butobarbital indications/contra

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 449 77-28-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butobarbitone
  • butobarbital
  • butobarbitural
  • hyperbutal
  • butethal
Butobarbital should be distinguished from Butabarbital (a synonym for Secbutabarbital)
  • Molecular weight: 212.25
  • Formula: C10H16N2O3
  • CLOGP: 1.71
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -2.22
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.15 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N05CA03 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Barbiturates, plain
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Severe anxiety (panic) indication 80583007
Insomnia indication 193462001
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Depressive disorder contraindication 35489007 DOID:2848
Hyperactive behavior contraindication 44548000
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Hepatic coma contraindication 72836002 DOID:12550
Sleep apnea contraindication 73430006 DOID:0050848
Kidney disease contraindication 90708001 DOID:2527
Disease of liver contraindication 235856003 DOID:409
Sleep automatism contraindication 247962006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Respiratory insufficiency contraindication 409623005
Porphyria contraindication 418470004 DOID:13268
Acute exacerbation of asthma contraindication 708038006
General anesthesia off-label use 50697003

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.93 acidic
pKa2 9.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
C0054249 UMLSCUI
D02618 KEGG_DRUG
6473 PUBCHEM_CID
19874 RXNORM
346359007 SNOMEDCT_US
395755006 SNOMEDCT_US
004458 NDDF
CHEMBL404422 ChEMBL_ID
CHEBI:134884 CHEBI
DB01353 DRUGBANK_ID
OHZ8QAW6YC UNII
C027712 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None