fenbendazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anthelminthics, tiabendazole derivatives 4536 43210-67-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fenbendazole
  • fenbendazol
  • febendazole
  • phenbendasol
Antinematodal benzimidazole used in veterinary medicine.
  • Molecular weight: 299.35
  • Formula: C15H13N3O2S
  • CLOGP: 4.18
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.01
  • ALOGS: -4.69
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P02CA06 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Benzimidazole derivatives
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents
CHEBI has role CHEBI:35444 antinematodal drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Removal and control of lungworm, Dictyocaulus viviparus Indication
Cattle Removal and control of stomach worm (adults) Indication
Cattle Removal and control of brown stomach wormd, Ostertagia ostertagi Indication
Cattle Removal and control of stomach worms (adults and 4th-stage larvae) Indication
Cattle Removal and control of barberpole worms, H placei Indication
Cattle Removal and control of small stomach worms, Trichostrongylus axei Indication
Cattle Removal and control of intestinal worms (adults and 4th-stage larvae) Indication
Cattle Removal and control of hookworm, Bunostomum phlebotomum Indication
Cattle Removal and control of threadnecked intestinal worms, Nematodirus helvetianus Indication
Cattle Removal and control of small intestinal worms, Cooperia punctata Indication
Cattle Removal and control of bankrupt worms, Trichostrongylus colubriformis Indication
Cattle Removal and control of nodular worm, Oesophagostomum radiatum Indication
Cattle Removal and control of barberpole worms, H placei Indication
Cattle Removal and control of small intestinal worms, C oncophora Indication
Goats Removal and control of stomach worms, Haemonchus contortus (adults) Indication
Goats Removal and control of stomach worms, Teladorsagia circumcincta Indication
Horses Control of large strongyles, Strongylus edentatus Indication
Horses Control of small strongyles, Cyathostomum species Indication
Horses Control of pinworms, Oxyuris equi Indication
Horses Control of ascarids (Parascaris equorum) Indication
Horses Control of large strongyles, S equinus Indication
Horses Control of large strongyles, S vulgaris Indication
Horses Control of small strongyles, Cylicocyclus species Indication
Horses Control of small strongyles, Cylicostephanus species Indication
Horses Control of small strongyles, Triodontophorus species Indication

🐶 Veterinary products

ProductApplicantIngredients
Panacur Suspension 10% Intervet Inc. 1
Panacur Granules 22.2% Intervet Inc. 1
panacur, safe-guard Intervet Inc. 1
Panacur C (OTC), Safe-Guard Canine (OTC), Panacur Granules 22.2% (Rx) Intervet Inc. 1
Safe-Guard , Panacur Intervet Inc. 1
Safe-Guard Intervet Inc. 1
Panacur 10% Paste, Safe-Guard Intervet Inc. 1
Safe-Guard Type A Medicated Article Intervet Inc. 1
Safe-Guard Intervet Inc. 1
SAFE-GUARD plus LINCOMIX Intervet Inc. 2
BMD / Safe-Guard Zoetis Inc. 2
Panacur Plus Intervet Inc. 3
Safe-Guard AquaSol Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.61 acidic
pKa2 13.2 acidic
pKa3 3.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mitogen-activated protein kinase 14 Kinase IC50 5.50 DRUG MATRIX
Beta-lactamase 1 Enzyme IC50 5.22 DRUG MATRIX

External reference:

IDSource
D04140 KEGG_DRUG
N0000166935 NUI
CHEBI:77092 CHEBI
CHEMBL37161 ChEMBL_ID
3395 INN_ID
DB11410 DRUGBANK_ID
621BVT9M36 UNII
4325 RXNORM
NOCODE MMSL
013514 NDDF
96134008 SNOMEDCT_US
C0015821 UMLSCUI
D005273 MESH_DESCRIPTOR_UI
3334 PUBCHEM_CID

Pharmaceutical products:

None