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protocatechualdehyde 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4612 | 139-85-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK19,CDK2,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT1,FLT3,FLT4,GRK2,GRK3,GSK3A,GSK3B,IGF1R,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,SRC,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 97 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,ACVRL1,AURKB,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FGFR1,GRK2,GSK3B,IRAK1,JAK2,KIT,MAP2K3,MAP2K6,MAP3K14,MAPK1,MAPK7,MAPK8,MARK4,PIK3CB,PIK3CD,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ULK1 | 39 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000925 | Anticoagulants |
| MeSH PA | D006401 | Hematologic Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.16 | acidic |
| pKa2 | 11.57 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 4.71 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:50205 | CHEBI |
| H6N | PDB_CHEM_ID |
| CHEMBL222021 | ChEMBL_ID |
| C005581 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11268 | DRUGBANK_ID |
| 4PVP2HCH4T | UNII |
| 1362689 | RXNORM |
| C0072487 | UMLSCUI |
| 8768 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| O HUI WHITE EXTREME CELLIGHT | HUMAN OTC DRUG LABEL | 1 | 53208-501 | EMULSION | 0.03 mL | TOPICAL | unapproved drug other | 9 sections |
| O HUI WHITE EXTREME CELLIGHT | HUMAN OTC DRUG LABEL | 1 | 53208-507 | CREAM | 0.03 mL | TOPICAL | unapproved drug other | 9 sections |