cadralazine indications/contra

Stem definitionDrug idCAS RN
antihypertensives, hydrazinephthalazine derivatives 461 64241-34-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cadralazine
  • cadral
  • cadraten
  • cadrilan
  • Molecular weight: 283.33
  • Formula: C12H21N5O3
  • CLOGP: 0.93
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 99.61
  • ALOGS: -2.65
  • ROTB: 8

Drug dosage:

DoseUnitRoute
15 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1988 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC C02DB04 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
Hydrazinophthalazine derivatives
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.34 acidic
pKa2 5.99 Basic
pKa3 3.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Myeloperoxidase Enzyme IC50 5.30 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel WOMBAT-PK

External reference:

scroll-->
IDSource
D01804 KEGG_DRUG
2515 PUBCHEM_CID
010894 NDDF
8T96I3U713 UNII
4670 INN_ID
CHEBI:31331 CHEBI
C031877 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2106561 ChEMBL_ID

Pharmaceutical products:

None