scopolamine butylbromide indications/contra

Stem definitionDrug idCAS RN
458 7182-53-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • buscopan
  • scopolamine butyl hydroxide
  • scopolamine butylbromide
  • hyoscine butylbromide
  • butylscopolamine
  • butylscopolammonium
  • butylscopolamine bromide
Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.
  • Molecular weight: 360.47
  • Formula: C21H30NO4
  • CLOGP: -0.89
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 59.06
  • ALOGS: -5.29
  • ROTB: 8

Drug dosage:

DoseUnitRoute
60 mg O
60 mg P
60 mg R

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1951 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 63.86 51.50 16 149 15831 3369863
Drug abuse 61.55 51.50 16 149 18314 3367380

Pharmacologic Action:

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SourceCodeDescription
ATC A03BB01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
BELLADONNA AND DERIVATIVES, PLAIN
Belladonna alkaloids, semisynthetic, quaternary ammonium compounds
ATC A03DB04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ANTISPASMODICS IN COMBINATION WITH ANALGESICS
Belladonna and derivatives in combination with analgesics

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Gastric spasm indication 196754001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M4 GPCR WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR WOMBAT-PK

External reference:

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IDSource
C2827093 UMLSCUI
0GH9JX37C8 UNII
149-64-4 SECONDARY_CAS_RN
395739004 SNOMEDCT_US
N0000166994 NDFRT
003459 NDDF
1851 RXNORM
317114008 SNOMEDCT_US
6852391 PUBCHEM_CID
CHEMBL1256901 ChEMBL_ID
D002086 MESH_DESCRIPTOR_UI
CHEMBL1618102 ChEMBL_ID
DB09300 DRUGBANK_ID
CHEBI:32123 CHEBI

Pharmaceutical products:

None