUMAN PRESCRIPTION DRUG LABEL	2	70556-100	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	28 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	72266-236	INJECTION	100 mg	INTRAVENOUS	NDA	29 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	72266-247	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	27 sections
Sodium Phenylacetate and Sodium Benzoate	HUMAN PRESCRIPTION DRUG LABEL	2	72266-247	INJECTION, SOLUTION, CONCENTRATE	100 mg	INTRAVENOUS	ANDA	27 sections