taurine indications/contra

Stem definitionDrug idCAS RN
4486 107-35-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • taurine
  • 2-Aminoethanesulfonic acid
  • taurine monopotassium
  • taurine potassium
  • taurine hydrochloride
A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.
  • Molecular weight: 125.14
  • Formula: C2H7NO3S
  • CLOGP: -4.79
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 80.39
  • ALOGS: -0.08
  • ROTB: 2

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Parenteral nutrition associated liver disease 614.79 0 50 16 0 3385793
Death 3.24 0 3 63 152321 3233472

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Nutritional support indication 278906000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.75 acidic
pKa2 9.3 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
2379 IUPHAR_LIGAND_ID
D00047 KEGG_DRUG
4018683 VUID
N0000146994 NUI
C0039350 UMLSCUI
1EQV5MLY3D UNII
6171 INN_ID
CHEMBL239243 ChEMBL_ID
DB01956 DRUGBANK_ID
D013654 MESH_DESCRIPTOR_UI
4018683 VANDF
10944007 SNOMEDCT_US
419158001 SNOMEDCT_US
N0000007100 NDFRT
N0000146994 NDFRT
10337 RXNORM
009160 NDDF
1123 PUBCHEM_CID
CHEBI:15891 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.03 g INTRAVENOUS NDA 12 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.02 g INTRAVENOUS NDA 12 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 12 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 15 mg INTRAVENOUS ANDA 12 sections
PRIMENE HUMAN PRESCRIPTION DRUG LABEL 19 0338-9577 INJECTION, SOLUTION 0.15 g INTRAVENOUS Unapproved drug for use in drug shortage 2 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4178 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 12 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4179 INJECTION, SOLUTION 70 mg INTRAVENOUS NDA 12 sections
Ginsamin Energy HUMAN OTC DRUG LABEL 3 44738-7001 LIQUID 1000 mg ORAL unapproved drug other 1 sections