stearic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4611	57-11-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

stearic acid
octadecanoic acid

Molecular weight: 284.48
Formula: C18H36O2
CLOGP: 8.27
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -6.63
ROTB: 16

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:83056	Daphnia magna metabolites
CHEBI has role	CHEBI:84735	algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.76	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Peroxisome proliferator-activated receptor alpha	Nuclear hormone receptor	Q07869	PPARA_HUMAN		IC50	5.96		CHEMBL
Peroxisome proliferator-activated receptor gamma	Nuclear hormone receptor	P37231	PPARG_HUMAN		IC50	4.52		CHEMBL
Tyrosine-protein phosphatase non-receptor type 1	Enzyme	P18031	PTN1_HUMAN		IC50	5.64		CHEMBL
Fatty acid-binding protein, adipocyte	Cytosolic other	P15090	FABP4_HUMAN		Kd	4.10		CHEMBL
Peroxisome proliferator-activated receptor delta	Nuclear hormone receptor	Q03181	PPARD_HUMAN		IC50	5.22		CHEMBL
Acetylcholinesterase	Enzyme		ACES_ELEEL		Ki	5.44		CHEMBL

External reference:

ID	Source
D00119	KEGG_DRUG
4020443	VUID
N0000178989	NUI
4020443	VANDF
CHEBI:28842	CHEBI
STE	PDB_CHEM_ID
CHEMBL46403	ChEMBL_ID
C031183	MESH_SUPPLEMENTAL_RECORD_UI
3377	IUPHAR_LIGAND_ID
DB03193	DRUGBANK_ID
4ELV7Z65AP	UNII
1310551	RXNORM
NOCODE	MMSL
003887	NDDF
259577009	SNOMEDCT_US
420674004	SNOMEDCT_US
C0038229	UMLSCUI
5281	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ISA KNOX AGELESS SERUM MAKEUP BASE 10	HUMAN OTC DRUG LABEL	6	53208-471	CREAM	0.18 mL	TOPICAL	OTC monograph not final	5 sections
ISAKNOX AGELESS SERUM MOIST PEARL BASE	HUMAN OTC DRUG LABEL	6	53208-478	LIQUID	0.18 mL	TOPICAL	OTC monograph not final	5 sections
Sha-lem	HUMAN OTC DRUG LABEL	5	59862-100	OINTMENT	7.25 g	TOPICAL	unapproved drug other	10 sections
Jinhwagwangsu Bubble	HUMAN OTC DRUG LABEL	1	69871-001	SOAP	120 mg	TOPICAL	unapproved drug other	7 sections
Obeo Baby Bubble	HUMAN OTC DRUG LABEL	1	69871-002	SOAP	120 mg	TOPICAL	unapproved drug other	7 sections
Jinhwagwangsu Hair	HUMAN OTC DRUG LABEL	1	69871-004	SOAP	12 g	TOPICAL	unapproved drug other	7 sections
ZENOL POWERFULX RECOVERYCREAM	HUMAN OTC DRUG LABEL	1	70042-0001	CREAM	1.50 g	TOPICAL	unapproved drug other	7 sections
RECOVERY	HUMAN OTC DRUG LABEL	1	70042-0002	CREAM	1.50 g	TOPICAL	unapproved drug other	7 sections
Doctor Plus	HUMAN OTC DRUG LABEL	1	70042-6001	CREAM	1.50 g	TOPICAL	unapproved drug other	7 sections
CELLBN FIRST CARE CLEANSER	HUMAN OTC DRUG LABEL	1	71450-0006	CREAM	16 g	TOPICAL	unapproved drug other	7 sections
Anubis Barcelona Spa Line	HUMAN OTC DRUG LABEL	22	83021-305	CREAM	1 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Spa Line	HUMAN OTC DRUG LABEL	22	83021-305	CREAM	1 g	TOPICAL	OTC monograph final	9 sections