taurine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4486 107-35-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • taurine
  • 2-Aminoethanesulfonic acid
  • taurine monopotassium
  • taurine potassium
  • taurine hydrochloride
A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.
  • Molecular weight: 125.14
  • Formula: C2H7NO3S
  • CLOGP: -4.79
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 80.39
  • ALOGS: -0.08
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA
Feb. 21, 2019 PMDA TAISHO PHARMACEUTICAL CO., LTD.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Retinogram abnormal 27.55 24.83 4 556 167 63488295

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Retinogram abnormal 46.32 23.72 7 775 346 79743260

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:64589 glycine receptor agonists
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Stroke-like episodes in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) indication 39925003 DOID:3687
Nutritional support indication 278906000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.75 acidic
pKa2 9.3 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00047 KEGG_DRUG
4018683 VUID
N0000146994 NUI
4018683 VANDF
CHEBI:15891 CHEBI
TAU PDB_CHEM_ID
CHEMBL239243 ChEMBL_ID
2379 IUPHAR_LIGAND_ID
6171 INN_ID
DB01956 DRUGBANK_ID
1EQV5MLY3D UNII
10337 RXNORM
009160 NDDF
10944007 SNOMEDCT_US
419158001 SNOMEDCT_US
C0039350 UMLSCUI
D013654 MESH_DESCRIPTOR_UI
1123 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.03 g INTRAVENOUS NDA 23 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.02 g INTRAVENOUS NDA 23 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 15 mg INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 15 mg INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 15 mg INTRAVENOUS ANDA 15 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0409-4178 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 14 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4178 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 13 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4178 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 13 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 70 mg INTRAVENOUS NDA 14 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 70 mg INTRAVENOUS NDA 14 sections
Ginsamin Energy HUMAN OTC DRUG LABEL 5 44738-7001 LIQUID 1000 mg ORAL unapproved drug other 6 sections
LINGTEA HUMAN OTC DRUG LABEL 1 72355-0001 POWDER 1 g ORAL unapproved drug other 6 sections