trypan blue Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
4608 72-57-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trypan blue free acid
  • trypan blue
  • trypane blue
  • naphthylamine blue
  • congo blue
A diazo-naphthalene sulfonate that is widely used as a stain.
  • Molecular weight: 872.87
  • Formula: C34H28N6O14S4
  • CLOGP: -2.26
  • LIPINSKI: 3
  • HAC: 20
  • HDO: 8
  • TPSA: 359.42
  • ALOGS: -4.86
  • ROTB: 9

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 2004 FDA DORC

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal oedema 89.57 0 9 2 597 3385251

Pharmacologic Action:

SourceCodeDescription
FDA EPC N0000175536 Diagnostic Dye
FDA MoA N0000175533 Dyes
MeSH PA D004396 Coloring Agents
CHEBI has role CHEBI:37958 dye

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 -1.81 acidic
pKa2 -1.43 acidic
pKa3 -0.91 acidic
pKa4 -0.53 acidic
pKa5 8.76 acidic
pKa6 9.36 acidic
pKa7 3.76 Basic
pKa8 3.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosine-protein phosphatase non-receptor type 1 Enzyme IC50 5.41 CHEMBL
Tyrosine-protein phosphatase 1 Enzyme IC50 5.13 CHEMBL

External reference:

IDSource
4024919 VUID
N0000167386 NUI
C0041213 UMLSCUI
768N7QO4KH UNII
2538-83-2 SECONDARY_CAS_RN
CHEMBL1640 ChEMBL_ID
CHEMBL1089641 ChEMBL_ID
DB09158 DRUGBANK_ID
D014343 MESH_DESCRIPTOR_UI
10878 RXNORM
60441008 SNOMEDCT_US
20134 MMSL
4024919 VANDF
N0000167386 NDFRT
N0000023102 NDFRT
005491 NDDF
417560000 SNOMEDCT_US
9562061 PUBCHEM_CID
CHEBI:78900 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VISIONBLUE HUMAN PRESCRIPTION DRUG LABEL 1 68803-612 INJECTION, SOLUTION 0.30 mg INTRAOCULAR NDA 15 sections
MEMBRANEBLUE HUMAN PRESCRIPTION DRUG LABEL 1 68803-672 INJECTION, SOLUTION 0.75 mg OPHTHALMIC NDA 14 sections