ubidecarenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists	4607	303-98-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: neuquinon ubidecarenone Vitamin Q	prevents hemorrhagic state Molecular weight: 863.37 Formula: C59H90O4 CLOGP: 12 LIPINSKI: 2 HAC: 4 HDO: 0 TPSA: 52.60 ALOGS: -6.65 ROTB: 31

Molecule

Description

Molfile Inchi Smiles

Synonyms:

neuquinon
ubidecarenone
Vitamin Q

prevents hemorrhagic state

Molecular weight: 863.37
Formula: C59H90O4
CLOGP: 12
LIPINSKI: 2
HAC: 4
HDO: 0
TPSA: 52.60
ALOGS: -6.65
ROTB: 31

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle spasticity	430.04	13.36	186	20411	21608	63446817
Ear pain	385.73	13.36	202	20395	35916	63432509
Body temperature increased	343.84	13.36	189	20408	37003	63431422
Respiratory disorder	340.51	13.36	191	20406	38891	63429534
Night sweats	316.26	13.36	197	20400	48617	63419808
Insomnia	167.31	13.36	271	20326	214981	63253444
Back pain	157.69	13.36	296	20301	263849	63204576
Urticaria	150.05	13.36	224	20373	165578	63302847
Sinusitis	147.88	13.36	264	20333	226389	63242036
Peripheral swelling	142.80	13.36	285	20312	265657	63202768

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fatigue	78.17	16.33	232	8299	370421	34577979
Blindness cortical	41.27	16.33	11	8520	382	34948018
Asthenia	32.56	16.33	132	8399	245119	34703281
Full blood count decreased	24.55	16.33	26	8505	18062	34930338
Dysgeusia	24.09	16.33	31	8500	26466	34921934
Constipation	21.63	16.33	78	8453	136904	34811496
Toxicity to various agents	21.57	16.33	11	8520	200351	34748049
Protein total increased	19.42	16.33	10	8521	2277	34946123
Abdominal discomfort	19.19	16.33	44	8487	59791	34888609
Dizziness	18.94	16.33	104	8427	218417	34729983

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle spasticity	204.31	12.58	106	22245	21369	79700668
Ear pain	197.52	12.58	120	22231	32749	79689288
Night sweats	151.86	12.58	122	22229	51973	79670064
Body temperature increased	142.33	12.58	110	22241	44310	79677727
Respiratory disorder	139.20	12.58	109	22242	44747	79677290
Back pain	95.23	12.58	241	22110	303939	79418098
Insomnia	87.11	12.58	204	22147	244966	79477071
Peripheral swelling	80.61	12.58	210	22141	269407	79452630
Asthenia	76.14	12.58	314	22037	511375	79210662
Toxicity to various agents	72.43	12.58	15	22336	421525	79300512

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C01EB09	CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:173084	ferroptosis inhibitors

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Congestive heart failure	indication	42343007	DOID:6000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
003911	NDDF
012958	NDDF
15490	MMSL
194138	MMSL
21406	RXNORM
233517	MMSL
270084	MMSL
33141	MMSL
33199	MMSL
33200	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
IQQU Acne Serum	HUMAN OTC DRUG LABEL	3	50403-226	LOTION	0.00 g	TOPICAL	UNAPPROVED DRUG OTHER	9 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	65121-301	CAPSULE, GELATIN COATED	50 mg	ORAL	unapproved drug other	5 sections
Vita-Rx Diabetic Vitamin	HUMAN PRESCRIPTION DRUG LABEL	14	69677-050	CAPSULE, GELATIN COATED	50 mg	ORAL	unapproved drug other	5 sections
Zyrexal	HUMAN PRESCRIPTION DRUG LABEL	8	72380-915	TABLET	75 mg	ORAL	unapproved drug other	8 sections

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