aclidinium bromide indications/contra

Stem definitionDrug idCAS RN
4484 320345-99-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aclidinium bromide
  • Tudorza Pressair
  • aclidinium
  • LAS 34273
  • LAS W-330
a long-acting, inhaled antimuscarinic; in phase I trial 8/2008
  • Molecular weight: 484.65
  • Formula: C26H30NO4S2
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 55.76
  • ALOGS: -5.53
  • RINGS: 5
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.64 mg Inhal.powder

Approvals:

DateAgencyCompanyOrphan
July 20, 2012 EMA
July 23, 2012 FDA ASTRAZENECA PHARMS

Pharmacologic Action:

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SourceCodeDescription
ATC R03AL05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics
ATC R03BB05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Anticholinergics
FDA EPC N0000175574 Anticholinergic
FDA MoA N0000175370 Cholinergic Antagonists
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:35523 bronchodilator agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Chronic obstructive lung disease indication 13645005 DOID:3083

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 10.15 CHEMBL CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 10.10 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 10.10 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR IC50 9.70 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR IC50 9.80 CHEMBL

External reference:

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IDSource
4031720 VANDF
N0000185730 NDFRT
014614 NDDF
1303097 RXNORM
28687 MMSL
703922001 SNOMEDCT_US
DB08897 DRUGBANK_ID
C542859 MESH_SUPPLEMENTAL_RECORD_UI
D08837 KEGG_DRUG
8544 INN_ID
UQW7UF9N91 UNII
CHEBI:65344 CHEBI
11519741 PUBCHEM_CID
7449 IUPHAR_LIGAND_ID
CHEMBL551466 ChEMBL_ID
CHEMBL1194325 ChEMBL_ID
N0000185730 NUI
C2699758 UMLSCUI
4031720 VUID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Tudorza Pressair HUMAN PRESCRIPTION DRUG LABEL 1 0310-0800 INHALANT 400 ug RESPIRATORY (INHALATION) NDA 17 sections
Tudorza Pressair HUMAN PRESCRIPTION DRUG LABEL 1 0456-0800 INHALANT 400 ug RESPIRATORY (INHALATION) NDA 18 sections